메뉴 건너뛰기




Volumn 3, Issue 4, 2015, Pages 273-282

IL-13 and TGF-β1: Core Mediators of Fibrosis

Author keywords

Fibrosis; IL 13; Liver; Macrophages; TGF 1

Indexed keywords


EID: 85002250605     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-015-0091-1     Document Type: Review
Times cited : (8)

References (134)
  • 1
  • 3
    • 79751506514 scopus 로고    scopus 로고
    • Pathogenesis of liver fibrosis
    • COI: 1:CAS:528:DC%2BC3MXjtVWrs7s%3D, PID: 21073339
    • Hernandez-Gea V, Friedman SL (2011) Pathogenesis of liver fibrosis. Annu Rev Pathol 6:425–456
    • (2011) Annu Rev Pathol , vol.6 , pp. 425-456
    • Hernandez-Gea, V.1    Friedman, S.L.2
  • 4
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • COI: 1:CAS:528:DC%2BD2sXnvFOgsrw%3D, PID: 17570226
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557–2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 5
    • 84928898387 scopus 로고    scopus 로고
    • Pathobiology of liver fibrosis: a translational success story
    • COI: 1:CAS:528:DC%2BC2MXotFKku7c%3D, PID: 25681399
    • Lee YA, Wallace MC, Friedman SL (2015) Pathobiology of liver fibrosis: a translational success story. Gut 64:830–841
    • (2015) Gut , vol.64 , pp. 830-841
    • Lee, Y.A.1    Wallace, M.C.2    Friedman, S.L.3
  • 6
    • 84896806249 scopus 로고    scopus 로고
    • Liver fibrosis and repair: immune regulation of wound healing in a solid organ
    • COI: 1:CAS:528:DC%2BC2cXivFyhs78%3D, PID: 24566915
    • Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA (2014) Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol 14:181–194
    • (2014) Nat Rev Immunol , vol.14 , pp. 181-194
    • Pellicoro, A.1    Ramachandran, P.2    Iredale, J.P.3    Fallowfield, J.A.4
  • 7
    • 84930654452 scopus 로고    scopus 로고
    • Hepatic fibrosis: concept to treatment
    • COI: 1:CAS:528:DC%2BC2MXnvFChur0%3D, PID: 25920084
    • Trautwein C, Friedman SL, Schuppan D, Pinzani M (2015) Hepatic fibrosis: concept to treatment. J Hepatol 62:S15–S24
    • (2015) J Hepatol , vol.62 , pp. S15-S24
    • Trautwein, C.1    Friedman, S.L.2    Schuppan, D.3    Pinzani, M.4
  • 8
    • 0033402403 scopus 로고    scopus 로고
    • TGF-beta and fibrosis
    • COI: 1:CAS:528:DC%2BD3cXjtFehsbk%3D, PID: 10611762
    • Branton MH, Kopp JB (1999) TGF-beta and fibrosis. Microbes Infect 1:1349–1365
    • (1999) Microbes Infect , vol.1 , pp. 1349-1365
    • Branton, M.H.1    Kopp, J.B.2
  • 9
  • 10
    • 0034960535 scopus 로고    scopus 로고
    • Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung
    • COI: 1:STN:280:DC%2BD3MzltVSkug%3D%3D, PID: 11413354
    • Coker RK, Laurent GJ, Jeffery PK, du Bois RM, Black CM, McAnulty RJ (2001) Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung. Thorax 56:549–556
    • (2001) Thorax , vol.56 , pp. 549-556
    • Coker, R.K.1    Laurent, G.J.2    Jeffery, P.K.3    du Bois, R.M.4    Black, C.M.5    McAnulty, R.J.6
  • 11
    • 67349222280 scopus 로고    scopus 로고
    • Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease
    • PID: 19186046
    • Mak JC, Chan-Yeung MM, Ho SP, Chan KS, Choo K, Yee KS, Chau CH, Cheung AH, Ip MS, C.S.G. Members of Hong Kong Thoracic Society (2009) Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease. Respir Med 103:1083–1089
    • (2009) Respir Med , vol.103 , pp. 1083-1089
    • Mak, J.C.1    Chan-Yeung, M.M.2    Ho, S.P.3    Chan, K.S.4    Choo, K.5    Yee, K.S.6    Chau, C.H.7    Cheung, A.H.8    Ip, M.S.9
  • 12
    • 0036241157 scopus 로고    scopus 로고
    • Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease
    • COI: 1:CAS:528:DC%2BD38Xjs1Kns7Y%3D, PID: 11925630
    • Chen WX, Li YM, Yu CH, Cai WM, Zheng M, Chen F (2002) Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease. World J Gastroenterol 8:379–381
    • (2002) World J Gastroenterol , vol.8 , pp. 379-381
    • Chen, W.X.1    Li, Y.M.2    Yu, C.H.3    Cai, W.M.4    Zheng, M.5    Chen, F.6
  • 13
    • 0033036099 scopus 로고    scopus 로고
    • Role of transforming growth factor beta type II receptor in hepatic fibrosis: studies of human chronic hepatitis C and experimental fibrosis in rats
    • COI: 1:CAS:528:DyaK1MXjvFOmsLw%3D, PID: 10347115
    • Roulot D, Sevcsik AM, Coste T, Strosberg AD, Marullo S (1999) Role of transforming growth factor beta type II receptor in hepatic fibrosis: studies of human chronic hepatitis C and experimental fibrosis in rats. Hepatology 29:1730–1738
