Protective effect of β-carotene on methotrexate-induced oxidative liver damage

Toxicologic Pathology

Volumn 38, Issue 4, 2010, Pages 592-597

  Vardi, Nigar ^a   Parlakpinar, Hakan ^a   Cetin, Asli ^a   Erdogan, Ali ^a   Ozturk, I Cetin ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

carotene; Antioxidants; Liver; Methotrexate; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA CAROTENE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHOTREXATE; SUPEROXIDE DISMUTASE; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; CYTOCHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIPID PEROXIDATION; LIVER; METABOLISM; MICROSCOPY; NONPARAMETRIC TEST; PATHOLOGY; TOXICITY; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BETA CAROTENE; DRUG-INDUCED LIVER INJURY; GLUTATHIONE PEROXIDASE; HISTOCYTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MALONDIALDEHYDE; METHOTREXATE; MICROSCOPY; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 77953672605     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310367806     Document Type: Article

References (30)

1. Babiak, R.M.V., Campello, A.P., Carnieri, E.G.S., and Oliveira, M.B.M. (1998). Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct 16, 283-293.
2. Bast, A., Haenen, G.R., and Van den Berg, H. (1998). Antioxidant effects of carotenoids. Int Vitam Nutr Res 68, 399-403.
3. Bayram, M., Ozogul, C., Dursun, A., Ercan, Z.S., Isik, I., and Dilekoz, E. (2005). Ligth and electron microscope examination of the effects of methotrexate on the endosalpinx. European Journal of Obstetrics & Gynecology and Reproductive Biology 120, 96-103.
4. Berryman, A.M., Maritim, A.C., Sanders, R.A., and Watkins, J.B. (2004). Influence of treatment of diabetic rats with combinations of pycnogenol, β-carotene, and alfa-lipoic acid on parameters of oxidative stress. J Biochem Molecular Toxicology 18, 345-352.
5. Buege, A.J., and Aust, S.D. (1978). Microsomal lipid peroxidation. Methods in Enzymology 52, 302-310.
6. Cetin, A., Kaynar, L., Kocyigit, I., Hacioglu, S.K., Saraymen, R., Ozturk, A., Sari, I., and Sagdic, O. (2008). Role of grape seed extract on methotrexate induced oxidative stres in rat liver. American Journal of Chinese Medicine 36, 1-12.
7. Cetinkaya, A., Bulbuloglu, E., Kurutas, E.B., and Kantarceken, B. (2006). N-acetylcycteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit 12, 274-278.
8. El-Demerdash, F.M., Yousef, M.I., Kedwany, F.S., and Baghdadi, H.H. (2004). Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food and Chemical Toxicology 42, 1563-1571.
9. Johovic, N., Cevik, H., Sehirli, O.A., Yegen, B.Ş., and Åžener, G. (2003). Melatonin prevents methotrexate- induced hepatorenal oxidative injury in rats. Journal of Pineal Research 34, 282-287.
10. Keen, C.L., Holt, R.R., Oteiza, P.I., Fraga, C.G., and Schmitz, H.H. (2005). Cocoa antioxidants and cardiovascular health. Am J Clin Nutr 81, 298-303.
11. Kheir-Eldin, A.A., Motawi, T.K., Gad, M.Z., and Abd-ElGawad, H.M. (2001). Protective effect of vitamin E, β-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharide. International Journal of Biochemistry & Cell Biology 33, 475-482.
12. Kim, J.C., Kim, K.H., and Chung, M.K. (1999). Testicular cytotoxicity of DA-125, a new anthracycline anticancer agent, in rats. Reprod Toxicol 13, 391-397.
13. Kuvandik, G., Duru, M., Nacar, A., Yoden, Z., Helvaci, R., Koc, A., Kozlu, T., Kaya, H., and Sogüt, S. (2008). Effects of erdostein on acetaminophen-induced hepatotoxicity in rats. Toxicol Pathol 36, 714-719.
14. Lawrance, R.A., and Burk, R.F. (1976). Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71, 952-958.
15. Lowry, O., Rosenbrough, N.J., Farr, A.L., and Randall, R.J. (1951). Protein measurements with the Folin phenol reagent. J Bio Chem 193, 265-275.
16. Luck, H. (1963). Methods of Enzymatic Analysis. Verlag Chemie, Academic Press, New York.
17. Matos, H.R., Marques, S.A., Gomes, O.F., Silva, A.A., Heimann, J.C., Di Mascio, P., and Medeiros, M.H. (2006). Lycopene and β-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Brazilian Journal of Medical and Biological Research 39, 203-210.
18. Prahalathan, C., Selvakumar, E., and Varalakshmi, P. (2005). Protective effect of lipoic acid on adriamycin- induced testicular toxicity. Clinica Chimica Acta 360, 160-166.
19. Ramos, S., Alia, M., Bravo, L., and Goya, L. (2005). Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (Hep G). J Agric Food Chem 53, 1271-1280.
20. Sergio, A.R., and Russel, R.M. (1999). β-carotene and other carotenoids as antioxidants. Journal of the American College of Nutrition 18, 426-433.
21. Stahl, W., and Sies, H. (2003). Antioxidant activity of carotenoids. Mol Aspects Med 24, 345-351.
22. Sugiura, M., Nakamura, M., Ikoma, Y., Yano, M., Ogawa, K., Matsumoto, H., Kato, M., Ohshima, M., and Nagao, A. (2006). Serum carotenoid concentrations are inversely associated with serum amino-transferases in hyperglycemic subjects. Diabetes Res Clin Pract 71, 82-91.
23. Sun, Y., Oberley, L.W., Li, Y.A. (1988). A simple method for clinical assay of superoxide dismutase. Clin Chem 34, 497-500.
24. Åžener, G., Demiralp, E.E., Cetiner, M., Ercan, F., Åžirvanci, S., Gedik, N., and Yegen, B.Ş. (2006 a). L-carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol 22, 47-60.
25. Åžener, G., Demiralp, E.E., Şetiner, M., Ercan, F., and Yegen, B.Ş. (2006 b). β-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects. European Journal of Pharmacology 542, 170-178.
26. Tsurusawa, M., Saeki, K., and Fujimoto, T. (1997). Differential induction of apoptosis on human lymphoblastic leukemia Nalm-6 and Molt-4 cells by various antitumor drugs. Int J Hematol 66, 79-88.
27. Uraz, S., Tahan, V., Aygun, C., Eren, F., Unluguzel, G., Yuksel, M., Senturk, O., Avsar, E., Haklar, G., Celikel, C., Hulagu, S., and Tozun, N. (2008). Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci 53, 1071-1077.
28. Vardi, N., Parlakpinar, H., Ates, B., Cetin, A., and Otlu, A. (2009). Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury. Fertil Steri 92, 2028-2033.
29. Vardi, N., Parlakpinar, H., Ozturk, F., Ates, B., Gul, M., Cetin, A., Erdogan, A., and Otlu, A. (2008). Potent protective effect of apricot and β-carotene on methotrexate induced intestinal oxidative damage in rats. Food and Chemical Toxicology 46, 3015-3022.
30. West, S.G. (1997). Methotrexate hepatoxicity. Rheum Dis Clin North Am 23, 883-915.