Kilham rat virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis

Virology

Volumn 468-470, Issue , 2014, Pages 19-27

  Alkanani, Aimon K ^a   Hara, Naoko ^a   Gianani, Roberto ^a   Zipris, Danny ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Innate immunity; Islets; Janus kinase; Kilham rat virus; LEW1.WR1 rat; Signal transducer and activator of transcription; Type 1 diabetes

Indexed keywords

ALPHA INTERFERON; CXCL11 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERFERON; INTERFERON REGULATORY FACTOR 7; JANUS KINASE 1; JANUS KINASE 2; STAT1 PROTEIN; TOLL LIKE RECEPTOR 9; VIRUS PROTEIN; STAT PROTEIN; JAK1 PROTEIN, RAT; JAK2 PROTEIN, RAT; STAT1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LATENT RAT PARVOVIRUS; NONHUMAN; PANCREAS ISLET BETA CELL; PARVOVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS TRANSCRIPTION; ENZYME ACTIVATION; KILHAM RAT VIRUS; PARVOVIRUS INFECTION; PROTEIN PHOSPHORYLATION; SPLEEN; VIRUS CELL INTERACTION; VIRUS DETECTION; ANIMAL; CYTOLOGY; GENETICS; GERMFREE ANIMAL; INBRED RAT STRAIN; INFLAMMATION; METABOLISM; PANCREAS ISLET; PARVOVIRIDAE; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

KILHAM RAT VIRUS; RATTUS;

ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 1; INFLAMMATION; ISLETS OF LANGERHANS; JANUS KINASE 1; JANUS KINASE 2; PARVOVIRUS; RATS; RATS, INBRED STRAINS; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; STAT1 TRANSCRIPTION FACTOR;

EID: 84906070217     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.07.041     Document Type: Article

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