Hypoxia-inducible vascular endothelial growth factor-engineered mesenchymal stem cells prevent myocardial ischemic injury

Molecular Therapy

Volumn 19, Issue 4, 2011, Pages 741-750

  Kim, Sun Hwa ^a   Moon, Hyung Ho ^a   Kim, Hyun Ah ^b   Hwang, Ki Chul ^a   Lee, Minhyung ^b   Choi, Donghoon ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFECTAMINE; POLYETHYLENEIMINE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL BASED GENE THERAPY; CELL COUNT; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC ENGINEERING; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN SYNTHESIS; RAT;

RATTUS;

EID: 79953329763     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.301     Document Type: Article

References (46)

1. Nabel, EG (2003). Cardiovascular disease. N Engl J Med 349: 60-72. (Pubitemid 36765105)
2. Robey, TE, Saiget, MK, Reinecke, H and Murry, CE (2008). Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol 45: 567-581.
3. Tae, SK, Lee, SH, Park, JS and Im, GI (2006). Mesenchymal stem cells for tissue engineering and regenerative medicine. Biomed Mater 1: 63-71.
4. Pittenger, MF and Martin, BJ (2004). Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95: 9-20. (Pubitemid 38931831)
5. Shake, JG, Gruber, PJ, Baumgartner, WA, Senechal, G, Meyers, J, Redmond, JM et al. (2002). Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 73: 1919-1925; discussion 1926.
6. Tang, YL, Zhao, Q, Zhang, YC, Cheng, L, Liu, M, Shi, J et al. (2004). Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 117: 3-10. (Pubitemid 37548393)
7. Saito, T, Kuang, JQ, Bittira, B, Al-Khaldi, A and Chiu, RC (2002). Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 74: 19-24; discussion 24. (Pubitemid 34741999)
8. Cheng, Z, Ou, L, Zhou, X, Li, F, Jia, X, Zhang, Y et al. (2008). Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther 16: 571-579. (Pubitemid 351314998)
9. Noiseux, N, Gnecchi, M, Lopez-Ilasaca, M, Zhang, L, Solomon, SD, Deb, A et al. (2006). Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 14: 840-850. (Pubitemid 44752717)
10. Borden, BA, Yockman, J and Kim, SW (2010). Thermoresponsive hydrogel as a delivery scaffold for transfected rat mesenchymal stem cells. Mol Pharm 7: 963-968.
11. Mosca, JD, Hendricks, JK, Buyaner, D, Davis-Sproul, J, Chuang, LC, Majumdar, MK et al. (2000). Mesenchymal stem cells as vehicles for gene delivery. Clin Orthop Relat Res (379 Suppl): S71-S90.
12. Ylä-Herttuala, S and Alitalo, K (2003). Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 9: 694-701. (Pubitemid 36749218)
13. Dulak, J, Zagorska, A, Wegiel, B, Loboda, A and Jozkowicz, A (2006). New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes. Cell Biochem Biophys 44: 31-42. (Pubitemid 43099569)
14. Pons, J, Huang, Y, Arakawa-Hoyt, J, Washko, D, Takagawa, J, Ye, J et al. (2008). VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun 376: 419-422.
15. Gao, F, He, T, Wang, H, Yu, S, Yi, D, Liu, W et al. (2007). A promising strategy for the treatment of ischemic heart disease: Mesenchymal stem cell-mediated vascular endothelial growth factor gene transfer in rats. Can J Cardiol 23: 891-898. (Pubitemid 350011270)
16. Lee, M, Bikram, M, Oh, S, Bull, DA and Kim, SW (2004). Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease. Pharm Res 21: 736-741. (Pubitemid 39011293)
17. Lee, M, Choi, D, Choi, MJ, Jeong, JH, Kim, WJ, Oh, S et al. (2006). Hypoxia-inducible gene expression system using the erythropoietin enhancer and 3'-untranslated region for the VEGF gene therapy. J Control Release 115: 113-119. (Pubitemid 44415080)
18. Lee, M, Rentz, J, Bikram, M, Han, S, Bull, DA and Kim, SW (2003). Hypoxia-inducible VEGF gene delivery to ischemic myocardium using water-soluble lipopolymer. Gene Ther 10: 1535-1542. (Pubitemid 37063258)
19. Yockman, JW, Choi, D, Whitten, MG, Chang, CW, Kastenmeier, A, Erickson, H et al. (2009). Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. Gene Ther 16: 127-135.
20. Haleem-Smith, H, Derfoul, A, Okafor, C, Tuli, R, Olsen, D, Hall, DJ et al. (2005). Optimization of high-efficiency transfection of adult human mesenchymal stem cells in vitro. Mol Biotechnol 30: 9-20.
21. Otani, K, Yamahara, K, Ohnishi, S, Obata, H, Kitamura, S and Nagaya, N (2009). Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles. J Control Release 133: 146-153.
