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Volumn 50, Issue 2, 2017, Pages

Can the outcomes of mesenchymal stem cell-based therapy for myocardial infarction be improved? Providing weapons and armour to cells

Author keywords

conditioning; genetic modification; heart failure; mesenchymal stem cells; microencapsulation; myocardial infarction

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BONE MORPHOGENETIC PROTEIN 2; CANDESARTAN; DIAZOXIDE; FIBROBLAST GROWTH FACTOR 2; HEAT SHOCK PROTEIN 90; HYDROGEN PEROXIDE; HYDROGEN SULFIDE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MELATONIN; NEUROPEPTIDE Y; NICORANDIL; OXYTOCIN; PIOGLITAZONE; SALVIANOLIC ACID B; SOMATOMEDIN C; STROMAL CELL DERIVED FACTOR 1; TRIMETAZIDINE; TUMOR NECROSIS FACTOR; VALSARTAN;

EID: 85006025220     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12316     Document Type: Review
Times cited : (49)

References (155)
  • 1
    • 84950104119 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2016 update: a report from the American Heart Association
    • Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016;133:e38–e360.
    • (2016) Circulation , vol.133 , pp. e38-e360
    • Mozaffarian, D.1    Benjamin, E.J.2    Go, A.S.3
  • 2
    • 0033851515 scopus 로고    scopus 로고
    • Myocardial infarction redefined–a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction
    • Alpert JS, Thygesen K, Antman E, et al. Myocardial infarction redefined–a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 959-969
    • Alpert, J.S.1    Thygesen, K.2    Antman, E.3
  • 3
    • 0037112134 scopus 로고    scopus 로고
    • Effectiveness of adjunctive stent implantation following directional coronary atherectomy for treatment of left anterior descending ostial stenosis
    • Bramucci E, Repetto A, Ferrario M, et al. Effectiveness of adjunctive stent implantation following directional coronary atherectomy for treatment of left anterior descending ostial stenosis. Am J Cardiol. 2002;90:1074–1078.
    • (2002) Am J Cardiol , vol.90 , pp. 1074-1078
    • Bramucci, E.1    Repetto, A.2    Ferrario, M.3
  • 5
    • 84859651605 scopus 로고    scopus 로고
    • Treatment options in end-stage heart failure: where to go from here?
    • Haeck ML, Hoogslag GE, Rodrigo SF, et al. Treatment options in end-stage heart failure: where to go from here? Neth Heart J. 2012;20:167–175.
    • (2012) Neth Heart J , vol.20 , pp. 167-175
    • Haeck, M.L.1    Hoogslag, G.E.2    Rodrigo, S.F.3
  • 7
    • 84938578435 scopus 로고    scopus 로고
    • Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction
    • Khan M, Nickoloff E, Abramova T, et al. Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. Circ Res. 2015;117:52–64.
    • (2015) Circ Res , vol.117 , pp. 52-64
    • Khan, M.1    Nickoloff, E.2    Abramova, T.3
  • 8
    • 84971663947 scopus 로고    scopus 로고
    • Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015)
    • Singh A, Singh A, Sen D. Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015). Stem Cell Res Ther. 2016;7:82.
    • (2016) Stem Cell Res Ther , vol.7 , pp. 82
    • Singh, A.1    Singh, A.2    Sen, D.3
  • 9
    • 33645113300 scopus 로고    scopus 로고
    • From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research
    • Solter D. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nat Rev Genet. 2006;7:319–327.
    • (2006) Nat Rev Genet , vol.7 , pp. 319-327
    • Solter, D.1
  • 10
    • 68449088160 scopus 로고    scopus 로고
    • Stem cell patents: a landscape analysis
    • Konski AF, Spielthenner DJ. Stem cell patents: a landscape analysis. Nat Biotechnol. 2009;27:722–726.
    • (2009) Nat Biotechnol , vol.27 , pp. 722-726
    • Konski, A.F.1    Spielthenner, D.J.2
  • 11
    • 11144356049 scopus 로고    scopus 로고
    • Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    • Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–668.
    • (2004) Nature , vol.428 , pp. 664-668
    • Murry, C.E.1    Soonpaa, M.H.2    Reinecke, H.3
  • 12
    • 84941259740 scopus 로고    scopus 로고
    • Involvement of miR-34c in high glucose-insulted mesenchymal stem cells leads to inefficient therapeutic effect on myocardial infarction
    • Kang HJ, Kang WS, Hong MH, et al. Involvement of miR-34c in high glucose-insulted mesenchymal stem cells leads to inefficient therapeutic effect on myocardial infarction. Cell Signal. 2015;27:2241–2251.
    • (2015) Cell Signal , vol.27 , pp. 2241-2251
    • Kang, H.J.1    Kang, W.S.2    Hong, M.H.3
  • 14
    • 84882666193 scopus 로고    scopus 로고
    • The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells
    • Yan X, Liang H, Deng T, et al. The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells. Mol Cancer. 2013;12:92.
    • (2013) Mol Cancer , vol.12 , pp. 92
    • Yan, X.1    Liang, H.2    Deng, T.3
  • 15
    • 84925843133 scopus 로고    scopus 로고
    • iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes
    • Martinez-Fernandez A, Nelson TJ, Reyes S, et al. iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. Circ Cardiovasc Genet. 2014;7:667–676.
    • (2014) Circ Cardiovasc Genet , vol.7 , pp. 667-676
    • Martinez-Fernandez, A.1    Nelson, T.J.2    Reyes, S.3
  • 16
    • 84923879592 scopus 로고    scopus 로고
    • Cell adhesion and long-term survival of transplanted mesenchymal stem cells: a prerequisite for cell therapy
    • Lee S, Choi E, Cha MJ, et al. Cell adhesion and long-term survival of transplanted mesenchymal stem cells: a prerequisite for cell therapy. Oxid Med Cell Longev. 2015;2015:632902.
    • (2015) Oxid Med Cell Longev , vol.2015 , pp. 632902
    • Lee, S.1    Choi, E.2    Cha, M.J.3
  • 17
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 18
    • 52049119289 scopus 로고    scopus 로고
    • Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment
    • Hale SL, Dai W, Dow JS, et al. Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment. Life Sci. 2008;83:511–515.
    • (2008) Life Sci , vol.83 , pp. 511-515
    • Hale, S.L.1    Dai, W.2    Dow, J.S.3
  • 19
    • 84877924806 scopus 로고    scopus 로고
    • The effect of bone marrow- and adipose tissue-derived mesenchymal stem cell transplantation on myocardial remodelling in the rat model of ischaemic heart failure
    • Karpov AA, Uspenskaya YK, Minasian SM, et al. The effect of bone marrow- and adipose tissue-derived mesenchymal stem cell transplantation on myocardial remodelling in the rat model of ischaemic heart failure. Int J Exp Pathol. 2013;94:169–177.
    • (2013) Int J Exp Pathol , vol.94 , pp. 169-177
    • Karpov, A.A.1    Uspenskaya, Y.K.2    Minasian, S.M.3
  • 20
    • 51849091575 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue
    • Peng L, Jia Z, Yin X, et al. Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev. 2008;17:761–773.
    • (2008) Stem Cells Dev , vol.17 , pp. 761-773
    • Peng, L.1    Jia, Z.2    Yin, X.3
  • 21
    • 0346995399 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium
    • Tang YL, Zhao Q, Zhang YC, et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept. 2004;117:3–10.
