Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: A prospective cohort study

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 123, Issue 6, 2016, Pages 983-993

  Azad, M B ^a,b   Konya, T ^c   Persaud, R R ^b   Guttman, D S ^d   Chari, R S ^a   Field, C J ^a   Sears, M R ^e   Mandhane, P J ^a   Turvey, S E ^f   Subbarao, P ^g   Becker, A B ^b   Scott, J A ^c   Kozyrskyj, A L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e MCMASTER UNIVERSITY   (Canada)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^g HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Breastfeeding; caesarean section; gut microbiome; gut microbiota; infant; intrapartum antibiotics

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ANTIBIOTIC PROPHYLAXIS; BACTEROIDES; BREAST FEEDING; CANADIAN; CESAREAN SECTION; CLOSTRIDIUM; COHORT ANALYSIS; CONTROLLED STUDY; DELIVERY; DYSBIOSIS; ELECTIVE SURGERY; EMERGENCY SURGERY; ENTEROCOCCUS; FECES ANALYSIS; GROUP B STREPTOCOCCAL INFECTION; HUMAN; INFANT; INTESTINE FLORA; INTRAPARTUM CARE; MICROBIAL DIVERSITY; NONHUMAN; NORMAL HUMAN; PARABACTEROIDES; PREMATURE FETUS MEMBRANE RUPTURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; SPECIES COMPOSITION; SPECIES RICHNESS; VAGINAL DELIVERY; ADVERSE EFFECTS; BIRTH; CHEMICALLY INDUCED; DRUG EFFECTS; FECES; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; PREGNANCY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BACTEROIDES; BREAST FEEDING; CESAREAN SECTION; CLOSTRIDIUM; DYSBIOSIS; ENTEROCOCCUS; FECES; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; GASTROINTESTINAL MICROBIOME; HUMANS; INFANT; PARTURITION; PREGNANCY; PROSPECTIVE STUDIES; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE;

EID: 84945397731     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.13601     Document Type: Review

References (44)

