메뉴 건너뛰기




Volumn 92, Issue 9, 2016, Pages 423-435

Maintenance of gut homeostasis by the mucosal immune system

Author keywords

Inflammatory bowel disease; Innate immunity; Intestinal microbiota; Mucosal barrier

Indexed keywords

ANIMAL; CYTOLOGY; EPITHELIUM CELL; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INNATE IMMUNITY; MICROBIOLOGY; MICROFLORA;

EID: 85002587181     PISSN: 03862208     EISSN: 13492896     Source Type: Journal    
DOI: 10.2183/pjab.92.423     Document Type: Review
Times cited : (54)

References (83)
  • 1
    • 84942564274 scopus 로고    scopus 로고
    • The gut microbiota and inflammatory bowel disease
    • Goto, Y., Kurashima, Y. and Kiyono, H. (2015) The gut microbiota and inflammatory bowel disease. Curr. Opin. Rheumatol. 27, 388-396.
    • (2015) Curr. Opin. Rheumatol , vol.27 , pp. 388-396
    • Goto, Y.1    Kurashima, Y.2    Kiyono, H.3
  • 2
    • 84946837224 scopus 로고    scopus 로고
    • Regulation of lung immunity and host defense by the intestinal microbiota
    • Samuelson, D.R., Welsh, D.A. and Shellito, J.E. (2015) Regulation of lung immunity and host defense by the intestinal microbiota. Front. Microbiol. 6, 1085.
    • (2015) Front. Microbiol , vol.6 , pp. 1085
    • Samuelson, D.R.1    Welsh, D.A.2    Shellito, J.E.3
  • 3
    • 84924787273 scopus 로고    scopus 로고
    • IBD and the gut microbiota-from bench to personalized medicine
    • Bellaguarda, E. and Chang, E.B. (2015) IBD and the gut microbiota-from bench to personalized medicine. Curr. Gastroenterol. Rep. 17, 15.
    • (2015) Curr. Gastroenterol. Rep , vol.17 , pp. 15
    • Bellaguarda, E.1    Chang, E.B.2
  • 4
    • 84960081564 scopus 로고    scopus 로고
    • Functions of innate immune cells and commensal bacteria in gut homeostasis
    • Kayama, H. and Takeda, K. (2016) Functions of innate immune cells and commensal bacteria in gut homeostasis. J. Biochem. 159, 141-149.
    • (2016) J. Biochem , vol.159 , pp. 141-149
    • Kayama, H.1    Takeda, K.2
  • 5
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. and Muller, W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 6
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda, K., Clausen, B.E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I. and Akira, S. (1999) Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Förster, I.6    Akira, S.7
  • 7
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • Kobayashi, M., Kweon, M.N., Kuwata, H., Schreiber, R.D., Kiyono, H., Takeda, K. and Akira, S. (2003) Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111, 1297-1308.
    • (2003) J. Clin. Invest , vol.111 , pp. 1297-1308
    • Kobayashi, M.1    Kweon, M.N.2    Kuwata, H.3    Schreiber, R.D.4    Kiyono, H.5    Takeda, K.6    Akira, S.7
  • 8
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: regulators of barrier function and immune homeostasis
    • Peterson, L.W. and Artis, D. (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14, 141-153.
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 9
    • 85017672793 scopus 로고    scopus 로고
    • The cross-talk between enterocytes and intraepithelial lymphocytes
    • Vitale, S., Picascia, S. and Gianfrani, C. (2016) The cross-talk between enterocytes and intraepithelial lymphocytes. Mol Cell Pediatr. 3, 20.
    • (2016) Mol Cell Pediatr , vol.3 , pp. 20
    • Vitale, S.1    Picascia, S.2    Gianfrani, C.3
  • 10
    • 70049090007 scopus 로고    scopus 로고
    • The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses
    • Strober, W. (2009) The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses. Immunity 31, 377-388.
    • (2009) Immunity , vol.31 , pp. 377-388
    • Strober, W.1
  • 11
    • 72049086490 scopus 로고    scopus 로고
    • Immunology: Dendritic-cell genealogy
    • Laffont, S. and Powrie, F. (2009) Immunology: Dendritic-cell genealogy. Nature 462, 732-733.
    • (2009) Nature , vol.462 , pp. 732-733
    • Laffont, S.1    Powrie, F.2
  • 13
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid
    • Sun, C.M., Hall, J.A., Blank, R.B., Bouladoux, N., Oukka, M., Mora, J.R. and Belkaid, Y. (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785.
    • (2007) J. Exp. Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 17
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • Kinnebrew, M.A., Buffie, C.G., Diehl, G.E., Zenewicz, L.A., Leiner, I., Hohl, T.M., Flavell, R.A., Littman, D.R. and Pamer, E.G. (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36, 276-287.
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1    Buffie, C.G.2    Diehl, G.E.3    Zenewicz, L.A.4    Leiner, I.5    Hohl, T.M.6    Flavell, R.A.7    Littman, D.R.8    Pamer, E.G.9
  • 18
    • 78751706261 scopus 로고    scopus 로고
    • CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg, G.F., Monticelli, L.A., Elloso, M.M., Fouser, L.A. and Artis, D. (2011) CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34, 122-134.
    • (2011) Immunity , vol.34 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3    Fouser, L.A.4    Artis, D.5
  • 19
    • 79955030498 scopus 로고    scopus 로고
    • Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    • Sonnenberg, G.F., Fouser, L.A. and Artis, D. (2011) Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12, 383-390.
    • (2011) Nat. Immunol , vol.12 , pp. 383-390
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 20
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang, S.C., Tan, X.Y., Luxenberg, D.P., Karim, R., Dunussi-Joannopoulos, K., Collins, M. and Fouser, L.A. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279.
    • (2006) J. Exp. Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 27
    • 77949911050 scopus 로고    scopus 로고
    • + dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    • + dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J. Immunol. 184, 2026-2037.
    • (2010) J. Immunol , vol.184 , pp. 2026-2037
    • Niess, J.H.1    Adler, G.2
  • 30
    • 84900019211 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology
    • Lombardi, V.C. and Khaiboullina, S.F. (2014) Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology. Clin. Immunol. 153, 165-177.
    • (2014) Clin. Immunol , vol.153 , pp. 165-177
    • Lombardi, V.C.1    Khaiboullina, S.F.2
  • 31
    • 79951729700 scopus 로고    scopus 로고
    • Prominent role for plasmacytoid dendritic cells in mucosal T cellindependent IgA induction
    • Tezuka, H., Abe, Y., Asano, J., Sato, T., Liu, J., Iwata, M. and Ohteki, T. (2011) Prominent role for plasmacytoid dendritic cells in mucosal T cellindependent IgA induction. Immunity 34, 247-257.
    • (2011) Immunity , vol.34 , pp. 247-257
    • Tezuka, H.1    Abe, Y.2    Asano, J.3    Sato, T.4    Liu, J.5    Iwata, M.6    Ohteki, T.7
  • 32
    • 78650412729 scopus 로고    scopus 로고
    • Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10
    • Ueda, Y., Kayama, H., Jeon, S.G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M. and Takeda, K. (2010) Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int. Immunol. 22, 953-962.
    • (2010) Int. Immunol , vol.22 , pp. 953-962
    • Ueda, Y.1    Kayama, H.2    Jeon, S.G.3    Kusu, T.4    Isaka, Y.5    Rakugi, H.6    Yamamoto, M.7    Takeda, K.8
  • 33
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C.L., Cheroutre, H. and Kronenberg, M. (2009) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat. Immunol. 10, 1178-1184.
    • (2009) Nat. Immunol , vol.10 , pp. 1178-1184
    • Murai, M.1    Turovskaya, O.2    Kim, G.3    Madan, R.4    Karp, C.L.5    Cheroutre, H.6    Kronenberg, M.7
  • 37
    • 84952324827 scopus 로고    scopus 로고
    • Immune-microbiota interactions in health and disease
    • Palm, N.W., de Zoete, M.R. and Flavell, R.A. (2015) Immune-microbiota interactions in health and disease. Clin. Immunol. 159, 122-127.
    • (2015) Clin. Immunol , vol.159 , pp. 122-127
    • Palm, N.W.1    de Zoete, M.R.2    Flavell, R.A.3
  • 38
    • 0002608319 scopus 로고
    • Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation
    • Pollard, M. and Sharon, N. (1970) Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation. Infect. Immun. 2, 96-100.
    • (1970) Infect. Immun , vol.2 , pp. 96-100
    • Pollard, M.1    Sharon, N.2
  • 39
    • 0034705397 scopus 로고    scopus 로고
    • A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    • Macpherson, A.J., Gatto, D., Sainsbury, E., Harriman, G.R., Hengartner, H. and Zinkernagel, R.M. (2000) A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222-2226.
    • (2000) Science , vol.288 , pp. 2222-2226
    • Macpherson, A.J.1    Gatto, D.2    Sainsbury, E.3    Harriman, G.R.4    Hengartner, H.5    Zinkernagel, R.M.6
  • 41
    • 0002461708 scopus 로고
    • Changes in the mouse's enteric microflora associated with enhanced susceptibility to Salmonella infection following streptomycin treatment
    • Mtller, C.P. and Bohnhoff, M. (1963) Changes in the mouse's enteric microflora associated with enhanced susceptibility to Salmonella infection following streptomycin treatment. J. Infect. Dis. 113, 59-66.
    • (1963) J. Infect. Dis , vol.113 , pp. 59-66
    • Mtller, C.P.1    Bohnhoff, M.2
  • 43
    • 0033006564 scopus 로고    scopus 로고
    • Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system
    • Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A. and Itoh, K. (1999) Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect. Immun. 67, 3504-3511.
    • (1999) Infect. Immun , vol.67 , pp. 3504-3511
    • Umesaki, Y.1    Setoyama, H.2    Matsumoto, S.3    Imaoka, A.4    Itoh, K.5
  • 47
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round, J.L., Lee, S.M., Li, J., Tran, G., Jabri, B., Chatila, T.A. and Mazmanian, S.K. (2011) The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332, 974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6    Mazmanian, S.K.7
  • 48
    • 84894263389 scopus 로고    scopus 로고
    • Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon
    • Shimada, Y., Kinoshita, M., Harada, K., Mizutani, M., Masahata, K., Kayama, H. and Takeda, K. (2013) Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS One 8, e80604.
    • (2013) PLoS One , vol.8
    • Shimada, Y.1    Kinoshita, M.2    Harada, K.3    Mizutani, M.4    Masahata, K.5    Kayama, H.6    Takeda, K.7
  • 51
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang, P.V., Hao, L., Offermanns, S. and Medzhitov, R. (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl. Acad. Sci. U.S.A. 111, 2247-2252.
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 57
    • 84871755412 scopus 로고    scopus 로고
    • Inflammatory bowel disease: an impaired barrier disease
    • Jager, S., Stange, E.F. and Wehkamp, J. (2013) Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch. Surg. 398, 1-12.
    • (2013) Langenbecks Arch. Surg , vol.398 , pp. 1-12
    • Jager, S.1    Stange, E.F.2    Wehkamp, J.3
  • 59
    • 84941349580 scopus 로고    scopus 로고
    • Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice
    • Tanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A. and Tsukita, S. (2015) Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice. Gut. 64, 1529-1538.
    • (2015) Gut , vol.64 , pp. 1529-1538
    • Tanaka, H.1    Takechi, M.2    Kiyonari, H.3    Shioi, G.4    Tamura, A.5    Tsukita, S.6
  • 65
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • Ayabe, T., Satchell, D.P., Wilson, C.L., Parks, W.C., Selsted, M.E. and Ouellette, A.J. (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113-118.
    • (2000) Nat. Immunol , vol.1 , pp. 113-118
    • Ayabe, T.1    Satchell, D.P.2    Wilson, C.L.3    Parks, W.C.4    Selsted, M.E.5    Ouellette, A.J.6
  • 66
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava, S., Yamamoto, M., Severson, K.M., Ruhn, K.A., Yu, X., Koren, O., Ley, R., Wakeland, E.K. and Hooper, L.V. (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255-258.
    • (2011) Science , vol.334 , pp. 255-258
