Contribution of acetate to butyrate formation by human faecal bacteria

British Journal of Nutrition

Volumn 91, Issue 6, 2004, Pages 915-923

  Duncan, Sylvia H ^a   Holtrop, Grietje ^a   Lobley, Gerald E ^a   Calder, A Graham ^a   Stewart, Colin S ^a   Flint, Harry J ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Acetate; Butyrate synthesis; Colon; Faecalibacterium prausnitzii; Roseburia intestinalis; Stable isotope

Indexed keywords

ACETIC ACID; ACETYL COENZYME A; AMYLOPECTIN; BUTYRIC ACID; CARBOHYDRATE; CARBON 13; GLUCOSE; INULIN; PECTIN; XYLAN; ACETIC ACID DERIVATIVE; BUTYRIC ACID DERIVATIVE;

ANAEROBIC FERMENTATION; ARTICLE; BACTERIUM CULTURE; CONTINUOUS CULTURE; COPROCOCCUS; ENERGY RESOURCE; FAECALIBACTERIUM PRAUSNITZII; FATTY ACID SYNTHESIS; FECES MICROFLORA; NONHUMAN; ROSEBURIA; TAXONOMICALLY UNCLASSIFIED BACTERIA; WHEAT; ANAEROBIC BACTERIUM; BIOLOGICAL MODEL; CEREAL; CULTURE MEDIUM; EUBACTERIUM; FECES; HUMAN; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED;

COPROCOCCUS; FAECALIBACTERIUM PRAUSNITZII; ROSEBURIA; ROSEBURIA INTESTINALIS; TRITICUM AESTIVUM;

ACETATES; AMYLOPECTIN; BACTERIA, ANAEROBIC; BUTYRATES; CEREALS; CULTURE MEDIA; EUBACTERIUM; FECES; GLUCOSE; HUMANS; INULIN; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PECTINS; XYLANS;

EID: 3142628485     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN20041150     Document Type: Article

References (32)