    • (1999) Hepatology , vol.29 , pp. 1730-1738
    • Roulot, D.1    Sevcsik, A.M.2    Coste, T.3    Strosberg, A.D.4    Marullo, S.5
  • 14
    • 0030427867 scopus 로고    scopus 로고
    • Signal transduction by members of the transforming growth factor-beta superfamily
    • COI: 1:CAS:528:DyaK2sXosFektA%3D%3D, PID: 9023056
    • Attisano L, Wrana JL (1996) Signal transduction by members of the transforming growth factor-beta superfamily. Cytokine Growth Factor Rev 7:327–339
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 327-339
    • Attisano, L.1    Wrana, J.L.2
  • 15
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • COI: 1:CAS:528:DyaK1cXislyhsrk%3D, PID: 9597127
    • Letterio JJ, Roberts AB (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol 16:137–161
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 16
    • 84877025203 scopus 로고    scopus 로고
    • Integrin-mediated regulation of TGFbeta in fibrosis
    • A comprehensive review illustrating the critical regualtory role played by integrins in the activation of the pro-fibtrotic cytokine TGF-beta
    • • Henderson, NC, Sheppard D. Integrin-mediated regulation of TGFbeta in fibrosis. Biochim Biophys Acta 2013;1832:891–6. A comprehensive review illustrating the critical regualtory role played by integrins in the activation of the pro-fibtrotic cytokine TGF-beta
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 891-896
    • Henderson, N.C.1    Sheppard, D.2
  • 17
    • 0038468558 scopus 로고    scopus 로고
    • Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta
    • COI: 1:CAS:528:DC%2BD3sXlsVegu7k%3D, PID: 12814934
    • Roberts AB, Russo A, Felici A, Flanders KC (2003) Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann N Y Acad Sci 995:1–10
    • (2003) Ann N Y Acad Sci , vol.995 , pp. 1-10
    • Roberts, A.B.1    Russo, A.2    Felici, A.3    Flanders, K.C.4
  • 18
    • 2542609844 scopus 로고    scopus 로고
    • Smad3 as a mediator of the fibrotic response
    • COI: 1:CAS:528:DC%2BD2cXlt1Wqsrg%3D, PID: 15154911
    • Flanders KC (2004) Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 85:47–64
    • (2004) Int J Exp Pathol , vol.85 , pp. 47-64
    • Flanders, K.C.1
  • 19
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • COI: 1:CAS:528:DC%2BD3sXnvV2hs7c%3D, PID: 14534577
    • Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577–584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 20
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • COI: 1:CAS:528:DC%2BD2MXjt1KqtbY%3D, PID: 15689496
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A (2005) TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 16:1987–2002
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 21
    • 35948964347 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis
    • COI: 1:CAS:528:DC%2BD2sXhsVSisbrI, PID: 17979495
    • Moreira RK (2007) Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 131:1728–1734
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1728-1734
    • Moreira, R.K.1
  • 22
    • 0029997830 scopus 로고    scopus 로고
    • Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis
    • COI: 1:STN:280:DyaK283psVShsQ%3D%3D, PID: 8731193
    • Gressner AM (1996) Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int Suppl 54:S39–45
    • (1996) Kidney Int Suppl , vol.54 , pp. S39-S45
    • Gressner, A.M.1
  • 23
    • 0032586690 scopus 로고    scopus 로고
    • The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo
    • COI: 1:CAS:528:DyaK1MXlt1SktA%3D%3D, PID: 9927153
    • Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA (1999) The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol 30:77–87
    • (1999) J Hepatol , vol.30 , pp. 77-87
    • Hellerbrand, C.1    Stefanovic, B.2    Giordano, F.3    Burchardt, E.R.4    Brenner, D.A.5
  • 24
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • COI: 1:CAS:528:DC%2BD2MXhtFyjs70%3D, PID: 15690074
    • Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209–218
    • (2005) J Clin Invest , vol.115 , pp. 209-218
    • Bataller, R.1    Brenner, D.A.2
  • 25
    • 22244492306 scopus 로고    scopus 로고
    • Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?
