Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans

International Journal of Obesity

Volumn 38, Issue 12, 2014, Pages 1525-1531

  Rahat Rozenbloom, S ^a   Fernandes, J ^a   Gloor, G B ^b   Wolever, T M S ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

colonic absorption; colonic microbiota; diet; short chain fatty acid

Indexed keywords

SHORT CHAIN FATTY ACID; CARBOHYDRATE DIET; FAT INTAKE; VOLATILE FATTY ACID;

ADULT; ARTICLE; CARBOHYDRATE INTAKE; CLINICAL ARTICLE; COLON ABSORPTION; COLON FLORA; CONTROLLED STUDY; DIETARY INTAKE; FAT INTAKE; FECES MICROFLORA; FEMALE; FIRMICUTES; GROUP DYNAMICS; HUMAN; MALE; OBESITY; PRIORITY JOURNAL; BODY WEIGHT; CARBOHYDRATE DIET; COLON; DIET; FECES; MEDICAL RECORD; METABOLISM; MICROBIOLOGY; PILOT STUDY; RECTAL ABSORPTION;

BACTERIA (MICROORGANISMS); FIRMICUTES;

ADULT; COLON; DIET; DIET RECORDS; DIETARY CARBOHYDRATES; DIETARY FATS; FATTY ACIDS, VOLATILE; FECES; FEMALE; HUMANS; MALE; OVERWEIGHT; PILOT PROJECTS; RECTAL ABSORPTION; THINNESS;

EID: 84927176473     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.46     Document Type: Article

References (56)

