11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis

Blood

Volumn 89, Issue 7, 1997, Pages 2516-2522

  Döhner, Hartmut ^a   Stilgenbauer, Stephan ^b   James, Michael R ^b   Benner, Axel ^b   Weilguni, Traudel ^b   Bentz, Martin ^b   Fischer, Konstanze ^b   Hunstein, Werner ^b   Lichter, Peter ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; B CELL LEUKEMIA; CANCER GROWTH; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; FEMALE; HUMAN; HUMAN CELL; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS;

EID: 1842328565     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.7.2516     Document Type: Article

References (36)

1. Juliusson G, Gahrton G: Chromosome aberrations in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 45:143, 1990
2. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ, Parker AC, Castoldi GL, Cuneo A, Knuutila S, Elonen E, Gahrton G: Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 323:720, 1990
3. Oscier DG: Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia. Blood Rev 8:88, 1994
4. Bosch F, Jares P, Campo E, Lopez-Guilllermo A, Piris MA, Villamor N, Tassies D, Jaffe SE, Montserrat E, Rozman C, Cardesa A: PRAD-1/Cyclin D1 gene overexpression in chronic lymphoproliferative disorders: A highly specific marker of mantle cell lymphoma. Blood 84:2726, 1994
5. Callen DF, Ford JH: Chromosome abnormalities in chronic lymphocytic leukemia revealed by TPA as a mitogen. Cancer Genet Cytogenet 10:87, 1983
6. Pittman S, Catovsky D: Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia. Br J Haematol 58:649, 1984
7. Ross FM, Stockdill G: Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood cultures. Cancer Genet Cytogenet 25:109, 1987
8. Fegan C, Robinson H, Thompson P, Whittaker JA, White D: Karyotypic evolution in CLL. Identification of a new subgroup of patients with deletions of 11q and advanced or progressive disease. Leukemia 9:2003, 1995
9. Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux L, van Hoof A, Verhoef G, Louwagie A, Scheiff JM, Michaux JL, Boogaerts M, van den Berghe H: Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria. Leukemia 9:2140, 1995
10. Johansson B, Mertens F, Mitelman F: Cytogenetic deletion maps of hematologic neoplasms: Circumstantial evidence for tumor suppressor loci. Genes Chromosom Cancer 8:205, 1993
11. Stilgenbauer S, Liebisch P, James MR, Schröder M, Schlegelberger B, Fischer K, Bentz M, Lichter P, Döhner H: Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.2-q23.1 in lymphoproliferative disorders. Proc Natl Acad Sci USA 93:11837, 1996
12. James MR, Richard III CW, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, Agrapart M, Imai T, Nakamura Y, Polymeropoulos M, Weissenbach J, Cox DR, Lathrop GM: A radiation hybrid map of 506 STS markers spanning human chromosome 11. Nat Genet 6:70, 1994
13. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS: Clinical staging of chronic lymphocytic leukemia. Blood 46:219, 1975
14. Joos S, Falk MH, Lichter P, Haluska FG, Henglein B, Lenoir GM, Bornkamm GW: Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8;14) translocation separate c-myc and the IgH locus up to several hundred kb. Hum Molec Genet 1:625, 1992
15. Taniwaki M, Matsuda F, Jauch A, Nishida K, Takashima T, Tagawa S, Sugiyama H, Misawa S, Abe T, Kashima K: Detection of 14q32 translocation in B-cell malignancies by in situ hybridization with yeast artificial chromosome clones containing the human IgH gene locus. Blood 83:2962, 1994
16. Szepetowski P, Perucca-Lostanlen D, Grosgeorge J, Le Paslier D, Brownstein BH, Carle GF, Gaudray P: Description of a 700-kb yeast artificial chromosome contig containing the BCL1 translocation breakpoint region at 11q13. Cytogenet Cell Genet 69:101, 1995
17. Lengauer C, Green ED, Cremer T: Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification. Genomics 13:286, 1992
