Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction

Stem Cells International

Volumn 2015, Issue , 2015, Pages

  Xue, Xiaodong ^a   Liu, Yu ^a,b   Zhang, Jian ^a   Liu, Tao ^a   Yang, Zhonglu ^a   Wang, Huishan ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; PROTEIN BCL XL; SOMATOMEDIN C; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BCL XL GENE; CELL SURVIVAL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CONVALESCENCE; DNA MODIFICATION; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEART INFARCTION; HEMATOPOIETIC STEM CELL; HISTOCHEMISTRY; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; SCAR FORMATION; TUNEL ASSAY;

RATTUS;

EID: 84930002928     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2015/176409     Document Type: Article

References (34)

1. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., "Multilineage potential of adult human mesenchymal stem cells," Science, vol. 284, no. 5411, pp. 143-147, 1999.
2. G. Ferrari, G. Cusella-De Angelis, M. Coletta et al., "Muscle regeneration by bone marrow-derived myogenic progenitors," Science, vol. 279, no. 5356, pp. 1528-1530, 1998.
3. C. Toma, M. F. Pittenger, K. S. Cahill, B. J. Byrne, and P. D. Kessler, "Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart," Circulation, vol. 105, no. 1, pp. 93-98, 2002.
4. A. Piryaei, M. R. Valojerdi, M. Shahsavani, and H. Baharvand, "Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells on nanofibers and their transplantation into a carbon tetrachloride-induced liver fibrosis model," Stem Cell Reviews and Reports, vol. 7, no. 1, pp. 103-118, 2011.
5. J. Chen, Y. Li, L. Wang, M. Lu, X. Zhang, and M. Chopp, "Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats," Journal of the Neurological Sciences, vol. 189, no. 1-2, pp. 49-57, 2001.
6. J. M. Sorrell, M. A. Baber, and A. I. Caplan, "Influence of adult mesenchymal stem cells on in vitro vascular formation," Tissue Engineering Part A, vol. 15, no. 7, pp. 1751-1761, 2009.
7. C. Pontikoglou, F. Deschaseaux, L. Sensebe, and H. A. Papadaki, "Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation," Stem Cell Reviews and Reports, vol. 7, no. 3, pp. 569-589, 2011.
8. F. Djouad, P. Plence, C. Bony et al., "Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals," Blood, vol. 102, no.10, pp. 3837-3844, 2003.
9. K. Le Blanc, C. Tammik, K. Rosendahl, E. Zetterberg, and O. Ringdén, "HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells," Experimental Hematology, vol. 31, no. 10, pp. 890-896, 2003.
10. M. Zhang, D. Methot, V. Poppa, Y. Fujio, K. Walsh, and C. E. Murry, "Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies," Journal of Molecular and Cellular Cardiology, vol. 33, no. 5, pp. 907-921, 2001.
11. L. Fan, C. Lin, S. Zhuo et al., "Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction," European Journal of Heart Failure, vol. 11, no. 11, pp. 1023-1030, 2009.
12. W. Li, N. Ma, L. L. Ong et al., "Bcl-2 engineered MSCs inhibited apoptosis and improved heart function," Stem Cells, vol. 25, no. 8, pp. 2118-2127, 2007.
13. J. Huang, Y. Ito, M. Morikawa et al., "Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury," Biochemical and Biophysical Research Communications, vol. 311, no. 1, pp. 64-70, 2003.
14. J. Huang, K. Nakamura, Y. Ito et al., "Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rats," Circulation, vol. 112, no. 1, pp. 76-83, 2005.
15. Y.-J. Geng, "Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure," Annals of the New York Academy of Sciences, vol. 1010, pp. 687-697, 2003.
16. Y. L. Tang, Y. Tang, Y. C. Zhang, K. Qian, L. Shen, and M. I. Phillips, "Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector," Journal of the American College of Cardiology, vol. 46, no.7, pp. 1339-1350, 2005.
17. O. Ham, S. Y. Lee, and B. W. Song, "Modulation of Fas-Fas ligand interaction rehabilitates hypoxia-induced apoptosis of mesenchymal stem cells in ischemic myocardium niche," Cell Transplantation. In press.
18. J. C. Reed, "Bcl-2 family proteins," Oncogene, vol. 17, no. 25, pp. 3225-3236, 1998.
19. H. Bai, K. Chen, Y.-X. Gao et al., "Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal," Stem Cell Research, vol. 8, no. 1, pp. 26-37, 2012.
20. A. Srinivasan, F. Li, A. Wong et al., "Bcl-x(L) functions down-stream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells," The Journal of Biological Chemistry, vol. 273, no. 8, pp. 4523-4529, 1998.
21. J. Liu, C. Liu, B. Sun et al., "Differentiation of rabbit bone mesenchymal stem cells into endothelial cells in vitro and promotion of defective bone regeneration in vivo," Cell Biochemistry and Biophysics, vol. 68, no. 3, pp. 479-487, 2014.
22. M. Gnecchi, H. He, O. D. Liang et al., "Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells," Nature Medicine, vol. 11, no. 4, pp. 367-368, 2005.
23. Y. L. Tang, Q. Zhao, X. Qin et al., "Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction," The Annals of Thoracic Surgery, vol. 80, no. 1, pp. 229-237, 2005.
24. Y. S. Yoon, A. Wecker, L. Heyd et al., "Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction," Journal of Clinical Investigation, vol. 115, no. 2, pp. 326-338, 2005.
25. M. Takahashi, T.-S. Li, R. Suzuki et al., "Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury," American Journal of Physiology: Heart and Circulatory Physiology, vol. 291, no. 2, pp. H886-H893, 2006.
26. M. S. Täng, B. Redfors, M. Lindbom et al., "Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling," Growth Hormone and IGF Research, vol. 22, no. 6, pp. 206-211, 2012.
27. J.-M. Tang, J.-N. Wang, L. Zhang et al., "VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart," Cardiovascular Research, vol. 91, no. 3, pp. 402-411, 2011.
28. Y. Tang, X. Gan, R. Cheheltani et al., "Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model," Nanomedicine: Nanotechnology, Biology, and Medicine, 2014.
29. A. Iervolino, D. Trisciuoglio, D. Ribatti et al., "Bcl-2 over-expression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity," The FASEB Journal, vol. 16, no. 11, pp. 1453-1455, 2002.
30. D. del Bufalo, D. Trisciuoglio, M. Scarsella, U. Zangemeister-Wittke, and G. Zupi, "Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity," Oncogene, vol. 22, no. 52, pp. 8441-8447, 2003.
31. B. Yang, K. He, F. Zheng et al., "Over-expression of hypoxia factor-1 alpha in vitro protects the cardiac fibroblasts from hypoxia-induced apoptosis," Journal of Cardiovascular Medicine, vol. 15, no. 7, pp. 579-586, 2014.
32. R. Fukuda, K. Hirota, F. Fan, Y. D. Jung, L. M. Ellis, and G. L. Semenza, "Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells," Journal of Biological Chemistry, vol. 277, no. 41, pp. 38205-38211, 2002.
33. H. D. Skinner, J. Z. Zheng, J. Fang, F. Agani, and B.-H. Jiang, "Vascular endothelial growth factor transcriptional activation is mediated byhypoxia-inducible factor 1α, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling," The Journal of Biological Chemistry, vol. 279, no. 44, pp. 45643-45651, 2004.
34. N. Chen, X. Chen, R. Huang et al., "BCL-xL is a target gene regulated by hypoxia-inducible factor-1α," The Journal of Biological Chemistry, vol. 284, no. 15, pp. 10004-10012, 2009.