1. Cummings JH. Short chain fatty acids in the human colon. Gut 1981; 22: 763-779
2. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: RoLes of resistant starch and nonstarch polysacchariDes. Physiol Rev 2001; 81: 1031-1064
3. Wong JMW, De Souza R, Kendall CWC, Emam A, Jenkins DJA. Colonic health: Fermentation and short chain fatty acids. J Clin Gastroenterol 2006; 40: 235-243
4. Ley RE, Bckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005; 102: 11070-11075
5. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesityassociated gut microbiome with increased capacity for energy harvest. Nature 2006; 444: 1027-1031
6. Schwiertz A, Taras D, Schfer K, Beijer S, Bos NA, Donus C et al. Microbiota and SCFA in Lean and overweight healthy subjects. Obesity 2010; 18: 190-195
7. Teixeira TFS, Grzekowiak L, Franceschini SCC, Bressan J, Ferreira CLLF, Peluzio MCG. Higher Level of faecal SCFA in women correlates with metabolic syndrome risk factors. Br J Nutr 2013; 109: 914-919
8. Duncan SH, LobLey GE, Holtrop G, Ince J, Johnstone AM, Louis P et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes 2008; 32: 1720-1724
9. Vogt JA, WoLever TMS. Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon. J Nutr 2003; 133: 3145-3148
10. El Oufir L, Barry JL, Flouri B, Cherbut C, Cloarec D, Bornet F et al. Relationships between transit time in man and in vitro fermentation of dietary fiber by fecal bacteria. Eur J Clin Nutr 2000; 54: 603-609
11. Haenen D, Zhang J, da Silva CS, Bosch G, Van Der Meer IM, Van Arkel J et al. A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine1-3. J Nutr 2013; 143: 274-283
12. Cummings JH, Beatty ER, Kingman SM, Bingham SA, Englyst HN. Digestion and physiological properties of resistant starch in the human large bowel. Br J Nutr 1996; 75: 733-747
13. Duncan SH, BeLenguer A, Holtrop G, Johnstone AM, Flint HJ, LobLey GE. Reduced dietary intake of carbohydrates by obese subjects results in Decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 2007; 73: 1073-1078
14. Bourriaud C, Robins RJ, Martin L, Kozlowski F, TenailLeau E, Cherbut C et al. Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is eviDent. J Appl Microbiol 2005; 99: 201-212
15. Ainsworth BE, Haskell WL, Leon AS, Jacobs Jr DR, Montoye HJ, Sallis JF et al. Compendium of physical activities: Classification of energy costs of human physical activities. Med Sci Sports Exerc 1993; 25: 71-80
16. Kriska AM, Caspersen CJ. ModifiabLe activity questionnaire. In: Kriska AM, Caspersen CJ (eds), A ColLection of Physical Activity Questionnaires for Health-Related Research. Med Sci Sports Exerc 1997; 29: S73-S78
17. FernanDes J, Wang A, Su W, Rozenbloom SR, Taibi A, Comelli EM et al. Age, dietary fiber, breath methane, and fecal short chain Fatty acids are interrelated in archaea-positive humans. J Nutr 2013; 143: 1269-1275
18. Edmonds CJ. Absorption of sodium and water by human rectum measured by a dialysis method. Gut 1971; 12: 356-362
19. McNeil NI, Cummings JH, James WPT. Short chain fatty acid absorption by the human large intestine. Gut 1978; 19: 819-822
20. Petrof EO, Gloor GB, Vanner SJ, Weese SJ, Carter D, Daigneault MC et al. Stool substitute transplant therapy for the eradication of Clostridium difficiLe infection: RePOOPulating the gut. Microbiome 2013; 1: 3
21. Bittinger K, Bushman FD, Caporaso JG, Costello EK, Fierer N, Goodrich JK et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010; 7: 335
22. Price MN, Dehal PS, Arkin AP. FastTree: computing large minimum evolution trees with profiLes instead of a distance matrix. Mol Biol Evol 2009; 26: 1641-1650
23. Edgar RC. MUSCLE: a multipLe sequence alignment method with reduced time and space compLexity. BMC Bioinformatics 2004; 5: 113
24. FernanDes AD, Macklaim JM, Linn TG, Reid G, Gloor GB. ANOVA-Like Differential Expression (ALDEx) Analysis for Mixed Population RNA-Seq. PLos One 2013; 8: e67019
25. Friedman J, Alm EJ. Inferring Correlation Networks from Genomic Survey Data. Plos Comput Biol 2012; 8: e1002687
26. Aitchison J. The Statistical Analysis Of Compositional Data. Chapman and Hall: New York, NY, USA, 1986
27. Jaynes ET. Probability Theory: The Logic Of Science. Cambridge University Press: New York, NY, USA, 2003
28. Strimmer K. Fdrtool: a versatiLe R package for estimating local and tail area-based false discovery rates. Bioinformatics 2008; 24: 1461-1462
29. Ppatil D, Pdhotre D, GchaVan S, Sultan A, Jain DS, Lanjekar VB et al. MoLecular analysis of gut microbiota in obesity among Indian individuals. J Biosci 2012; 37: 647-657