    • (2004) Regul Pept , vol.117 , pp. 3-10
    • Tang, Y.L.1    Zhao, Q.2    Zhang, Y.C.3
  • 22
    • 84861999021 scopus 로고    scopus 로고
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    • Ratajczak MZ, Kucia M, Jadczyk T, et al. Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Leukemia. 2012;26:1166–1173.
    • (2012) Leukemia , vol.26 , pp. 1166-1173
    • Ratajczak, M.Z.1    Kucia, M.2    Jadczyk, T.3
  • 23
    • 79151471175 scopus 로고    scopus 로고
    • Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
    • Mirotsou M, Jayawardena TM, Schmeckpeper J, et al. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol. 2011;50:280–289.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 280-289
    • Mirotsou, M.1    Jayawardena, T.M.2    Schmeckpeper, J.3
  • 24
    • 3142663241 scopus 로고    scopus 로고
    • Mesenchymal stem cells and their potential as cardiac therapeutics
    • Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. 2004;95:9–20.
    • (2004) Circ Res , vol.95 , pp. 9-20
    • Pittenger, M.F.1    Martin, B.J.2
  • 25
    • 77958012860 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    • Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010;107:913–922.
    • (2010) Circ Res , vol.107 , pp. 913-922
    • Hatzistergos, K.E.1    Quevedo, H.2    Oskouei, B.N.3
  • 26
    • 33846467107 scopus 로고    scopus 로고
    • Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche
    • Mazhari R, Hare JM. Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche. Nat Clin Pract Cardiovasc Med. 2007;4(suppl 1):S21–S26.
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. S21-S26
    • Mazhari, R.1    Hare, J.M.2
  • 27
    • 2942523981 scopus 로고    scopus 로고
    • Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    • Oswald J, Boxberger S, Jorgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004;22:377–384.
    • (2004) Stem Cells , vol.22 , pp. 377-384
    • Oswald, J.1    Boxberger, S.2    Jorgensen, B.3
  • 28
    • 19944432052 scopus 로고    scopus 로고
    • Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    • Silva GV, Litovsky S, Assad JA, et al. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation. 2005;111:150–156.
    • (2005) Circulation , vol.111 , pp. 150-156
    • Silva, G.V.1    Litovsky, S.2    Assad, J.A.3
  • 29
    • 0036142213 scopus 로고    scopus 로고
    • Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    • Toma C, Pittenger MF, Cahill KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105:93–98.
    • (2002) Circulation , vol.105 , pp. 93-98
    • Toma, C.1    Pittenger, M.F.2    Cahill, K.S.3
  • 30
    • 0035810240 scopus 로고    scopus 로고
    • Bone marrow cells regenerate infarcted myocardium
    • Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705.
    • (2001) Nature , vol.410 , pp. 701-705
    • Orlic, D.1    Kajstura, J.2    Chimenti, S.3
  • 31
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi M, Zhang Z, Ni A, et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. 2008;103:1204–1219.
    • (2008) Circ Res , vol.103 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3
  • 32
    • 84940529193 scopus 로고    scopus 로고
    • Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials
    • Afzal MR, Samanta A, Shah ZI, et al. Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials. Circ Res. 2015;117:558–575.
    • (2015) Circ Res , vol.117 , pp. 558-575
    • Afzal, M.R.1    Samanta, A.2    Shah, Z.I.3
  • 33
    • 84920061766 scopus 로고    scopus 로고
    • Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials
    • Liu B, Duan CY, Luo CF, et al. Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials. Int J Cardiol. 2014;177:764–770.
    • (2014) Int J Cardiol , vol.177 , pp. 764-770
    • Liu, B.1    Duan, C.Y.2    Luo, C.F.3
  • 34
    • 84900422755 scopus 로고    scopus 로고
    • Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trials
    • de Jong R, Houtgraaf JH, Samiei S, et al. Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trials. Circ Cardiovasc Interv. 2014;7:156–167.
    • (2014) Circ Cardiovasc Interv , vol.7 , pp. 156-167
    • de Jong, R.1    Houtgraaf, J.H.2    Samiei, S.3
  • 35
    • 33646269967 scopus 로고    scopus 로고
    • A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction
    • Freyman T, Polin G, Osman H, et al. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J. 2006;27:1114–1122.
    • (2006) Eur Heart J , vol.27 , pp. 1114-1122
    • Freyman, T.1    Polin, G.2    Osman, H.3
  • 36
    • 53549131225 scopus 로고    scopus 로고
    • Systems approaches to preventing transplanted cell death in cardiac repair
    • Robey TE, Saiget MK, Reinecke H, et al. Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol. 2008;45:567–581.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 567-581
    • Robey, T.E.1    Saiget, M.K.2    Reinecke, H.3
  • 37
    • 34547104819 scopus 로고    scopus 로고
    • Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells
    • Song H, Chang W, Lim S, et al. Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells. Stem Cells. 2007;25:1431–1438.
    • (2007) Stem Cells , vol.25 , pp. 1431-1438
    • Song, H.1    Chang, W.2    Lim, S.3
  • 38
    • 0346753451 scopus 로고    scopus 로고
    • Anoikis in the cardiovascular system: known and unknown extracellular mediators
    • Michel JB. Anoikis in the cardiovascular system: known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol. 2003;23:2146–2154.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 2146-2154
    • Michel, J.B.1
  • 39
    • 33746333507 scopus 로고    scopus 로고
    • Oxidative stress on progenitor and stem cells in cardiovascular diseases
    • Yao EH, Yu Y, Fukuda N. Oxidative stress on progenitor and stem cells in cardiovascular diseases. Curr Pharm Biotechnol. 2006;7:101–108.
    • (2006) Curr Pharm Biotechnol , vol.7 , pp. 101-108
    • Yao, E.H.1    Yu, Y.2    Fukuda, N.3
  • 40
    • 77950564444 scopus 로고    scopus 로고
    • Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex
    • Song H, Cha MJ, Song BW, et al. Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex. Stem Cells. 2010;28:555–563.
    • (2010) Stem Cells , vol.28 , pp. 555-563
    • Song, H.1    Cha, M.J.2    Song, B.W.3
  • 41
    • 47949101704 scopus 로고    scopus 로고
    • Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
    • Mylotte LA, Duffy AM, Murphy M, et al. Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment. Stem Cells. 2008;26:1325–1336.
    • (2008) Stem Cells , vol.26 , pp. 1325-1336
    • Mylotte, L.A.1    Duffy, A.M.2    Murphy, M.3
  • 42
    • 33745739299 scopus 로고    scopus 로고
    • Targeting the inflammatory response in healing myocardial infarcts
    • Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem. 2006;13:1877–1893.
    • (2006) Curr Med Chem , vol.13 , pp. 1877-1893
    • Frangogiannis, N.G.1
  • 43
    • 84888099766 scopus 로고    scopus 로고
    • Anti-death strategies against oxidative stress in grafted mesenchymal stem cells
    • Chang W, Song BW, Moon JY, et al. Anti-death strategies against oxidative stress in grafted mesenchymal stem cells. Histol Histopathol. 2013;28:1529–1536.
    • (2013) Histol Histopathol , vol.28 , pp. 1529-1536
    • Chang, W.1    Song, B.W.2    Moon, J.Y.3
  • 44
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838–3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 45
    • 26444547962 scopus 로고    scopus 로고
    • Persistence of marrow stromal cells implanted into acutely infarcted myocardium: observations in a xenotransplant model
    • MacDonald DJ, Luo J, Saito T, et al. Persistence of marrow stromal cells implanted into acutely infarcted myocardium: observations in a xenotransplant model. J Thorac Cardiovasc Surg. 2005;130:1114–1121.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 1114-1121
    • MacDonald, D.J.1    Luo, J.2    Saito, T.3
  • 46
    • 84878998858 scopus 로고    scopus 로고
    • Cardiac cell therapy: boosting mesenchymal stem cells effects
    • Samper E, Diez-Juan A, Montero JA, et al. Cardiac cell therapy: boosting mesenchymal stem cells effects. Stem Cell Rev. 2013;9:266–280.