    • COI: 1:CAS:528:DC%2BD2MXmt1ehtr0%3D, PID: 16024595, discussion 5995
    • Thompson EW, Newgreen DF, Tarin D (2005) Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 65:5991–5995 discussion 5995
    • (2005) Cancer Res , vol.65 , pp. 5991-5995
    • Thompson, E.W.1    Newgreen, D.F.2    Tarin, D.3
  • 26
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BD1MXntVCjtr0%3D, PID: 19487818
    • Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 27
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • COI: 1:CAS:528:DC%2BD1MXntVCjtro%3D, PID: 19487819
    • Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119:1429–1437
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 28
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    • COI: 1:CAS:528:DC%2BD1MXntVCjtrs%3D, PID: 19487820
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119:1438–1449
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 29
    • 84901227582 scopus 로고    scopus 로고
    • Mechanisms of fibrogenesis in liver cirrhosis: the molecular aspects of epithelial-mesenchymal transition
    • PID: 24799989
    • Lee SJ, Kim KH, Park KK (2014) Mechanisms of fibrogenesis in liver cirrhosis: the molecular aspects of epithelial-mesenchymal transition. World J Hepatol 6:207–216
    • (2014) World J Hepatol , vol.6 , pp. 207-216
    • Lee, S.J.1    Kim, K.H.2    Park, K.K.3
  • 30
    • 0035006390 scopus 로고    scopus 로고
    • IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway
    • COI: 1:CAS:528:DC%2BD3MXkvFels7s%3D, PID: 11398077
    • Hashimoto S, Gon Y, Takeshita I, Maruoka S, Horie T (2001) IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway. J Allergy Clin Immunol 107:1001–1008
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1001-1008
    • Hashimoto, S.1    Gon, Y.2    Takeshita, I.3    Maruoka, S.4    Horie, T.5
  • 31
    • 84865678756 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induced epithelial-mesenchymal transition in hepatic fibrosis
    • COI: 1:CAS:528:DC%2BC38XhsF2itbjF, PID: 22369740
    • Bi WR, Yang CQ, Shi Q (2012) Transforming growth factor-beta1 induced epithelial-mesenchymal transition in hepatic fibrosis. Hepatogastroenterology 59:1960–1963
    • (2012) Hepatogastroenterology , vol.59 , pp. 1960-1963
    • Bi, W.R.1    Yang, C.Q.2    Shi, Q.3
  • 32
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • COI: 1:CAS:528:DC%2BD2sXosVyrsb8%3D, PID: 17562716
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R (2007) Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282:23337–23347
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 33
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • PID: 21520179
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, Stanger BZ, Wells RG (2011) Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 53:1685–1695
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6    Stanger, B.Z.7    Wells, R.G.8
  • 34
    • 77956158103 scopus 로고    scopus 로고
    • Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice
    • COI: 1:CAS:528:DC%2BC3cXhtV2iurjK, PID: 20546735
    • Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T (2010) Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 139:987–998
    • (2010) Gastroenterology , vol.139 , pp. 987-998
    • Scholten, D.1    Osterreicher, C.H.2    Scholten, A.3    Iwaisako, K.4    Gu, G.5    Brenner, D.A.6    Kisseleva, T.7
  • 36
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • COI: 1:CAS:528:DyaK2MXlt1ensLk%3D, PID: 8790603
    • Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1:71–81
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 39
    • 1542269059 scopus 로고    scopus 로고
    • Circulating fibrocytes: collagen-secreting cells of the peripheral blood
    • COI: 1:CAS:528:DC%2BD2cXhvFSmurY%3D, PID: 15010326
    • Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R (2004) Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 36:598–606
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 598-606
    • Quan, T.E.1    Cowper, S.2    Wu, S.P.3    Bockenstedt, L.K.4    Bucala, R.5
  • 40
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BD2cXmsVyruw%3D%3D, PID: 14722616
    • Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH (2004) Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113:243–252
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3    Chensue, S.W.4    Phan, S.H.5
  • 41
    • 70350738517 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BD1MXhtlyjs7jO, PID: 19581373
    • Strieter RM, Keeley EC, Hughes MA, Burdick MD, Mehrad B (2009) The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 86:1111–1118
