In vitro antiviral and immunomodulatory activity of arbidol and structurally related derivatives in herpes simplex virus type 1-infected human keratinocytes (HaCat)

Journal of Medical Microbiology

Volumn 63, Issue , 2014, Pages 1474-1483

  Perfetto, Brunella ^a   Filosa, Rosanna ^a   Gregorio, Vincenza De ^a   Peduto, Antonella ^b   Gatta, Annalisa La ^a   Caprariis, Paolo De ^b   Tufano, Maria Antonietta ^a   Donnarumma, Giovanna ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ARBIDOL; BETA ACTIN; DRUG DERIVATIVE; IMMUNOMODULATING AGENT; INTERLEUKIN 6; PROTEIN VP16; PYRROLIDINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN ICP27; INDOLE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ADSORPTION; GENE EXPRESSION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HOST CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; KERATINOCYTE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; CELL LINE; CHEMISTRY; DRUG EFFECTS; VIROLOGY;

ANTIVIRAL AGENTS; CELL LINE; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOMODULATION; INDOLES; KERATINOCYTES; VIRUS REPLICATION;

EID: 84908317950     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.076612-0     Document Type: Article

References (39)

1. Amici, C., Rossi, A., Costanzo, A., Ciafré, S., Marinari, B., Balsamo, M., Levrero, M. & Santoro, M. G. (2006). Herpes simplex virus disrupts NF-kB regulation by blocking its recruitment on the IkBa promoter and directing the factor on viral genes. J Biol Chem 281, 7110–7117.
2. Arena, A., Bisignano, C., Stassi, G., Mandalari, G., Wickham, M. S. & Bisignano, G. (2010). Immunomodulatory and antiviral activity of almond skins. Immunol Lett 132, 18–23.
3. Ayala, F., Grimaldi, E., Perfetto, B., Donnarumma, M., De Filippis, A., Donnarumma, G. & Tufano, M A. (2008). 5-aminolaevulinic acid and photodynamic therapy reduce HSV-1 replication in HaCat cells through an apoptosis-independent mechanism. Photodermatol Photoimmunol Photomed 24, 237–243.
4. Baroni, A., Paoletti, I., Ruocco, E., Ayala, F., Corrado, F., Wolf, R., Tufano, M. A. & Donnarumma, G. (2007). Antiviral effects of quinine sulfate on HSV-1 HaCat cells infected: analysis of the molecular mechanisms involved. J Dermatol Sci 47, 253–255.
5. Boriskin, Y. S., Pécheur, E. I. & Polyak, S. J. (2006). Arbidol: a broadspectrum antiviral that inhibits acute and chronic HCV infection. Virol J 3, 56–63.
6. Boriskin, Y. S., Leneva, I. A., Pécheur, E. I. & Polyak, S. J. (2008). Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem 15, 997–1005.
7. Brancato, V., Peduto, A., Wharton, S., Martin, S., More, V., Di Mola, A., Massa, A., Perfetto, B., Donnarumma, G. & other authors (2013). Design of inhibitors of influenza virus membrane fusion: synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series. Antiviral Res 99, 125–135.
8. Brooks, M. J., Sasadeusz, J. J. & Tannock, G. A. (2004). Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what’s in the pipeline? Curr Opin Pulm Med 10, 197–203.
9. Delogu, I., Pastorino, B., Baronti, C., Nougairé de, A., Bonnet, E. & de Lamballerie, X. (2011). In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant. Antiviral Res 90, 99–107.
10. Donnarumma, G., De Gregorio, V., Fusco, A., Farina, E., Baroni, A., Esposito, V., Contaldo, M., Petruzzi, M., Pannone, G. & Serpico, R. (2010). Inhibition of HSV-1 replication by laser diode-irradiation: possible mechanism of action. Int J Immunopathol Pharmacol 23, 1167–1176.
11. Filosa, R., Peduto, A., de Caprariis, P., Saturnino, C., Festa, M., Petrella, A., Pau, A., Pinna, G. A., La Colla, P. & other authors (2007). Synthesis and antiproliferative properties of N3/8-disubstituted 3,8- diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl-piperazine. Eur J Med Chem 42, 293–306.
12. Filosa, R., Peduto, A., Aparoy, P., Schaible, A. M., Luderer, S., Krauth, V., Petronzi, C., Massa, A., de Rosa, M. & other authors (2013). Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. Eur J Med Chem 67, 269–279.
13. Flint, S. J., Enquist, L. W., Krug, R. M., Racaniello, V. R. & Skalka, A. M. (2000). Principles of Virology, p. 804. Washington, D.C: American Society for Microbiology.
14. Haid, S., Pietschmann, T. & Pécheur, E. I. (2009). Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition, and density of virus particles. J Biol Chem 284, 17657–17667.
15. Jubelt, B., Mihai, C., Li, T. M. & Veerapaneni, P. (2011). Rhombencephalitis/brainstem encephalitis. Curr Neurol Neurosci Rep 11, 543–552.