30. Murphy EF, Cotter PD, Healy S, Marques TM, O'SulliVan O, Fouhy F et al. Composition and energy harvesting capacity of the gut microbiota: Relationship to diet, obesity and time in mouse moDels. Gut 2010; 59: 1635-1642
31. Gomes MO, Beraldo MC, Putarov TC, Brunetto MA, Zaine L, Glria MB et al. Old beagLe dogs have lower faecal concentrations of some fermentation products and lower peripheral lymphocyte counts than young adult beagLes. Br J Nutr 2011; 106 : S187-S190
32. WoLever TMS, FernanDes J, Rao AV. Serum acetate:propionate ratio is related to serum choLesterol in men but not women. J Nutr 1996; 126: 2790-2797
33. Stein J, Zores M, SchrDer O. Short-chain fatty acid (SCFA) uptake into Caco-2 cells, by a pH-DepenDent and carrier mediated transport mechanism. Eur J Nutr 2000; 39: 121-125
34. FLeming SE, Choi SY, Fitch MD. Absorption of short-chain fatty acids from the rat cecum in vivo. J Nutr 1991; 121: 1787-1797
35. Cummings JH, Pomare EW, Branch WJ, Naylor CPE, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987; 28: 1221-1227
36. Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE et al. Expression and membrane localization of MCT isoforms along the Length of the human intestine. Am J Physiol-Cell Physiol 2005; 289: C846-C852
37. Iwanaga T, Takebe K, Kato I, Karaki S-, Kuwahara A. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomed Res 2006; 27: 243-254
38. Borthakur A, Priyamvada S, Kumar A, Natarajan AA, Gill RK, Alrefai WA et al. A novel nutrient sensing mechanism unDerlies substrate-induced regulation of monocarboxylate transporter-1. Am J Physiol-Gastrointest Liver Physiol 2012; 303: G1126-G1133
39. Zhou J, Hegsted M, McCutcheon KL, Keenan MJ, Xi A, Raggio AM et al. PeptiDe YY and proglucagon mRNA expression patterns and regulation in the gut. Obesity 2006; 14: 683-689
40. Freeland KR, WoLever TMS. Acute effects of intravenous and rectal acetate on glucagon-like peptiDe-1, peptiDe YY, ghrelin, adiponectin and tumour necrosis factor-Alpha. Br J Nutr 2010; 103: 460-466
41. De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, PoulLet JB, Massart S et al. Impact of diet in shaping gut microbiota reveaLed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010; 107: 14691-14696
42. Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A et al. Characterizing a moDel human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci USA 2009; 106: 5859-5864
43. Gabert L, Vors C, Louche-Plissier C, Sauvinet V, Lambert-Porcheron S, Drai J et al. 13C tracer recovery in human stools after digestion of a fat-rich meal labelLed with [1, 1, 1-13C3]tripalmitin and [1, 1, 1-13C3]trioLein. Rapid Commun Mass Spectrometry 2011; 25: 2697-2703
44. HilDebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen Y et al. High-Fat Diet Determines the Composition of the Murine Gut Microbiome InDepenDently of Obesity. Gastroenterology 2009; 137: 1716-1724 e2
45. Kim K-A, Gu W, Lee I-A, Joh E-H, Kim D-H. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One 2012; 7: e47713
46. Mujico JR, Baccan GC, Gheorghe A, Daz LE, Marcos A. Changes in gut microbiota due to suppLemented fatty acids in diet-induced obese mice. Br J Nutr 2013; 110: 711-720
47. Fava F, Gitau R, Griffin BA, Gibson GR, Tuohy KM, Lovegrove JA. The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome 'at-risk' population. Int J Obes 2013; 37: 216-223
48. Brinkworth GD, Noakes M, Clifton PM, Bird AR. Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations. Br J Nutr 2009; 101: 1493-1502
49. Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI et al. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 2011; 94: 58-65
50. Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W et al. Interactions between gut microbiota, host genetics and diet reLeVant to Development of metabolic syndromes in mice. ISME J 2010; 4: 232-241
51. Ley RE, Turnbaugh PJ, KLein S, Gordon JI. Microbial ecology: Human gut microbes associated with obesity. Nature 2006; 444: 1022-1023
52. Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA 2009; 106: 2365-2370
53. Lewis SJ, Heaton KW. Increasing butyrate concentration in the distal colon by acceLerating intestinal transit. Gut 1997; 41: 245-251
54. El Oufir L, Flouri B, BruLey Des Varannes S, Barry JL, Cloarec D, Bornet F et al. Relations between transit time, fermentation products, and hydrogen consuming flora in healthy humans. Gut 1996; 38: 870-877
55. Stephen AM, Wiggins HS, Cummings JH. Effect of changing transit time on colonic microbial metabolism in man. Gut 1987; 28: 601-609
56. Saad RJ, Rao SSC, Koch KL, Kuo B, Parkman HP, McCallum RW et al. Do stool form and frequency correlate with whoLe-gut and colonic transit results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol 2010; 105: 403-411.