    • (2013) Stem Cell Rev , vol.9 , pp. 266-280
    • Samper, E.1    Diez-Juan, A.2    Montero, J.A.3
  • 47
    • 33646676295 scopus 로고    scopus 로고
    • The effects of mesenchymal stem cells transduced with Akt in a porcine myocardial infarction model
    • Lim SY, Kim YS, Ahn Y, et al. The effects of mesenchymal stem cells transduced with Akt in a porcine myocardial infarction model. Cardiovasc Res. 2006;70:530–542.
    • (2006) Cardiovasc Res , vol.70 , pp. 530-542
    • Lim, S.Y.1    Kim, Y.S.2    Ahn, Y.3
  • 48
    • 84866024490 scopus 로고    scopus 로고
    • Toll-like receptor 4 ablation improves stem cell survival after hypoxic injury
    • Brewster BD, Rouch JD, Wang M, et al. Toll-like receptor 4 ablation improves stem cell survival after hypoxic injury. J Surg Res. 2012;177:330–333.
    • (2012) J Surg Res , vol.177 , pp. 330-333
    • Brewster, B.D.1    Rouch, J.D.2    Wang, M.3
  • 49
    • 84885394905 scopus 로고    scopus 로고
    • Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression
    • McGinley LM, McMahon J, Stocca A, et al. Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. Hum Gene Ther. 2013;24:840–851.
    • (2013) Hum Gene Ther , vol.24 , pp. 840-851
    • McGinley, L.M.1    McMahon, J.2    Stocca, A.3
  • 50
    • 0141796313 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    • Mangi AA, Noiseux N, Kong D, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003;9:1195–1201.
    • (2003) Nat Med , vol.9 , pp. 1195-1201
    • Mangi, A.A.1    Noiseux, N.2    Kong, D.3
  • 51
    • 78649967662 scopus 로고    scopus 로고
    • TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection
    • Wang Y, Abarbanell AM, Herrmann JL, et al. TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection. PLoS ONE. 2010;5:e14206.
    • (2010) PLoS ONE , vol.5
    • Wang, Y.1    Abarbanell, A.M.2    Herrmann, J.L.3
  • 52
    • 77951868977 scopus 로고    scopus 로고
    • Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia
    • Tsubokawa T, Yagi K, Nakanishi C, et al. Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia. Am J Physiol Heart Circ Physiol. 2010;298:H1320–H1329.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1320-H1329
    • Tsubokawa, T.1    Yagi, K.2    Nakanishi, C.3
  • 53
    • 73349099336 scopus 로고    scopus 로고
    • Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors
    • Wang X, Zhao T, Huang W, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. 2009;27:3021–3031.
    • (2009) Stem Cells , vol.27 , pp. 3021-3031
    • Wang, X.1    Zhao, T.2    Huang, W.3
  • 54
    • 78649759739 scopus 로고    scopus 로고
    • Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival
    • Li H, Zuo S, He Z, et al. Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. Am J Physiol Heart Circ Physiol. 2010;299:H1772–H1781.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H1772-H1781
    • Li, H.1    Zuo, S.2    He, Z.3
  • 55
    • 34547901409 scopus 로고    scopus 로고
    • Bcl-2 engineered MSCs inhibited apoptosis and improved heart function
    • Li W, Ma N, Ong LL, et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells. 2007;25:2118–2127.
    • (2007) Stem Cells , vol.25 , pp. 2118-2127
    • Li, W.1    Ma, N.2    Ong, L.L.3
  • 56
    • 84930002928 scopus 로고    scopus 로고
    • Bcl-xL genetic modification enhanced the therapeutic efficacy of mesenchymal stem cell transplantation in the treatment of heart infarction
    • Xue X, Liu Y, Zhang J, et al. Bcl-xL genetic modification enhanced the therapeutic efficacy of mesenchymal stem cell transplantation in the treatment of heart infarction. Stem Cells Int. 2015;2015:176409.
    • (2015) Stem Cells Int , vol.2015 , pp. 176409
    • Xue, X.1    Liu, Y.2    Zhang, J.3
  • 57
    • 77953919762 scopus 로고    scopus 로고
    • Connexin43 promotes survival of mesenchymal stem cells in ischaemic heart
    • Wang D, Shen W, Zhang F, et al. Connexin43 promotes survival of mesenchymal stem cells in ischaemic heart. Cell Biol Int. 2010;34:415–423.
    • (2010) Cell Biol Int , vol.34 , pp. 415-423
    • Wang, D.1    Shen, W.2    Zhang, F.3
  • 58
    • 70350690284 scopus 로고    scopus 로고
    • Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction
    • Fan L, Lin C, Zhuo S, et al. Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction. Eur J Heart Fail. 2009;11:1023–1030.
    • (2009) Eur J Heart Fail , vol.11 , pp. 1023-1030
    • Fan, L.1    Lin, C.2    Zhuo, S.3
  • 59
    • 84872722077 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair
    • Cerrada I, Ruiz-Sauri A, Carrero R, et al. Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair. Stem Cells Dev. 2013;22:501–511.
    • (2013) Stem Cells Dev , vol.22 , pp. 501-511
    • Cerrada, I.1    Ruiz-Sauri, A.2    Carrero, R.3
  • 60
    • 84880843626 scopus 로고    scopus 로고
    • Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction
    • Gao L, Bledsoe G, Yin H, et al. Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction. Circ J. 2013;77:2134–2144.
    • (2013) Circ J , vol.77 , pp. 2134-2144
    • Gao, L.1    Bledsoe, G.2    Yin, H.3
  • 61
    • 84899088403 scopus 로고    scopus 로고
    • Mesenchymal stem cells with overexpression of midkine enhance cell survival and attenuate cardiac dysfunction in a rat model of myocardial infarction
    • Zhao SL, Zhang YJ, Li MH, et al. Mesenchymal stem cells with overexpression of midkine enhance cell survival and attenuate cardiac dysfunction in a rat model of myocardial infarction. Stem Cell Res Ther. 2014;5:37.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 37
    • Zhao, S.L.1    Zhang, Y.J.2    Li, M.H.3
  • 62
    • 84876456221 scopus 로고    scopus 로고
    • Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction
    • Huang F, Li ML, Fang ZF, et al. Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction. Cardiology. 2013;125:18–30.
    • (2013) Cardiology , vol.125 , pp. 18-30
    • Huang, F.1    Li, M.L.2    Fang, Z.F.3
  • 63
    • 84925484043 scopus 로고    scopus 로고
    • MicroRNA-133a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart
    • Dakhlallah D, Zhang J, Yu L, et al. MicroRNA-133a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart. J Cardiovasc Pharmacol. 2015;65:241–251.
    • (2015) J Cardiovasc Pharmacol , vol.65 , pp. 241-251
    • Dakhlallah, D.1    Zhang, J.2    Yu, L.3
  • 64
    • 84901008516 scopus 로고    scopus 로고
    • MicroRNA-23a is involved in tumor necrosis factor-alpha induced apoptosis in mesenchymal stem cells and myocardial infarction
    • Mao J, Lv Z, Zhuang Y. MicroRNA-23a is involved in tumor necrosis factor-alpha induced apoptosis in mesenchymal stem cells and myocardial infarction. Exp Mol Pathol. 2014;97:23–30.
