Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives

European Journal of Medicinal Chemistry

Volumn 40, Issue 10, 2005, Pages 991-1001

  Cao, R ^a   Chen, H ^a   Peng, W ^a   Ma, Y ^a   Hou, X ^a   Guan, H ^a   Liu, X ^a   Xu, A ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Carboline; Acute toxicity; Antitumor; Cytotoxic; SAR; Synthesis

Indexed keywords

1,9 DIMETHYL BETA CARBOLINE; 2,9 DIBENZYL 1 METHYL BETA CARBOLINIUM BROMATE; 2,9 DIBENZYL 3 ETHOXYCARBONYL 1 METHYL BETA CARBOLINIUM BROMATE; 2,9 DIBENZYL BETA CARBOLINIUM BROMATE; 2,9 DIETHYL BETA CARBOLINIUM IODATE; 2,9 DIMETHYL BETA CARBOLINIUM IODATE; 3 [(ETHOXYCARBONYL)AMINO] 9 BENZYL BETA CARBOLINE; 3 [(ETHOXYCARBONYL)AMINO] 9 ETHYL BETA CARBOLINE; 3 [(METHOXYCARBONYL)AMINO] 9 ETHYL BETA CARBOLINE; 3 AMINO BETA CARBOLINE; 3 AZIDOCARBONYL 9 BENZYL BETA CARBOLINE; 3 AZIDOCARBONYL 9 ETHYL BETA CARBOLINE; 3 CARBOHYDRAZIDE 9 ETHYL BETA CARBOLINE; 3 CARBOXYAZIDE 9 BENZYL BETA CARBOLINE; 9 (2',3',4',5',6' PENTAFLUORO)BENZYL 1 METHYL BETA CARBOLINE; 9 BENZYL 1 METHYL BETA CARBOLINE; 9 ETHYL 1 METHYL BETA CARBOLINE; 9 N BUTYL 1 METHYL BETA CARBOLINE; 9 PHENYLPROPYL 1 METHYL BETA CARBOLINE; ANTINEOPLASTIC AGENT; BENZYL 9 BENZYL BETA CARBOLINE 3 CARBOXYLATE; BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; BETA CARBOLINE DERIVATIVE; CARBAMIC ACID METHYL ESTER; ETHYL 9 BENZYL BETA CARBOLINE 3 CARBOXYLATE; HARMINE; HYDRAZIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; URETHAN;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NEUROTOXICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TOXICITY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444497133     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.04.008     Document Type: Article

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