18. Lichter P, Tang CC, Call K, Hermanson G, Evans GA, Housman D, Ward DC: High resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247:64, 1990
19. Stilgenbauer S, Döhner H, Bulgay-Mörschel M, Weitz S, Bentz M, Lichter P: High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood 81:2118, 1993
20. Döhner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, Diehl D, Schlenk R, Coy J, Stilgenbauer S, Volkmann M, Galle PR, Poustka A, Hunstein W, Lichter P: p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 85:1580, 1995
21. Kalbfleisch JD, Prentice RL: The Statistical Analysis of Failure Time Data. New York, NY, Wiley, 1980
22. Cox DR: Regression models and life tables (with discussion). J Roy Stat Soc B 34:187, 1972
23. Harrell FE: Design: S-Plus functions for biostatistical/epidemiologic modelling, testing, estimation, validation, graphics, prediction and typesetting by storing enhanced model design attributes in the fit. Programs available from statlib@lib.stat.cmu.edu. Send E-mail "send design from S," Durham, NC, Division of Biometry, Duke University Medical Center, 1994
24. Stilgenbauer S, Leupolt E, Ohl S, Weiß G, Schröder M, Fischer K, Bentz M, Lichter P, Döhner H: Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by FISH. Cancer Res 55:3475, 1995
25. Döhner H, Pohl S, Bulgay-Mörschel M, Stilgenbauer S, Bentz M, Lichter P: Detection of trisomy 12 in chronic lymphoid leukemias using fluorescence in situ hybridization. Leukemia 7:516, 1993
26. Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM: Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 224:1403, 1984
27. Rosenberg CL, Wong E, Petty EM, Bale AE, Tsujimoto Y, Harris NL, Arnold A: PRAD1, a candidate BCL1 oncogene: Mapping and expression in centrocytic lymphoma. Proc Natl Acad Sci USA 88:9638, 1991
28. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA, Chaganti RSK, Larson RA, Le Beau MM, Diaz MO, Rowley JD: Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 329:909, 1993
29. Akao Y, Seto M, Takahashi T, Kubonishi I, Miyoshi I, Nakazawa S, Tsujimoto Y, Croce CM, Ueda R: Molecular cloning of the chromosomal breakpoint of a B-cell lymphoma with the t(11;14) (q23;q32) translocation. Cancer Res 51:1574, 1991
30. Meerabux J, Yaspo ML, Roebroek AJ, Van de Ven WJM, Lister TA, Young BD: A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas. Cancer Res 56:448, 1996
31. Galiègue-Zouitina S, Quiet S, Hildebrand MP, Denis C, Lec-ocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJS, Kerckaert JP: The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3:11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231). Leukemia 10:579, 1996
32. Anastasi J, Le Beau MM, Vardiman JW, Fernald AA, Larson RA, Rowley JD: Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: A simple and sensitive method. Blood 79:1796, 1992
33. Que TH, Garcia Marco J, Ellis J, Matutes E, Brito-Babapulle V, Boyle S, Catovsky D: Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Analysis by stage, immunophenotype, and morphology. Blood 82:571, 1993
34. Bentz M, Huck K, du Manoir S, Joos S, Fischer K, Döhner H, Lichter P: Comparative genomic hybridization in chronic B-cell leukemias reveals a high incidence of chromosomal gains and losses. Blood 85:3610, 1995
35. De Rossi G, Mandelli F, Covelli A, Luciani M, Martelli M, Resegotti L, Alberti A, Cajozzo A, Deriu L, De Biasi R, Broccia G, Abbadessa A, Caronia F, Leone P: Chronic lymphocytic leukemia (CLL) in younger adults: A retrospective study of 133 cases. Hematol Oncol 7:127, 1989
36. Montserrat E, Gomis F, Vallespi T, Ríos A, Romero A, Soler J, Alcalá A, Morey M, Ferrán C, Díaz-Mediavilla J, Flores A, Woessner S, Batlle J, González-Aza C, Rovira M, Reverter JC, Rozman C: Presenting features and prognosis of chronic lymphocytic leukemia in younger adults. Blood 78:1545, 1991