1. Stokholm J, Schjorring S, Pedersen L, Bischoff AL, Folsgaard N, Carson CG, et al., Prevalence and predictors of antibiotic administration during pregnancy and birth. PLoS One 2013; 8: e82932.
2. Persaud RR, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL,. Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study. J Matern Fetal Neonatal Med 2015; 28: 1190-5.
3. Fairlie T, Zell ER, Schrag S,. Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease. Obstet Gynecol 2013; 121: 570-7.
4. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 120: use of prophylactic antibiotics in labor and delivery. Obstet Gynecol 2011; 117: 1472-83.
5. van Schalkwyk J, Van Eyk N, Society of Obstetricians and Gynaecologists of Canada Infectious Diseases Committee. Antibiotic prophylaxis in obstetric procedures. J Obstet Gynaecol Can 2010; 32: 878-92.
6. Public Health Agency of Canada. Perinatal Health Indicators for Canada 2011, 2012.
7. Johri AK, Paoletti LC, Glaser P, Dua M, Sharma PK, Grandi G, et al., Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol 2006; 4: 932-42.
8. Opoien HK, Valbo A, Grinde-Andersen A, Walberg M,. Post-cesarean surgical site infections according to CDC standards: rates and risk factors. A prospective cohort study. Acta Obstet Gynecol Scand 2007; 86: 1097-102.
9. Homer CS, Scarf V, Catling C, Davis D,. Culture-based versus risk-based screening for the prevention of group B streptococcal disease in newborns: a review of national guidelines. Women Birth 2014; 27: 46-51.
10. Didier C, Streicher MP, Chognot D, Campagni R, Schnebelen A, Messer J, et al., Late-onset neonatal infections: incidences and pathogens in the era of antenatal antibiotics. Eur J Pediatr 2012; 171: 681-7.
11. Azad MB, Bridgman S, Becker AB, Kozyrskyj AL,. Infant antibiotic exposure and the development of childhood overweight and central adiposity. Int J Obes (Lond) 2014; 38: 1290-8.
12. Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ,. Infant antibiotic exposures and early-life body mass. Int J Obes (Lond) 2013; 37: 16-23.
13. Risnes KR, Belanger K, Murk W, Bracken MB,. Antibiotic exposure by 6 months and asthma and allergy at 6 years: findings in a cohort of 1,401 US children. Am J Epidemiol 2011; 173: 310-8.
14. Penders J, Kummeling I, Thijs C,. Infant antibiotic use and wheeze and asthma risk: a systematic review and meta-analysis. Eur Respir J 2011; 38: 295-302.
15. Vael C, Verhulst SL, Nelen V, Goossens H, Desager KN,. Intestinal microflora and body mass index during the first three years of life: an observational study. Gut Pathog 2011; 3: 8.
16. Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, et al., Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 2007; 56: 661-7.
17. Fouhy F, Guinane CM, Hussey S, Wall R, Ryan CA, Dempsey EM, et al., High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother 2012; 56: 5811-20.
18. Tanaka S, Kobayashi T, Songjinda P, Tateyama A, Tsubouchi M, Kiyohara C, et al., Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota. FEMS Immunol Med Microbiol 2009; 56: 80-7.
19. Aloisio I, Mazzola G, Corvaglia LT, Tonti G, Faldella G, Biavati B, et al., Influence of intrapartum antibiotic prophylaxis against group B Streptococcus on the early newborn gut composition and evaluation of the anti-Streptococcus activity of Bifidobacterium strains. Appl Microbiol Biotechnol 2014; 98: 6051-60.
20. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, et al., Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 2013; 185: 385-94.
21. Savino F, Roana J, Mandras N, Tarasco V, Locatelli E, Tullio V,. Faecal microbiota in breast-fed infants after antibiotic therapy. Acta Paediatr 2011; 100: 75-8.
22. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, et al., Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 2015; 45: 632-43.
23. Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Huntley J, Fierer N, et al., Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. ISME J 2012; 6: 1621-4.
24. Eggesbo M, Moen B, Peddada S, Baird D, Rugtveit J, Midtvedt T, et al., Development of gut microbiota in infants not exposed to medical interventions. APMIS 2011; 119: 17-35.
25. Jakobsson HE, Abrahamsson TR, Jenmalm MC, Harris K, Quince C, Jernberg C, et al., Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section. Gut 2014; 63: 559-66.
26. Bennet R, Nord CE,. Development of the faecal anaerobic microflora after caesarean section and treatment with antibiotics in newborn infants. Infection 1987; 15: 332-6.
27. Fallani M, Young D, Scott J, Norin E, Amarri S, Adam R, et al., Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr 2010; 51: 77-84.
28. Fallani M, Amarri S, Uusijarvi A, Adam R, Khanna S, Aguilera M, et al., Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres. Microbiology 2011; 157: 1385-92.
29. Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, et al., Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 2014; 158: 705-21.
30. Privitera G, Scarpellini P, Ortisi G, Nicastro G, Nicolin R, de Lalla F,. Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery. Antimicrob Agents Chemother 1991; 35: 208-10.
31. Kristich CJ, Rice LB, Arias CA,. Enterococcal infection-treatment and antibiotic resistance. In:, Gilmore MS, Clewell DB, Ike Y, Shankar N, editors. Enterococci: From Commensals to Leading Causes of Drug Resistant Infection [Internet]. Boston: Massachusetts Eye and Ear Infirmary; 2014. pp. 87-134.
32. Adam HJ, Baxter MR, Davidson RJ, Rubinstein E, Fanella S, Karlowsky JA, et al., Comparison of pathogens and their antimicrobial resistance patterns in paediatric, adult and elderly patients in Canadian hospitals. J Antimicrob Chemother 2013; 68 (Suppl 1): i31-7.
33. Newton DF, Macfarlane S, Macfarlane GT,. Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms. Antimicrob Agents Chemother 2013; 57: 2016-25.
34. Penders J, Gerhold K, Stobberingh EE, Thijs C, Zimmermann K, Lau S, et al., Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol 2013; 13: 601-7.
35. Soto A, Martin V, Jimenez E, Mader I, Rodriguez JM, Fernandez L,. Lactobacilli and Bifidobacteria in human breast milk: influence of antibiotherapy and other host and clinical factors. J Pediatr Gastroenterol Nutr 2014; 59: 78-88.
36. Pandey PK, Verma P, Kumar H, Bavdekar A, Patole MS, Shouche YS,. Comparative analysis of fecal microflora of healthy full-term Indian infants born with different methods of delivery (vaginal vs cesarean): Acinetobacter sp. prevalence in vaginally born infants. J Biosci 2012; 37: 989-98.
37. Acred P, Brown DM, Turner DH, Wilson MJ,. Pharmacology and chemotherapy of ampicillin-a new broad-spectrum penicillin. Br J Pharmacol Chemother 1962; 18: 356-69.
38. Hesla HM, Stenius F, Jaderlund L, Nelson R, Engstrand L, Alm J, et al., Impact of lifestyle on the gut microbiota of healthy infants and their mothers-the Aladdin Birth Cohort. FEMS Microbiol Ecol 2014; 90: 791-801.
39. Cabrera-Rubio R, Collado MC, Laitinen K, Salminen S, Isolauri E, Mira A,. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr 2012; 96: 544-51.
40. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, et al., Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006; 118: 511-21.
41. Bezirtzoglou E, Tsiotsias A, Welling GW,. Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe 2011; 17: 478-82.
42. Bergstrom A, Skov TH, Bahl MI, Roager HM, Christensen LB, Ejlerskov KT, et al., Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol 2014; 80: 2889-900.
43. Santos F, Oraichi D, Berard A,. Prevalence and predictors of anti-infective use during pregnancy. Pharmacoepidemiol Drug Saf 2010; 19: 418-27.
44. Hakansson S, Kallen K, Bullarbo M, Holmgren PA, Bremme K, Larsson A, et al., Real-time PCR-assay in the delivery suite for determination of group B streptococcal colonization in a setting with risk-based antibiotic prophylaxis. J Matern Fetal Neonatal Med 2014; 27: 328-32.