Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine

European Journal of Medicinal Chemistry

Volumn 42, Issue 3, 2007, Pages 293-306

  Filosa, Rosanna ^a   Peduto, Antonella ^a   de Caprariis, Paolo ^a   Saturnino, Carmela ^a   Festa, Michela ^a   Petrella, Antonello ^a   Pau, Amedeo ^b   Pinna, Gérard Aimé ^b   La Colla, Paolo ^c   Busonera, Bernardetta ^c   Loddo, Roberta ^c  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c Virologia Generale e Biotecnologie Microbiche   (Italy)

Author keywords

3,8 Diazabicyclo 3.2.1 octane; Piperazine

Indexed keywords

3,8 BIS(3 PHENYLBENZYL) 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[(2 PHENYLPYRIDIN 4 YL)METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[(BIPHENYL 1 YL)METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[(PHENANTHREN 3 YL)METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[(PHENYL 1 YL)METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[2 (NAPHTHALEN 1 YL)METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3 ACETAMIDOPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3 HYDROXYPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3 METHOXYPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3 NITROPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3 TOLYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (3,4,5 TRIMETHOXYPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 ACETAMIDOPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 CHLOROPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 HYDROXYPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 METHOXYPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 NITROPHENYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; 3,8 BIS[[2 (4 TOLYL)PYRIDIN 4 YL]METHYL] 3,8 DIAZABICYCLO[3.2.1]OCTANE; ANTINEOPLASTIC AGENT; HETEROCYCLIC COMPOUND; MERCAPTOPURINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CANCER CELL CULTURE; CANCER INHIBITION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; SOLID TUMOR; TUMOR CELL LINE; TUMOR GROWTH;

ALKYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; COLORING AGENTS; DIPLOIDY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INDICATORS AND REAGENTS; MICROWAVES; PIPERAZINES; PROPIDIUM; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847618727     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.11.013     Document Type: Article

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