1. Avivi-Green C, Polak-Charson S, Madar Z & Schwartz B (2000) Apoptosis cascade proteins are regulated in vivo by high intra-colonic butyrate concentration: correlation with colon cancer inhibition. Oncol Res 12, 83-95.
2. Barcenilla A, Pryde SE, Martin JC, Duncan SH, Stewart CS, Henderson C & Flint HJ (2000) Phylogenetic relationships of dominant butyrate producing bacteria from the human gut. Appl Environ Microbiol 66, 1654-1661.
3. Bryant MP (1972) Commentary on the Hungate technique for cultivation of anaerobic bacteria. Am J Clin Nutr 25, 1324-1328.
4. Calder AG, Garden KE, Anderson SE & Lobley GE (1999) Quantitation of blood and plasma amino acids using isotope dilution electron impact gas chromotography/mass spectrometry with U-13C amino acids as internal standards. Rapid Commun Mass Spectrom 13, 2080-2083.
5. Cavaglieri C, Nishiyama A, Fernandes LC, Curi R, Miles EA & Calder PC (2003) Differential effects of short chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sci 73, 1683-1690.
6. Csordas A (1996) Butyrate, aspirin and colorectal cancer. Eur J Cancer Prev 5, 221-231.
7. Cummings HJ (1995) Short chain fatty acids. In Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology, pp. 101-130 [GR Gibson and GT Macfarlane]. Boca Raton, FL: CRC Press.
8. Duncan SH, Barcenilla A, Stewart CS, Pryde SE & Flint HJ (2002a) Acetate utilization and butyryl coenzyme A (CoA): acetate-CoA transferase in butyrate-producing bacteria from the human large intestine. Appl Environ Microbiol 68, 5186-5190.
9. Duncan SH, Hold GL, Barcenilla A, Stewart CS & Flint HJ (2002b) Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces. Int J Syst Evol Microbiol 52, 1615-1620.
10. Duncan SH, Hold GL, Harmsen HJM, Stewart CS & Flint HJ (2002c) Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov. Int J Syst Evol Microbiol 52, 2141-2146.
11. Duncan SH, Scott KP, Ramsay AG, Harmsen HJM, Welling GW, Stewart CS & Flint HJ (2003) Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system. Appl Environ Microbiol 69, 1136-1142.
12. Englyst HN, Hay S & Macfarlane GT (1987) Polysaccharide breakdown by mixed populations of human fecal bacteria. FEMS Microbiol Ecol 95, 163-171.
13. Hague A, Elder DJE, Hicks DJ & Paraskeva AC (1995) Apoptosis in colorectal tumour cells - induction by the short chain fatty acids butyrate, propionate and acetate and acetate by the bile salt deoxycholate. Int J Cancer 60, 400-406.
14. Hillman K, Murdoch TA, Spencer RJ & Stewart CS (1994) Inhibition of enterotoxigenic Escherichia coli by the microflora of the porcine ileum, in an in vitro semi-continuous culture system. J Appl Bacteriol 76, 294-300.
15. Hold GL, Schwiertz A, Aminov RI, Blaut M & Flint HJ (2003) Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces. Appl Environ Microbiol 69, 4320-4324.
16. Kleessen B, Hartmann L & Blaut M (2001) Oligofructose and long chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br J Nutr 86, 291-300.
17. Macfarlane GT & Gibson GR (1997) Carbohydrate fermentation, energy transduction and gas metabolism in the human large intestine. In Gastrointestinal Microbiology, vol. 1. pp. 269-318 [RI Mackie and BA White, editors]. New York: B. A. Chapman and Hall Microbiology Series.
18. Macfarlane GT, Hay S & Gibson GR (1989) Influence of mucin on glycosidase, protease and arylamidase activities of human gut bacteria grown in a 3-stage continuous culture system. J Appl Bacteriol 66, 407-417.
19. McIntyre A, Gibson PR & Young GP (1993) Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 34, 386-391.
20. Mariadason JM, Corner GA & Augenlight LH (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcurmin and implications for chemoprevention of colon cancer. Cancer Res 60, 4561-4572.
21. Miller TL & Wolin MJ (1996) Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora. Appl Environ Microbiol 62, 1589-1592.
22. 14. Anaerobe 3, 373-381.
23. Pryde SE, Duncan SH, Hold GL, Stewart CS & Flint HJ (2002) The microbiology of butyrate formation in the human colon. FEMS Microbiol Letts 217, 133-139.
24. Richardson AJ, Calder GC, Stewart CS & Smith A (1989) Simultaneous determination of volatile and non-volatile fermentation products of anaerobes by capillary gas chromatography. Lett Appl Microbiol 9, 5-8.
25. Scheppach W, Luehrs H & Menzel T (2001) Beneficial health effects of low digestible carbohydrate consumption. Br J Nutr 85, S23-S30.
26. Shipley RA & Clark RE (1972) Tracer Methods for In Vivo Kinetics, Theory and Applications. New York: Academic Press, New York.
27. Suau A, Rochet V, Sghir A, Gramet G, Breways S, Sutern M, Rigottier-Gois L & Dore J (2001) Fusobacterium prausnitzii and related species represent a dominant group within the human fecal flora. Syst Appl Microbiol 24, 139-145.
28. Titgemeyer EC, Bourquin LD, Fahey GC Jr & Garleb KA (1991) Fermentability of various fiber sources by human fecal bacteria in vitro. Am J Clin Nutr 53, 1418-1424.
29. Topping DL & Clifton PM (2001) Short chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81, 1031-1064.
30. Wachtershauser A & Stein J (2000) Rationale for the luminal provision of butyrate in intestinal disease. Eur J Nutr 39, 164-171.
31. Weaver GA, Krause JA, Miller TL & Wolin MJ (1992) Cornstarch fermentation by the colonic microbial community yields more butyrate than does cabbage fibre fermentation -cornstarch fermentation rates correlate negatively with methanogenesis. Am J Clin Nutr 55, 70-77.
32. Wolin MJ, Miller TJ, Yerry S. Zhang YC, Bank S & Weaver GA (1999) Changes in fermentation pattern of fecal microbial communities associated with a drug treatment that increases dietary starch in the human colon. Appl Environ Microbiol 65, 2807-2812.