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Volumn 18, Issue 1, 2017, Pages 18-31

Gut microbial metabolism defines host metabolism: an emerging perspective in obesity and allergic inflammation

Author keywords

Gut; microbiota; overweight; short chain fatty acids

Indexed keywords

ACETIC ACID; BUTYRIC ACID; HISTONE DEACETYLASE; LACTIC ACID; MUCIN; PROPIONIC ACID; SEROTONIN; SHORT CHAIN FATTY ACID; VOLATILE FATTY ACID;

EID: 85003011821     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12484     Document Type: Review
Times cited : (93)

References (118)
  • 2
    • 84880155188 scopus 로고    scopus 로고
    • Ecology and physiology of the intestinal tract
    • Blaut M. Ecology and physiology of the intestinal tract. Curr Top Microbiol Immunol 2013; 358: 247–272.
    • (2013) Curr Top Microbiol Immunol , vol.358 , pp. 247-272
    • Blaut, M.1
  • 4
    • 84978619185 scopus 로고    scopus 로고
    • Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
    • Dominguez-Bello MG, De Jesus-Laboy KM, Shen N et al. Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Nat Med 2016; 22: 250–253.
    • (2016) Nat Med , vol.22 , pp. 250-253
    • Dominguez-Bello, M.G.1    De Jesus-Laboy, K.M.2    Shen, N.3
  • 6
    • 84927939405 scopus 로고    scopus 로고
    • The infant gut microbiome: evidence for obesity risk and dietary intervention
    • Koleva PT, Bridgman SL, Kozyrskyj AL. The infant gut microbiome: evidence for obesity risk and dietary intervention. Nutrients 2015; 7: 2237–2260.
    • (2015) Nutrients , vol.7 , pp. 2237-2260
    • Koleva, P.T.1    Bridgman, S.L.2    Kozyrskyj, A.L.3
  • 7
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59–65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 8
    • 84958841613 scopus 로고    scopus 로고
    • The gut microbiota and host health: a new clinical frontier
    • Marchesi JR, Adams DH, Fava F et al. The gut microbiota and host health: a new clinical frontier. Gut 2016; 65: 330–339.
    • (2016) Gut , vol.65 , pp. 330-339
    • Marchesi, J.R.1    Adams, D.H.2    Fava, F.3
  • 9
    • 84861978076 scopus 로고    scopus 로고
    • Host–gut microbiota metabolic interactions
    • Nicholson JK, Holmes E, Kinross J et al. Host–gut microbiota metabolic interactions. Science 2012; 336: 1262–1267.
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.3
  • 10
    • 84931575689 scopus 로고    scopus 로고
    • Review article: dietary fibre–microbiota interactions
    • Simpson HL, Campbell BJ. Review article: dietary fibre–microbiota interactions. Aliment Pharmacol Ther 2015; 42: 158–179.
    • (2015) Aliment Pharmacol Ther , vol.42 , pp. 158-179
    • Simpson, H.L.1    Campbell, B.J.2
  • 11
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • Gill SR, Pop M, Deboy RT et al. Metagenomic analysis of the human distal gut microbiome. Science 2006; 312: 1355–1359.
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1    Pop, M.2    Deboy, R.T.3
  • 12
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009; 1: 6ra14.
    • (2009) Sci Transl Med , vol.1 , pp. 6ra14
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3    Rey, F.E.4    Knight, R.5    Gordon, J.I.6
  • 13
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987; 28: 1221–1227.
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 16
    • 0023879881 scopus 로고
    • Faecal concentrations and production rates of short chain fatty acids in normal neonates
    • Rasmussen HS, Holtug K, Ynggard C, Mortensen PB. Faecal concentrations and production rates of short chain fatty acids in normal neonates. Acta Paediatr Scand 1988; 77: 365–368.
    • (1988) Acta Paediatr Scand , vol.77 , pp. 365-368
    • Rasmussen, H.S.1    Holtug, K.2    Ynggard, C.3    Mortensen, P.B.4
  • 17
    • 84896471221 scopus 로고    scopus 로고
    • Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers
    • Martin FP, Moco S, Montoliu I et al. Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers. Pediatr Res 2014; 75: 535–543.
    • (2014) Pediatr Res , vol.75 , pp. 535-543
    • Martin, F.P.1    Moco, S.2    Montoliu, I.3
  • 18
    • 84929297936 scopus 로고    scopus 로고
    • Dynamics and stabilization of the human gut microbiome during the first year of life
    • Backhed F, Roswall J, Peng Y et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 852.
