Synthesis and biological evaluation of (2S)- and (2R)-2-(3′-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3811-3817

  Filosa, Rosanna ^a   Marinozzi, Maura ^a   Costantino, Gabriele ^a   Hermit, Mette Brunsgaard ^b   Thomsen, Christian ^b   Pellicciari, Roberto ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b H LUNDBECK A S   (Denmark)

Author keywords

Metabotropic glutamate receptors; Neuroprotection; Propellane

Indexed keywords

2 (3' PHOSPHONOBICYCLO[1.1.1]PENTYL)GLYCINE; CYCLIC AMP; FORSKOLIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 8; METABOTROPIC RECEPTOR AGONIST; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC 50; ISOMER; NONHUMAN; PROTEIN EXPRESSION; STEREOCHEMISTRY;

ANIMALS; BICYCLO COMPOUNDS; CELL LINE; CELLS, CULTURED; CRICETINAE; GLYCINE; HUMANS; LIGANDS; MOLECULAR CONFORMATION; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33646042869     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.027     Document Type: Article

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