    • (2009) J Leukoc Biol , vol.86 , pp. 1111-1118
    • Strieter, R.M.1    Keeley, E.C.2    Hughes, M.A.3    Burdick, M.D.4    Mehrad, B.5
  • 42
    • 42049092789 scopus 로고    scopus 로고
    • Fibrogenesis of parenchymal organs
    • PID: 18403330
    • Kisseleva T, Brenner DA (2008) Fibrogenesis of parenchymal organs. Proc Am Thorac Soc 5:338–342
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 338-342
    • Kisseleva, T.1    Brenner, D.A.2
  • 44
    • 33847364936 scopus 로고    scopus 로고
    • The role of CXC chemokines in pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BD2sXis12htr8%3D, PID: 17332882
    • Strieter RM, Gomperts BN, Keane MP (2007) The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 117:549–556
    • (2007) J Clin Invest , vol.117 , pp. 549-556
    • Strieter, R.M.1    Gomperts, B.N.2    Keane, M.P.3
  • 45
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • COI: 1:CAS:528:DC%2BD2cXjvVOnt70%3D, PID: 15117886
    • Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816–827
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 48
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
    • COI: 1:CAS:528:DyaK2sXlsFejurs%3D, PID: 9259574
    • Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J (1997) Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100:768–776
    • (1997) J Clin Invest , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 52
    • 0033854016 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats
    • COI: 1:CAS:528:DC%2BD3cXlvVyjt74%3D, PID: 10915731
    • Nakamura T, Sakata R, Ueno T, Sata M, Ueno H (2000) Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 32:247–255
    • (2000) Hepatology , vol.32 , pp. 247-255
    • Nakamura, T.1    Sakata, R.2    Ueno, T.3    Sata, M.4    Ueno, H.5
  • 53
    • 84865820041 scopus 로고    scopus 로고
    • TGF-beta activation and lung fibrosis
    • COI: 1:CAS:528:DC%2BC38XhsVKju7zL, PID: 22802287
    • Tatler AL, Jenkins G (2012) TGF-beta activation and lung fibrosis. Proc Am Thorac Soc 9:130–136
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 130-136
    • Tatler, A.L.1    Jenkins, G.2
  • 54
    • 67650501166 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
    • COI: 1:CAS:528:DC%2BD1MXhtVWjtb3F, PID: 19422482
    • Latella G, Vetuschi A, Sferra R, Catitti V, D’Angelo A, Zanninelli G, Flanders KC, Gaudio E (2009) Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int 29:997–1009
    • (2009) Liver Int , vol.29 , pp. 997-1009
    • Latella, G.1    Vetuschi, A.2    Sferra, R.3    Catitti, V.4    D’Angelo, A.5    Zanninelli, G.6    Flanders, K.C.7    Gaudio, E.8
  • 56
    • 0141537244 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
    • COI: 1:CAS:528:DC%2BD3sXotlegsbo%3D, PID: 14507636
    • Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB (2003) Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol 163:1261–1273
    • (2003) Am J Pathol , vol.163 , pp. 1261-1273
    • Ma, L.J.1    Yang, H.2    Gaspert, A.3    Carlesso, G.4    Barty, M.M.5    Davidson, J.M.6    Sheppard, D.7    Fogo, A.B.8
  • 59
    • 0032007351 scopus 로고    scopus 로고
    • IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    • COI: 1:CAS:528:DyaK1cXhsVChurc%3D, PID: 9492006
    • Urban JF Jr, Noben-Trauth N, Donaldson DD, Madden KB, Morris SC, Collins M, Finkelman FD (1998) IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8:255–264
    • (1998) Immunity , vol.8 , pp. 255-264
    • Urban, J.F.1    Noben-Trauth, N.2    Donaldson, D.D.3    Madden, K.B.4    Morris, S.C.5    Collins, M.6    Finkelman, F.D.7
  • 60
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • COI: 1:CAS:528:DyaK1MXmtFGltbs%3D, PID: 10491413
    • Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104:777–785
    • (1999) J Clin Invest , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 61
    • 33746806604 scopus 로고    scopus 로고
    • Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
    • COI: 1:CAS:528:DC%2BD28Xnsl2iurY%3D, PID: 16892038
    • Anthony RM, Urban JF Jr, Alem F, Hamed HA, Rozo CT, Boucher JL, Van Rooijen N, Gause WC (2006) Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med 12:955–960
    • (2006) Nat Med , vol.12 , pp. 955-960
    • Anthony, R.M.1    Urban, J.F.2    Alem, F.3    Hamed, H.A.4    Rozo, C.T.5    Boucher, J.L.6    Van Rooijen, N.7    Gause, W.C.8
  • 62
    • 20344379481 scopus 로고    scopus 로고
    • Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
    • COI: 1:CAS:528:DC%2BD2MXks1eqsbk%3D, PID: 15933199
    • Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C, Grencis RK (2005) Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science 308:1463–1465
    • (2005) Science , vol.308 , pp. 1463-1465
    • Cliffe, L.J.1    Humphreys, N.E.2    Lane, T.E.3    Potten, C.S.4    Booth, C.5    Grencis, R.K.6
  • 64
    • 0038445768 scopus 로고    scopus 로고
    • Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves
    • COI: 1:CAS:528:DC%2BD3sXltFymu7k%3D, PID: 12847266
    • Zhao A, McDermott J, Urban JF Jr, Gause W, Madden KB, Yeung KA, Morris SC, Finkelman FD, Shea-Donohue T (2003) Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol 171:948–954
    • (2003) J Immunol , vol.171 , pp. 948-954
    • Zhao, A.1    McDermott, J.2    Urban, J.F.3    Gause, W.4    Madden, K.B.5    Yeung, K.A.6    Morris, S.C.7    Finkelman, F.D.8    Shea-Donohue, T.9
  • 65
    • 84860254344 scopus 로고    scopus 로고
    • Allergic host defences
    • COI: 1:CAS:528:DC%2BC38Xmt1WitLc%3D, PID: 22538607
    • Palm NW, Rosenstein RK, Medzhitov R (2012) Allergic host defences. Nature 484:465–472
    • (2012) Nature , vol.484 , pp. 465-472
    • Palm, N.W.1    Rosenstein, R.K.2    Medzhitov, R.3
  • 66
    • 79957583362 scopus 로고    scopus 로고
    • Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens
    • COI: 1:CAS:528:DC%2BC3MXmt1Omtb8%3D, PID: 21589896
    • Allen JE, Wynn TA (2011) Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog 7:e1002003
    • (2011) PLoS Pathog , vol.7
    • Allen, J.E.1    Wynn, T.A.2
  • 67
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    • COI: 1:CAS:528:DC%2BC38XpvFGgtLc%3D, PID: 22772564
    • Wynn TA, Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 18:1028–1040
    • (2012) Nat Med , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 68
    • 84928583743 scopus 로고    scopus 로고
    • Type 2 cytokines: Mechanisms and therapeutic strategies
    • A fairly comprehensive review describing the various endogenous inhibitory mechanisms that cooperate to slow the progression of type-2 cytokine driven disease
    • • Wynn TA. Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol. 2015;15:271–2. A fairly comprehensive review describing the various endogenous inhibitory mechanisms that cooperate to slow the progression of type-2 cytokine driven disease
    • (2015) Nat Rev Immunol , vol.15 , pp. 271-272
    • Wynn, T.A.1
  • 70
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • COI: 1:CAS:528:DyaK3sXkvFegtLc%3D, PID: 8101483
    • Zurawski SM, Vega F Jr, Huyghe B, Zurawski G (1993) Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 12:2663–2670
    • (1993) EMBO J , vol.12 , pp. 2663-2670
    • Zurawski, S.M.1    Vega, F.2    Huyghe, B.3    Zurawski, G.4
  • 71
    • 84872968300 scopus 로고    scopus 로고
    • Innate lymphoid cells–how did we miss them?
    • COI: 1:CAS:528:DC%2BC3sXjslGjsQ%3D%3D, PID: 23292121
    • Walker JA, Barlow JL, McKenzie AN (2013) Innate lymphoid cells–how did we miss them? Nat Rev Immunol 13:75–87
    • (2013) Nat Rev Immunol , vol.13 , pp. 75-87
    • Walker, J.A.1    Barlow, J.L.2    McKenzie, A.N.3
  • 72
    • 44449167278 scopus 로고    scopus 로고
    • Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
    • COI: 1:CAS:528:DC%2BD1cXmsFCqsrY%3D, PID: 18480254
    • Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME (2008) Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci USA 105:7240–7245
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7240-7245
    • Munitz, A.1    Brandt, E.B.2    Mingler, M.3    Finkelman, F.D.4    Rothenberg, M.E.5
  • 73
    • 0033010373 scopus 로고    scopus 로고
    • The IL-4 receptor: signaling mechanisms and biologic functions
    • COI: 1:CAS:528:DyaK1MXjtVWmtLs%3D, PID: 10358772
    • Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 17:701–738
    • (1999) Annu Rev Immunol , vol.17 , pp. 701-738
    • Nelms, K.1    Keegan, A.D.2    Zamorano, J.3    Ryan, J.J.4    Paul, W.E.5
  • 74
    • 0030068217 scopus 로고    scopus 로고
    • Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor
    • COI: 1:CAS:528:DyaK28Xjslykug%3D%3D, PID: 8552669
    • Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci USA 93:497–501
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 497-501
    • Hilton, D.J.1    Zhang, J.G.2    Metcalf, D.3    Alexander, W.S.4    Nicola, N.A.5    Willson, T.A.6
  • 75
    • 0028917463 scopus 로고
    • Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15
    • COI: 1:CAS:528:DyaK2MXltVOnsrc%3D, PID: 7721786
    • Obiri NI, Debinski W, Leonard WJ, Puri RK (1995) Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J Biol Chem 270:8797–8804