    • (2014) Exp Mol Pathol , vol.97 , pp. 23-30
    • Mao, J.1    Lv, Z.2    Zhuang, Y.3
  • 65
    • 84876974545 scopus 로고    scopus 로고
    • Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
    • Chang W, Lee CY, Park JH, et al. Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. J Vet Sci. 2013;14:69–76.
    • (2013) J Vet Sci , vol.14 , pp. 69-76
    • Chang, W.1    Lee, C.Y.2    Park, J.H.3
  • 66
    • 84920416144 scopus 로고    scopus 로고
    • miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation
    • Xu J, Huang Z, Lin L, et al. miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation. Sci China Life Sci. 2014;57:989–997.
    • (2014) Sci China Life Sci , vol.57 , pp. 989-997
    • Xu, J.1    Huang, Z.2    Lin, L.3
  • 67
    • 84939807947 scopus 로고    scopus 로고
    • let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3
    • Ham O, Lee SY, Lee CY, et al. let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3. Stem Cell Res Ther. 2015;6:147.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 147
    • Ham, O.1    Lee, S.Y.2    Lee, C.Y.3
  • 68
    • 77953812469 scopus 로고    scopus 로고
    • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium
    • Huang J, Zhang Z, Guo J, et al. Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res. 2010;106:1753–1762.
    • (2010) Circ Res , vol.106 , pp. 1753-1762
    • Huang, J.1    Zhang, Z.2    Guo, J.3
  • 69
    • 84881411006 scopus 로고    scopus 로고
    • Overexpression of CXCL12 chemokine up-regulates connexin and integrin expression in mesenchymal stem cells through PI3K/Akt pathway
    • Xiaowei C, Jia M, Xiaowei W, et al. Overexpression of CXCL12 chemokine up-regulates connexin and integrin expression in mesenchymal stem cells through PI3K/Akt pathway. Cell Commun Adhes. 2013;20:67–72.
    • (2013) Cell Commun Adhes , vol.20 , pp. 67-72
    • Xiaowei, C.1    Jia, M.2    Xiaowei, W.3
  • 70
    • 84866993025 scopus 로고    scopus 로고
    • Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts
    • Wang S, Qin X, Sun D, et al. Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts. Cell Biochem Funct. 2012;30:574–581.
    • (2012) Cell Biochem Funct , vol.30 , pp. 574-581
    • Wang, S.1    Qin, X.2    Sun, D.3
  • 71
    • 39149089319 scopus 로고    scopus 로고
    • Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium
    • Zhang D, Fan GC, Zhou X, et al. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol. 2008;44:281–292.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 281-292
    • Zhang, D.1    Fan, G.C.2    Zhou, X.3
  • 72
    • 39849097361 scopus 로고    scopus 로고
    • Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance
    • Cheng Z, Ou L, Zhou X, et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther. 2008;16:571–579.
    • (2008) Mol Ther , vol.16 , pp. 571-579
    • Cheng, Z.1    Ou, L.2    Zhou, X.3
  • 73
    • 77953537513 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction
    • Tang J, Wang J, Guo L, et al. Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction. Mol Cells. 2010;29:9–19.
    • (2010) Mol Cells , vol.29 , pp. 9-19
    • Tang, J.1    Wang, J.2    Guo, L.3
  • 74
    • 77953173235 scopus 로고    scopus 로고
    • Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups
    • Yang ZJ, Chen B, Sheng Z, et al. Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups. Mol Biol Rep. 2010;37:2075–2081.
    • (2010) Mol Biol Rep , vol.37 , pp. 2075-2081
    • Yang, Z.J.1    Chen, B.2    Sheng, Z.3
  • 75
    • 84909986752 scopus 로고    scopus 로고
    • Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells
    • Zhang J, Wang LL, Du W, et al. Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells. PLoS ONE. 2014;9:e111246.
    • (2014) PLoS ONE , vol.9
    • Zhang, J.1    Wang, L.L.2    Du, W.3
  • 76
    • 34247624143 scopus 로고    scopus 로고
    • Integrin-linked kinase production prevents anoikis in human mesenchymal stem cells
    • Benoit DS, Tripodi MC, Blanchette JO, et al. Integrin-linked kinase production prevents anoikis in human mesenchymal stem cells. J Biomed Mater Res A. 2007;81:259–268.
    • (2007) J Biomed Mater Res A , vol.81 , pp. 259-268
    • Benoit, D.S.1    Tripodi, M.C.2    Blanchette, J.O.3
  • 77
    • 84911993707 scopus 로고    scopus 로고
    • Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction
    • Mao Q, Lin C, Gao J, et al. Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction. Mol Cell Biochem. 2014;397:203–214.
    • (2014) Mol Cell Biochem , vol.397 , pp. 203-214
    • Mao, Q.1    Lin, C.2    Gao, J.3
  • 78
    • 79952068625 scopus 로고    scopus 로고
    • Myocardial injection with GSK-3beta-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction
    • Cho J, Zhai P, Maejima Y, et al. Myocardial injection with GSK-3beta-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ Res. 2011;108:478–489.
    • (2011) Circ Res , vol.108 , pp. 478-489
    • Cho, J.1    Zhai, P.2    Maejima, Y.3
  • 79
    • 45449097636 scopus 로고    scopus 로고
    • Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction
    • Liu XH, Bai CG, Xu ZY, et al. Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction. Microvasc Res. 2008;76:23–30.
    • (2008) Microvasc Res , vol.76 , pp. 23-30
    • Liu, X.H.1    Bai, C.G.2    Xu, Z.Y.3
  • 80
    • 49249101551 scopus 로고    scopus 로고
    • Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts
    • Grauss RW, van Tuyn J, Steendijk P, et al. Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts. Stem Cells. 2008;26:1083–1093.
    • (2008) Stem Cells , vol.26 , pp. 1083-1093
    • Grauss, R.W.1    van Tuyn, J.2    Steendijk, P.3
  • 81
    • 35648974227 scopus 로고    scopus 로고
    • Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells
    • Sze SK, de Kleijn DP, Lai RC, et al. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007;6:1680–1689.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 1680-1689
    • Sze, S.K.1    de Kleijn, D.P.2    Lai, R.C.3
  • 82
    • 84959362513 scopus 로고    scopus 로고
    • Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell
    • Ge L, Jiang M, Duan D, et al. Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell. Stem Cells Int. 2016;2016:1243659.
    • (2016) Stem Cells Int , vol.2016 , pp. 1243659
    • Ge, L.1    Jiang, M.2    Duan, D.3
  • 83
    • 84860425709 scopus 로고    scopus 로고
    • Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue
    • Hsiao ST, Asgari A, Lokmic Z, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev. 2012;21:2189–2203.
    • (2012) Stem Cells Dev , vol.21 , pp. 2189-2203
    • Hsiao, S.T.1    Asgari, A.2    Lokmic, Z.3
  • 84
    • 34247520435 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction
    • Sun L, Cui M, Wang Z, et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction. Biochem Biophys Res Commun. 2007;357:779–784.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 779-784
    • Sun, L.1    Cui, M.2    Wang, Z.3
  • 85
    • 10744233934 scopus 로고    scopus 로고
    • Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor
    • Duan HF, Wu CT, Wu DL, et al. Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther. 2003;8:467–474.
