Efficient colonic mucosal wound repair requires Trem2 signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 1, 2009, Pages 256-261

  Seno, Hiroshi ^a   Miyoshi, Hiroyuki ^a   Brown, Sarah L ^a   Geske, Michael J ^a   Colonna, Marco ^a   Stappenbeck, Thaddeus S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biopsy injury; Epithelium; Macrophage; Stem cell; Wound healing

Indexed keywords

ARGINASE 1; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; MANNOSE RECEPTOR; NITRIC OXIDE SYNTHASE; REGULATOR PROTEIN; TREM2 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; COLON INJURY; COLON MUCOSA; CONTROLLED STUDY; EPIDERMIS CELL; IN VIVO STUDY; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUNCH BIOPSY; SIGNAL TRANSDUCTION; SKIN BIOPSY; STEM CELL; STEM CELL TRANSPLANTATION; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANIMALS; CELL PROLIFERATION; COLON; CYTOKINES; EPITHELIAL CELLS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MUCOUS MEMBRANE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; STEM CELLS; WOUND HEALING;

MUS;

EID: 58549094584     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803343106     Document Type: Article

References (33)

1. Chang WW, Leblond CP (1971) Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: Vacuolated-columnar, mucous and argentaffin. Am J Anat 131:73-99.
2. Savage DC (1977) Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31:107-133.
3. Hooper LV, Gordon JI (2001) Commensal host-bacterial relationships in the gut. Science 292:1115-1118.
4. Strober W, Fuss IJ, Blumberg RS (2002) The immunology of mucosal models of inflammation. Annu Rev Immunol 20:495-549.
5. Elson CO, et al. (2005) Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 206:260-276.
6. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229-241.
7. Pull SL, Doherty JM, Mills JC, Gordon JI, Stappenbeck TS (2005) Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci USA 102:99-104.
8. Fukata M, et al. (2005) Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in amurine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 288:G1055-G1065.
9. Martin P (1997) Wound healing - aiming for perfect skin regeneration. Science 276:75-81.
10. Becker C, et al. (2004) TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21:491-501.
11. Becker C, et al. (2005) In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut 54:950-954.
12. Tamagawa H, et al. (2003) Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region. Lab Invest 83:1045-1053.
13. Owen RL (1999) Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches a personal and historical perspective. Semin Immunol 11:157-163.
14. Clayburgh DR, Shen L, Turner JR (2004) A porous defense: The leaky epithelial barrier in intestinal disease. Lab Invest 84:282-291.
15. Brown SL, et al. (2007) Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest 117:258-269.
16. Wipke BT, Allen PM (2001) Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167:1601-1608.
17. Schreiber RD, Hicks LJ, Celada A, Buchmeier NA, Gray PW (1985) Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol 134:1609-1618.
18. Sheehan KC, Ruddle NH, Schreiber RD (1989) Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol 142:3884-3893.
19. Mandik-Nayak L, Huang G, Sheehan KC, Erikson J, Chaplin DD (2001) Signaling through TNF receptor p55 in TNF-alpha-deficient mice alters the CXCL13/CCL19/CCL21 ratio in the spleen and induces maturation and migration of anergic B cells into the B cell follicle. J Immunol 167:1920-1928.
20. Miller LS, et al. (2006) Myd88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24:79-91.
21. Takahashi K, Rochford CD, Neumann H (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201:647-657.
22. Cella M, et al. (2003) Impaired differentiation of osteoclasts in TREM-2 deficient individuals. J Exp Med 198:645-651.
23. Hamerman JA, et al. (2006) Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 177:2051-2055.
24. Turnbull IR, et al. (2006) Cutting edge: TREM2 attenuates macrophage activation. J Immunol 177:3520-3524.
25. Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. (2007) TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 4:675-689.
26. Klesney-Tait J, Turnbull IR, Colonna M (2006) The TREM receptor family and signal integration. Nat Immunol 7:1266-1273.
27. Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35.
28. Mantovani A, et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677-686.
29. H2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med 12:955-960.
30. Ray RM, Zimmerman BJ, McCormack SA, Patel TB, Johnson LR (2001) Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms. Am J Physiol Gastrointest Liver Physiol 281:G37-G43.
31. Liu L, et al. (2005) Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation. Am J Physiol Cell Physiol 288:C89-C99.
32. Greaves DL, et al. (2006) Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc Natl Acad Sci USA 103:714-719.
33. Pena JA, et al. (2004) Genotypic and phenotypic studies of murine intestinal lactobacilli: Species differences in mice with and without colitis. Appl Environ Microbiol 70:558-568.