Potent protective effect of apricot and β-carotene on methotrexate-induced intestinal oxidative damage in rats

Food and Chemical Toxicology

Volumn 46, Issue 9, 2008, Pages 3015-3022

  Vardi, Nigar ^a   Parlakpinar, Hakan ^a   Ozturk, Feral ^a   Ates, Burhan ^a   Gul, Mehmet ^a   Cetin, Asli ^a   Erdogan, Ali ^a   Otlu, Ali ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Carotene; Apricot; Methotrexate; Oxidative damage

Indexed keywords

BETA CAROTENE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHOTREXATE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APRICOT; ARTICLE; CELL DAMAGE; CELL INFILTRATION; CONTROLLED STUDY; DESQUAMATION; ENZYME ACTIVITY; FOOD INTAKE; GOBLET CELL; INFLAMMATORY CELL; INTESTINE INJURY; INTESTINE VILLUS; LAMINA PROPRIA; MALE; MICROVILLUS; NONHUMAN; OXIDATIVE STRESS; RAT; SINGLE DRUG DOSE;

ANIMALS; BETA CAROTENE; CATALASE; FOLIC ACID ANTAGONISTS; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTESTINES; LIPID PEROXIDATION; MALE; METHOTREXATE; MICROSCOPY, ELECTRON; OXIDATIVE STRESS; PEROXIDASE; PHENOLS; PICRATES; PLANT EXTRACTS; PROTECTIVE AGENTS; PRUNUS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

PRUNUS ARMENIACA; RATTUS;

EID: 50249176999     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.05.039     Document Type: Article

References (46)

