Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats

Biomedicine and Pharmacotherapy

Volumn 87, Issue , 2017, Pages 437-442

  Famurewa, Ademola C ^a   Ufebe, Odomero G ^a   Egedigwe, Chima A ^a   Nwankwo, Onyebuchi E ^b   Obaje, Godwin S ^a  

^a ALEX EKWUEME FEDERAL UNIVERSITY NDUFU ALIKE   (Nigeria)

^b EBONYI STATE UNIVERSITY   (Nigeria)

Author keywords

Chemotherapy; Hepatotoxicity; Lipid peroxidation; Methotrexate; Oxidative stress; Virgin coconut oil

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATALASE; COCONUT OIL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIVER PROTECTIVE AGENT; MALONALDEHYDE; METHOTREXATE; PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VIRGIN COCONUT OIL; ANTINEOPLASTIC AGENT; VEGETABLE OIL;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DIET SUPPLEMENTATION; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; DIAGNOSTIC IMAGING; DIETARY SUPPLEMENT; DRUG EFFECTS; LIPID PEROXIDATION; LIVER; METABOLISM; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CATALASE; COCONUT OIL; DIETARY SUPPLEMENTS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; LIVER; MALE; MALONDIALDEHYDE; METHOTREXATE; OXIDATIVE STRESS; PLANT OILS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 85008354775     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.12.123     Document Type: Article

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