Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase

European Journal of Medicinal Chemistry

Volumn 67, Issue , 2013, Pages 269-279

  Filosa, Rosanna ^a   Peduto, Antonella ^a   Aparoy, Polamarasetty ^b   Schaible, Anja M ^c   Luderer, Susann ^d   Krauth, Verena ^c   Petronzi, Carmen ^a   Massa, Antonio ^a   De Rosa, Mario ^e   Reddanna, Pallu ^f   Werz, Oliver ^c  

^a UNIVERSITY OF SALERNO   (Italy)

^b CENTRAL UNIVERSITY OF HIMACHAL PRADESH   (India)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f UNIVERSITY OF HYDERABAD   (India)

Author keywords

5 Lipoxygenase; Benzoquinone; Leukotriene; Molecular docking; Resorcinol

Indexed keywords

1 (2,4 DIHYDROXYPHENYL) 2 (NAPHTHALEN 3 YL)ETHANONE; 1 (4 DIBENZOFURANYL) 2,4 BENZENDIOL; 1,4 BENZOQUINONE DERIVATIVE; 3 (CYCLOHEXYLMETHYL) 2,5 DIHYDROXYCYCLOHEXA 2,5 DIENE 1,4 DIONE; 3 BENZYL 2 HYDROXY 5 METHOXY 2,5 CYCLOHEXADIENE 1,4 DIONE; 3 [(2 NAPHTHYL)METHYL] 2 HYDROXY 5 METHOXY 2,5 CYCLOHEXADIENE 1,4 DIONE; 3 [(DECAHYDRONAPHTHYLEN 3 YL)METHYL] 2,5 DIHYDROXY 2,5 CYCLOHEXADIENE 1,4 DIONE; 4 [BENZO(B)THIOPHEN 3 YL]BENZENE 1,3 DIOL; 5 (4 DIBENZOFURANYL) 2 HYDROXY 2,5 CYCLOHEXADIENE 1,4 DIONE; 6 [(4 HYDROXY 3,6 DIOXOCYCLOHEXA 1,4 DIENYL)METHYL] NAPHTHALENE 2 CARBOXYLIC ACID; RESORCINOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

5-LIPOXYGENASE; BENZOQUINONE; LEUKOTRIENE; MOLECULAR DOCKING; RESORCINOL;

ARACHIDONATE 5-LIPOXYGENASE; BENZOQUINONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; RESORCINOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882491647     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.039     Document Type: Article

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