Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 492-498

  Peduto, Antonella ^a,b   Bruno, Ferdinando ^b   Dehm, Friedrike ^c   Krauth, Verena ^c   De Caprariis, Paolo ^b   Weinigel, Christina ^d   Barz, Dagmar ^d   Massa, Antonio ^e   De Rosa, Mario ^a   Werz, Oliver ^c   Filosa, Rosanna ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Department of Pharmaceutical and Biomedical Sciences ^*  (Italy)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d JENA UNIVERSITY HOSPITAL   (Germany)

^e UNIVERSITY OF SALERNO   (Italy)

Author keywords

5 Lipoxygenase; Indoles; Leukotriene

Indexed keywords

2 PHENYLTHIOMETHYL INDOLE DERIVATIVE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE INHIBITOR; CHLORINE; ENZYME INHIBITOR; ETHYL 2 [(2,4 DIFLUOROPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 2 [(2,6 CHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 2 [(2,6 DIMETHYLPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 2 [(3 CHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 2 [(3,5 DIMETHYLPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 2 [(4 FLUOROPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXT 2 (MESILYLTHIOMETHYL/0 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 1 METHYL 2 (PHENYLTHIOMETHYL) 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 1 METHYL 2 [[2 (TRIFLUOROMETHYL) PHENYLTHIO]METHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 1 METHYL 2 [[4 (TRIFLUOROMETHYL) PHENYLTHIO]METHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 2 (MESITYLTHIOMETHYL) 1 METHYL 1H INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 2 [(4 METHOXYPHENYLTHIO)METHYL] 1 METHYL 1H INDOLE 3 CARBOXYLATE; LIPID HYDROPEROXIDE; THIOPHENOL; UNCLASSIFIED DRUG; ZILEUTON; 2-PHENYLTHIOMETHYL-INDOLE; INDOLE DERIVATIVE; LIPOXYGENASE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKOCYTE; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; SYNTHESIS;

ARACHIDONATE 5-LIPOXYGENASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901449257     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.033     Document Type: Article

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