    • (2015) Cell Host Microbe , vol.17 , pp. 852
    • Backhed, F.1    Roswall, J.2    Peng, Y.3
  • 19
    • 84886799652 scopus 로고    scopus 로고
    • Effects of infant cereals with different carbohydrate profiles on colonic function—randomised and double-blind clinical trial in infants aged between 6 and 12 months—pilot study
    • Bernal MJ, Periago MJ, Martinez R et al. Effects of infant cereals with different carbohydrate profiles on colonic function—randomised and double-blind clinical trial in infants aged between 6 and 12 months—pilot study. Eur J Pediatr 2013; 172: 1535–1542.
    • (2013) Eur J Pediatr , vol.172 , pp. 1535-1542
    • Bernal, M.J.1    Periago, M.J.2    Martinez, R.3
  • 20
    • 84890385655 scopus 로고    scopus 로고
    • Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
    • den Besten G, Lange K, Havinga R et al. Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids. Am J Physiol Gastrointest Liver Physiol 2013; 305: G900–G910.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G900-G910
    • den Besten, G.1    Lange, K.2    Havinga, R.3
  • 21
    • 84899892790 scopus 로고    scopus 로고
    • The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
    • Frost G, Sleeth ML, Sahuri-Arisoylu M et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 2014; 5: 3611.
    • (2014) Nat Commun , vol.5 , pp. 3611
    • Frost, G.1    Sleeth, M.L.2    Sahuri-Arisoylu, M.3
  • 22
    • 84860571162 scopus 로고    scopus 로고
    • Effects of prebiotic-containing infant formula on gastrointestinal tolerance and fecal microbiota in a randomized controlled trial
    • Holscher HD, Faust KL, Czerkies LA et al. Effects of prebiotic-containing infant formula on gastrointestinal tolerance and fecal microbiota in a randomized controlled trial. JPEN J Parenter Enteral Nutr 2012; 36: 95S–105S.
    • (2012) JPEN J Parenter Enteral Nutr , vol.36 , pp. 95S-105S
    • Holscher, H.D.1    Faust, K.L.2    Czerkies, L.A.3
  • 24
    • 54949153045 scopus 로고
    • Acetogenesis and the Wood–Ljungdahl pathway of CO(2) fixation
    • Ragsdale SW, Pierce E. Acetogenesis and the Wood–Ljungdahl pathway of CO(2) fixation. Biochim Biophys Acta 1784; 2008: 1873–1898.
    • (1784) Biochim Biophys Acta , vol.2008 , pp. 1873-1898
    • Ragsdale, S.W.1    Pierce, E.2
  • 26
    • 84898646785 scopus 로고    scopus 로고
    • Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants
    • Bergstrom A, Skov TH, Bahl MI et al. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol 2014; 80: 2889–2900.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 2889-2900
    • Bergstrom, A.1    Skov, T.H.2    Bahl, M.I.3
  • 27
    • 84877805753 scopus 로고    scopus 로고
    • Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity
    • Azad MB, Konya T, Maughan H et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol 2013; 9: 15.
    • (2013) Allergy Asthma Clin Immunol , vol.9 , pp. 15
    • Azad, M.B.1    Konya, T.2    Maughan, H.3
  • 29
    • 0026604806 scopus 로고
    • Effect of short-chain fatty acids on the human colonic mucosa in vitro
    • Scheppach W, Bartram P, Richter A et al. Effect of short-chain fatty acids on the human colonic mucosa in vitro. JPEN J Parenter Enteral Nutr 1992; 16: 43–48.
    • (1992) JPEN J Parenter Enteral Nutr , vol.16 , pp. 43-48
    • Scheppach, W.1    Bartram, P.2    Richter, A.3
  • 30
    • 79955579989 scopus 로고    scopus 로고
    • The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    • Donohoe DR, Garge N, Zhang X et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab 2011; 13: 517–526.
    • (2011) Cell Metab , vol.13 , pp. 517-526
    • Donohoe, D.R.1    Garge, N.2    Zhang, X.3
  • 32
    • 8144224956 scopus 로고    scopus 로고
    • Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product
    • Duncan SH, Louis P, Flint HJ. Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol 2004; 70: 5810–5817.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 5810-5817
    • Duncan, S.H.1    Louis, P.2    Flint, H.J.3
  • 33
    • 84899787502 scopus 로고    scopus 로고
    • Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data
    • Vital M, Howe AC, Tiedje JM. Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data. MBio 2014; 5: e00889.
    • (2014) MBio , vol.5
    • Vital, M.1    Howe, A.C.2    Tiedje, J.M.3
  • 34
    • 84901251583 scopus 로고    scopus 로고
    • Phylogenetic distribution of three pathways for propionate production within the human gut microbiota
    • Reichardt N, Duncan SH, Young P et al. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota. ISME J 2014; 8: 1323–1335.
