In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression

Molecular and Cellular Endocrinology

Volumn 399, Issue , 2015, Pages 50-59

  Sangan, Caroline B ^a   Jover, Ramiro ^b   Heimberg, Harry ^c   Tosh, David ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF VALENCIA   (Spain)

^c DIABETES RESEARCH CENTER   (Belgium)

Author keywords

Alpha cell; Beta cell; Glucagon; HNF4 ; Insulin; Pancreatic polypeptide

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; PANCREAS POLYPEPTIDE; TRANSCRIPTION FACTOR PAX4; DIFFERENTIATION ANTIGEN; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL FUNCTION; CELL LEVEL; CELL SPECIFICITY; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; GENETICS; METABOLISM;

ANIMALS; ANTIGENS, DIFFERENTIATION; CELL LINE; CELLULAR REPROGRAMMING; GLUCAGON-SECRETING CELLS; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN-SECRETING CELLS; MICE;

EID: 84908592489     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.09.009     Document Type: Article

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