Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 21, 2014, Pages 6014-6025

  Di Mola, Antonia ^a   Peduto, Antonella ^a,d   La Gatta, Annalisa ^a   Delang, Leen ^b   Pastorino, Boris ^c   Neyts, Johan ^b   Leyssen, Pieter ^b   De Rosa, Mario ^a   Filosa, Rosanna ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c Aix Marseille University IRD 190 Inserm 1207   (France)

^d Dermofarma   (Italy)

Author keywords

Arbidol; Chikungunya virus; Indoles

Indexed keywords

3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(2 TRIFLUOROMETHYLPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(2,4 DIFLUOROPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(2,4,6 TRIMETHYLPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(4 CHLOROPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(4 FLUOROPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(4 TRIFLUOROMETHOXYPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(4 TRIFLUOROMETHYLPENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(METHOXYPHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; 3 TERT BUTYL 5 ETHYL 1 METHYL 2 [(PHENYLTHIO)METHYL] 1H INDOL 3,5 DICARBOXYLIC ACID; ARBIDOL; DIETHYL 2 (2,4 DIFLUOROPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; DIETHYL 2 (2,6 DICHLOROPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; DIETHYL 2 (4 FLUOROPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; DIETHYL 2 (4 METHOXYPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; DIETHYL 2 (4 TRIFLUOROMETHOXYPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; DIETHYL 2 (4 TRIFLUOROMETHYLPHENYLTHIO)METHYL 1 METHYL 1H INDOL 3,5 DICARBOXYLIC ACID; ETHYL 2 [(2,4 DIFLUOROPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; ETHYL 2 [(2,6 DICHLOROPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; ETHYL 2 [(4 FLUOROPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; ETHYL 2 [(4 METHOXYPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; ETHYL 2 [(4 TRIFLUOROMETHOXYPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; ETHYL 2 [(4 TRIFLUOROMETHYLPHENYLTHIO)METHYL] 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; TERT BUTYL 2 (2,4 DIFLUOROPHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; TERT BUTYL 2 (4 FLUOROPHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; TERT BUTYL 2 (4 METHOXYPHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC; TERT BUTYL 2 (4 TRIFLUOROMETHOXYPHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; TERT BUTYL 2 (4 TRIFLUOROMETHYLPHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC; TERT BUTYL 2 (PHENYLTHIOMETHYL) 5 HYDROXYMETHYL 1 METHYL 1H INDOL 3 CARBOXYLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIVIRUS AGENT; INDOLE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA ALPHAVIRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SCREENING; DRUG STRUCTURE; GENE SEQUENCE; LIPOPHILICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; VERO CELL LINE; VIRUS REPLICATION; ANIMAL; CHEMISTRY; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; HUMAN; PHYSIOLOGY;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; HUMANS; INDOLES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRUS REPLICATION;

EID: 84908396777     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.013     Document Type: Article

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