    • (2014) ISME J , vol.8 , pp. 1323-1335
    • Reichardt, N.1    Duncan, S.H.2    Young, P.3
  • 35
    • 0037509909 scopus 로고    scopus 로고
    • Regulation of short-chain fatty acid production
    • Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc 2003; 62: 67–72.
    • (2003) Proc Nutr Soc , vol.62 , pp. 67-72
    • Macfarlane, S.1    Macfarlane, G.T.2
  • 36
    • 10444226583 scopus 로고    scopus 로고
    • Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces
    • Matsuki T, Watanabe K, Fujimoto J, Takada T, Tanaka R. Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces. Appl Environ Microbiol 2004; 70: 7220–7228.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 7220-7228
    • Matsuki, T.1    Watanabe, K.2    Fujimoto, J.3    Takada, T.4    Tanaka, R.5
  • 37
    • 0028897124 scopus 로고
    • Colonic lactate metabolism and D-lactic acidosis
    • Hove H, Mortensen PB. Colonic lactate metabolism and D-lactic acidosis. Dig Dis Sci 1995; 40: 320–330.
    • (1995) Dig Dis Sci , vol.40 , pp. 320-330
    • Hove, H.1    Mortensen, P.B.2
  • 38
    • 84872773145 scopus 로고    scopus 로고
    • Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome
    • Mayeur C, Gratadoux JJ, Bridonneau C et al. Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome. PLoS One 2013; 8: e54335.
    • (2013) PLoS One , vol.8
    • Mayeur, C.1    Gratadoux, J.J.2    Bridonneau, C.3
  • 42
    • 84914814586 scopus 로고    scopus 로고
    • Impact of lifestyle on the gut microbiota of healthy infants and their mothers—the ALADDIN birth cohort
    • Hesla HM, Stenius F, Jaderlund L et al. Impact of lifestyle on the gut microbiota of healthy infants and their mothers—the ALADDIN birth cohort. FEMS Microbiol Ecol 2014; 90: 791–801.
    • (2014) FEMS Microbiol Ecol , vol.90 , pp. 791-801
    • Hesla, H.M.1    Stenius, F.2    Jaderlund, L.3
  • 43
    • 0026074777 scopus 로고
    • Co-utilization of polymerized carbon sources by Bacteroides ovatus grown in a two-stage continuous culture system
    • MacFarlane GT, Gibson GR. Co-utilization of polymerized carbon sources by Bacteroides ovatus grown in a two-stage continuous culture system. Appl Environ Microbiol 1991; 57: 1–6.
    • (1991) Appl Environ Microbiol , vol.57 , pp. 1-6
    • MacFarlane, G.T.1    Gibson, G.R.2
  • 44
    • 55949101353 scopus 로고    scopus 로고
    • Isolation of lactate-utilizing butyrate-producing bacteria from human feces and in vivo administration of Anaerostipes caccae strain L2 and galacto-oligosaccharides in a rat model
    • Sato T, Matsumoto K, Okumura T et al. Isolation of lactate-utilizing butyrate-producing bacteria from human feces and in vivo administration of Anaerostipes caccae strain L2 and galacto-oligosaccharides in a rat model. FEMS Microbiol Ecol 2008; 66: 528–536.
    • (2008) FEMS Microbiol Ecol , vol.66 , pp. 528-536
    • Sato, T.1    Matsumoto, K.2    Okumura, T.3
  • 45
    • 0033068825 scopus 로고    scopus 로고
    • Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers
    • Kanauchi O, Fujiyama Y, Mitsuyama K et al. Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers. Int J Mol Med 1999; 3: 175–179.
    • (1999) Int J Mol Med , vol.3 , pp. 175-179
    • Kanauchi, O.1    Fujiyama, Y.2    Mitsuyama, K.3
  • 46
    • 84884671126 scopus 로고    scopus 로고
    • Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches
    • Jost T, Lacroix C, Braegger C, Chassard C. Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches. Br J Nutr 2013; 110: 1253–1262.
    • (2013) Br J Nutr , vol.110 , pp. 1253-1262
    • Jost, T.1    Lacroix, C.2    Braegger, C.3    Chassard, C.4
  • 47
    • 0036327879 scopus 로고    scopus 로고
    • Stimulation of butyrate production by gluconic acid in batch culture of pig cecal digesta and identification of butyrate-producing bacteria
    • Tsukahara T, Koyama H, Okada M, Ushida K. Stimulation of butyrate production by gluconic acid in batch culture of pig cecal digesta and identification of butyrate-producing bacteria. J Nutr 2002; 132: 2229–2234.