    • Vaishnava, S.1    Yamamoto, M.2    Severson, K.M.3    Ruhn, K.A.4    Yu, X.5    Koren, O.6    Ley, R.7    Wakeland, E.K.8    Hooper, L.V.9
  • 67
    • 34547762705 scopus 로고    scopus 로고
    • MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    • Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R.P. and Pamer, E.G. (2007) MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J. Exp. Med. 204, 1891-1900.
    • (2007) J. Exp. Med , vol.204 , pp. 1891-1900
    • Brandl, K.1    Plitas, G.2    Schnabl, B.3    DeMatteo, R.P.4    Pamer, E.G.5
  • 68
    • 33748039462 scopus 로고    scopus 로고
    • Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    • Cash, H.L., Whitham, C.V., Behrendt, C.L. and Hooper, L.V. (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130.
    • (2006) Science , vol.313 , pp. 1126-1130
    • Cash, H.L.1    Whitham, C.V.2    Behrendt, C.L.3    Hooper, L.V.4
  • 70
    • 84938812082 scopus 로고    scopus 로고
    • The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease
    • Worthington, J.J. (2015) The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease. Biochem. Soc. Trans. 43, 727-733.
    • (2015) Biochem. Soc. Trans , vol.43 , pp. 727-733
    • Worthington, J.J.1
  • 73
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    • Mabbott, N.A., Donaldson, D.S., Ohno, H., Williams, I.R. and Mahajan, A. (2013) Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 6, 666-677.
    • (2013) Mucosal Immunol , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 75
    • 84954286513 scopus 로고    scopus 로고
    • Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
    • von Moltke, J., Ji, M., Liang, H.E. and Locksley, R.M. (2016) Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221-225.
    • (2016) Nature , vol.529 , pp. 221-225
    • von Moltke, J.1    Ji, M.2    Liang, H.E.3    Locksley, R.M.4
  • 77
    • 84925996764 scopus 로고    scopus 로고
    • Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages
    • Saia, R.S., Mestriner, F.L., Bertozi, G., Cunha, F.Q. and Carnio, E.C. (2014) Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages. Mediators Inflamm. 2014, 896029.
    • (2014) Mediators Inflamm , vol.2014
    • Saia, R.S.1    Mestriner, F.L.2    Bertozi, G.3    Cunha, F.Q.4    Carnio, E.C.5
  • 78
    • 84874410778 scopus 로고    scopus 로고
    • Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men
    • Mann, E.R., Landy, J.D., Bernardo, D., Peake, S.T., Hart, A.L., Al-Hassi, H.O. and Knight, S.C. (2013) Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men. Immunol. Lett. 150, 30-40.
    • (2013) Immunol. Lett , vol.150 , pp. 30-40
    • Mann, E.R.1    Landy, J.D.2    Bernardo, D.3    Peake, S.T.4    Hart, A.L.5    Al-Hassi, H.O.6    Knight, S.C.7
  • 79
    • 84920404296 scopus 로고    scopus 로고
    • How informative is the mouse for human gut microbiota research?
    • Nguyen, T.L., Vieira-Silva, S., Liston, A. and Raes, J. (2015) How informative is the mouse for human gut microbiota research? Dis. Model. Mech. 8, 1-16.
    • (2015) Dis. Model. Mech , vol.8 , pp. 1-16
    • Nguyen, T.L.1    Vieira-Silva, S.2    Liston, A.3    Raes, J.4
  • 80
    • 84918522920 scopus 로고    scopus 로고
    • IL-6 stimulates intestinal epithelial proliferation and repair after injury
    • Kuhn, K.A., Manieri, N.A., Liu, T.C. and Stappenbeck, T.S. (2014) IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One 9, e114195.
    • (2014) PLoS One , vol.9
    • Kuhn, K.A.1    Manieri, N.A.2    Liu, T.C.3    Stappenbeck, T.S.4
  • 82
    • 11844279745 scopus 로고    scopus 로고
    • Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
    • Pull, S.L., Doherty, J.M., Mills, J.C., Gordon, J.I. and Stappenbeck, T.S. (2005) Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. U.S.A. 102, 99-104.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 99-104
    • Pull, S.L.1    Doherty, J.M.2    Mills, J.C.3    Gordon, J.I.4    Stappenbeck, T.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.