22. Cavazzana-Calvo, M, Lagresle, C, Hacein-Bey-Abina, S and Fischer, A (2005). Gene therapy for severe combined immunodeficiency. Annu Rev Med 56: 585-602. (Pubitemid 40299798)
23. Gao, X, Kim, KS and Liu, D (2007). Nonviral gene delivery: what we know and what is next. AAPS J 9: E92-104.
24. Kim, H, Kim, HA, Bae, YM, Choi, JS and Lee, M (2009). Dexamethasone-conjugated polyethylenimine as an efficient gene carrier with an anti-apoptotic effect to cardiomyocytes. J Gene Med 11: 515-522.
25. Hoffmann, J, Glassford, AJ, Doyle, TC, Robbins, RC, Schrepfer, S and Pelletier, MP (2010). Angiogenic effects despite limited cell survival of bone marrow-derived mesenchymal stem cells under ischemia. Thorac Cardiovasc Surg 58: 136-142.
26. Guo, Z, Yang, NS, Jiao, S, Sun, J, Cheng, L, Wolff, JA et al. (1996). Efficient and sustained transgene expression in mature rat oligodendrocytes in primary culture. J Neurosci Res 43: 32-41. (Pubitemid 26044215)
27. Toma, C, Pittenger, MF, Cahill, KS, Byrne, BJ and Kessler, PD (2002). Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105: 93-98. (Pubitemid 34049148)
28. Dvorak, HF, Brown, LF, Detmar, M and Dvorak, AM (1995). Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039.
29. Silva, GV, Litovsky, S, Assad, JA, Sousa, AL, Martin, BJ, Vela, D et al. (2005). Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111: 150-156. (Pubitemid 40139725)
30. Mangi, AA, Noiseux, N, Kong, D, He, H, Rezvani, M, Ingwall, JS et al. (2003). Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9: 1195-1201. (Pubitemid 37173705)
31. Sadat, S, Gehmert, S, Song, YH, Yen, Y, Bai, X, Gaiser, S et al. (2007). The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem Biophys Res Commun 363: 674-679. (Pubitemid 47513683)
32. Maltepe, E and Saugstad, OD (2009). Oxygen in health and disease: regulation of oxygen homeostasis-clinical implications. Pediatr Res 65: 261-268.
33. Riley, PR and Smart, N (2009). Thymosin beta4 induces epicardium-derived neovascularization in the adult heart. Biochem Soc Trans 37(Pt 6) 1218-1220.
34. Deasy, BM, Feduska, JM, Payne, TR, Li, Y, Ambrosio, F and Huard, J (2009). Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle. Mol Ther 17: 1788-1798.
35. Levenberg, S, Rouwkema, J, Macdonald, M, Garfein, ES, Kohane, DS, Darland, DC et al. (2005). Engineering vascularized skeletal muscle tissue. Nat Biotechnol 23: 879-884. (Pubitemid 43093132)
36. Tang, YL, Zhao, Q, Qin, X, Shen, L, Cheng, L, Ge, J et al. (2005). Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 80: 229-236; discussion 236.
37. Gnecchi, M, He, H, Noiseux, N, Liang, OD, Zhang, L, Morello, F et al. (2006). Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20: 661-669. (Pubitemid 44933310)
38. Oshima, H, Payne, TR, Urish, KL, Sakai, T, Ling, Y, Gharaibeh, B et al. (2005). Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12: 1130-1141. (Pubitemid 41723047)
39. Germani, A, Di Carlo, A, Mangoni, A, Straino, S, Giacinti, C, Turrini, P et al. (2003). Vascular endothelial growth factor modulates skeletal myoblast function. Am J Pathol 163: 1417-1428. (Pubitemid 37175089)
40. Rissanen, TT and Ylä-Herttuala, S (2007). Current status of cardiovascular gene therapy. Mol Ther 15: 1233-1247. (Pubitemid 46965318)
41. Thiel, C and Nix, M (2006). Efficient transfection of primary cells relevant for cardiovascular research by nucleofection. Methods Mol Med 129: 255-266.
42. Song, H, Chang, W, Lim, S, Seo, HS, Shim, CY, Park, S et al. (2007). Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells. Stem Cells 25: 1431-1438. (Pubitemid 47106010)
43. Chang, W, Song, BW, Lim, S, Song, H, Shim, CY, Cha, MJ et al. (2009). Mesenchymal stem cells pretreated with delivered Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury. Stem Cells 27: 2283-2292.
44. Lee, M, Rentz, J, Han, SO, Bull, DA and Kim, SW (2003). Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium. Gene Ther 10: 585-593. (Pubitemid 36432610)
45. Jiang, B, Dong, H, Zhang, Z, Wang, W, Zhang, Y and Xu, X (2007). Hypoxic response elements control expression of human vascular endothelial growth factor(165) genes transferred to ischemia myocardium in vivo and in vitro. J Gene Med 9: 788-796. (Pubitemid 47386863)
46. Shibata, T, Akiyama, N, Noda, M, Sasai, K and Hiraoka, M (1998). Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 42: 913-916. (Pubitemid 28559442)