Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition

European Journal of Medicinal Chemistry

Volumn 108, Issue , 2016, Pages 466-475

  Peduto, Antonella ^a   Krauth, Verena ^b   Collarile, Selene ^a   Dehm, Fiederike ^b   Ambruosi, Marika ^a   Belardo, Carmela ^a   Guida, Francesca ^a   Massa, Antonio ^c   Esposito, Veronica ^d   Maione, Sabatino ^a   De Rosa, Mario ^a   Werz, Oliver ^b   Filosa, Rosanna ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

5 lipoxygenase Leukotriene Indoles

Indexed keywords

2 PHENYLTHIOMETHYL BENZOINDOLE DERIVATIVE; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN INHIBITOR; ETHYL 2 ([2,3 DICHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 ([2,6 DIMETHYLPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 ETHOXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 ETHOXY1 ETHYL 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1 METHYL 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 METHOXY 1 METHYL 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2 CHLOROPHENYLTHIO)METHYL] 5 METHOXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(2,6 DIMETHYLPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(3 CHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(3,4 DICHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(3,5 DICHLOROPHENYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 2 [(ORTHO TOLYLTHIO)METHYL] 5 HYDROXY 1H BENZO[G]INDOLE 3 CARBOXYLATE; ETHYL 5 HYDROXY 2 [(MESITYLTHIO)METHYL] 1H BENZO[G]INDOLE 3 CARBOXYLATE; INDOLE DERIVATIVE; METHYL GROUP; PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; ZILEUTON; 2-PHENYLTHIOMETHYL-BENZOINDOLE; CARRAGEENAN; LIPOXYGENASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CELL ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; IN VIVO STUDY; MALE; MOUSE; NEUTROPHIL; NONHUMAN; STRUCTURE ACTIVITY RELATION; ADULT; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; EDEMA; ENZYMOLOGY; INFLAMMATION; METABOLISM; SYNTHESIS;

ADULT; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HUMANS; INDOLES; INFLAMMATION; LIPOXYGENASE INHIBITORS; MICE; MOLECULAR STRUCTURE; NEUTROPHILS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84951325887     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.11.048     Document Type: Article

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