    • (2003) Mol Ther , vol.8 , pp. 467-474
    • Duan, H.F.1    Wu, C.T.2    Wu, D.L.3
  • 86
    • 84945161551 scopus 로고    scopus 로고
    • Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair
    • Zhu K, Wu M, Lai H, et al. Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair. Biomaterials. 2016;74:188–199.
    • (2016) Biomaterials , vol.74 , pp. 188-199
    • Zhu, K.1    Wu, M.2    Lai, H.3
  • 87
    • 58149345104 scopus 로고    scopus 로고
    • IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair
    • Haider H, Jiang S, Idris NM, et al. IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair. Circ Res. 2008;103:1300–1308.
    • (2008) Circ Res , vol.103 , pp. 1300-1308
    • Haider, H.1    Jiang, S.2    Idris, N.M.3
  • 88
    • 37349036435 scopus 로고    scopus 로고
    • Locally overexpressing hepatocyte growth factor prevents post-ischemic heart failure by inhibition of apoptosis via calcineurin-mediated pathway and angiogenesis
    • Guo Y, He J, Wu J, et al. Locally overexpressing hepatocyte growth factor prevents post-ischemic heart failure by inhibition of apoptosis via calcineurin-mediated pathway and angiogenesis. Arch Med Res. 2008;39:179–188.
    • (2008) Arch Med Res , vol.39 , pp. 179-188
    • Guo, Y.1    He, J.2    Wu, J.3
  • 89
    • 84890154858 scopus 로고    scopus 로고
    • MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine
    • Moon HH, Joo MK, Mok H, et al. MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine. Biomaterials. 2014;35:1744–1754.
    • (2014) Biomaterials , vol.35 , pp. 1744-1754
    • Moon, H.H.1    Joo, M.K.2    Mok, H.3
  • 90
    • 79953329763 scopus 로고    scopus 로고
    • Hypoxia-inducible vascular endothelial growth factor-engineered mesenchymal stem cells prevent myocardial ischemic injury
    • Kim SH, Moon HH, Kim HA, et al. Hypoxia-inducible vascular endothelial growth factor-engineered mesenchymal stem cells prevent myocardial ischemic injury. Mol Ther. 2011;19:741–750.
    • (2011) Mol Ther , vol.19 , pp. 741-750
    • Kim, S.H.1    Moon, H.H.2    Kim, H.A.3
  • 91
    • 35348924779 scopus 로고    scopus 로고
    • A promising strategy for the treatment of ischemic heart disease: mesenchymal stem cell-mediated vascular endothelial growth factor gene transfer in rats
    • Gao F, He T, Wang H, et al. A promising strategy for the treatment of ischemic heart disease: mesenchymal stem cell-mediated vascular endothelial growth factor gene transfer in rats. Can J Cardiol. 2007;23:891–898.
    • (2007) Can J Cardiol , vol.23 , pp. 891-898
    • Gao, F.1    He, T.2    Wang, H.3
  • 92
    • 79951950114 scopus 로고    scopus 로고
    • In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice
    • Lian WS, Cheng WT, Cheng CC, et al. In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice. Life Sci. 2011;88:455–464.
    • (2011) Life Sci , vol.88 , pp. 455-464
    • Lian, W.S.1    Cheng, W.T.2    Cheng, C.C.3
  • 93
    • 84896044877 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells carrying the human receptor activity-modifying protein 1 gene improves cardiac function and inhibits neointimal proliferation in the carotid angioplasty and myocardial infarction rabbit model
    • Shi B, Long X, Zhao R, et al. Transplantation of mesenchymal stem cells carrying the human receptor activity-modifying protein 1 gene improves cardiac function and inhibits neointimal proliferation in the carotid angioplasty and myocardial infarction rabbit model. Exp Biol Med (Maywood). 2014;239:356–365.
    • (2014) Exp Biol Med (Maywood) , vol.239 , pp. 356-365
    • Shi, B.1    Long, X.2    Zhao, R.3
  • 94
    • 84878881266 scopus 로고    scopus 로고
    • Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury
    • Liang H, Hou H, Yi W, et al. Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury. Eur Heart J. 2013;34:1681–1690.
    • (2013) Eur Heart J , vol.34 , pp. 1681-1690
    • Liang, H.1    Hou, H.2    Yi, W.3
  • 95
    • 78649673599 scopus 로고    scopus 로고
    • Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells
    • Chacko SM, Ahmed S, Selvendiran K, et al. Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol. 2010;299:C1562–C1570.
    • (2010) Am J Physiol Cell Physiol , vol.299 , pp. C1562-C1570
    • Chacko, S.M.1    Ahmed, S.2    Selvendiran, K.3
  • 96
    • 63349093610 scopus 로고    scopus 로고
    • Anoxic preconditioning: a way to enhance the cardioprotection of mesenchymal stem cells
    • Wang JA, He A, Hu X, et al. Anoxic preconditioning: a way to enhance the cardioprotection of mesenchymal stem cells. Int J Cardiol. 2009;133:410–412.
    • (2009) Int J Cardiol , vol.133 , pp. 410-412
    • Wang, J.A.1    He, A.2    Hu, X.3
  • 97
    • 40949085086 scopus 로고    scopus 로고
    • Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis
    • Hu X, Yu SP, Fraser JL, et al. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg. 2008;135:799–808.
    • (2008) J Thorac Cardiovasc Surg , vol.135 , pp. 799-808
    • Hu, X.1    Yu, S.P.2    Fraser, J.L.3
  • 98
    • 42649118760 scopus 로고    scopus 로고
    • Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy
    • Li JH, Zhang N, Wang JA. Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy. J Endocrinol Invest. 2008;31:103–110.
    • (2008) J Endocrinol Invest , vol.31 , pp. 103-110
    • Li, J.H.1    Zhang, N.2    Wang, J.A.3
  • 99
    • 55049084643 scopus 로고    scopus 로고
    • Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
    • Rosova I, Dao M, Capoccia B, et al. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells. 2008;26:2173–2182.
    • (2008) Stem Cells , vol.26 , pp. 2173-2182
    • Rosova, I.1    Dao, M.2    Capoccia, B.3
  • 100
    • 84884220766 scopus 로고    scopus 로고
    • Preconditioning mesenchymal stem cells with caspase inhibition and hyperoxia prior to hypoxia exposure increases cell proliferation
    • Saini U, Gumina RJ, Wolfe B, et al. Preconditioning mesenchymal stem cells with caspase inhibition and hyperoxia prior to hypoxia exposure increases cell proliferation. J Cell Biochem. 2013;114:2612–2623.
    • (2013) J Cell Biochem , vol.114 , pp. 2612-2623
    • Saini, U.1    Gumina, R.J.2    Wolfe, B.3
  • 101
    • 84867431419 scopus 로고    scopus 로고
    • Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton's Jelly mesenchymal stem cells after myocardial infarction
    • Zhang J, Chen GH, Wang YW, et al. Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton's Jelly mesenchymal stem cells after myocardial infarction. Chin Med J (Engl). 2012;125:3472–3478.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 3472-3478
    • Zhang, J.1    Chen, G.H.2    Wang, Y.W.3
  • 102
    • 84859932387 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats
    • Xie X, Sun A, Zhu W, et al. Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats. Tohoku J Exp Med. 2012;226:29–36.
    • (2012) Tohoku J Exp Med , vol.226 , pp. 29-36
    • Xie, X.1    Sun, A.2    Zhu, W.3
  • 103
    • 80051983744 scopus 로고    scopus 로고
    • Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis
    • Numasawa Y, Kimura T, Miyoshi S, et al. Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis. Stem Cells. 2011;29:1405–1414.
