메뉴 건너뛰기




Volumn 17, Issue 4, 2015, Pages

IBD and the Gut Microbiota—from Bench to Personalized Medicine

Author keywords

Antibiotics; Crohn s disease; Dysbiosis; Fecal microbiota transplantation; Gut microbiome; Host microbe interactions; IBD; Intestinal inflammation; Mucosal immunology; Prebiotics; Precision medicine; Probiotics; Ulcerative colitis; Western diet

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; METRONIDAZOLE; PLACEBO; PROBIOTIC AGENT; RIFAXIMIN;

EID: 84924787273     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-015-0439-z     Document Type: Review
Times cited : (54)

References (102)
  • 1
    • 84889636549 scopus 로고    scopus 로고
    • Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFalpha therapy: results from the COIN study
    • PID: 23135759
    • van der Valk ME, Mangen MJ, Leenders M, Dijkstra G, van Bodegraven AA, Fidder HH, et al. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFalpha therapy: results from the COIN study. Gut. 2014;63(1):72–9.
    • (2014) Gut , vol.63 , Issue.1 , pp. 72-79
    • van der Valk, M.E.1    Mangen, M.J.2    Leenders, M.3    Dijkstra, G.4    van Bodegraven, A.A.5    Fidder, H.H.6
  • 2
    • 84871626246 scopus 로고    scopus 로고
    • The economic burden of inflammatory bowel disease: clear problem, unclear solution
    • PID: 23086111
    • Stone CD. The economic burden of inflammatory bowel disease: clear problem, unclear solution. Dig Dis Sci. 2012;57(12):3042–4.
    • (2012) Dig Dis Sci , vol.57 , Issue.12 , pp. 3042-3044
    • Stone, C.D.1
  • 3
    • 84880098487 scopus 로고    scopus 로고
    • Epidemiology of inflammatory bowel diseases in Iran and Asia; a mini review
    • PID: 24031103
    • Safarpour AR, Hosseini SV, Mehrabani D. Epidemiology of inflammatory bowel diseases in Iran and Asia; a mini review. Iran J Med Sci. 2013;38(2 Suppl):140–9.
    • (2013) Iran J Med Sci , vol.38 , Issue.2 , pp. 140-149
    • Safarpour, A.R.1    Hosseini, S.V.2    Mehrabani, D.3
  • 4
    • 84879962392 scopus 로고    scopus 로고
    • Inflammatory bowel disease epidemiology
    • COI: 1:CAS:528:DC%2BC3sXptVOjtr4%3D, PID: 23695429
    • Burisch J, Munkholm P. Inflammatory bowel disease epidemiology. Curr Opin Gastroenterol. 2013;29(4):357–62.
    • (2013) Curr Opin Gastroenterol , vol.29 , Issue.4 , pp. 357-362
    • Burisch, J.1    Munkholm, P.2
  • 5
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: common pathways with other diseases
    • COI: 1:CAS:528:DC%2BC38XmsFCktw%3D%3D, PID: 21300624
    • Lees CW, Barrett JC, Parkes M, Satsangi J. New IBD genetics: common pathways with other diseases. Gut. 2011;60(12):1739–53.
    • (2011) Gut , vol.60 , Issue.12 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 6
    • 84858413324 scopus 로고    scopus 로고
    • Current concepts on the immunopathogenesis of inflammatory bowel disease
    • Vora P, Shih DQ, McGovern DP, Targan SR. Current concepts on the immunopathogenesis of inflammatory bowel disease. Front Biosci (Elite Ed). 2012;4:1451–77.
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 1451-1477
    • Vora, P.1    Shih, D.Q.2    McGovern, D.P.3    Targan, S.R.4
  • 7
    • 50249143099 scopus 로고    scopus 로고
    • Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases
    • PID: 18515412
    • Bernstein CN, Shanahan F. Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases. Gut. 2008;57(9):1185–91.
    • (2008) Gut , vol.57 , Issue.9 , pp. 1185-1191
    • Bernstein, C.N.1    Shanahan, F.2
  • 8
    • 83655165390 scopus 로고    scopus 로고
    • The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding
    • COI: 1:CAS:528:DC%2BC38XmsVKluw%3D%3D, PID: 22168424
    • Mathis D, Benoist C. The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding. Immunol Rev. 2012;245(1):239–49.
    • (2012) Immunol Rev , vol.245 , Issue.1 , pp. 239-249
    • Mathis, D.1    Benoist, C.2
  • 9
    • 84898829898 scopus 로고    scopus 로고
    • Role of the microbiome in energy regulation and metabolism, Gastroenterology:
    • Nieuwdorp M, Gilijamse PW, Pai N, Kaplan LM. Role of the microbiome in energy regulation and metabolism. Gastroenterology. 2014.
    • (2014) Kaplan LM
    • Nieuwdorp, M.1    Gilijamse, P.W.2    Pai, N.3
  • 10
    • 84898538639 scopus 로고    scopus 로고
    • Gut microbiota and allergic disease: new findings
    • West CE. Gut microbiota and allergic disease: new findings. Curr Opin Clin Nutr Metab Care. 2014.
    • (2014) Curr Opin Clin Nutr Metab Care
    • West, C.E.1
  • 11
    • 17444412705 scopus 로고
    • Bacillus acidophilus and its therapeutic application
    • Rettger L, Cheplin H. Bacillus acidophilus and its therapeutic application. Arch Intern Med. 1922;29:357–67.
