Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 1, 2017, Pages 327-337

  Scuotto, Maria ^a,f   Abdelnabi, Rana ^d,f   Collarile, Selene ^a,f   Schiraldi, Chiara ^a   Delang, Leen ^d   Massa, Antonio ^c   Ferla, Salvatore ^e   Brancale, Andrea ^e   Leyssen, Pieter ^d   Neyts, Johan ^d   Filosa, Rosanna ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Consorzio Sannio Tech ^*  (Italy)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF SALERNO   (Italy)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f NONE

Author keywords

Arbidol; Chikungunya; Replication; Virus

Indexed keywords

ARBIDOL; INDOLE DERIVATIVE; TERT BUTYL 2 [(2,6 DICHLOROPHENYLSULFINYL)METHYL] 4 [(DIMETHYLAMINO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; TERT BUTYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL] 6 BROMO 4 [(DIMETHYLAMINO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; TERT BUTYL 2 [[2 (TRIFLUOROMETHYL)PHENYLSULFINYL]METHYL] 4 [(DIMETHYLAMINO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; TERT BUTYL 2 [[2 (TRIFLUOROMETHYL)PHENYLSULFINYL]METHYL] 6 BROMO 4 [(DIMETHYLAMINO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(2 TRIFLUOROMETHYLPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(2 TRIFLUOROMETHYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(2,6 DICHLOROPHENYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 CHLOROPHENYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 CHLOROPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 FLUOROPHENYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 FLUOROPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 TRIFLUOROMETHYLPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 5 HYDROXY 1 METHYL 2 [(4 TRIFLUOROMETHYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 6 BROMO 5 HYDROXY 1 METHYL 2 [(2 TRIFLUOROMETHYLPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 6 BROMO 5 HYDROXY 1 METHYL 2 [(2 TRIFLUOROMETHYLSULFYNYL)METHYL]INDOLE 3 CARBOXYLATE; TERT BUTYL 6 BROMO 5 HYDROXY 1 METHYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL]INDOLE 3 CARBOXYLATE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; GLYCOPROTEIN; SULFOXIDE; TERT-BUTYL 5-HYDROXY-1-METHYL-2-(2-TRIFLUOROMETHYSULFYNYL)METHYL)INDOLE-3-CARBOXYLATE; VIRUS ENVELOPE PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROTECTION; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; SEMLIKI FOREST VIRUS; SINDBIS VIRUS; STRUCTURE ACTIVITY RELATION; VERO CELL LINE; VIRUS REPLICATION; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; PHYSIOLOGY; SYNTHESIS;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CHIKUNGUNYA VIRUS; GLYCOPROTEINS; INDOLES; MOLECULAR DOCKING SIMULATION; SULFOXIDES; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 85006489409     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.10.037     Document Type: Article

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