    • (2011) Stem Cells , vol.29 , pp. 1405-1414
    • Numasawa, Y.1    Kimura, T.2    Miyoshi, S.3
  • 104
    • 33751090979 scopus 로고    scopus 로고
    • Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes
    • Matsushita K, Wu Y, Okamoto Y, et al. Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension. 2006;48:1095–1102.
    • (2006) Hypertension , vol.48 , pp. 1095-1102
    • Matsushita, K.1    Wu, Y.2    Okamoto, Y.3
  • 105
    • 84920934809 scopus 로고    scopus 로고
    • Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt
    • Gong X, Fan G, Wang W, et al. Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt. Cell Physiol Biochem. 2014;34:2245–2255.
    • (2014) Cell Physiol Biochem , vol.34 , pp. 2245-2255
    • Gong, X.1    Fan, G.2    Wang, W.3
  • 106
    • 84861157772 scopus 로고    scopus 로고
    • Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia
    • Xu H, Zhu G, Tian Y. Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia. J Huazhong Univ Sci Technolog Med Sci. 2012;32:36–41.
    • (2012) J Huazhong Univ Sci Technolog Med Sci , vol.32 , pp. 36-41
    • Xu, H.1    Zhu, G.2    Tian, Y.3
  • 107
    • 65649150660 scopus 로고    scopus 로고
    • Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression
    • Wisel S, Khan M, Kuppusamy ML, et al. Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression. J Pharmacol Exp Ther. 2009;329:543–550.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 543-550
    • Wisel, S.1    Khan, M.2    Kuppusamy, M.L.3
  • 108
    • 77949467364 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats
    • Cui X, Wang H, Guo H, et al. Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats. Tohoku J Exp Med. 2010;220:139–147.
    • (2010) Tohoku J Exp Med , vol.220 , pp. 139-147
    • Cui, X.1    Wang, H.2    Guo, H.3
  • 109
    • 84934275997 scopus 로고    scopus 로고
    • Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
    • Zhang F, Cui J, Lv B, et al. Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis. Int J Mol Med. 2015;36:415–423.
    • (2015) Int J Mol Med , vol.36 , pp. 415-423
    • Zhang, F.1    Cui, J.2    Lv, B.3
  • 110
    • 70349143140 scopus 로고    scopus 로고
    • Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction
    • Yao Y, Zhang F, Wang L, et al. Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci. 2009;16:74.
    • (2009) J Biomed Sci , vol.16 , pp. 74
    • Yao, Y.1    Zhang, F.2    Wang, L.3
  • 111
    • 84921027423 scopus 로고    scopus 로고
    • Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro
    • Wang F, Zhou H, Du Z, et al. Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. Eur J Pharmacol. 2015;748:157–165.
    • (2015) Eur J Pharmacol , vol.748 , pp. 157-165
    • Wang, F.1    Zhou, H.2    Du, Z.3
  • 112
    • 84956921553 scopus 로고    scopus 로고
    • Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
    • Han D, Huang W, Li X, et al. Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway. J Pineal Res. 2015;60:178–192.
    • (2015) J Pineal Res , vol.60 , pp. 178-192
    • Han, D.1    Huang, W.2    Li, X.3
  • 113
    • 84929302745 scopus 로고    scopus 로고
    • Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction
    • Liu C, Fan Y, Zhou L, et al. Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction. Int J Cardiol. 2015;188:22–32.
    • (2015) Int J Cardiol , vol.188 , pp. 22-32
    • Liu, C.1    Fan, Y.2    Zhou, L.3
  • 114
    • 85027952594 scopus 로고    scopus 로고
    • Transplantation of salvianolic acid B pretreated mesenchymal stem cells improves cardiac function in rats with myocardial infarction through angiogenesis and paracrine mechanisms
    • Guo HD, Cui GH, Tian JX, et al. Transplantation of salvianolic acid B pretreated mesenchymal stem cells improves cardiac function in rats with myocardial infarction through angiogenesis and paracrine mechanisms. Int J Cardiol. 2014;177:538–542.
    • (2014) Int J Cardiol , vol.177 , pp. 538-542
    • Guo, H.D.1    Cui, G.H.2    Tian, J.X.3
  • 115
    • 84858166658 scopus 로고    scopus 로고
    • Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury
    • Kim YS, Ahn Y, Kwon JS, et al. Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury. Cells Tissues Organs. 2012;195:428–442.
    • (2012) Cells Tissues Organs , vol.195 , pp. 428-442
    • Kim, Y.S.1    Ahn, Y.2    Kwon, J.S.3
  • 116
    • 79952129848 scopus 로고    scopus 로고
    • Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function
    • Shinmura D, Togashi I, Miyoshi S, et al. Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function. Stem Cells. 2011;29:357–366.
    • (2011) Stem Cells , vol.29 , pp. 357-366
    • Shinmura, D.1    Togashi, I.2    Miyoshi, S.3
  • 117
    • 73549117183 scopus 로고    scopus 로고
    • Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction
    • Wang Y, Zhang D, Ashraf M, et al. Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2010;298:H275–H286.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H275-H286
    • Wang, Y.1    Zhang, D.2    Ashraf, M.3
  • 118
    • 84885580970 scopus 로고    scopus 로고
    • Atorvastatin improves microenvironment to enhance the beneficial effects of BMSCs therapy in a rabbit model of acute myocardial infarction
    • Qu Z, Xu H, Tian Y, et al. Atorvastatin improves microenvironment to enhance the beneficial effects of BMSCs therapy in a rabbit model of acute myocardial infarction. Cell Physiol Biochem. 2013;32:380–389.
    • (2013) Cell Physiol Biochem , vol.32 , pp. 380-389
    • Qu, Z.1    Xu, H.2    Tian, Y.3
  • 119
    • 84908241065 scopus 로고    scopus 로고
    • Atorvastatin treatment improves the effects of mesenchymal stem cell transplantation on acute myocardial infarction: the role of the RhoA/ROCK/ERK pathway
    • Zhang Q, Wang H, Yang YJ, et al. Atorvastatin treatment improves the effects of mesenchymal stem cell transplantation on acute myocardial infarction: the role of the RhoA/ROCK/ERK pathway. Int J Cardiol. 2014;176:670–679.
    • (2014) Int J Cardiol , vol.176 , pp. 670-679
    • Zhang, Q.1    Wang, H.2    Yang, Y.J.3
  • 120
    • 84878607366 scopus 로고    scopus 로고
    • Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase
    • Song L, Yang YJ, Dong QT, et al. Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase. PLoS ONE. 2013;8:e65702.
    • (2013) PLoS ONE , vol.8
    • Song, L.1    Yang, Y.J.2    Dong, Q.T.3
  • 121
    • 36749001126 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction
    • Guo J, Lin G, Bao C, et al. Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction. J Biomed Sci. 2008;15:89–97.
    • (2008) J Biomed Sci , vol.15 , pp. 89-97
    • Guo, J.1    Lin, G.2    Bao, C.3
  • 122
    • 84937548834 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 treatment of MSCs attenuates inflammation and cardiac dysfunction following MI
    • Guo J, Zheng D, Li WF, et al. Insulin-like growth factor 1 treatment of MSCs attenuates inflammation and cardiac dysfunction following MI. Inflammation. 2014;37:2156–2163.
    • (2014) Inflammation , vol.37 , pp. 2156-2163
    • Guo, J.1    Zheng, D.2    Li, W.F.3
  • 123
    • 38849108184 scopus 로고    scopus 로고
    • Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium
    • Pasha Z, Wang Y, Sheikh R, et al. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res. 2008;77:134–142.