    • (1922) Arch Intern Med , vol.29 , pp. 357-367
    • Rettger, L.1    Cheplin, H.2
  • 12
    • 84924786485 scopus 로고
    • Treatise on the transformation of intestinal flora with special reference to the implantation of Bacillus acidophilus
    • Rettger L, Cheplin H. Treatise on the transformation of intestinal flora with special reference to the implantation of Bacillus acidophilus. Yale University Press. 1921.
    • (1921) Yale University Press
    • Rettger, L.1    Cheplin, H.2
  • 13
    • 17444428116 scopus 로고
    • The streptococci present in the feces of patients with non-specific ulcerative colitis, and the effect of oral administration of sulfonamide compounds upon them
    • Rodaniche E, Palmer W, Kirsner J. The streptococci present in the feces of patients with non-specific ulcerative colitis, and the effect of oral administration of sulfonamide compounds upon them. J Infect Dis. 1943;72:222–7.
    • (1943) J Infect Dis , vol.72 , pp. 222-227
    • Rodaniche, E.1    Palmer, W.2    Kirsner, J.3
  • 14
    • 0025887076 scopus 로고
    • Effect of faecal stream diversion on recurrence of Crohn’s disease in the neoterminal ileum
    • COI: 1:STN:280:DyaK38%2Fhs1Olsw%3D%3D, PID: 1681159
    • Rutgeerts P, Goboes K, Peeters M, Hiele M, Penninckx F, Aerts R, et al. Effect of faecal stream diversion on recurrence of Crohn’s disease in the neoterminal ileum. Lancet. 1991;338(8770):771–4.
    • (1991) Lancet , vol.338 , Issue.8770 , pp. 771-774
    • Rutgeerts, P.1    Goboes, K.2    Peeters, M.3    Hiele, M.4    Penninckx, F.5    Aerts, R.6
  • 15
    • 0031915148 scopus 로고    scopus 로고
    • Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum
    • PID: 9453485
    • D’Haens GR, Geboes K, Peeters M, Baert F, Penninckx F, Rutgeerts P. Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology. 1998;114(2):262–7.
    • (1998) Gastroenterology , vol.114 , Issue.2 , pp. 262-267
    • D’Haens, G.R.1    Geboes, K.2    Peeters, M.3    Baert, F.4    Penninckx, F.5    Rutgeerts, P.6
  • 16
    • 80054905060 scopus 로고    scopus 로고
    • The human microbiome project in 2011 and beyond
    • COI: 1:CAS:528:DC%2BC3MXhtlKisbbL, PID: 22018227
    • Proctor LM. The human microbiome project in 2011 and beyond. Cell Host Microbe. 2011;10(4):287–91.
    • (2011) Cell Host Microbe , vol.10 , Issue.4 , pp. 287-291
    • Proctor, L.M.1
  • 18
    • 54349126970 scopus 로고    scopus 로고
    • High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota
    • COI: 1:CAS:528:DC%2BD1cXhtl2gtr%2FI, PID: 18941009
    • Zoetendal EG, Rajilic-Stojanovic M, de Vos WM. High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut. 2008;57(11):1605–15.
    • (2008) Gut , vol.57 , Issue.11 , pp. 1605-1615
    • Zoetendal, E.G.1    Rajilic-Stojanovic, M.2    de Vos, W.M.3
  • 19
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • COI: 1:CAS:528:DC%2BC38Xhtleru7jO, PID: 22972295
    • Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220–30.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3    Jansson, J.K.4    Knight, R.5
  • 20
    • 77954627922 scopus 로고    scopus 로고
    • Viruses in the faecal microbiota of monozygotic twins and their mothers
    • COI: 1:CAS:528:DC%2BC3cXosl2rs7c%3D, PID: 20631792
    • Reyes A, Haynes M, Hanson N, Angly FE, Heath AC, Rohwer F, et al. Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature. 2010;466(7304):334–8.
    • (2010) Nature , vol.466 , Issue.7304 , pp. 334-338
    • Reyes, A.1    Haynes, M.2    Hanson, N.3    Angly, F.E.4    Heath, A.C.5    Rohwer, F.6
  • 21
    • 84880509968 scopus 로고    scopus 로고
    • Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome
    • COI: 1:CAS:528:DC%2BC3sXptVahs7g%3D, PID: 23748443
    • Modi SR, Lee HH, Spina CS, Collins JJ. Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature. 2013;499(7457):219–22.
    • (2013) Nature , vol.499 , Issue.7457 , pp. 219-222
    • Modi, S.R.1    Lee, H.H.2    Spina, C.S.3    Collins, J.J.4
  • 22
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease
    • COI: 1:CAS:528:DC%2BD3MXksVShur8%3D, PID: 11385577
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature. 2001;411(6837):603–6.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 23
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease
    • COI: 1:CAS:528:DC%2BD3MXksVShtLY%3D, PID: 11385576
    • Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411(6837):599–603.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cezard, J.P.5    Belaiche, J.6
  • 25
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • PID: 20839241
    • Frank DN, Robertson CE, Hamm CM, Kpadeh Z, Zhang T, Chen H, et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis. 2011;17(1):179–84.
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.1 , pp. 179-184
    • Frank, D.N.1    Robertson, C.E.2    Hamm, C.M.3    Kpadeh, Z.4    Zhang, T.5    Chen, H.6
  • 26
    • 84902002690 scopus 로고    scopus 로고
    • Advances in IBD genetics, Nat Rev Gastroenterol Hepatol:
    • Van Limbergen J, Radford-Smith G, Satsangi J. Advances in IBD genetics. Nat Rev Gastroenterol Hepatol. 2014.