    • (2002) J Nutr , vol.132 , pp. 2229-2234
    • Tsukahara, T.1    Koyama, H.2    Okada, M.3    Ushida, K.4
  • 48
    • 79960839633 scopus 로고    scopus 로고
    • Rates of production and utilization of lactate by microbial communities from the human colon
    • Belenguer A, Holtrop G, Duncan SH et al. Rates of production and utilization of lactate by microbial communities from the human colon. FEMS Microbiol Ecol 2011; 77: 107–119.
    • (2011) FEMS Microbiol Ecol , vol.77 , pp. 107-119
    • Belenguer, A.1    Holtrop, G.2    Duncan, S.H.3
  • 49
    • 0141528785 scopus 로고    scopus 로고
    • Megasphaera elsdenii JCM1772T normalizes hyperlactate production in the large intestine of fructooligosaccharide-fed rats by stimulating butyrate production
    • Hashizume K, Tsukahara T, Yamada K, Koyama H, Ushida K. Megasphaera elsdenii JCM1772T normalizes hyperlactate production in the large intestine of fructooligosaccharide-fed rats by stimulating butyrate production. J Nutr 2003; 133: 3187–3190.
    • (2003) J Nutr , vol.133 , pp. 3187-3190
    • Hashizume, K.1    Tsukahara, T.2    Yamada, K.3    Koyama, H.4    Ushida, K.5
  • 50
    • 84870976148 scopus 로고    scopus 로고
    • Lactate and acrylate metabolism by Megasphaera elsdenii under batch and steady-state conditions
    • Prabhu R, Altman E, Eiteman MA. Lactate and acrylate metabolism by Megasphaera elsdenii under batch and steady-state conditions. Appl Environ Microbiol 2012; 78: 8564–8570.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 8564-8570
    • Prabhu, R.1    Altman, E.2    Eiteman, M.A.3
  • 51
    • 80055045344 scopus 로고    scopus 로고
    • Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
    • Conterno L, Fava F, Viola R, Tuohy KM. Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? Genes Nutr 2011; 6: 241–260.
    • (2011) Genes Nutr , vol.6 , pp. 241-260
    • Conterno, L.1    Fava, F.2    Viola, R.3    Tuohy, K.M.4
  • 52
    • 84939465385 scopus 로고    scopus 로고
    • Gut microbiota: a key player in health and disease. A review focused on obesity
    • Villanueva-Millan MJ, Perez-Matute P, Oteo JA. Gut microbiota: a key player in health and disease. A review focused on obesity. J Physiol Biochem 2015; 71: 509–525.
    • (2015) J Physiol Biochem , vol.71 , pp. 509-525
    • Villanueva-Millan, M.J.1    Perez-Matute, P.2    Oteo, J.A.3
  • 53
    • 84898807099 scopus 로고    scopus 로고
    • The intestinal metabolome: an intersection between microbiota and host
    • Ursell LK, Haiser HJ, Van Treuren W et al. The intestinal metabolome: an intersection between microbiota and host. Gastroenterology 2014; 146: 1470–1476.
    • (2014) Gastroenterology , vol.146 , pp. 1470-1476
    • Ursell, L.K.1    Haiser, H.J.2    Van Treuren, W.3
  • 54
    • 84859322825 scopus 로고    scopus 로고
    • The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization
    • Payne AN, Chassard C, Zimmermann M, Muller P, Stinca S, Lacroix C. The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization. Nutr Diabetes 2011; 1: e12.
    • (2011) Nutr Diabetes , vol.1
    • Payne, A.N.1    Chassard, C.2    Zimmermann, M.3    Muller, P.4    Stinca, S.5    Lacroix, C.6
  • 55
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko T, Rey FE, Manary MJ et al. Human gut microbiome viewed across age and geography. Nature 2012; 486: 222–227.
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1    Rey, F.E.2    Manary, M.J.3
  • 56
    • 84859587827 scopus 로고    scopus 로고
    • Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms
    • Lin HV, Frassetto A, Kowalik EJ Jr et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 2012; 7: e35240.
    • (2012) PLoS One , vol.7
    • Lin, H.V.1    Frassetto, A.2    Kowalik, E.J.3
  • 57
    • 34347384676 scopus 로고    scopus 로고
    • Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats
    • Yamashita H, Fujisawa K, Ito E et al. Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats. Biosci Biotechnol Biochem 2007; 71: 1236–1243.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1236-1243
    • Yamashita, H.1    Fujisawa, K.2    Ito, E.3
  • 58
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao Z, Yin J, Zhang J et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009; 58: 1509–1517.
