The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: Protective effect of caffeic acid phenethyl ester

Molecular and Cellular Biochemistry

Volumn 291, Issue 1-2, 2006, Pages 63-68

  Uzar, Ertugrul ^a   Koyuncuoglu, Hasan Rifat ^a   Uz, Efkan ^a   Yilmaz, H Ramazan ^a   Kutluhan, Suleyman ^a   Kilbas, Serkan ^a   Gultekin, Fatih ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Caffeic acid phenethyl ester; Catalase; Cerebellum; Malondialdehyde; Methotrexate; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; CAFFEIC ACID PHENETHYL ESTER; CATALASE; MALONALDEHYDE; METHOTREXATE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTIOXIDANTS; CAFFEIC ACIDS; CATALASE; CEREBELLUM; MALE; MALONDIALDEHYDE; METHOTREXATE; PHENYLETHYL ALCOHOL; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 33750911068     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9196-5     Document Type: Article

References (42)

1. Mahoney DH Jr, Shuster JJ, Nitschke R, Lauer SJ, Steuber CP, Winick N, Camitta B: Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: An association with intermediate-dose intravenous methotrexate and intrathecal triple therapy: A Pediatric Oncology Group study. J Clin Oncol 16: 1712-1722, 1998
2. Linnebank M, Pels H, Kleczar N, Farmand S, Fliessbach K, Urbach H, Orlopp K, Klockgether T, Schmidt-Wolf IG, Schlegel U: MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. Neurology 64: 912-913, 2005
3. Brock S, Jenning HR: Fatal encephalomyelitis after a single dose of intrathecal methotrexate. Pharmacotherapy 24: 673-676, 2004
4. Uzar E, Sahin O, Koyuncuoglu HR, Uz E, Bas O, Kilbas S, Yilmaz HR, Yurekli VA, Kucuker H, Songur A: The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: Protective effect of caffeic acid phenethyl ester. Toxicology 218(2/3): 125-133, 2006
5. Lesnik PG, Ciesielski KT, Hart BL, Benzel EC, Sanders JA: Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: Enhanced data analysis using an effect size model. Arch Neurol 55: 1561-1568, 1998
6. El-Badawi MG, Fatani JA, Bahakim H, Abdalla MA: Light and electron microscopic observations on the cerebellum of guinea pigs following low-dose methotrexate. Exp Mol Pathol 53: 211-222, 1990
7. Gilbert MR, Harding BL, Grossman SA: Methotrexate neurotoxicity: In vitro studies using cerebellar explants from rats. Cancer Res 49: 2502-2505, 1989
8. Vezmar S, Becker A, Bode U, Jaehde U: Biochemical and clinical aspects of methotrexate neurotoxicity. Chemotherapy 49: 92-104, 2003
9. Kishi S, Griener J, Cheng C, Das S, Cook EH, Pei D, Hudson M, Rubnitz J, Sandlund JT, Pui CH, Relling MV: Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 21: 3084-3091, 2003
10. Quinn CT, Griener JC, Bottiglieri T, Arning E, Winick NJ: Effects of intraventricular methotrexate on folate, adenosine and homocysteine metabolism in cerebrospinal fluid. J Pediatr Hematol Oncol 26: 386-388, 2004
11. Kishi T, Tanaka Y, Ueda K: Evidence for hypomethylation in two children with acute lymphoblastic leukemia and leukoencephalopathy. Cancer 89: 925-931, 2000
12. Caro AA, Cederbaum AI: Antioxidant properties of S-adenosyl-sc l-methionine in Fe (2+)-initiated oxidations. Free Radic Biol Med 36, 1303-1316, 2004
13. Villalobos MA, De La Cruz JP, Cuerda MA, Ortiz P, Smith-Agreda JM, Sanchez De La Cuesta F: Effect of S-adenosyl methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion. Brain Res 883: 31-40, 2000
14. Frouin I, Prosperi E, Denegri M, Negri C, Donzelli M, Rossi L, Riva F, Stefanini M, Scovassi AI: Different effects of methotrexate on DNA mismatch repair proficient and deficient cells. Eur J Cancer 37(9): 1173-1180, 2001
15. Neuman MG, Cameron RG, Haber JA, Katz GG, Malkewcz IM, Shear NH: Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatotoxicity. Clin Biochem 32: 519-536, 1999
16. Miketova P, Kaemingk K, Hockenberry M, Pasvogel A, Hutter J, Krull K, Moore IM: Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia. Biol Res Nurs 6: 187-195, 2005