    • (2014) Satsangi J
    • Van Limbergen, J.1    Radford-Smith, G.2
  • 27
    • 84891746717 scopus 로고    scopus 로고
    • Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn’s disease
    • COI: 1:CAS:528:DC%2BC2cXkslartrs%3D, PID: 23376290, One of the first studies associating genetics, microbiome and clinical response to biologic therapy
    • Gutierrez A, Scharl M, Sempere L, Holler E, Zapater P, Almenta I, et al. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn’s disease. Gut. 2014;63(2):272–80. One of the first studies associating genetics, microbiome and clinical response to biologic therapy.
    • (2014) Gut , vol.63 , Issue.2 , pp. 272-280
    • Gutierrez, A.1    Scharl, M.2    Sempere, L.3    Holler, E.4    Zapater, P.5    Almenta, I.6
  • 28
    • 34247566585 scopus 로고    scopus 로고
    • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn’s disease and is independent of CARD15 and IBD5
    • COI: 1:CAS:528:DC%2BD2sXmsVymsrY%3D, PID: 17484864
    • Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn’s disease and is independent of CARD15 and IBD5. Gastroenterology. 2007;132(5):1665–71.
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1665-1671
    • Prescott, N.J.1    Fisher, S.A.2    Franke, A.3    Hampe, J.4    Onnie, C.M.5    Soars, D.6
  • 30
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine
    • COI: 1:CAS:528:DC%2BC3cXovFartbo%3D, PID: 20602997
    • Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, et al. Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine. Cell. 2010;141(7):1135–45.
    • (2010) Cell , vol.141 , Issue.7 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3    Liu, T.C.4    Ng, A.C.5    Storer, C.E.6
  • 31
    • 83755219473 scopus 로고    scopus 로고
    • Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    • 142(1):46–54 e42; quiz e30
    • Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54 e42; quiz e30.
    • (2012) Gastroenterology
  • 32
    • 46249085739 scopus 로고    scopus 로고
    • Evolution of mammals and their gut microbes
    • COI: 1:CAS:528:DC%2BD1cXnt1Oju7o%3D, PID: 18497261
    • Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, et al. Evolution of mammals and their gut microbes. Science. 2008;320(5883):1647–51.
    • (2008) Science , vol.320 , Issue.5883 , pp. 1647-1651
    • Ley, R.E.1    Hamady, M.2    Lozupone, C.3    Turnbaugh, P.J.4    Ramey, R.R.5    Bircher, J.S.6
  • 33
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • COI: 1:CAS:528:DC%2BC3MXht1Gms77K, PID: 21885731
    • Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334(6052):105–8.
    • (2011) Science , vol.334 , Issue.6052 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3    Bittinger, K.4    Chen, Y.Y.5    Keilbaugh, S.A.6
  • 34
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • PID: 20679230, An important study of human populations that demonstrate a correlation between diet and gut microbiota
    • De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010;107(33):14691–6. An important study of human populations that demonstrate a correlation between diet and gut microbiota.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.33 , pp. 14691-14696
    • De Filippo, C.1    Cavalieri, D.2    Di Paola, M.3    Ramazzotti, M.4    Poullet, J.B.5    Massart, S.6
  • 35
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice
    • COI: 1:CAS:528:DC%2BC38XpvVSmsLc%3D, PID: 22722865, One of the first studies to show how western diets can create a colitis promoting dysbiosis in genetically susceptible hosts
    • Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice. Nature. 2012;487(7405):104–8. One of the first studies to show how western diets can create a colitis promoting dysbiosis in genetically susceptible hosts.
    • (2012) Nature , vol.487 , Issue.7405 , pp. 104-108
    • Devkota, S.1    Wang, Y.2    Musch, M.W.3    Leone, V.4    Fehlner-Peach, H.5    Nadimpalli, A.6
  • 36
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased E. coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • PID: 23598352
    • Martinez-Medina M, Denizot J, Dreux N, Robin F, Billard E, Bonnet R, et al. Western diet induces dysbiosis with increased E. coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut. 2014;63(1):116–24.
    • (2014) Gut , vol.63 , Issue.1 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3    Robin, F.4    Billard, E.5    Bonnet, R.6
  • 37
    • 84901006573 scopus 로고    scopus 로고
    • Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn’s disease patients
    • PID: 24283712
    • Marlow G, Ellett S, Ferguson IR, Zhu S, Karunasinghe N, Jesuthasan AC, et al. Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn’s disease patients. Hum Genomics. 2013;7:24.
    • (2013) Hum Genomics , vol.7 , pp. 24
    • Marlow, G.1    Ellett, S.2    Ferguson, I.R.3    Zhu, S.4    Karunasinghe, N.5    Jesuthasan, A.C.6
  • 38
    • 84866348811 scopus 로고    scopus 로고
    • Alterations in the gut microbiome of children with severe ulcerative colitis
    • PID: 22170749
    • Michail S, Durbin M, Turner D, Griffiths AM, Mack DR, Hyams J, et al. Alterations in the gut microbiome of children with severe ulcerative colitis. Inflamm Bowel Dis. 2012;18(10):1799–808.
    • (2012) Inflamm Bowel Dis , vol.18 , Issue.10 , pp. 1799-1808
    • Michail, S.1    Durbin, M.2    Turner, D.3    Griffiths, A.M.4    Mack, D.R.5    Hyams, J.6
  • 39
    • 79959961092 scopus 로고    scopus 로고
    • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
    • PID: 21621540
    • Lepage P, Hasler R, Spehlmann ME, Rehman A, Zvirbliene A, Begun A, et al. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 2011;141(1):227–36.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 227-236
    • Lepage, P.1    Hasler, R.2    Spehlmann, M.E.3    Rehman, A.4    Zvirbliene, A.5    Begun, A.6
  • 40
    • 78650973052 scopus 로고    scopus 로고
    • High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    • PID: 21219646
    • Walker AW, Sanderson JD, Churcher C, Parkes GC, Hudspith BN, Rayment N, et al. High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol. 2011;11:7.