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3
  • 59
    • 79952447465 scopus 로고    scopus 로고
    • Propionate. Anti-obesity and satiety enhancing factor?
    • Arora T, Sharma R, Frost G. Propionate. Anti-obesity and satiety enhancing factor? Appetite 2011; 56: 511–515.
    • (2011) Appetite , vol.56 , pp. 511-515
    • Arora, T.1    Sharma, R.2    Frost, G.3
  • 60
    • 84945202481 scopus 로고    scopus 로고
    • Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
    • Chambers ES, Viardot A, Psichas A et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 2015; 64: 1744–1754.
    • (2015) Gut , vol.64 , pp. 1744-1754
    • Chambers, E.S.1    Viardot, A.2    Psichas, A.3
  • 61
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh N, Gurav A, Sivaprakasam S et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014; 40: 128–139.
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1    Gurav, A.2    Sivaprakasam, S.3
  • 62
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown AJ, Goldsworthy SM, Barnes AA et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003; 278: 11312–11319.
    • (2003) J Biol Chem , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3
  • 63
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
    • Le PE, Loison C, Struyf S et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003; 278: 25481–25489.
    • (2003) J Biol Chem , vol.278 , pp. 25481-25489
    • Le, P.E.1    Loison, C.2    Struyf, S.3
  • 64
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • Nilsson NE, Kotarsky K, Owman C, Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 2003; 303: 1047–1052.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 65
    • 84884693129 scopus 로고    scopus 로고
    • GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes
    • Nohr MK, Pedersen MH, Gille A et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 2013; 154: 3552–3564.
    • (2013) Endocrinology , vol.154 , pp. 3552-3564
    • Nohr, M.K.1    Pedersen, M.H.2    Gille, A.3
  • 66
    • 84901327600 scopus 로고    scopus 로고
    • Identification of the porcine G protein-coupled receptor 41 and 43 genes and their expression pattern in different tissues and development stages
    • Li G, Su H, Zhou Z, Yao W. Identification of the porcine G protein-coupled receptor 41 and 43 genes and their expression pattern in different tissues and development stages. PLoS One 2014; 9: e97342.
    • (2014) PLoS One , vol.9
    • Li, G.1    Su, H.2    Zhou, Z.3    Yao, W.4
  • 67
    • 0742305675 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
    • Xiong Y, Miyamoto N, Shibata K et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A 2004; 101: 1045–1050.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1045-1050
    • Xiong, Y.1    Miyamoto, N.2    Shibata, K.3
  • 68
    • 84973667684 scopus 로고    scopus 로고
    • Acetate mediates a microbiome–brain–beta-cell axis to promote metabolic syndrome
    • Perry RJ, Peng L, Barry NA et al. Acetate mediates a microbiome–brain–beta-cell axis to promote metabolic syndrome. Nature 2016; 534: 213–217.
    • (2016) Nature , vol.534 , pp. 213-217
    • Perry, R.J.1    Peng, L.2    Barry, N.A.3
  • 69
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • Tolhurst G, Heffron H, Lam YS et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 2012; 61: 364–371.
    • (2012) Diabetes , vol.61 , pp. 364-371
    • Tolhurst, G.1    Heffron, H.2    Lam, Y.S.3
  • 70
    • 84924700879 scopus 로고    scopus 로고
    • The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
    • Psichas A, Sleeth ML, Murphy KG et al. The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. Int J Obes (Lond) 2015; 39: 424–429.
    • (2015) Int J Obes (Lond) , vol.39 , pp. 424-429
    • Psichas, A.1    Sleeth, M.L.2    Murphy, K.G.3
  • 71
    • 34547965812 scopus 로고    scopus 로고
    • Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats
    • Cani PD, Hoste S, Guiot Y, Delzenne NM. Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 2007; 98: 32–37.
    • (2007) Br J Nutr , vol.98 , pp. 32-37
    • Cani, P.D.1    Hoste, S.2    Guiot, Y.3    Delzenne, N.M.4
  • 73
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gut–brain neural circuits
    • De Vadder F, Kovatcheva-Datchary P, Goncalves D et al. Microbiota-generated metabolites promote metabolic benefits via gut–brain neural circuits. Cell 2014; 156: 84–96.
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1    Kovatcheva-Datchary, P.2    Goncalves, D.3
  • 74
    • 84876107265 scopus 로고    scopus 로고
    • The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing
    • Delaere F, Duchampt A, Mounien L et al. The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing. Mol Metab 2012; 2: 47–53.