    • (2008) Cardiovasc Res , vol.77 , pp. 134-142
    • Pasha, Z.1    Wang, Y.2    Sheikh, R.3
  • 124
    • 77955486750 scopus 로고    scopus 로고
    • Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways
    • Gao F, Hu XY, Xie XJ, et al. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. J Zhejiang Univ Sci B. 2010;11:608–617.
    • (2010) J Zhejiang Univ Sci B , vol.11 , pp. 608-617
    • Gao, F.1    Hu, X.Y.2    Xie, X.J.3
  • 125
    • 39549105786 scopus 로고    scopus 로고
    • Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction
    • Hahn JY, Cho HJ, Kang HJ, et al. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol. 2008;51:933–943.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 933-943
    • Hahn, J.Y.1    Cho, H.J.2    Kang, H.J.3
  • 126
    • 84889644839 scopus 로고    scopus 로고
    • Platelet rich plasma clot releasate preconditioning induced PI3K/AKT/NFkappaB signaling enhances survival and regenerative function of rat bone marrow mesenchymal stem cells in hostile microenvironments
    • Peng Y, Huang S, Wu Y, et al. Platelet rich plasma clot releasate preconditioning induced PI3K/AKT/NFkappaB signaling enhances survival and regenerative function of rat bone marrow mesenchymal stem cells in hostile microenvironments. Stem Cells Dev. 2013;22:3236–3251.
    • (2013) Stem Cells Dev , vol.22 , pp. 3236-3251
    • Peng, Y.1    Huang, S.2    Wu, Y.3
  • 127
    • 84903266491 scopus 로고    scopus 로고
    • Co-treating mesenchymal stem cells with IL1beta and TNF-alpha increases VCAM-1 expression and improves post-ischemic myocardial function
    • Wang CM, Guo Z, Xie YJ, et al. Co-treating mesenchymal stem cells with IL1beta and TNF-alpha increases VCAM-1 expression and improves post-ischemic myocardial function. Mol Med Rep. 2014;10:792–798.
    • (2014) Mol Med Rep , vol.10 , pp. 792-798
    • Wang, C.M.1    Guo, Z.2    Xie, Y.J.3
  • 128
    • 84877794454 scopus 로고    scopus 로고
    • Autologous serum enhances cardiomyocyte differentiation of rat bone marrow mesenchymal stem cells in the presence of transforming growth factor-beta1 (TGF-beta1)
    • Rouhi L, Kajbafzadeh AM, Modaresi M, et al. Autologous serum enhances cardiomyocyte differentiation of rat bone marrow mesenchymal stem cells in the presence of transforming growth factor-beta1 (TGF-beta1). Vitro Cell Dev Biol Anim. 2013;49:287–294.
    • (2013) Vitro Cell Dev Biol Anim , vol.49 , pp. 287-294
    • Rouhi, L.1    Kajbafzadeh, A.M.2    Modaresi, M.3
  • 129
    • 84892776788 scopus 로고    scopus 로고
    • Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells
    • Sullivan KE, Quinn KP, Tang KM, et al. Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells. Stem Cell Res Ther. 2014;5:14.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 14
    • Sullivan, K.E.1    Quinn, K.P.2    Tang, K.M.3
  • 130
    • 77952289057 scopus 로고    scopus 로고
    • Co-culture with cardiomyocytes enhanced the myogenic conversion of mesenchymal stromal cells in a dose-dependent manner
    • He XQ, Chen MS, Li SH, et al. Co-culture with cardiomyocytes enhanced the myogenic conversion of mesenchymal stromal cells in a dose-dependent manner. Mol Cell Biochem. 2010;339:89–98.
    • (2010) Mol Cell Biochem , vol.339 , pp. 89-98
    • He, X.Q.1    Chen, M.S.2    Li, S.H.3
  • 131
    • 85047290173 scopus 로고    scopus 로고
    • Cardiac stem cell hybrids enhance myocardial repair
    • Quijada P, Salunga HT, Hariharan N, et al. Cardiac stem cell hybrids enhance myocardial repair. Circ Res. 2015;117:695–706.
    • (2015) Circ Res , vol.117 , pp. 695-706
    • Quijada, P.1    Salunga, H.T.2    Hariharan, N.3
  • 132
    • 84949293824 scopus 로고    scopus 로고
    • How to improve the survival of transplanted mesenchymal stem cell in ischemic heart?
    • Li L, Chen X, Wang WE, et al. How to improve the survival of transplanted mesenchymal stem cell in ischemic heart? Stem Cells Int. 2016;2016:9682757.
    • (2016) Stem Cells Int , vol.2016 , pp. 9682757
    • Li, L.1    Chen, X.2    Wang, W.E.3
  • 133
    • 33645740062 scopus 로고    scopus 로고
    • Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
    • Miyahara Y, Nagaya N, Kataoka M, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006;12:459–465.
    • (2006) Nat Med , vol.12 , pp. 459-465
    • Miyahara, Y.1    Nagaya, N.2    Kataoka, M.3
  • 134
    • 38849117016 scopus 로고    scopus 로고
    • Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction
    • Wang CC, Chen CH, Lin WW, et al. Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction. Cardiovasc Res. 2008;77:515–524.
    • (2008) Cardiovasc Res , vol.77 , pp. 515-524
    • Wang, C.C.1    Chen, C.H.2    Lin, W.W.3
  • 135
    • 84875837259 scopus 로고    scopus 로고
    • A translational approach in using cell sheet fragments of autologous bone marrow-derived mesenchymal stem cells for cellular cardiomyoplasty in a porcine model
    • Huang CC, Tsai HW, Lee WY, et al. A translational approach in using cell sheet fragments of autologous bone marrow-derived mesenchymal stem cells for cellular cardiomyoplasty in a porcine model. Biomaterials. 2013;34:4582–4591.
    • (2013) Biomaterials , vol.34 , pp. 4582-4591
    • Huang, C.C.1    Tsai, H.W.2    Lee, W.Y.3
  • 136
    • 84926135977 scopus 로고    scopus 로고
    • Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study
    • Tano N, Narita T, Kaneko M, et al. Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study. Mol Ther. 2014;22:1864–1871.
    • (2014) Mol Ther , vol.22 , pp. 1864-1871
    • Tano, N.1    Narita, T.2    Kaneko, M.3
  • 137
    • 84863464420 scopus 로고    scopus 로고
    • Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction
    • Lee EJ, Park SJ, Kang SK, et al. Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction. Mol Ther. 2012;20:1424–1433.
    • (2012) Mol Ther , vol.20 , pp. 1424-1433
    • Lee, E.J.1    Park, S.J.2    Kang, S.K.3
  • 138
    • 85046550001 scopus 로고    scopus 로고
    • Spheroid formation and enhanced cardiomyogenic potential of adipose-derived stem cells grown on chitosan
    • Liu BH, Yeh HY, Lin YC, et al. Spheroid formation and enhanced cardiomyogenic potential of adipose-derived stem cells grown on chitosan. Biores Open Access. 2013;2:28–39.
    • (2013) Biores Open Access , vol.2 , pp. 28-39
    • Liu, B.H.1    Yeh, H.Y.2    Lin, Y.C.3
  • 139
    • 46149099328 scopus 로고    scopus 로고
    • Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair
    • Wei HJ, Chen CH, Lee WY, et al. Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair. Biomaterials. 2008;29:3547–3556.