    • (2011) BMC Microbiol , vol.11 , pp. 7
    • Walker, A.W.1    Sanderson, J.D.2    Churcher, C.3    Parkes, G.C.4    Hudspith, B.N.5    Rayment, N.6
  • 41
    • 84896092821 scopus 로고    scopus 로고
    • The treatment-naive microbiome in new-onset Crohn’s disease
    • COI: 1:CAS:528:DC%2BC2cXks1Omu7Y%3D, PID: 24629344, This is one of the few studies defining the microbiome and dysbiosis in treatment-naïve patients with early onset of Crohn’s disease
    • Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W, Ren B, et al. The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host Microbe. 2014;15(3):382–92. This is one of the few studies defining the microbiome and dysbiosis in treatment-naïve patients with early onset of Crohn’s disease.
    • (2014) Cell Host Microbe , vol.15 , Issue.3 , pp. 382-392
    • Gevers, D.1    Kugathasan, S.2    Denson, L.A.3    Vazquez-Baeza, Y.4    Van Treuren, W.5    Ren, B.6
  • 42
    • 84904050121 scopus 로고    scopus 로고
    • A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
    • Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2013.
    • (2013) Gut
    • Machiels, K.1    Joossens, M.2    Sabino, J.3    De Preter, V.4    Arijs, I.5    Eeckhaut, V.6
  • 43
    • 84893029775 scopus 로고    scopus 로고
    • Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC2cXhsVGksbzK, PID: 24478468
    • Wang W, Chen L, Zhou R, Wang X, Song L, Huang S, et al. Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. J Clin Microbiol. 2014;52(2):398–406.
    • (2014) J Clin Microbiol , vol.52 , Issue.2 , pp. 398-406
    • Wang, W.1    Chen, L.2    Zhou, R.3    Wang, X.4    Song, L.5    Huang, S.6
  • 44
    • 39649093188 scopus 로고    scopus 로고
    • Dysbiosis in inflammatory bowel disease: a role for bacteriophages?
    • COI: 1:STN:280:DC%2BD1c7gvFeksg%3D%3D, PID: 18268057
    • Lepage P, Colombet J, Marteau P, Sime-Ngando T, Dore J, Leclerc M. Dysbiosis in inflammatory bowel disease: a role for bacteriophages? Gut. 2008;57(3):424–5.
    • (2008) Gut , vol.57 , Issue.3 , pp. 424-425
    • Lepage, P.1    Colombet, J.2    Marteau, P.3    Sime-Ngando, T.4    Dore, J.5    Leclerc, M.6
  • 46
    • 84924811270 scopus 로고    scopus 로고
    • Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn’s disease
    • Li Q, Wang C, Tang C, He Q, Li N, Li J. Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn’s disease. J Clin Gastroenterol. 2013.
    • (2013) J Clin Gastroenterol
    • Li, Q.1    Wang, C.2    Tang, C.3    He, Q.4    Li, N.5    Li, J.6
  • 47
    • 79952763661 scopus 로고    scopus 로고
    • Succession of microbial consortia in the developing infant gut microbiome
    • COI: 1:CAS:528:DC%2BC3MXjvVCkurs%3D, PID: 20668239
    • Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4578–85.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4578-4585
    • Koenig, J.E.1    Spor, A.2    Scalfone, N.3    Fricker, A.D.4    Stombaugh, J.5    Knight, R.6
  • 48
    • 84897628732 scopus 로고    scopus 로고
    • Role of the gut microbiota in human nutrition and metabolism
    • COI: 1:CAS:528:DC%2BC3sXhvVamsbrO, PID: 24251697
    • Ramakrishna BS. Role of the gut microbiota in human nutrition and metabolism. J Gastroenterol Hepatol. 2013;28 Suppl 4:9–17.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 9-17
    • Ramakrishna, B.S.1
  • 49
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • COI: 1:CAS:528:DC%2BC38XptVKksb8%3D, PID: 22726443
    • Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 2012;149(7):1578–93.
    • (2012) Cell , vol.149 , Issue.7 , pp. 1578-1593
    • Chung, H.1    Pamp, S.J.2    Hill, J.A.3    Surana, N.K.4    Edelman, S.M.5    Troy, E.B.6
  • 50
    • 79551683580 scopus 로고    scopus 로고
    • Modulation of immune homeostasis by commensal bacteria
    • COI: 1:CAS:528:DC%2BC3MXhvV2qtrs%3D, PID: 21215684, Outstanding review of the role of gut microbiota in maintaining immune homeostasis
    • Ivanov II, Littman DR. Modulation of immune homeostasis by commensal bacteria. Curr Opin Microbiol. 2011;14(1):106–14. Outstanding review of the role of gut microbiota in maintaining immune homeostasis.
    • (2011) Curr Opin Microbiol , vol.14 , Issue.1 , pp. 106-114
    • Ivanov, I.I.1    Littman, D.R.2
  • 51
    • 84894541081 scopus 로고    scopus 로고
    • Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers
    • COI: 1:CAS:528:DC%2BC2cXisFKgsLY%3D, PID: 24013298
    • Said HS, Suda W, Nakagome S, Chinen H, Oshima K, Kim S, et al. Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res. 2014;21(1):15–25.
