Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Nature

Volumn 508, Issue 7495, 2014, Pages 222-227

  Huber, Kilian V M ^a   Salah, Eidarus ^b   Radic, Branka ^a   Gridling, Manuela ^a   Elkins, Jonathan M ^b   Stukalov, Alexey ^a   Jemth, Ann Sofie ^c   Göktürk, Camilla ^c   Sanjiv, Kumar ^c   Strömberg, Kia ^c   Pham, Therese ^c   Berglund, Ulrika Warpman ^c   Colinge, Jacques ^a   Bennett, Keiryn L ^a   Loizou, Joanna I ^a   Helleday, Thomas ^c   Knapp, Stefan ^b   Superti Furga, Giulio ^a  

^a CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences ^*  (Austria)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CRIZOTINIB; K RAS PROTEIN; MEMBRANE PROTEIN; MTH1 PROTEIN; NUCLEOTIDE; UNCLASSIFIED DRUG; 8 OXODGTPASE; 8-OXODGTPASE; AMINOQUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; RAS PROTEIN; SCH 51344;

BIOTRANSFORMATION; CANCER; CATALYSIS; CATALYST; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; DRUG; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; ORGANIC COMPOUND; TUMOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CRYSTAL STRUCTURE; DRUG TARGETING; ENANTIOMER; ENZYMATIC ASSAY; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEOMICS; STEREOSPECIFICITY; TUMOR GROWTH; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; COLON TUMOR; CRYSTALLIZATION; DISEASE MODEL; DNA REPAIR; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; FEMALE; GENETICS; METABOLISM; MOUSE; PATHOLOGY; PROTEIN CONFORMATION; SCID MOUSE; SINGLE STRANDED DNA BREAK;

ANIMALIA;

AMINOQUINOLINES; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; CRYSTALLIZATION; DISEASE MODELS, ANIMAL; DNA BREAKS, SINGLE-STRANDED; DNA REPAIR; DNA REPAIR ENZYMES; FEMALE; HOMEOSTASIS; HUMANS; MICE; MICE, SCID; MODELS, MOLECULAR; NUCLEOTIDES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEOMICS; PROTO-ONCOGENE PROTEINS; PYRAZOLES; PYRIDINES; RAS PROTEINS; SUBSTRATE SPECIFICITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899619048     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13194     Document Type: Article

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