Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: Design, synthesis, and cytotoxic evaluation

Journal of Experimental and Clinical Cancer Research

Volumn 32, Issue 1, 2013, Pages

  Petronzi, Carmen ^a   Festa, Michela ^a   Peduto, Antonella ^a   Castellano, Maria ^c   Marinello, Jessica ^b   Massa, Antonio ^a   Capasso, Anna ^a   Capranico, Giovanni ^b   La Gatta, Annalisa ^c   De Rosa, Mario ^c   Caraglia, Michele ^c   Filosa, Rosanna ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Apoptosis; Benzoquinones; Cytotoxicity; Melanoma cell line M14; PARP; Reactive oxygen species

Indexed keywords

1,4 BENZOQUINONE DERIVATIVE; 2 HEXYL 5 HYDROXYCYCLOHEXA 2,5 DIENE 1,4 DIONE; 2 HYDROXY 5 METHOXY 3 HEXYL CYCLOHEXA 2,5 DIENE 1,4 DIONE; 2,5 DIMETHOXY 3 HEXYL 2,5 CYCLOHEXADIENE 1,4 DIONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE; CYCLOHEXA 2,5 DIENE 1,4 DIONE DERIVATIVE; HU 331; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL DEATH; CELL VIABILITY; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; MALE; MELANOMA; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; CANNABIDIOL; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOPOISOMERASE INHIBITORS;

EID: 84876810152     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-32-24     Document Type: Article

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