    • (2014) DNA Res , vol.21 , Issue.1 , pp. 15-25
    • Said, H.S.1    Suda, W.2    Nakagome, S.3    Chinen, H.4    Oshima, K.5    Kim, S.6
  • 52
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • COI: 1:CAS:528:DC%2BD1cXhtleks7%2FI, PID: 18936492, One of the best papers demonstrating the clinical efficacy of specific microbes in mitigating inflammation in IBD
    • Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105(43):16731–6. One of the best papers demonstrating the clinical efficacy of specific microbes in mitigating inflammation in IBD.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.43 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3    Lakhdari, O.4    Bermudez-Humaran, L.G.5    Gratadoux, J.J.6
  • 53
    • 84898738612 scopus 로고    scopus 로고
    • The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models
    • PID: 24418903, One of the best papers demonstrating the clinical efficacy of specific microbes in mitigating inflammation in IBD
    • Martin R, Chain F, Miquel S, Lu J, Gratadoux JJ, Sokol H, et al. The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models. Inflamm Bowel Dis. 2014;20(3):417–30. One of the best papers demonstrating the clinical efficacy of specific microbes in mitigating inflammation in IBD.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.3 , pp. 417-430
    • Martin, R.1    Chain, F.2    Miquel, S.3    Lu, J.4    Gratadoux, J.J.5    Sokol, H.6
  • 54
    • 84866549438 scopus 로고    scopus 로고
    • Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    • COI: 1:CAS:528:DC%2BC38XhvVKjtrjF, PID: 23013615
    • Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 2012;13(9):R79.
    • (2012) Genome Biol , vol.13 , Issue.9 , pp. R79
    • Morgan, X.C.1    Tickle, T.L.2    Sokol, H.3    Gevers, D.4    Devaney, K.L.5    Ward, D.V.6
  • 55
    • 84870322666 scopus 로고    scopus 로고
    • Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn’s disease
    • COI: 1:CAS:528:DC%2BC38XhvVGjsbfK, PID: 23209564
    • Erickson AR, Cantarel BL, Lamendella R, Darzi Y, Mongodin EF, Pan C, et al. Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn’s disease. PLoS One. 2012;7(11):e49138.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e49138
    • Erickson, A.R.1    Cantarel, B.L.2    Lamendella, R.3    Darzi, Y.4    Mongodin, E.F.5    Pan, C.6
  • 56
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • COI: 1:CAS:528:DC%2BC3sXhtFyjsr3P, PID: 23828891
    • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341(6145):569–73.
    • (2013) Science , vol.341 , Issue.6145 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3    Michaud, M.4    Gallini, C.A.5    Bohlooly, Y.M.6
  • 57
    • 84903997473 scopus 로고    scopus 로고
    • Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis
    • Lennon G, Balfe A, Bambury N, Lavelle A, Maguire A, Docherty NG, et al. Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis. Colorectal Dis. 2013.
    • (2013) Colorectal Dis
    • Lennon, G.1    Balfe, A.2    Bambury, N.3    Lavelle, A.4    Maguire, A.5    Docherty, N.G.6
  • 59
    • 84869228196 scopus 로고    scopus 로고
    • Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis
    • PID: 22434643
    • De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, Schuit F, et al. Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis. Inflamm Bowel Dis. 2012;18(12):2371–80.
    • (2012) Inflamm Bowel Dis , vol.18 , Issue.12 , pp. 2371-2380
    • De Preter, V.1    Arijs, I.2    Windey, K.3    Vanhove, W.4    Vermeire, S.5    Schuit, F.6
  • 60
    • 84870916445 scopus 로고    scopus 로고
    • Microbial pathways in colonic sulfur metabolism and links with health and disease
    • COI: 1:CAS:528:DC%2BC3sXht1ejtLbF, PID: 23226130
    • Carbonero F, Benefiel AC, Alizadeh-Ghamsari AH, Gaskins HR. Microbial pathways in colonic sulfur metabolism and links with health and disease. Front Physiol. 2012;3:448.
    • (2012) Front Physiol , vol.3 , pp. 448
    • Carbonero, F.1    Benefiel, A.C.2    Alizadeh-Ghamsari, A.H.3    Gaskins, H.R.4
  • 61
    • 77951626542 scopus 로고    scopus 로고
    • DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells
    • COI: 1:CAS:528:DC%2BC3cXksV2ktLY%3D, PID: 20120018
    • Attene-Ramos MS, Nava GM, Muellner MG, Wagner ED, Plewa MJ, Gaskins HR. DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells. Environ Mol Mutagen. 2010;51(4):304–14.
    • (2010) Environ Mol Mutagen , vol.51 , Issue.4 , pp. 304-314
    • Attene-Ramos, M.S.1    Nava, G.M.2    Muellner, M.G.3    Wagner, E.D.4    Plewa, M.J.5    Gaskins, H.R.6
  • 62
    • 84873513423 scopus 로고    scopus 로고
    • Host-derived nitrate boosts growth of E. coli in the inflamed gut
    • COI: 1:CAS:528:DC%2BC3sXhvFOktro%3D, PID: 23393266
    • Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013;339(6120):708–11.
    • (2013) Science , vol.339 , Issue.6120 , pp. 708-711
    • Winter, S.E.1    Winter, M.G.2    Xavier, M.N.3    Thiennimitr, P.4    Poon, V.5    Keestra, A.M.6
  • 63
    • 84893687483 scopus 로고    scopus 로고
    • Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn’s disease, and pouchitis: meta-analysis of randomized controlled trials
    • PID: 24280877, Important meta-analysis evaluating the effect of probiotics in UC
    • Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn’s disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis. 2014;20(1):21–35. Important meta-analysis evaluating the effect of probiotics in UC.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.1 , pp. 21-35
    • Shen, J.1    Zuo, Z.X.2    Mao, A.P.3
  • 64
    • 0033860601 scopus 로고    scopus 로고
    • Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
    • COI: 1:STN:280:DC%2BD3cvgtl2ltw%3D%3D, PID: 10930365
    • Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G, et al. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology. 2000;119(2):305–9.