    • (1995) J Biol Chem , vol.270 , pp. 8797-8804
    • Obiri, N.I.1    Debinski, W.2    Leonard, W.J.3    Puri, R.K.4
  • 76
    • 38649137731 scopus 로고    scopus 로고
    • Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
    • COI: 1:CAS:528:DC%2BD1cXhvVSrtbo%3D, PID: 18243101
    • LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell 132:259–272
    • (2008) Cell , vol.132 , pp. 259-272
    • LaPorte, S.L.1    Juo, Z.S.2    Vaclavikova, J.3    Colf, L.A.4    Qi, X.5    Heller, N.M.6    Keegan, A.D.7    Garcia, K.C.8
  • 77
    • 77649146245 scopus 로고    scopus 로고
    • Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2
    • COI: 1:CAS:528:DC%2BC3cXjtVCntrg%3D, PID: 20223216
    • Lupardus PJ, Birnbaum ME, Garcia KC (2010) Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure 18:332–342
    • (2010) Structure , vol.18 , pp. 332-342
    • Lupardus, P.J.1    Birnbaum, M.E.2    Garcia, K.C.3
  • 81
    • 9644268915 scopus 로고    scopus 로고
    • Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease
    • COI: 1:CAS:528:DC%2BD2MXhs1Ohtg%3D%3D, PID: 15546394
    • Mentink-Kane MM, Wynn TA (2004) Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol Rev 202:191–202
    • (2004) Immunol Rev , vol.202 , pp. 191-202
    • Mentink-Kane, M.M.1    Wynn, T.A.2
  • 83
    • 0034923170 scopus 로고    scopus 로고
    • Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    • COI: 1:CAS:528:DC%2BD3MXmtVGqt70%3D, PID: 11481612
    • Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA (2001) Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34:273–282
    • (2001) Hepatology , vol.34 , pp. 273-282
    • Chiaramonte, M.G.1    Cheever, A.W.2    Malley, J.D.3    Donaldson, D.D.4    Wynn, T.A.5
  • 86
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • COI: 1:CAS:528:DyaK1MXhvFaku70%3D, PID: 10079098
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103:779–788
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6    Zhang, Y.7    Elias, J.A.8
  • 87
    • 33847324516 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13
    • COI: 1:CAS:528:DC%2BD2sXisVSnsb0%3D, PID: 17307869
    • Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH (2007) Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci USA 104:2827–2830
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2827-2830
    • Aliprantis, A.O.1    Wang, J.2    Fathman, J.W.3    Lemaire, R.4    Dorfman, D.M.5    Lafyatis, R.6    Glimcher, L.H.7
  • 88
    • 0035871623 scopus 로고    scopus 로고
    • Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma
    • COI: 1:CAS:528:DC%2BD3MXivVKmsb0%3D, PID: 11290806
    • Blease K, Jakubzick C, Westwick J, Lukacs N, Kunkel SL, Hogaboam CM (2001) Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma. J Immunol 166:5219–5224
    • (2001) J Immunol , vol.166 , pp. 5219-5224
    • Blease, K.1    Jakubzick, C.2    Westwick, J.3    Lukacs, N.4    Kunkel, S.L.5    Hogaboam, C.M.6
  • 89
    • 0035987319 scopus 로고    scopus 로고
    • Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    • COI: 1:CAS:528:DC%2BD38XmsF2ktLw%3D, PID: 12100061
    • Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster PS (2002) Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 32:1104–1111
    • (2002) Clin Exp Allergy , vol.32 , pp. 1104-1111
    • Kumar, R.K.1    Herbert, C.2    Yang, M.3    Koskinen, A.M.4    McKenzie, A.N.5    Foster, P.S.6
  • 91
    • 1642333177 scopus 로고    scopus 로고
    • Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    • COI: 1:CAS:528:DC%2BD2cXitlOqs7k%3D, PID: 15034018
    • Kolodsick JE, Toews GB, Jakubzick C, Hogaboam C, Moore TA, McKenzie A, Wilke CA, Chrisman CJ, Moore BB (2004) Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol 172:4068–4076
    • (2004) J Immunol , vol.172 , pp. 4068-4076
    • Kolodsick, J.E.1    Toews, G.B.2    Jakubzick, C.3    Hogaboam, C.4    Moore, T.A.5    McKenzie, A.6    Wilke, C.A.7    Chrisman, C.J.8    Moore, B.B.9
  • 92
    • 0000459367 scopus 로고    scopus 로고
    • Schistosomiasis
    • Chapter 19, Unit 19
    • Lewis F. Schistosomiasis. Curr Protoc Immunol. Chapter 19; 2001 Unit 19 11
    • (2001) Curr Protoc Immunol , vol.11
    • Lewis, F.1
  • 93
    • 0034163317 scopus 로고    scopus 로고
    • Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    • COI: 1:CAS:528:DC%2BD3cXhsVKht70%3D, PID: 10679097
    • Fallon PG, Richardson EJ, McKenzie GJ, McKenzie AN (2000) Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol 164:2585–2591
    • (2000) J Immunol , vol.164 , pp. 2585-2591
