In vivo antinociceptive and anti-inflammatory activities of dried and fermented processed virgin coconut oil

Medical Principles and Practice

Volumn 20, Issue 3, 2011, Pages 231-236

  Zakaria, Z A ^a,b   Somchit, M N ^a   Mat Jais, A M ^a   Teh, L K ^b   Salleh, M Z ^b   Long, K ^c  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c Biotechnology Research Centre   (Malaysia)

Author keywords

Anti inflammatory activity; Antinociceptive activity; Virgin coconut oil

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; COCONUT OIL; MORPHINE; UNCLASSIFIED DRUG; VIRGIN COCONUT OIL A; VIRGIN COCONUT OIL B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DILUTION; DOSE RESPONSE; DRUG DECOMPOSITION; DRUG SYNTHESIS; GRANULOMATOUS INFLAMMATION; HOT PLATE TEST; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; WRITHING TEST;

ABDOMEN; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; EDEMA; GRANULOMA; MALAYSIA; MALE; MICE; MICE, INBRED BALB C; MUSCLE CONTRACTION; PAIN; PAIN MEASUREMENT; PHYTOTHERAPY; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79953660215     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323756     Document Type: Article

References (21)

1. Zakaria ZA, Reezal I, Mat Jais AM, Marmin AHI, Sidek H, Husin SH, Rahim MHA, Sabtu L, Somchit MN, Sulaiman MR: The antiinflammatory, antipyretic and wound healing activities of Cocos nucifera (MATAG Types) fresh juice and kernel extracts in experimental animals. J Pharmacol Toxicol 2006; 1: 516-526.
2. Marina AM, Che Man YB, Nazimah AH: Chemical properties of virgin coconut oil. J Am Oil Chem Soc 2009; 86: 301-307.
3. Nevin KG, Rajamohan T: Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin Biochem 2004; 37: 830-835. (Pubitemid 39141127)
4. Nevn KG, Rajamohan T: Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague-Dawley rats. Eur J Clin Nutr Metab 2008; 3: 1-8.
5. Nevin KG, Rajamohan T: Virgin coconut oil supplemented diet increases the antioxidant status in rats. Food Chem 2006; 99: 260-266.
6. Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-110. (Pubitemid 13058546)
7. Zakaria ZA, Raden Mohd Nor RNS, Hanan Kumar G, Abdul Ghani ZDF, Sulaiman MR, Rathna Devi G, Mat Jais AM, Somchit MN, Fatimah CA: Antinociceptive, anti-inflammatory and anti-pyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Can J Physiol Pharmacol 2006; 84: 1291-1299. (Pubitemid 46707378)
8. Zakaria ZA, Hanan Kumar G, Zainal H, Mohd Pojan NH, Morsid NA, Aris A, Sulaiman MR: Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. Yakugaku Zasshi 2006; 126: 1171-1178.
9. Zakaria ZA, Hanan Kumar G, Raden Mohd Nor RNS, Sulaiman MR, Fatimah CA, Mat Jais AM, Somchit MN, Ismail MS: Antinociceptive, anti-inflammatory and antipyretic properties of Corchorus capsularis leaves aqueous extract in experimental animal models. Pharm Biol 2009; 47: 104-110.
10. Zakaria ZA, Sulaiman MR, Hanan Kumar G, Abdul Ghani ZDF, Raden Mohd Nor RNS, Rathna Devi G, Mat Jais AM, Fatimah CA: Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models. Yakugaku Zasshi 2007; 127: 359-365.
11. Sulaiman MR, Zakaria ZA, Chiong HS, Lai SK, Israf DA, Tg Azam Shah TM: Antinociceptive and anti-inflammatory effects of Stachytarpheta jamaicensis (L.) Vahl. ( Verbenaceae ) in experimental animal models. Med Princ Pract 2009; 18: 272-279.
12. Bentley GA, Newton SH, Starr J: Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum. Br J Pharmacol 1981; 73: 325-332. (Pubitemid 11112381)
13. Pini LA, Vitale G, Ottani A, Sandrini M: Naloxone-reversible antinociception by paracetamol in the rat. J Pharmacol Exp Ther 1997; 280: 934-940. (Pubitemid 27171358)
14. Zakaria ZA, Hanan Kumar G, Mat Jais AM, Sulaiman MR, Somchit MN: Antinociceptive, anti-inflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. Methods Find Exp Clin Pharmacol 2008; 30: 355-362.
15. Winter CA, Risley EA, Nuss GW: Carrageenan- induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962; 111: 544-547.
16. Kahn MA, Solomon LW: Acute Inflammation/ Wound Healing and Repair II. http:// ocw.tufts.edu/data/51/551543.pdf. 2007.
17. Dos Santos MD, Almeida MC, Lopes NP, de Souza GEP: Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 2006; 29: 2236-2240. (Pubitemid 44690948)
18. Küpeli E, Pinar SF, Ihsan C, Yesilada E, Ezer N: Phenolic compounds of Sideritis ozturkii and their in vivo anti-inflammatory and antinociceptive activities. J Ethnopharmacol 2007; 112: 356-360. (Pubitemid 46756079)
19. Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB: Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 1996; 93: 9090-9095. (Pubitemid 26282023)
20. Zakaria ZA, Ahmad Z, Somchit MN, Arifah AK, Sulaiman MR, Teh LK, Salleh MZ, Long K: Antihypercholesterolemia property and fatty acid composition of MARDI-produced virgin coconut oils. Afr J Pharm Pharmacol 2010;4:636-644.
21. Zakaria ZA, Sulaiman MR, Goh YM, Mat Jais AM, Somchit MN: Determination of the amino acid and fatty acid compositions of the aqueous extract of Channa striatus (Haruan) that exhibits antinociceptive activity. Clin Exp Pharmacol Physiol 2007; 34: 198-204. (Pubitemid 46148262)