    • (2000) Gastroenterology , vol.119 , Issue.2 , pp. 305-309
    • Gionchetti, P.1    Rizzello, F.2    Venturi, A.3    Brigidi, P.4    Matteuzzi, D.5    Bazzocchi, G.6
  • 65
    • 9144254035 scopus 로고    scopus 로고
    • Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
    • COI: 1:STN:280:DC%2BD2c%2FhtlensA%3D%3D, PID: 14684584
    • Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, et al. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut. 2004;53(1):108–14.
    • (2004) Gut , vol.53 , Issue.1 , pp. 108-114
    • Mimura, T.1    Rizzello, F.2    Helwig, U.3    Poggioli, G.4    Schreiber, S.5    Talbot, I.C.6
  • 66
    • 84883486415 scopus 로고    scopus 로고
    • The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis
    • COI: 1:CAS:528:DC%2BC3sXhsVSiurzO, PID: 23957603
    • Persborn M, Gerritsen J, Wallon C, Carlsson A, Akkermans LM, Soderholm JD. The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis. Aliment Pharmacol Ther. 2013;38(7):772–83.
    • (2013) Aliment Pharmacol Ther , vol.38 , Issue.7 , pp. 772-783
    • Persborn, M.1    Gerritsen, J.2    Wallon, C.3    Carlsson, A.4    Akkermans, L.M.5    Soderholm, J.D.6
  • 67
    • 84893778910 scopus 로고    scopus 로고
    • Long-term use of probiotics Lactobacillus and Bifidobacterium has a prophylactic effect on the occurrence and severity of pouchitis: a randomized prospective study
    • PID: 24579075
    • Tomasz B, Zoran S, Jaroslaw W, Ryszard M, Marcin G, Robert B, et al. Long-term use of probiotics Lactobacillus and Bifidobacterium has a prophylactic effect on the occurrence and severity of pouchitis: a randomized prospective study. Biomed Res Int. 2014;2014:208064.
    • (2014) Biomed Res Int , vol.2014 , pp. 208064
    • Tomasz, B.1    Zoran, S.2    Jaroslaw, W.3    Ryszard, M.4    Marcin, G.5    Robert, B.6
  • 68
    • 84871986920 scopus 로고    scopus 로고
    • VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-kappaB pathway in rat model of DSS-induced colitis
    • COI: 1:CAS:528:DC%2BC3sXnsFem, PID: 23271629
    • Dai C, Zheng CQ, Meng FJ, Zhou Z, Sang LX, Jiang M. VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-kappaB pathway in rat model of DSS-induced colitis. Mol Cell Biochem. 2013;374(1–2):1–11.
    • (2013) Mol Cell Biochem , vol.374 , Issue.1-2 , pp. 1-11
    • Dai, C.1    Zheng, C.Q.2    Meng, F.J.3    Zhou, Z.4    Sang, L.X.5    Jiang, M.6
  • 69
    • 7644232718 scopus 로고    scopus 로고
    • Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition
    • COI: 1:CAS:528:DC%2BD2cXhtVKisr3I, PID: 15521016
    • Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, et al. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology. 2004;127(5):1474–87.
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1474-1487
    • Petrof, E.O.1    Kojima, K.2    Ropeleski, M.J.3    Musch, M.W.4    Tao, Y.5    De Simone, C.6
  • 70
    • 59449084229 scopus 로고    scopus 로고
    • The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis
    • COI: 1:CAS:528:DC%2BD1MXhtlOqtb0%3D, PID: 18612822
    • Lee SK, Kim YW, Chi SG, Joo YS, Kim HJ. The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis. Dig Dis Sci. 2009;54(2):255–63.
    • (2009) Dig Dis Sci , vol.54 , Issue.2 , pp. 255-263
    • Lee, S.K.1    Kim, Y.W.2    Chi, S.G.3    Joo, Y.S.4    Kim, H.J.5
  • 71
    • 46349091181 scopus 로고    scopus 로고
    • Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn’s disease in remission
    • COI: 1:CAS:528:DC%2BD1cXnslKqsb8%3D
    • Vilela EG, Ferrari MDD, Torres HOD, Pinto AG, Aguirre ACC, Martins FP, et al. Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn’s disease in remission. Scand J Gastroenterol. 2008;43(7):842–8.
    • (2008) Scand J Gastroenterol , vol.43 , Issue.7 , pp. 842-848
    • Vilela, E.G.1    Ferrari, M.D.D.2    Torres, H.O.D.3    Pinto, A.G.4    Aguirre, A.C.C.5    Martins, F.P.6
  • 73
    • 84888235196 scopus 로고    scopus 로고
    • Probiotics
    • PID: 24246993
    • Kruis W. Probiotics. Dig Dis. 2013;31(3–4):385–7.
    • (2013) Dig Dis , vol.31 , Issue.3-4 , pp. 385-387
    • Kruis, W.1
  • 74
    • 84872145972 scopus 로고    scopus 로고
    • Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations
    • PID: 23040453
    • Van Assche G, Dignass A, Bokemeyer B, Danese S, Gionchetti P, Moser G, et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations. J Crohns Colitis. 2013;7(1):1–33.
