Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

European Journal of Medicinal Chemistry

Volumn 94, Issue , 2015, Pages 132-139

  Filosa, Rosanna ^a   Peduto, Antonella ^a,b   Schaible, Anja M ^c   Krauth, Verena ^c   Weinigel, Christina ^d   Barz, Dagmar ^d   Petronzi, Carmen ^a   Bruno, Ferdinando ^a   Roviezzo, Fiorentina ^e   Spaziano, Giuseppe ^a   D'Agostino, Bruno ^a   De Rosa, Mario ^a   Werz, Oliver ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Dermofarma   (Italy)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d JENA UNIVERSITY HOSPITAL   (Germany)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

5 Lipoxygenase; Arachidonic acid; Benzoquinone; Inflammation; Microsomal prostaglandin E2 synthase 1

Indexed keywords

2 HYDROXY 5 METHOXY 1,4 BENZOQUINONE; 2,5 DIHYDROXY 1,4 BENZOQUINONE; 2,5 DIHYDROXY 3 UNDECYL 1,4 BENZOQUINONE; 2,5 DIMETHOXY 1,4 BENZOQUINONE; 2,5 HYDROXY 1,4 BENZOQUINONE; 4,5 DIMETHOXY 3 DODECYL 1,2 BENZOQUINONE; 5 DIHYDROXY 1,4 BENZOQUINONE; ARACHIDONATE 5 LIPOXYGENASE; BENZOQUINONE DERIVATIVE; CALCIMYCIN; EMBELIN; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; ZILEUTON; ALOX15 PROTEIN, HUMAN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; BENZOQUINONE; ISOMERASE; PROSTAGLANDIN E SYNTHASE;

A549 CELL LINE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; IC50; NEUTROPHIL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BENZOQUINONES; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; LIPOXYGENASE INHIBITORS; NEUTROPHILS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925843313     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.02.042     Document Type: Article

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