A critical role for the type i interferon receptor in virus-induced autoimmune diabetes in rats

Diabetes

Volumn 66, Issue 1, 2017, Pages 145-157

  Qaisar, Natasha ^a   Lin, Suvana ^a   Ryan, Glennice ^a   Yang, Chaoxing ^a   Oikemus, Sarah R ^a   Brodsky, Michael H ^a   Bortel, Rita ^a   Mordes, John P ^a   Wang, Jennifer P ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; POLYINOSINIC POLYCYTIDYLIC ACID; INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DIABETOGENESIS; DISEASE SEVERITY; EMBRYO; FEMALE; GENE DISRUPTION; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS INFECTION; ANIMAL; CELL CULTURE; GENETICS; INNATE IMMUNITY; METABOLISM; PARVOVIRIDAE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

ANIMALS; CELLS, CULTURED; CRISPR-CAS SYSTEMS; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNITY, INNATE; INTERFERON TYPE I; MALE; PARVOVIRUS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, INTERFERON ALPHA-BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 85007359252     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0462     Document Type: Article

References (49)

1. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet 2014;383:69-82
2. Polychronakos C, Li Q. Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 2011;12:781-792
3. Akerblom HK, Vaarala O, Hyöty H, Ilonen J, Knip M. Environmental factors in the etiology of type 1 diabetes. Am J Med Genet 2002;115:18-29
4. Hawa MI, Beyan H, Buckley LR, Leslie RD. Impact of genetic and nongenetic factors in type 1 diabetes. Am J Med Genet 2002;115:8-17
5. Drescher KM, von Herrath M, Tracy S. Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine. Rev Med Virol 2015;25:19-32
6. Kondrashova A, Hyöty H. Role of viruses and other microbes in the pathogenesis of type 1 diabetes. Int Rev Immunol 2014;33:284-295
7. Boettler T, von Herrath M. Protection against or triggering of type 1 diabetes? Different roles for viral infections. Expert Rev Clin Immunol 2011;7:45-53
8. Mordes JP, Zipris D, Liu Z, Blankenhorn EP. Viruses and autoimmune diabetes in rats. In Diabetes and Viruses. Taylor K, Ed. New York, Springer, 2013, p. 57-70
9. Mordes JP, Guberski DL, Leif JH, et al. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes 2005;54:2727-2733
10. Tirabassi RS, Guberski DL, Blankenhorn EP, et al. Infection with viruses from several families triggers autoimmune diabetes in LEW∗1WR1 rats: prevention of diabetes by maternal immunization. Diabetes 2010;59:110-118
11. Smyth DJ, Cooper JD, Bailey R, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006;38:617-619
12. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-389
13. Heinig M, Petretto E, Wallace C, et al.; Cardiogenics Consortium. A transacting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 2010;467:460-464
14. Shimoda K, Kato K, Aoki K, et al. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 2000;13:561-571
15. Mein CA, Esposito L, Dunn MG, et al. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet 1998;19:297-300
16. Izumi K, Mine K, Inoue Y, et al. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun 2015;6:6748
17. Geurts AM, Cost GJ, Freyvert Y, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science 2009;325:433
18. Guan Y, Shao Y, Li D, Liu M. Generation of site-specific mutations in the rat genome via CRISPR/Cas9. Methods Enzymol 2014;546:297-317
19. Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Diabetes 2002;51:3254-3262
20. Guide for the Care and Use of Laboratory Animals. Washington, DC, National Academies Press, 1996
21. Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013;339:819-823
22. Wilson KA, Chateau ML, Porteus MH. Design and development of artificial zinc finger transcription factors and zinc finger nucleases to the hTERT locus. Mol Ther Nucleic Acids 2013;2:e87
23. Wang H, Yang H, Shivalila CS, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013;153:910-918
24. Hara N, Alkanani AK, Dinarello CA, Zipris D. Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade. Innate Immun 2014;20:574-584
25. Zipris D, Hillebrands JL, Welsh RM, et al. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol 2003;170:3592-3602
26. Guy M, Chilmonczyk S, Crucière C, Eloit M, Bakkali-Kassimi L. Efficient infection of buffalo rat liver-resistant cells by encephalomyocarditis virus requires binding to cell surface sialic acids. J Gen Virol 2009;90:187-196
27. Bewick V, Cheek L, Ball J. Statistics review 12: survival analysis. Crit Care 2004;8:389-394
28. Kato H, Takeuchi O, Sato S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;441:101-105
29. Gitlin L, Barchet W, Gilfillan S, et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A 2006;103:8459-8464
30. Hwang SY, Hertzog PJ, Holland KA, et al. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc Natl Acad Sci U S A 1995;92:11284-11288
31. Müller U, Steinhoff U, Reis LF, et al. Functional role of type I and type II interferons in antiviral defense. Science 1994;264:1918-1921
32. Yoon JW, McClintock PR, Onodera T, Notkins AL. Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J Exp Med 1980;152:878-892
33. Psalla D, Psychas V, Spyrou V, Billinis C, Papaioannou N, Vlemmas I. Pathogenesis of experimental encephalomyocarditis: a histopathological, immunohistochemical and virological study in rats. J Comp Pathol 2006;134:30-39
34. Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes 2005;54:1233-1237
35. Alkanani AK, Hara N, Gianani R, Zipris D. Kilham rat virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis. Virology 2014;468-470:19-27
36. Crow MK. Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res Ther 2010;12(Suppl. 1):S5
37. Ferreira RC, Guo H, Coulson RM, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes 2014;63:2538-2550
38. Kallionpää H, Elo LL, Laajala E, et al. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes 2014;63:2402-2414
39. Ewel CH, Sobel DO, Zeligs BJ, Bellanti JA. Poly I: C accelerates development of diabetes mellitus in diabetes-prone BB rat. Diabetes 1992;41:1016-1021
40. Wu J, Chen ZJ. Innate immune sensing and signaling of cytosolic nucleic acids. Annu Rev Immunol 2014;32:461-488
41. Funabiki M, Kato H, Miyachi Y, et al. Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 2014;40:199-212
42. Shigemoto T, Kageyama M, Hirai R, Zheng J, Yoneyama M, Fujita T. Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J Biol Chem 2009;284:13348-13354
43. Lincez PJ, Shanina I, Horwitz MS. Reduced expression of the MDA5 gene IFIH1 prevents autoimmune diabetes. Diabetes 2015;64:2184-2193
44. Zipris D, Lien E, Nair A, et al. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetesresistant rat. J Immunol 2007;178:693-701
45. Ellerman KE, Richards CA, Guberski DL, Shek WR, Like AA. Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat. Diabetes 1996;45:557-562
46. Moran A, Bundy B, Becker DJ, et al.; Type 1 Diabetes TrialNet Canakinumab Study Group; AIDA Study Group. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet 2013;381:1905-1915
47. Mandrup-Poulsen T, Pickersgill L, Donath MY. Blockade of interleukin 1 in type 1 diabetes mellitus. Nat Rev Endocrinol 2010;6:158-166
48. Mattei LM, Cotmore SF, Tattersall P, Iwasaki A. Parvovirus evades interferondependent viral control in primary mouse embryonic fibroblasts. Virology 2013;442:20-27
49. de Beeck AO, Eizirik DL. Viral infections in type 1 diabetes mellitus-why the β cells? Nat Rev Endocrinol 2016;12:263-273