17. Husain K, Morris C, Whitworth C, Trammell GL, Rybak LP, Somani SM: Protection by ebselen against cisplatin-induced nephrotoxicity: Antioxidant system. Mol Cell Biochem 178: 127-133, 1998
18. Uz E, Oktem F, Yilmaz HR, Uzar E, Ozguner F: The activities of purine-catabolizing enzymes and the level of nitric oxid e in rat kidneys subjected to methotrexate: Protective effect of caffeic acid phenethyl ester. Mol Cell Biochem 277(1/2): 165-170, 2005
19. Oktem F, Ozguner F, Sulak O, Olgar, S. Akturk O, Yilmaz HR, Altuntas I: Lithium-induced renal toxicity in rats: Protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem 277: 109-115, 2005
20. Musavi S, Kakkar P: Effect of diazepam treatment and its withdrawal on pro/antioxidative processes in rat brain. Mol Cell Biochem 245: 51-56, 2003
21. Cicek E, Sutcu R, Gokalp O, Yilmaz HR, Ozer MK, Uz E, Ozcelik N, Delibas N: The effects of isoniazid on hippocampal NMDA receptors: Protective role of erdosteine. Mol Cell Biochem 277: 131-135, 2005
22. Cetiner M, Sener G, Sehirli AO, Eksioglu-Demiralp E, Ercan F, Sirvanci S, Gedik N, Akpolat S, Tecimer T, Yegen BC: Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol Appl Pharmacol 209(1): 39-50, 2005
23. Miyazono Y, Gao F, Horie T: Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol 39: 1119-1127, 2004
24. Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G: Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 34: 282-287, 2003
25. Babiak RM, Campello AP, Carnieri EG, Oliveira MB: Methotrexate: Pentose cycle and oxidative stress. Cell Biochem Funct 16: 283-293, 1998
26. Ilhan A, Koltuksuz U, Ozen S, Uz E, Ciralik H, Akyol O: The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia reperfusion injury in rabbits. Eur J Cardiothorac Surg 16: 458-463, 1999
27. Ilhan A, Iraz M, Gurel A, Armutcu F, Akyol O: Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice. Neurochem Res 29: 2287-2292, 2004
28. Ozguner F, Oktem F, Armagan A, Yilmaz R, Koyu A, Demirel R, Vural H, Uz E: Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. Mol Cell Biochem 276: 31-37, 2005
29. Ozguner F, Bardak Y, Comlekci S: Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: A comparative study. Mol Cell Biochem 282: 83-88, 2006
30. Park EH, Kahng JH: Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res 22: 554-558, 1999
31. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ: Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59: 2347-2352, 1999
32. Chen YJ, Shiao MS, Wang SY: The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs 12: 143-149, 2001
33. Fesen MR, Pommier Y, Leteurtre E, Hiroguchi S, Yung J, Kohn KW: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 48: 595-608, 1994
34. Noelker C, Bacher M, Gocke P, Wei X, Klockgether T, Du Y, Dodel R: The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity. Neurosci Lett 383: 239-243, 2005
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Clin Chem 193: 265-75, 1951
36. Draper HH, Hadley M: Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186: 421-431, 1990
37. Sun Y, Oberley LW, Li Y: A simple method for clinical assay of superoxide dismutase. Clin Chem 34: 497-500, 1988
38. Aebi H: Catalase in vitro. Methods Enzymol 105: 121-126, 1984
39. Krokower GR, Kamen BA: In situ methotrexate polyglutamate formation in rat tissues. J Pharmacol Exp Ther 227: 633-638, 1983
40. Irmak MK, Fadillioglu E, Sogut S, Erdogan H, Gulec M, Ozer M, Yagmurca M, Gozukara ME: Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain. Cell Biochem Funct 21: 283-289, 2003
41. Yilmaz HR, Uz E, Yucel N, Altuntas I, Ozcelik N: Protective effect of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxicol 18: 234-238, 2004
42. Yagmurca M, Erdogan H, Iraz M, Songur A, Ucar M, Fadillioglu E: Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clin Chim Acta 348: 27-34, 2004