1. Atessahin A., Ceribasi{dotless} A.O., and Yi{dotless}lmaz S. Lycopene, a carotenoids, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats. Clin. Pharmacol. Toxicol. 100 (2007) 372-376
2. Babiak R.M.V., Campello A.P., Carnieri E.G.S., and Oliveira M.B.M. Methotrexate: pentose cycle and oxidative stress. Cell Biochem. Funct. 16 (1998) 283-293
3. Bayram M., Ozogul C., Dursun A., Ercan Z.S., Isik I., and Dilekoz E. Light and electron microscope examination of the effects of methotrexate on the endosalpinx. Eur. J. Obstet. Gynecol. Reprod. Biol. 120 (2005) 96-103
4. Broekmans W.M.R., Klöpping-Ketelaars I.A.A., Schuurman C.R.W.C., Verhagen H., Berg H.D., Kok F.J., and Poppel G. Fruits and vegetables plasma carotenoids and vitamins and decrease homocysteine in humans. J. Nutr. 130 (2000) 1578-1583
5. Buege A.J., and Aust S.D. Microsomal lipid peroxidation. Meth. Enzymol. 52 (1978) 302-310
6. De Koning B.A.E., Der Sluis M.V., Lindenbergh-Kortleve D.J., Velcich A., Pietres R., Büller H.A., Einerhand A.W.C., and Renes I.B. Methotrexate-induced mucositis in mucin 2-deficient mice. J. Cell Physiol. 210 (2007) 144-152
7. Durmaz G., and Alpaslan M. Antioxidant properties of roasted apricot (Prunus armeniaca L.) kernel. Food Chem. 100 3 (2007) 1177-1181
8. Eastwood M.A. Interaction of diertary antioxidants in vivo: how fruit and vegetables prevent disease. Q. J. Med. 92 (1999) 527-530
9. Edge R., McGarvey D.J., and Truscott T.G. The carotenoids as anti-oxidants - a review. J. Photochem. Photobiol. B 41 (1997) 189-200
10. El-Demerdash F.M., Yousef M.I., Kedwany F.S., and Baghdadi H.H. Cadmium-induced changes in lipid peroxidation, blood hemotology, biochemical parameters and semen quality of male rats: protective role of vitamins E and β-carotene. Food Chem. Toxicol. 42 (2004) 1563-1571
11. 1 prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats. Life Sci. 71 9 (2002) 1091-1099
12. Gao F., Tomitori H., Igarashi K., and Horie T. Correlation between methotrexate-induced intestinal damage and decrease in polyamine content. Life Sci. 72 (2002) 669-676
13. Gerber M. The comprehensive approach to diet: a critical review. J. Nutr. 131 (2001) 3051S-3055S
14. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J. Natl. Cancer Inst. 91 (1999) 317-331
15. Hillegass L.M., Griswold D.E., Brickson B., and Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J. Pharmacol. Meth. 24 (1990) 285-295
16. Howard L.R., Pandjaitan N., Morelock T., and Gil M.I. Antioxidant capacity and phenolic content of as affected by genetics and growing season. J. Agric. Food Chem. 50 (2002) 5891-5896
17. Ikediobi C.O., Badisa V.L., Ayuk-Takem L.T., Latinwo L.M., and West J. Response of antioxidant enzymes and redox metobolites to cadmium-induced oxidative stress in CRL-1439 normal liver cells. Int. J. Mol. Med. 14 (2004) 87-92
18. Johovic N., Cevik H., Sehirli O.A., Yegen B.C., and Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J. Pineal. Res. 34 (2003) 282-287
19. Johovic N., Sener G., Cevik H., Ersoy Y., and Arbak S. Amelioration of methotrexate-induced enteritis by melatonin in rats. Cell Biochem. Funct. 22 (2004) 169-178
20. Jolivet J., Cowan K.H., Curt G.A., Clendeninn N.J., and Chabner B.A. The pharmacology and clinical use of methotrexate. N. Engl. J. Med. 309 (1983) 1094-1104
21. Kosakai Y., Horie T., and Awazu S. Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells. Pharmacol. Toxicol. 69 (1991) 291-295
22. Lawrance R.A., and Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71 (1976) 952-958
23. Lowry O., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurements with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
24. Luck H. Methods of Enzymatic Analysis (1963), Verlag Chemie, Academic Press, New York, USA pp. 885-888
25. Matos H.R., Marques S.A., Gomes O.F., Silva A.A., Heimann J.C., Di Mascio P., and Medeiros M.H.G. Lycopene and β-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Braz. J. Med. Biol. Res. 39 (2006) 203-210
26. Middleton E., Kadaswami C., and Theoharides T. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Res. 52 (2000) 673-751
27. Miyazono Y., Gao F., and Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand. J. Gastroenterol. 39 (2004) 1119-1127
28. Naik S.R., and Panda V.S. Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Liver Int. 27 (2007) 393-399
29. Neuman M.G., Cameron R.G., Haber J.A., Katz G.G., Malkewez I.M., and Shear N.H. Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatotoxicity. Clin. Biochem. 32 (1999) 519-536
30. Pietta P.G. Flavonoids as antioxidants. J. Natl. Prod. 63 (2000) 1035-1042
31. Ramos S., Alia M., Bravo L., and Goya L. Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (Hep G). J. Agric. Food Chem. 53 (2005) 1271-1280
32. Ruiz D., Egea J., Gil M.I., and Barberan F.A.T. Characterization and quantitation of phenolic compounds in new apricot (Prunus armeniaca L.) varieties. J. Agric. Food Chem. 53 (2005) 9544-9552
33. Ruiz D., Egea J., Tomas-Barberan F.A., and Gil M.I. Characterization from apricot (Prunus armeniaca L.) varieties and their relationship with flesh and skin color. J. Agric. Food Chem. 53 (2005) 6368-6374
34. Sener G., Demiralp E.E., Cetiner M., Ercan F., Sirvanci{dotless} S., Gedik N., and Yegen B.C. L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol. Toxicol. 22 (2006) 47-60
35. Sergio A.R., and Russel R.M. β-Carotene and other carotenoids as antioxidants. J. Am. Coll. Nutr. 18 5 (1999) 426-433
36. Shimada K., Fujikawa K., Yahara K., and Nakamura T. Antioxidative properties of xantan on the autoxidation of soybean oil in cyclodextrin emulsion. J. Agric. Food Chem. 40 (1992) 945-948
37. Stahl W., and Sies H. Antioxidant activity of carotenoids. Mol. Aspects Med. 24 6 (2003) 345-351
38. Sullivan G.W., Sarembock I.J., and Linden J. The role of inflammation in vascular diseases. J. Leukoc. Biol. 67 (2000) 591-602
39. Sun Y., Oberley L.W., and Li Y.A. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34 (1988) 497-500
40. Theodorus P., Akerboom M., and Sies H. Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples. Meth. Enzymol. 77 (1981) 373-383
41. Uzar E., Koyuncuoglu H.R., Uz E., Yilmaz H.R., Kutluhan S., Kilbas S., and Gultekin F. The activities of antioxidant enzymes and the level malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenetyl ester. Mol. Cell Biochem. 291 (2006) 63-68
42. Verburg M., Renes I.B., Meijer H.P., Taminiau J.A.J.M., Büller H.A., Einerhand A.W.C., and Dekker J. Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats. Am. J. Physiol. Gastrointest Liver Physiol. 279 (2000) 1037-1047
43. Xian C.J., Howarth G.S., Mardell C.E., Cool J.C., Familari M., Read L.C., and Giraud A.S. Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced dage and repair. Am. J. Physiol. 277 (1999) 785-795
44. Young A.J., and Lowe G.M. Antioxidant and prooxidant properties of carotenoids. Arch Biochem. Biophys. 385 (2001) 20-27
45. Yuncu M., Eralp A., and Celik A. Effects of aged garlic extract against methotrexate-induced damage to the small intestine in rats. Phytother. Res. 20 (2006) 504-510
46. Zhao W., Han Y., Zhao B., Hirota S., Hou J., and Xin W. Effect of carotenoids on the respiratory burst of rat peritoneal macrophages. Biochim. Biophys. Acta. 1381 (1998) 77-88