    • (2013) J Crohns Colitis , vol.7 , Issue.1 , pp. 1-33
    • Van Assche, G.1    Dignass, A.2    Bokemeyer, B.3    Danese, S.4    Gionchetti, P.5    Moser, G.6
  • 76
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • COI: 1:CAS:528:DC%2BC3MXjvVCktbo%3D, PID: 20847294
    • Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4554–61.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 77
    • 84864756231 scopus 로고    scopus 로고
    • The human microbiome: ecosystem resilience and health
    • PID: 22861804
    • Relman DA. The human microbiome: ecosystem resilience and health. Nutr Rev. 2012;70 Suppl 1:S2–9.
    • (2012) Nutr Rev , vol.70 , pp. S2-S9
    • Relman, D.A.1
  • 78
    • 84867173210 scopus 로고    scopus 로고
    • Antibiotic exposure and IBD development among children: a population-based cohort study
    • PID: 23008454, Large population-based study determining increased risk for IBD development after antianaerobic antibiotic exposure in the childhood
    • Kronman MP, Zaoutis TE, Haynes K, Feng R, Coffin SE. Antibiotic exposure and IBD development among children: a population-based cohort study. Pediatrics. 2012;130(4):e794–803. Large population-based study determining increased risk for IBD development after antianaerobic antibiotic exposure in the childhood.
    • (2012) Pediatrics , vol.130 , Issue.4 , pp. e794-e803
    • Kronman, M.P.1    Zaoutis, T.E.2    Haynes, K.3    Feng, R.4    Coffin, S.E.5
  • 79
    • 79952748287 scopus 로고    scopus 로고
    • Unravelling the effects of the environment and host genotype on the gut microbiome
    • COI: 1:CAS:528:DC%2BC3MXjt1WntL4%3D, PID: 21407244
    • Spor A, Koren O, Ley R. Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol. 2011;9(4):279–90.
    • (2011) Nat Rev Microbiol , vol.9 , Issue.4 , pp. 279-290
    • Spor, A.1    Koren, O.2    Ley, R.3
  • 80
    • 79953781975 scopus 로고    scopus 로고
    • Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3MXkt1eiurg%3D, PID: 21407187
    • Khan KJ, Ullman TA, Ford AC, Abreu MT, Abadir A, Marshall JK, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):661–73.
    • (2011) Am J Gastroenterol , vol.106 , Issue.4 , pp. 661-673
    • Khan, K.J.1    Ullman, T.A.2    Ford, A.C.3    Abreu, M.T.4    Abadir, A.5    Marshall, J.K.6
  • 81
    • 84867282079 scopus 로고    scopus 로고
    • Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38XhvVKgtLvN, PID: 23226773
    • Wang SL, Wang ZR, Yang CQ. Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease. Exp Ther Med. 2012;4(6):1051–6.
    • (2012) Exp Ther Med , vol.4 , Issue.6 , pp. 1051-1056
    • Wang, S.L.1    Wang, Z.R.2    Yang, C.Q.3
  • 82
    • 84856960246 scopus 로고    scopus 로고
    • Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn’s disease
    • 142(3):473–81 e4. Important phase II randomized controlled trial demonstrating potential benefit of rifaximin-extended intestinal release in Crohn’s disease treatment
    • Prantera C, Lochs H, Grimaldi M, Danese S, Scribano ML, Gionchetti P, et al. Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn’s disease. Gastroenterology. 2012;142(3):473–81 e4. Important phase II randomized controlled trial demonstrating potential benefit of rifaximin-extended intestinal release in Crohn’s disease treatment.
    • (2012) Gastroenterology
  • 83
    • 84876355564 scopus 로고    scopus 로고
    • Ciprofloxacin for the prevention of postoperative recurrence in patients with Crohn’s disease: a randomized, double-blind, placebo-controlled pilot study
    • PID: 23511031
    • Herfarth HH, Katz JA, Hanauer SB, Sandborn WJ, Loftus Jr EV, Sands BE, et al. Ciprofloxacin for the prevention of postoperative recurrence in patients with Crohn’s disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis. 2013;19(5):1073–9.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.5 , pp. 1073-1079
    • Herfarth, H.H.1    Katz, J.A.2    Hanauer, S.B.3    Sandborn, W.J.4    Loftus, E.V.5    Sands, B.E.6
  • 84
    • 84884612439 scopus 로고    scopus 로고
    • Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn’s disease: a randomized, double-blind, placebo-controlled trial
    • PID: 23689809
    • Manosa M, Cabre E, Bernal I, Esteve M, Garcia-Planella E, Ricart E, et al. Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn’s disease: a randomized, double-blind, placebo-controlled trial. Inflamm Bowel Dis. 2013;19(9):1889–95.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.9 , pp. 1889-1895
    • Manosa, M.1    Cabre, E.2    Bernal, I.3    Esteve, M.4    Garcia-Planella, E.5    Ricart, E.6
  • 85
    • 53249097726 scopus 로고    scopus 로고
    • Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn’s disease: a controlled randomized trial
    • PID: 18727929
    • D’Haens GR, Vermeire S, Van Assche G, Noman M, Aerden I, Van Olmen G, et al. Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn’s disease: a controlled randomized trial. Gastroenterology. 2008;135(4):1123–9.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1123-1129
    • D’Haens, G.R.1    Vermeire, S.2    Van Assche, G.3    Noman, M.4    Aerden, I.5    Van Olmen, G.6
  • 86
    • 0019977612 scopus 로고
    • Metronidazole therapy for perineal Crohn’s disease: a follow-up study
    • COI: 1:STN:280:DyaL383htFKnsg%3D%3D, PID: 7084615
    • Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perineal Crohn’s disease: a follow-up study. Gastroenterology. 1982;83(2):383–7.