16. Keadle, T. L., Usui, N., Laycock, K. A., Miller, J. K., Pepose, J. S. & Stuart, P. M. (2000). IL-1 and TNF-a are important factors in the pathogenesis of murine recurrent herpetic stromal keratitis. Invest Ophthalmol Vis Sci 41, 96–102.
17. Knipe, D. M., Samuel, C. E. & Palese, P. (2001). Fields Virology, 4th edn, p. 133. Philadelphia, PA: Lippincott, Williams & Wilkins.
18. Lai, J. S. & Herr, W. (1997). Interdigitated residues within a small region of VP16 interact with Oct-1, HCF, and DNA. Mol Cell Biol 17, 3937–3946.
19. Leneva, I. A., Russell, R. J., Boriskin, Y. S. & Hay, A. J. (2009). Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res 81, 132–140.
20. Li, H., Zhang, J., Kumar, A., Zheng, M., Atherton, S. S. & Yu, F. S. (2006). Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells. Immunology 117, 167–176.
21. Lucey, D. R., Clerici, M. & Shearer, G. M. (1996). Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 9, 532–562.
22. Melchjorsen, J., Sørensen, L. N. & Paludan, S. R. (2003). Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function. J Leukoc Biol 74, 331–343.
23. Méndez-Samperio, P., Hernandez, M. & Ayala, H. E. (2000). Induction of transforming growth factor-b 1 production in human cells by herpes simplex virus. J Interferon Cytokine Res 20, 273–280.
24. Mogensen, T. H., Melchjorsen, J., Malmgaard, L., Casola, A. & Paludan, S. R. (2004). Suppression of proinflammatory cytokine expression by herpes simplex virus type 1. J Virol 78, 5883–5890.
25. Nicola, A. V., Hou, J., Major, E. O. & Straus, S. E. (2005). Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway. J Virol 79, 7609–7616.
26. Pécheur, E. I., Lavillette, D., Alcaras, F., Molle, J., Boriskin, Y. S., Roberts, M., Cosset, F. L. & Polyak, S. J. (2007). Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Biochemistry 46, 6050–6059.
27. Peduto, A., Massa, A., Di Mola, A., de Caprariis, P., La Colla, P., Loddo, R., Altamura, S., Maga, G. & Filosa, R. (2011). 2,3-Dihydro- 1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors. Chem Biol Drug Des 77, 441–449.
28. Petronzi, C., Filosa, R., Peduto, A., Monti, M. C., Margarucci, L., Massa, A., Ercolino, S. F., Bizzarro, V., Parente, L. & other authors (2011). Structure-based design, synthesis and preliminary antiinflammatory activity of bolinaquinone analogues. Eur J Med Chem 46, 488–496.
29. Petronzi, C., Festa, M., Peduto, A., Castellano, M., Marinello, J., Massa, A., Capasso, A., Capranico, G., La Gatta, A. & other authors (2013). Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation. J Exp Clin Cancer Res 32, 24.
30. Pollara, G., Jones, M., Handley, M. E., Rajpopat, M., Kwan, A., Coffin, R. S., Foster, G., Chain, B. & Katz, D. R. (2004). Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion. J Immunol 173, 4108–4119.
31. Roizman, B. & Knipe, D. M. (2001). Herpes simplex viruses and their replication. In Fields Virology, 4th edn, pp. 2399–2460. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Raven Press.
32. Romagnani, S. (1997). The Th1/Th2 paradigm. Immunol Today 18, 263–266.
33. Schaible, A. M., Traber, H., Temml, V., Noha, S. M., Filosa, R., Peduto, A., Weinigel, C., Barz, D., Schuster, D. & Werz, O. (2013). Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. Biochem Pharmacol 86, 476–486.
34. Schelhaas, M., Jansen, M., Haase, I. & Knebel-Mörsdorf, D. (2003). Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells. J Gen Virol 84, 2473–2484.
35. Scherbik, S. V. & Brinton, M. A. (2010). Virus-Induced Ca2+ Influx Extends Survival of West Nile Virus-Infected Cells. J Virol 84(17), 8721–8731.
36. Sellitto, G., Faruolo, A., de Caprariis, P., Altamura, S., Paonessa, G. & Ciliberto, G. (2010). Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro. Bioorg Med Chem 18, 6143–6148.
37. Teissier, E., Zandomeneghi, G., Loquet, A., Lavillette, D., Lavergne, J. P., Montserret, R., Cosset, F. L., Böckmann, A., Meier, B. H. & other authors (2011). Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol. PLoS ONE 6, e15874–e15880.
38. Us, T., Cetin, E., Kaşifoǧlu, N., Kaşifoǧlu, T. & Akgün, Y. (2011). [Investigation of Epstein-Barr virus and herpes simplex virus markers by serological and molecular methods in patients with rheumatoid arthritis and systemic lupus erythematosus]. Mikrobiyol Bul 45, 677–683 (in Turkish).
39. Zak-Prelich, M., Halliday, K. E., Walker, C., Yates, C. M., Norval, M. & McKenzie, R. C. (2001). Infection of murine keratinocytes with herpes simplex virus type 1 induces the expression of interleukin-10, but not interleukin-1a or tumour necrosis factor-a. Immunology 104, 468–475.