    • (2008) Biomaterials , vol.29 , pp. 3547-3556
    • Wei, H.J.1    Chen, C.H.2    Lee, W.Y.3
  • 140
    • 84868648325 scopus 로고    scopus 로고
    • Repairing chronic myocardial infarction with autologous mesenchymal stem cells engineered tissue in rat promotes angiogenesis and limits ventricular remodeling
    • Maureira P, Marie PY, Yu F, et al. Repairing chronic myocardial infarction with autologous mesenchymal stem cells engineered tissue in rat promotes angiogenesis and limits ventricular remodeling. J Biomed Sci. 2012;19:93.
    • (2012) J Biomed Sci , vol.19 , pp. 93
    • Maureira, P.1    Marie, P.Y.2    Yu, F.3
  • 141
    • 84870660564 scopus 로고    scopus 로고
    • Localization of mesenchymal stem cells grafted with a hyaluronan-based scaffold in the infarcted heart
    • Fiumana E, Pasquinelli G, Foroni L, et al. Localization of mesenchymal stem cells grafted with a hyaluronan-based scaffold in the infarcted heart. J Surg Res. 2013;179:e21–e29.
    • (2013) J Surg Res , vol.179 , pp. e21-e29
    • Fiumana, E.1    Pasquinelli, G.2    Foroni, L.3
  • 142
    • 84894644058 scopus 로고    scopus 로고
    • Cardiac fibroblast-derived 3D extracellular matrix seeded with mesenchymal stem cells as a novel device to transfer cells to the ischemic myocardium
    • Schmuck EG, Mulligan JD, Ertel RL, et al. Cardiac fibroblast-derived 3D extracellular matrix seeded with mesenchymal stem cells as a novel device to transfer cells to the ischemic myocardium. Cardiovasc Eng Technol. 2014;5:119–131.
    • (2014) Cardiovasc Eng Technol , vol.5 , pp. 119-131
    • Schmuck, E.G.1    Mulligan, J.D.2    Ertel, R.L.3
  • 143
    • 64549125639 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells within a poly(lactide-co-epsilon-caprolactone) scaffold improves cardiac function in a rat myocardial infarction model
    • Jin J, Jeong SI, Shin YM, et al. Transplantation of mesenchymal stem cells within a poly(lactide-co-epsilon-caprolactone) scaffold improves cardiac function in a rat myocardial infarction model. Eur J Heart Fail. 2009;11:147–153.
    • (2009) Eur J Heart Fail , vol.11 , pp. 147-153
    • Jin, J.1    Jeong, S.I.2    Shin, Y.M.3
  • 144
    • 84871462355 scopus 로고    scopus 로고
    • Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction
    • Mathieu E, Lamirault G, Toquet C, et al. Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction. PLoS ONE. 2012;7:e51991.
    • (2012) PLoS ONE , vol.7
    • Mathieu, E.1    Lamirault, G.2    Toquet, C.3
  • 145
    • 84855363594 scopus 로고    scopus 로고
    • Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: a quantitative comparison with endocardial injection
    • Le Visage C, Gournay O, Benguirat N, et al. Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: a quantitative comparison with endocardial injection. Tissue Eng Part A. 2012;18:35–44.
    • (2012) Tissue Eng Part A , vol.18 , pp. 35-44
    • Le Visage, C.1    Gournay, O.2    Benguirat, N.3
  • 146
    • 84901794673 scopus 로고    scopus 로고
    • Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization
    • Guex AG, Frobert A, Valentin J, et al. Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization. Acta Biomater. 2014;10:2996–3006.
    • (2014) Acta Biomater , vol.10 , pp. 2996-3006
    • Guex, A.G.1    Frobert, A.2    Valentin, J.3
  • 147
    • 84959519446 scopus 로고    scopus 로고
    • Human mesenchymal stem cell delivery system modulates ischemic cardiac remodeling with an increase of coronary artery blood flow
    • Lee YS, Joo WS, Kim HS, et al. Human mesenchymal stem cell delivery system modulates ischemic cardiac remodeling with an increase of coronary artery blood flow. Mol Ther. 2016;24:805–811.
    • (2016) Mol Ther , vol.24 , pp. 805-811
    • Lee, Y.S.1    Joo, W.S.2    Kim, H.S.3
  • 148
    • 84896490457 scopus 로고    scopus 로고
    • Injection of composite with bone marrow-derived mesenchymal stem cells and a novel synthetic hydrogel after myocardial infarction: a protective role in left ventricle function
    • Chen J, Guo R, Zhou Q, et al. Injection of composite with bone marrow-derived mesenchymal stem cells and a novel synthetic hydrogel after myocardial infarction: a protective role in left ventricle function. Kaohsiung J Med Sci. 2014;30:173–180.
    • (2014) Kaohsiung J Med Sci , vol.30 , pp. 173-180
    • Chen, J.1    Guo, R.2    Zhou, Q.3
  • 149
    • 33750622827 scopus 로고    scopus 로고
    • Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells
    • Xiang Z, Liao R, Kelly MS, et al. Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006;12:2467–2478.
    • (2006) Tissue Eng , vol.12 , pp. 2467-2478
    • Xiang, Z.1    Liao, R.2    Kelly, M.S.3
  • 150
    • 84896496594 scopus 로고    scopus 로고
    • Evaluation of polyelectrolyte complex-based scaffolds for mesenchymal stem cell therapy in cardiac ischemia treatment
    • Ceccaldi C, Bushkalova R, Alfarano C, et al. Evaluation of polyelectrolyte complex-based scaffolds for mesenchymal stem cell therapy in cardiac ischemia treatment. Acta Biomater. 2014;10:901–911.
    • (2014) Acta Biomater , vol.10 , pp. 901-911
    • Ceccaldi, C.1    Bushkalova, R.2    Alfarano, C.3
  • 151
    • 84899619435 scopus 로고    scopus 로고
    • Stem cell-loaded nanofibrous patch promotes the regeneration of infarcted myocardium with functional improvement in rat model
    • Kai D, Wang QL, Wang HJ, et al. Stem cell-loaded nanofibrous patch promotes the regeneration of infarcted myocardium with functional improvement in rat model. Acta Biomater. 2014;10:2727–2738.
    • (2014) Acta Biomater , vol.10 , pp. 2727-2738
    • Kai, D.1    Wang, Q.L.2    Wang, H.J.3
  • 152
    • 77954384544 scopus 로고    scopus 로고
    • The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat
    • Yu J, Du KT, Fang Q, et al. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. 2010;31:7012–7020.
    • (2010) Biomaterials , vol.31 , pp. 7012-7020
    • Yu, J.1    Du, K.T.2    Fang, Q.3
  • 153
    • 84876510681 scopus 로고    scopus 로고
    • Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial effect on failing pig hearts
    • Wright EJ, Farrell KA, Malik N, et al. Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial effect on failing pig hearts. Stem Cells Transl Med. 2012;1:759–769.
    • (2012) Stem Cells Transl Med , vol.1 , pp. 759-769
    • Wright, E.J.1    Farrell, K.A.2    Malik, N.3
  • 155
    • 84955595002 scopus 로고    scopus 로고
    • A large-scale investigation of hypoxia-preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates: paracrine activity without remuscularization
    • Hu X, Xu Y, Zhong Z, et al. A large-scale investigation of hypoxia-preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates: paracrine activity without remuscularization. Circ Res. 2016;118:970–983.
    • (2016) Circ Res , vol.118 , pp. 970-983
    • Hu, X.1    Xu, Y.2    Zhong, Z.3


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