    • Fallon, P.G.1    Richardson, E.J.2    McKenzie, G.J.3    McKenzie, A.N.4
  • 96
    • 0032080803 scopus 로고    scopus 로고
    • IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
    • COI: 1:CAS:528:DyaK1cXjtVCmurw%3D, PID: 9574553
    • Wynn TA, Cheever AW, Williams ME, Hieny S, Caspar P, Kuhn R, Muller W, Sher A (1998) IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. J Immunol 160:4473–4480
    • (1998) J Immunol , vol.160 , pp. 4473-4480
    • Wynn, T.A.1    Cheever, A.W.2    Williams, M.E.3    Hieny, S.4    Caspar, P.5    Kuhn, R.6    Muller, W.7    Sher, A.8
  • 97
    • 81855209855 scopus 로고    scopus 로고
    • Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Ralpha2
    • COI: 1:CAS:528:DC%2BC3MXhsFSjt7rO, PID: 21864478
    • Mentink-Kane MM, Cheever AW, Wilson MS, Madala SK, Beers LM, Ramalingam TR, Wynn TA (2011) Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Ralpha2. Gastroenterology 141:2200–2209
    • (2011) Gastroenterology , vol.141 , pp. 2200-2209
    • Mentink-Kane, M.M.1    Cheever, A.W.2    Wilson, M.S.3    Madala, S.K.4    Beers, L.M.5    Ramalingam, T.R.6    Wynn, T.A.7
  • 101
    • 58149306389 scopus 로고    scopus 로고
    • Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model
    • COI: 1:CAS:528:DC%2BD1cXhtFarurzJ, PID: 18802068
    • Shimamura T, Fujisawa T, Husain SR, Kioi M, Nakajima A, Puri RK (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol 181:4656–4665
    • (2008) J Immunol , vol.181 , pp. 4656-4665
    • Shimamura, T.1    Fujisawa, T.2    Husain, S.R.3    Kioi, M.4    Nakajima, A.5    Puri, R.K.6
  • 103
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • COI: 1:CAS:528:DC%2BC3sXms1WlsLs%3D, PID: 23619691
    • Wynn TA, Chawla A, Pollard JW (2013) Macrophage biology in development, homeostasis and disease. Nature 496:445–455
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 105
    • 79955565441 scopus 로고    scopus 로고
    • Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
    • COI: 1:CAS:528:DC%2BC3MXmsFClsbc%3D, PID: 21292997
    • Barron L, Wynn TA (2011) Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol 300:G723–728
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G723-G728
    • Barron, L.1    Wynn, T.A.2
  • 106
    • 84872334083 scopus 로고    scopus 로고
    • Host responses in tissue repair and fibrosis
    • COI: 1:CAS:528:DC%2BC3sXltVKqs74%3D, PID: 23092186
    • Duffield JS, Lupher M, Thannickal VJ, Wynn TA (2013) Host responses in tissue repair and fibrosis. Annu Rev Pathol 8:241–276
    • (2013) Annu Rev Pathol , vol.8 , pp. 241-276
    • Duffield, J.S.1    Lupher, M.2    Thannickal, V.J.3    Wynn, T.A.4
  • 107
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • COI: 1:CAS:528:DC%2BC3MXhtlWltb%2FE, PID: 21997792
    • Murray PJ, Wynn TA (2011) Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 11:723–737
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 108
    • 84902986588 scopus 로고    scopus 로고
    • The journey from stem cell to macrophage
    • COI: 1:CAS:528:DC%2BC2cXhsVOiur%2FJ, PID: 24673186
    • Pittet MJ, Nahrendorf M, Swirski FK (2014) The journey from stem cell to macrophage. Ann N Y Acad Sci 1319:1–18
    • (2014) Ann N Y Acad Sci , vol.1319 , pp. 1-18
    • Pittet, M.J.1    Nahrendorf, M.2    Swirski, F.K.3
  • 109
    • 77954961992 scopus 로고    scopus 로고
    • Macrophages: master regulators of inflammation and fibrosis
    • COI: 1:CAS:528:DC%2BC3cXhtV2nsL3N, PID: 20665377
    • Wynn TA, Barron L (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30:245–257
    • (2010) Semin Liver Dis , vol.30 , pp. 245-257
    • Wynn, T.A.1    Barron, L.2
  • 110
    • 84928589982 scopus 로고    scopus 로고
    • Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
    • This paper identifies a critical role for CD11b+F4/80+ macrophages in the maintenance of fibrosis induced by IL-13
    • • Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA. Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis. Mucosal Immunol. 2015. This paper identifies a critical role for CD11b+F4/80+ macrophages in the maintenance of fibrosis induced by IL-13
    • (2015) Mucosal Immunol
    • Borthwick, L.A.1    Barron, L.2    Hart, K.M.3    Vannella, K.M.4    Thompson, R.W.5    Oland, S.6    Cheever, A.7    Sciurba, J.8    Ramalingam, T.R.9    Fisher, A.J.10    Wynn, T.A.11
  • 112
    • 0033779575 scopus 로고    scopus 로고
    • Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts
    • COI: 1:CAS:528:DC%2BD3cXmslKgu7c%3D, PID: 11006014
    • Song E, Ouyang N, Horbelt M, Antus B, Wang M, Exton MS (2000) Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol 204:19–28
