Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 21, 2016, Pages 5284-5289

  Di Mola, Antonia ^a   Gatta, Elena ^b   Petronzi, Carmen ^a,c   Cupello, Aroldo ^b   De Caprariis, Paolo ^a   Robello, Mauro ^b   Massa, Antonio ^a   Filosa, Rosanna ^a,c  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Granule cells; Isoindolinones; Rat cerebellum

Indexed keywords

3 [2 (4 METHYLPIPERAZIN 1 YL) 2 OXOETHYL] 2 (5 NITROPYRIDIN 2 YL)ISOINDOLIN 1 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; FLUMAZENIL; ISOINDOLE DERIVATIVE; PARTIAL AGONIST; PIPERAZINE; UNCLASSIFIED DRUG; ZOPICLONE; CHLORIDE CHANNEL;

ANIMAL CELL; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; ELECTROPHYSIOLOGICAL ASSAY; GRANULE CELL; NERVE CELL CULTURE; NONHUMAN; RAT; WHOLE CELL PATCH CLAMP; ANIMAL; CELL CULTURE; CELL GRANULE; CEREBELLUM; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; PATCH CLAMP TECHNIQUE;

ANIMALS; CELLS, CULTURED; CEREBELLUM; CHLORIDE CHANNELS; CYTOPLASMIC GRANULES; GAMMA-AMINOBUTYRIC ACID; ISOINDOLES; PATCH-CLAMP TECHNIQUES; RATS;

EID: 84993953540     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.09.042     Document Type: Article

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