    • (2012) Mol Metab , vol.2 , pp. 47-53
    • Delaere, F.1    Duchampt, A.2    Mounien, L.3
  • 75
    • 84962129359 scopus 로고    scopus 로고
    • Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARgamma-dependent switch from lipogenesis to fat oxidation
    • den Besten G, Bleeker A, Gerding A et al. Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARgamma-dependent switch from lipogenesis to fat oxidation. Diabetes 2015; 64: 2398–2408.
    • (2015) Diabetes , vol.64 , pp. 2398-2408
    • den Besten, G.1    Bleeker, A.2    Gerding, A.3
  • 76
    • 84875258449 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma
    • Alex S, Lange K, Amolo T et al. Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma. Mol Cell Biol 2013; 33: 1303–1316.
    • (2013) Mol Cell Biol , vol.33 , pp. 1303-1316
    • Alex, S.1    Lange, K.2    Amolo, T.3
  • 77
    • 84906323486 scopus 로고    scopus 로고
    • Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs
    • Souza da Silva C, Haenen D, Koopmans SJ et al. Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs. Animal 2014; 8: 1402–1411.
    • (2014) Animal , vol.8 , pp. 1402-1411
    • Souza da Silva, C.1    Haenen, D.2    Koopmans, S.J.3
  • 78
    • 84937394501 scopus 로고    scopus 로고
    • Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells
    • Reigstad CS, Salmonson CE, Rainey JF 3rd et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 2015; 29: 1395–1403.
    • (2015) FASEB J , vol.29 , pp. 1395-1403
    • Reigstad, C.S.1    Salmonson, C.E.2    Rainey, J.F.3
  • 79
    • 84923212941 scopus 로고    scopus 로고
    • Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
    • Crane JD, Palanivel R, Mottillo EP et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 2015; 21: 166–172.
    • (2015) Nat Med , vol.21 , pp. 166-172
    • Crane, J.D.1    Palanivel, R.2    Mottillo, E.P.3
  • 80
    • 84872334045 scopus 로고    scopus 로고
    • Metabolism and the circadian clock converge
    • Eckel-Mahan K, Sassone-Corsi P. Metabolism and the circadian clock converge. Physiol Rev 2013; 93: 107–135.
    • (2013) Physiol Rev , vol.93 , pp. 107-135
    • Eckel-Mahan, K.1    Sassone-Corsi, P.2
  • 81
    • 84958582064 scopus 로고    scopus 로고
    • Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
    • Montagner A, Korecka A, Polizzi A et al. Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep 2016; 6: 20127.
    • (2016) Sci Rep , vol.6 , pp. 20127
    • Montagner, A.1    Korecka, A.2    Polizzi, A.3
  • 82
    • 84929300092 scopus 로고    scopus 로고
    • Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism
    • Leone V, Gibbons SM, Martinez K et al. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe 2015; 17: 681–689.
    • (2015) Cell Host Microbe , vol.17 , pp. 681-689
    • Leone, V.1    Gibbons, S.M.2    Martinez, K.3
  • 83
    • 0025321505 scopus 로고
    • Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
    • Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 1990; 70: 567–590.
    • (1990) Physiol Rev , vol.70 , pp. 567-590
    • Bergman, E.N.1
  • 86
    • 84927176473 scopus 로고    scopus 로고
    • Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans
    • Rahat-Rozenbloom S, Fernandes J, Gloor GB, Wolever TM. Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans. Int J Obes (Lond) 2014; 38: 1525–1531.
    • (2014) Int J Obes (Lond) , vol.38 , pp. 1525-1531
    • Rahat-Rozenbloom, S.1    Fernandes, J.2    Gloor, G.B.3    Wolever, T.M.4
  • 87
    • 0141528823 scopus 로고    scopus 로고
    • Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon
    • Vogt JA, Wolever TM. Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon. J Nutr 2003; 133: 3145–3148.
    • (2003) J Nutr , vol.133 , pp. 3145-3148
    • Vogt, J.A.1    Wolever, T.M.2
  • 88
    • 84941183248 scopus 로고    scopus 로고
    • The role of short chain fatty acids in appetite regulation and energy homeostasis
    • Byrne CS, Chambers ES, Morrison DJ, Frost G. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int J Obes (Lond) 2015; 39: 1331–1338.
    • (2015) Int J Obes (Lond) , vol.39 , pp. 1331-1338
    • Byrne, C.S.1    Chambers, E.S.2    Morrison, D.J.3    Frost, G.4
  • 89
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259–1260.
    • (1989) BMJ , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 90
    • 33646175398 scopus 로고    scopus 로고
    • The ‘microflora hypothesis’ of allergic diseases
    • Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy 2005; 35: 1511–1520.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1511-1520
    • Noverr, M.C.1    Huffnagle, G.B.2
  • 91
    • 84919709430 scopus 로고    scopus 로고
    • The gut microbiota and its role in the development of allergic disease: a wider perspective
    • West CE, Jenmalm MC, Prescott SL. The gut microbiota and its role in the development of allergic disease: a wider perspective. Clin Exp Allergy 2015; 45: 43–53.