    • (2000) Cell Immunol , vol.204 , pp. 19-28
    • Song, E.1    Ouyang, N.2    Horbelt, M.3    Antus, B.4    Wang, M.5    Exton, M.S.6
  • 115
    • 0035576207 scopus 로고    scopus 로고
    • Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of l-arginine metabolism
    • COI: 1:CAS:528:DC%2BD3MXovVCiurw%3D, PID: 11714822
    • Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA (2001) Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of l-arginine metabolism. J Immunol 167:6533–6544
    • (2001) J Immunol , vol.167 , pp. 6533-6544
    • Hesse, M.1    Modolell, M.2    La Flamme, A.C.3    Schito, M.4    Fuentes, J.M.5    Cheever, A.W.6    Pearce, E.J.7    Wynn, T.A.8
  • 117
    • 67649216604 scopus 로고    scopus 로고
    • Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
    • COI: 1:CAS:528:DC%2BD1MXmtlaku7g%3D, PID: 19465907
    • Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R (2009) Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 10:713–720
    • (2009) Nat Immunol , vol.10 , pp. 713-720
    • Sokol, C.L.1    Chu, N.Q.2    Yu, S.3    Nish, S.A.4    Laufer, T.M.5    Medzhitov, R.6
  • 119
    • 67649227119 scopus 로고    scopus 로고
    • Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells
    • COI: 1:CAS:528:DC%2BD1MXmtlakurY%3D, PID: 19465908
    • Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, Nakanishi K (2009) Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 10:706–712
    • (2009) Nat Immunol , vol.10 , pp. 706-712
    • Yoshimoto, T.1    Yasuda, K.2    Tanaka, H.3    Nakahira, M.4    Imai, Y.5    Fujimori, Y.6    Nakanishi, K.7
  • 121
    • 70049101757 scopus 로고    scopus 로고
    • Biology of lung dendritic cells at the origin of asthma
    • COI: 1:CAS:528:DC%2BD1MXhsVejt7fO, PID: 19766084
    • Lambrecht BN, Hammad H (2009) Biology of lung dendritic cells at the origin of asthma. Immunity 31:412–424
    • (2009) Immunity , vol.31 , pp. 412-424
    • Lambrecht, B.N.1    Hammad, H.2
  • 126
    • 0035892755 scopus 로고    scopus 로고
    • Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases
    • COI: 1:CAS:528:DC%2BD3MXptFGiurg%3D, PID: 11739522
    • Vaillant B, Chiaramonte MG, Cheever AW, Soloway PD, Wynn TA (2001) Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol 167:7017–7026
    • (2001) J Immunol , vol.167 , pp. 7017-7026
    • Vaillant, B.1    Chiaramonte, M.G.2    Cheever, A.W.3    Soloway, P.D.4    Wynn, T.A.5
  • 127
    • 80052654374 scopus 로고    scopus 로고
    • IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-beta-independent Smad signaling
    • COI: 1:CAS:528:DC%2BC3MXhtVGmsb3J, PID: 21804025
    • Liu Y, Meyer C, Muller A, Herweck F, Li Q, Mullenbach R, Mertens PR, Dooley S, Weng HL (2011) IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-beta-independent Smad signaling. J Immunol 187:2814–2823
    • (2011) J Immunol , vol.187 , pp. 2814-2823
    • Liu, Y.1    Meyer, C.2    Muller, A.3    Herweck, F.4    Li, Q.5    Mullenbach, R.6    Mertens, P.R.7    Dooley, S.8    Weng, H.L.9
  • 128
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • COI: 1:CAS:528:DC%2BD38Xls12msb4%3D, PID: 12091879
    • Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8:885–889
    • (2002) Nat Med , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3    Chang, G.H.4    Dolganov, G.M.5    Zhu, Z.6    Elias, J.A.7    Sheppard, D.8    Erle, D.J.9
  • 129
    • 0034764068 scopus 로고    scopus 로고
    • Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types
    • COI: 1:CAS:528:DC%2BD3MXos1eju70%3D, PID: 11694453
    • Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D (2001) Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol 25:474–485
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 474-485
    • Lee, J.H.1    Kaminski, N.2    Dolganov, G.3    Grunig, G.4    Koth, L.5    Solomon, C.6    Erle, D.J.7    Sheppard, D.8
  • 132
    • 84891947803 scopus 로고    scopus 로고
    • Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma
    • COI: 1:CAS:528:DC%2BC2cXnsVGlsQ%3D%3D, PID: 24283478
    • Agrawal S, Townley RG (2014) Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma. Expert Opin Biol Ther 14:165–181
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 165-181
    • Agrawal, S.1    Townley, R.G.2
  • 134
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
    • COI: 1:STN:280:DC%2BC3cbgtlOltw%3D%3D, PID: 20956165
    • Oh CK, Geba GP, Molfino N (2010) Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 19:46–54
    • (2010) Eur Respir Rev , vol.19 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.