    • (1982) Gastroenterology , vol.83 , Issue.2 , pp. 383-387
    • Brandt, L.J.1    Bernstein, L.H.2    Boley, S.J.3    Frank, M.S.4
  • 87
    • 0021264732 scopus 로고
    • Metronidazole therapy for Crohn’s disease and associated fistulae
    • COI: 1:STN:280:DyaL2c3ltlKrsA%3D%3D, PID: 6741906
    • Jakobovits J, Schuster MM. Metronidazole therapy for Crohn’s disease and associated fistulae. Am J Gastroenterol. 1984;79(7):533–40.
    • (1984) Am J Gastroenterol , vol.79 , Issue.7 , pp. 533-540
    • Jakobovits, J.1    Schuster, M.M.2
  • 88
    • 84891748257 scopus 로고    scopus 로고
    • Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn’s disease: a randomised, double-blind, placebo controlled trial (ADAFI)
    • COI: 1:CAS:528:DC%2BC2cXkslartrk%3D, PID: 23525574, Important study showing increased rates of fistula closure when using combination therapy, however response was not sustained after ciprofloxacin was discontinued
    • Dewint P, Hansen BE, Verhey E, Oldenburg B, Hommes DW, Pierik M, et al. Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn’s disease: a randomised, double-blind, placebo controlled trial (ADAFI). Gut. 2014;63(2):292–9. Important study showing increased rates of fistula closure when using combination therapy, however response was not sustained after ciprofloxacin was discontinued.
    • (2014) Gut , vol.63 , Issue.2 , pp. 292-299
    • Dewint, P.1    Hansen, B.E.2    Verhey, E.3    Oldenburg, B.4    Hommes, D.W.5    Pierik, M.6
  • 89
    • 0024498413 scopus 로고
    • Treatment of ulcerative colitis by implantation of normal colonic flora
    • COI: 1:STN:280:DyaL1M%2Fps1Wksw%3D%3D, PID: 2563083
    • Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic flora. Lancet. 1989;1(8630):164.
    • (1989) Lancet , vol.1 , Issue.8630 , pp. 164
    • Bennet, J.D.1    Brinkman, M.2
  • 90
    • 79751505371 scopus 로고    scopus 로고
    • Fecal matters
    • COI: 1:CAS:528:DC%2BC3MXhsFyqtbY%3D, PID: 21297602
    • Palmer R. Fecal matters. Nat Med. 2011;17(2):150–2.
    • (2011) Nat Med , vol.17 , Issue.2 , pp. 150-152
    • Palmer, R.1
  • 91
    • 84885479748 scopus 로고    scopus 로고
    • Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation
    • COI: 1:CAS:528:DC%2BC3sXhsF2nsLrO, PID: 24060759, One of the few studies correlating the gut microbiome dynamic after FMT in UC patients with clinical outcome
    • Angelberger S, Reinisch W, Makristathis A, Lichtenberger C, Dejaco C, Papay P, et al. Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation. Am J Gastroenterol. 2013;108(10):1620–30. One of the few studies correlating the gut microbiome dynamic after FMT in UC patients with clinical outcome.
    • (2013) Am J Gastroenterol , vol.108 , Issue.10 , pp. 1620-1630
    • Angelberger, S.1    Reinisch, W.2    Makristathis, A.3    Lichtenberger, C.4    Dejaco, C.5    Papay, P.6
  • 92
    • 84880601378 scopus 로고    scopus 로고
    • Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection
    • PID: 23669309
    • De Leon LM, Watson JB, Kelly CR. Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin Gastroenterol Hepatol. 2013;11(8):1036–8.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.8 , pp. 1036-1038
    • De Leon, L.M.1    Watson, J.B.2    Kelly, C.R.3
  • 93
    • 84894234528 scopus 로고    scopus 로고
    • Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn’s disease and recurrent Clostridium difficile infection
    • PID: 24184170
    • Quera R, Espinoza R, Estay C, Rivera D. Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn’s disease and recurrent Clostridium difficile infection. J Crohns Colitis. 2014;8(3):252–3.
    • (2014) J Crohns Colitis , vol.8 , Issue.3 , pp. 252-253
    • Quera, R.1    Espinoza, R.2    Estay, C.3    Rivera, D.4
  • 94
    • 84924786481 scopus 로고    scopus 로고
    • A patient with severe Crohn’s colitis responds to faecal microbiota transplantation, J Crohns Colitis:
    • Gordon H, Harbord M. A patient with severe Crohn’s colitis responds to faecal microbiota transplantation. J Crohns Colitis. 2013.
    • (2013) Harbord M
    • Gordon, H.1
  • 95
    • 84884585915 scopus 로고    scopus 로고
    • Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis
    • PID: 23899544
    • Kump PK, Grochenig HP, Lackner S, Trajanoski S, Reicht G, Hoffmann KM, et al. Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis. Inflamm Bowel Dis. 2013;19(10):2155–65.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.10 , pp. 2155-2165
    • Kump, P.K.1    Grochenig, H.P.2    Lackner, S.3    Trajanoski, S.4    Reicht, G.5    Hoffmann, K.M.6
  • 96
    • 84879071481 scopus 로고    scopus 로고
    • Patient perceptions of fecal microbiota transplantation for ulcerative colitis
    • PID: 23624888
    • Kahn SA, Vachon A, Rodriquez D, Goeppinger SR, Surma B, Marks J, et al. Patient perceptions of fecal microbiota transplantation for ulcerative colitis. Inflamm Bowel Dis. 2013;19(7):1506–13.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.7 , pp. 1506-1513
    • Kahn, S.A.1    Vachon, A.2    Rodriquez, D.3    Goeppinger, S.R.4    Surma, B.5    Marks, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.