    • (2015) Clin Exp Allergy , vol.45 , pp. 43-53
    • West, C.E.1    Jenmalm, M.C.2    Prescott, S.L.3
  • 92
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski KM, Vieira AT, Ng A et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461: 1282–1286.
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3
  • 93
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia L, Tan J, Vieira AT et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 2015; 6: 6734.
    • (2015) Nat Commun , vol.6 , pp. 6734
    • Macia, L.1    Tan, J.2    Vieira, A.T.3
  • 94
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith PM, Howitt MR, Panikov N et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569–573.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 95
    • 64149112596 scopus 로고    scopus 로고
    • Faecal short chain fatty acid pattern and allergy in early childhood
    • Sandin A, Braback L, Norin E, Bjorksten B. Faecal short chain fatty acid pattern and allergy in early childhood. Acta Paediatr 2009; 98: 823–827.
    • (2009) Acta Paediatr , vol.98 , pp. 823-827
    • Sandin, A.1    Braback, L.2    Norin, E.3    Bjorksten, B.4
  • 96
    • 0033692480 scopus 로고    scopus 로고
    • Microflora-associated characteristics in faeces from allergic and nonallergic infants
    • Bottcher MF, Nordin EK, Sandin A, Midtvedt T, Bjorksten B. Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clin Exp Allergy 2000; 30: 1590–1596.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1590-1596
    • Bottcher, M.F.1    Nordin, E.K.2    Sandin, A.3    Midtvedt, T.4    Bjorksten, B.5
  • 97
    • 84942874856 scopus 로고    scopus 로고
    • Early infancy microbial and metabolic alterations affect risk of childhood asthma
    • 307ra152
    • Arrieta MC, Stiemsma LT, Dimitriu PA et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med 2015; 7: 307ra152.
    • (2015) Sci Transl Med , vol.7
    • Arrieta, M.C.1    Stiemsma, L.T.2    Dimitriu, P.A.3
  • 98
    • 84995897792 scopus 로고    scopus 로고
    • Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies
    • Alduraywish SA, Standl M, Lodge CJ et al. Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies. Pediatr Allergy Immunol 2016. DOI: 10.1111/pai.12651.
    • (2016) Pediatr Allergy Immunol
    • Alduraywish, S.A.1    Standl, M.2    Lodge, C.J.3
  • 99
    • 84923429956 scopus 로고    scopus 로고
    • Infant gut microbiota and food sensitization: associations in the first year of life
    • Azad MB, Konya T, Guttman DS et al. Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 2015; 45: 632–643.
    • (2015) Clin Exp Allergy , vol.45 , pp. 632-643
    • Azad, M.B.1    Konya, T.2    Guttman, D.S.3
  • 100
    • 84975168249 scopus 로고    scopus 로고
    • Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways
    • Tan J, McKenzie C, Vuillermin PJ et al. Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep 2016; 15: 2809–2824.
    • (2016) Cell Rep , vol.15 , pp. 2809-2824
    • Tan, J.1    McKenzie, C.2    Vuillermin, P.J.3
  • 101
    • 84942154798 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants
    • Berni Canani R, Sangwan N, Stefka AT et al. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J 2016; 10: 742–750.
    • (2016) ISME J , vol.10 , pp. 742-750
    • Berni Canani, R.1    Sangwan, N.2    Stefka, A.T.3
  • 102
    • 84924618612 scopus 로고    scopus 로고
    • Administration of a probiotic with peanut oral immunotherapy: a randomized trial
    • e8
    • Tang ML, Ponsonby AL, Orsini F et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol 2015; 135: 737–744 e8.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 737-744
    • Tang, M.L.1    Ponsonby, A.L.2    Orsini, F.3
  • 103
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A, Gollwitzer ES, Yadava K et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20: 159–166.
    • (2014) Nat Med , vol.20 , pp. 159-166
    • Trompette, A.1    Gollwitzer, E.S.2    Yadava, K.3
  • 104
    • 84859404292 scopus 로고    scopus 로고
    • Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology
    • Lambrecht BN, Hammad H. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annu Rev Immunol 2012; 30: 243–270.
    • (2012) Annu Rev Immunol , vol.30 , pp. 243-270
    • Lambrecht, B.N.1    Hammad, H.2
  • 105
    • 84934987107 scopus 로고    scopus 로고
    • Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
    • Thorburn AN, McKenzie CI, Shen S et al. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun 2015; 6: 7320.
