Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis

Stem Cells

Volumn 29, Issue 9, 2011, Pages 1405-1414

  Numasawa, Yohei ^a   Kimura, Takehiro ^a   Miyoshi, Shunichiro ^a   Nishiyama, Nobuhiro ^a   Hida, Naoko ^a   Tsuji, Hiroko ^a   Tsuruta, Hikaru ^a   Segawa, Kaoru ^a   Ogawa, Satoshi ^a   Umezawa, Akihiro ^b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Angiotensin; Bone marrow stromal cells; Stem cell transplantation; Transdifferentiation

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; LOSARTAN; OLMESARTAN; PROTEIN ANTIBODY; TELMISARTAN; TROPONIN I ANTIBODY; UNCLASSIFIED DRUG; VALSARTAN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; ECHOCARDIOGRAPHY; FEMALE; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; NONHUMAN; NUDE RAT; RAT; SURVIVAL TIME; SYSTOLE;

ANGIOTENSIN RECEPTOR ANTAGONISTS; ANIMALS; BENZIMIDAZOLES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICROSCOPY, CONFOCAL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, INBRED F344; RATS, NUDE; TETRAZOLES;

RATTUS;

EID: 80051983744     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.691     Document Type: Article

References (21)

1. Boheler K.R., Czyz J., Tweedie D. et al. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res 2002;91:189-201. (Pubitemid 34875673)
2. Makino S., Fukuda K., Miyoshi S. et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705. (Pubitemid 29122423)
3. Orlic D., Kajstura J., Chimenti S. et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705. (Pubitemid 32290358)
4. Tomita S., Li R.K., Weisel R.D. et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999;100:II247-II256. (Pubitemid 29523543)
5. Asahara T., Murohara T., Sullivan A. et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967. (Pubitemid 27087709)
6. Tsuji H., Miyoshi S., Ikegami Y. et al. Xenografted human amniotic membrane- derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes. Circ Res 2010;106:1613-1623.
7. Terai M., Uyama T., Sugiki T. et al. Immortalization of human fetal cells: The life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol Biol Cell 2005;16:1491-1499. (Pubitemid 40349582)
8. Takeda Y., Mori T., Imabayashi H. et al. Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation? J Gene Med 2004;6:833-845. (Pubitemid 40228099)
9. Hida N., Nishiyama N., Miyoshi S. et al. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. Stem Cells 2008;26:1695-1704.
10. Nishiyama N., Miyoshi S., Hida N. et al. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells 2007;25:2017-2024. (Pubitemid 47258179)
11. Okamoto K., Miyoshi S., Toyoda M. et al. 'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells. Exp Cell Res 2007;313:2550-2562. (Pubitemid 46977342)
12. Grauss R.W., Winter E.M., Van Tuyn J. et al. Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction. Am J Physiol Heart Circ Physiol 2007;293:H2438-H2447. (Pubitemid 47605891)
13. Hou M., Yang K.M., Zhang H. et al. Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. Int J Cardiol 2007;115:220-228. (Pubitemid 46157045)
14. Chen S.L., Fang W.W., Ye F. et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004;94:92-95. (Pubitemid 38813459)
15. Hare J.M., Traverse J.H., Henry T.D. et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009;54:2277-2286.
16. Matsushita K., Wu Y., Okamoto Y. et al. Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension 2006;48:1095-1102. (Pubitemid 44772713)
17. Iwanami J., Mogi M., Li J.M. et al. Deletion of angiotensin II type 2 receptor attenuates protective effects of bone marrow stromal cell treatment on ischemia-reperfusion brain injury in mice. Stroke 2008;39:2554-2559.
18. Ikegami Y., Miyoshi S., Nishiyama N. et al. Serum-independent cardiomyogenic transdifferentiation in human endometrium-derived mesenchymal cells. Artif Organs 2010;34:280-288.
19. Shinmura D., Togashi I., Miyoshi S. et al. Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function. Stem Cells 2010 (in press).
20. Kami D., Shiojima I., Makino H. et al. Gremlin enhances the determined path to cardiomyogenesis. PLoS One 2008;3:e2407.
21. Gnecchi M., He H., Liang O. et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005;11:367-368. (Pubitemid 40562318)