Genetic modification of mesenchymal stem cells overexpressing ccr1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium

Circulation Research

Volumn 106, Issue 11, 2010, Pages 1753-1762

  Huang, Jing ^a   Zhang, Zhiping ^a   Guo, Jian ^a   Ni, Aiguo ^a   Deb, Arjun ^a   Zhang, Lunan ^a   Mirotsou, Maria ^a   Pratt, Richard E ^a   Dzau, Victor J ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemokine receptor; Engraftment; Mesenchymal stem cells; Myocardial repair

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CXCR2; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DNA MODIFICATION; DOWN REGULATION; ENGRAFTMENT; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; UPREGULATION;

ANIMALS; APOPTOSIS; CAPILLARIES; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; FIBROSIS; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, CCR1; RECEPTORS, INTERLEUKIN-8B; RECOVERY OF FUNCTION; REGENERATION; RNA INTERFERENCE; TIME FACTORS; TRANSDUCTION, GENETIC; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 77953812469     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.196030     Document Type: Article

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