    • (2015) Nat Commun , vol.6 , pp. 7320
    • Thorburn, A.N.1    McKenzie, C.I.2    Shen, S.3
  • 106
    • 84971268506 scopus 로고    scopus 로고
    • Memory CD8(+) T cells require increased concentrations of acetate induced by stress for optimal function
    • Balmer ML, Ma EH, Bantug GR et al. Memory CD8(+) T cells require increased concentrations of acetate induced by stress for optimal function. Immunity 2016; 44: 1312–1324.
    • (2016) Immunity , vol.44 , pp. 1312-1324
    • Balmer, M.L.1    Ma, E.H.2    Bantug, G.R.3
  • 107
    • 0141645569 scopus 로고    scopus 로고
    • Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts
    • Willemsen LE, Koetsier MA, van Deventer SJ, van Tol EA. Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts. Gut 2003; 52: 1442–1447.
    • (2003) Gut , vol.52 , pp. 1442-1447
    • Willemsen, L.E.1    Koetsier, M.A.2    van Deventer, S.J.3    van Tol, E.A.4
  • 108
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    • Johansson ME, Gustafsson JK, Holmen-Larsson J et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 2014; 63: 281–291.
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.1    Gustafsson, J.K.2    Holmen-Larsson, J.3
  • 109
    • 84922160830 scopus 로고    scopus 로고
    • The composition of the gut microbiota shapes the colon mucus barrier
    • Jakobsson HE, Rodriguez-Pineiro AM, Schutte A et al. The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep 2015; 16: 164–177.
    • (2015) EMBO Rep , vol.16 , pp. 164-177
    • Jakobsson, H.E.1    Rodriguez-Pineiro, A.M.2    Schutte, A.3
  • 110
    • 0028796718 scopus 로고
    • Colonic mucin synthesis is increased by sodium butyrate
    • Finnie IA, Dwarakanath AD, Taylor BA, Rhodes JM. Colonic mucin synthesis is increased by sodium butyrate. Gut 1995; 36: 93–99.
    • (1995) Gut , vol.36 , pp. 93-99
    • Finnie, I.A.1    Dwarakanath, A.D.2    Taylor, B.A.3    Rhodes, J.M.4
  • 111
    • 82355190924 scopus 로고    scopus 로고
    • Breastfeeding and body composition in children: will there ever be conclusive empirical evidence for a protective effect against overweight?
    • Beyerlein A, von Kries R. Breastfeeding and body composition in children: will there ever be conclusive empirical evidence for a protective effect against overweight? Am J Clin Nutr 2011; 94: 1772S–1775S.
    • (2011) Am J Clin Nutr , vol.94 , pp. 1772S-1775S
    • Beyerlein, A.1    von Kries, R.2
  • 112
    • 84959450310 scopus 로고    scopus 로고
    • Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
    • Victora CG, Bahl R, Barros AJ et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet 2016; 387: 475–490.
    • (2016) Lancet , vol.387 , pp. 475-490
    • Victora, C.G.1    Bahl, R.2    Barros, A.J.3
  • 113
    • 12244299228 scopus 로고    scopus 로고
    • An anthroposophic lifestyle and intestinal microflora in infancy
    • Alm JS, Swartz J, Bjorksten B et al. An anthroposophic lifestyle and intestinal microflora in infancy. Pediatr Allergy Immunol 2002; 13: 402–411.
    • (2002) Pediatr Allergy Immunol , vol.13 , pp. 402-411
    • Alm, J.S.1    Swartz, J.2    Bjorksten, B.3
  • 114
    • 84899799625 scopus 로고    scopus 로고
    • Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation
    • Chow J, Panasevich MR, Alexander D et al. Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation. J Proteome Res 2014; 13: 2534–2542.
    • (2014) J Proteome Res , vol.13 , pp. 2534-2542
    • Chow, J.1    Panasevich, M.R.2    Alexander, D.3
  • 115
    • 84945397731 scopus 로고    scopus 로고
    • Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study
    • Azad MB, Konya T, Persaud RR et al. Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study. BJOG 2016; 123: 983–993.
    • (2016) BJOG , vol.123 , pp. 983-993
    • Azad, M.B.1    Konya, T.2    Persaud, R.R.3
  • 117
    • 80054886353 scopus 로고    scopus 로고
    • Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways
    • Marcobal A, Barboza M, Sonnenburg ED et al. Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways. Cell Host Microbe 2011; 10: 507–514.
    • (2011) Cell Host Microbe , vol.10 , pp. 507-514
    • Marcobal, A.1    Barboza, M.2    Sonnenburg, E.D.3


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