메뉴 건너뛰기




Volumn 187, Issue 5, 2011, Pages 2814-2823

IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent smad signaling

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; CONNECTIVE TISSUE GROWTH FACTOR; INTERLEUKIN 13; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; SMAD1 PROTEIN; SMAD2 PROTEIN; STAT6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 80052654374     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003260     Document Type: Article
Times cited : (100)

References (54)
  • 1
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • DOI 10.1172/JCI30542
    • Iredale, J. P. 2007. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest. 117: 539-548. (Pubitemid 46348508)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.3 , pp. 539-548
    • Iredale, J.P.1
  • 2
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • Friedman, S. L. 2008. Mechanisms of hepatic fibrogenesis. Gastroenterology 134: 1655-1669. (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 5
    • 0034767501 scopus 로고    scopus 로고
    • Transforming growth factor beta and the liver
    • DOI 10.1053/jhep.2001.28457
    • Bissell, D. M., D. Roulot, and J. George. 2001. Transforming growth factor beta and the liver. Hepatology 34: 859-867. (Pubitemid 33032019)
    • (2001) Hepatology , vol.34 , Issue.5 , pp. 859-867
    • Bissell, D.M.1    Roulot, D.2    George, J.3
  • 7
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • DOI 10.1146/annurev.immunol.21.120601.141142
    • Wynn, T. A. 2003. IL-13 effector functions. Annu. Rev. Immunol. 21: 425-456. (Pubitemid 37174537)
    • (2003) Annual Review of Immunology , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 8
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T(H)1/T(H)2 paradigm
    • Wynn, T. A. 2004. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 4: 583-594.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 9
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • DOI 10.1002/path.2277
    • Wynn, T. A. 2008. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214: 199-210. (Pubitemid 351160157)
    • (2008) Journal of Pathology , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 13
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • Zurawski, S. M., F. Vega, Jr., B. Huyghe, and G. Zurawski. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12: 2663-2670. (Pubitemid 23218315)
    • (1993) EMBO Journal , vol.12 , Issue.7 , pp. 2663-2670
    • Zurawsli, S.M.1    Vega Jr., F.2    Huyghe, B.3    Zurawski, G.4
  • 14
    • 0034163317 scopus 로고    scopus 로고
    • Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    • Fallon, P. G., E. J. Richardson, G. J. McKenzie, and A. N. McKenzie. 2000. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J. Immunol. 164: 2585-2591. (Pubitemid 30115489)
    • (2000) Journal of Immunology , vol.164 , Issue.5 , pp. 2585-2591
    • Fallon, P.G.1    Richardson, E.J.2    McKenzie, G.J.3    McKenzie, A.N.J.4
  • 15
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte, M. G., D. D. Donaldson, A. W. Cheever, and T. A. Wynn. 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104: 777-785. (Pubitemid 29536363)
    • (1999) Journal of Clinical Investigation , vol.104 , Issue.6 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 16
    • 1642333177 scopus 로고    scopus 로고
    • Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts
    • Kolodsick, J. E., G. B. Toews, C. Jakubzick, C. Hogaboam, T. A. Moore, A. McKenzie, C. A. Wilke, C. J. Chrisman, and B. B. Moore. 2004. Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J. Immunol. 172: 4068-4076. (Pubitemid 38375218)
    • (2004) Journal of Immunology , vol.172 , Issue.7 , pp. 4068-4076
    • Kolodsick, J.E.1    Toews, G.B.2    Jakubzick, C.3    Hogaboam, C.4    Moore, T.A.5    McKenzie, A.6    Wilke, C.A.7    Chrisman, C.J.8    Moore, B.B.9
  • 18
    • 58149306389 scopus 로고    scopus 로고
    • Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model
    • Shimamura, T., T. Fujisawa, S. R. Husain, M. Kioi, A. Nakajima, and R. K. Puri. 2008. Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J. Immunol. 181: 4656-4665.
    • (2008) J. Immunol. , vol.181 , pp. 4656-4665
    • Shimamura, T.1    Fujisawa, T.2    Husain, S.R.3    Kioi, M.4    Nakajima, A.5    Puri, R.K.6
  • 20
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio, J. J., and A. B. Roberts. 1998. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16: 137-161.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 21
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • DOI 10.1172/JCI200419603
    • Daniels, C. E., M. C. Wilkes, M. Edens, T. J. Kottom, S. J. Murphy, A. H. Limper, and E. B. Leof. 2004. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J. Clin. Invest. 114: 1308-1316. (Pubitemid 40385302)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.9 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3    Kottom, T.J.4    Murphy, S.J.5    Limper, A.H.6    Leof, E.B.7
  • 22
    • 48949084865 scopus 로고    scopus 로고
    • Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases
    • Gressner, O. A., and A. M. Gressner. 2008. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int. 28: 1065-1079.
    • (2008) Liver Int. , vol.28 , pp. 1065-1079
    • Gressner, O.A.1    Gressner, A.M.2
  • 23
    • 68949101788 scopus 로고    scopus 로고
    • Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - But without modulating bone morphogenetic protein 7 signaling
    • Gressner, O. A., B. Lahme, M. Siluschek, K. Rehbein, R. Weiskirchen, and A. M. Gressner. 2009. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - but without modulating bone morphogenetic protein 7 signaling. Hepatology 49: 2021-2030.
    • (2009) Hepatology , vol.49 , pp. 2021-2030
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Weiskirchen, R.5    Gressner, A.M.6
  • 24
    • 0035476418 scopus 로고    scopus 로고
    • Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy
    • DOI 10.1042/0264-6021:3590077
    • Wahab, N. A., N. Yevdokimova, B. S. Weston, T. Roberts, X. J. Li, H. Brinkman, and R. M. Mason. 2001. Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem. J. 359: 77-87. (Pubitemid 32939209)
    • (2001) Biochemical Journal , vol.359 , Issue.1 , pp. 77-87
    • Wahab, N.A.1    Yevdokimova, N.2    Weston, B.S.3    Roberts, T.4    Li, X.J.5    Brinkman, H.6    Mason, R.M.7
  • 25
    • 0033957976 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
    • Riser, B. L., M. Denichilo, P. Cortes, C. Baker, J. M. Grondin, J. Yee, and R. G. Narins. 2000. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J. Am. Soc. Nephrol. 11: 25-38. (Pubitemid 30020423)
    • (2000) Journal of the American Society of Nephrology , vol.11 , Issue.1 , pp. 25-38
    • Riser, B.L.1    Denichilo, M.2    Cortes, P.3    Baker, C.4    Grondin, J.M.5    Yee, J.6    Narins, R.G.7
  • 26
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGf-beta action on fibroblasts
    • DOI 10.1016/S1359-6101(97)00010-5, PII S1359610197000105
    • Grotendorst, G. R. 1997. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8: 171-179. (Pubitemid 28077925)
    • (1997) Cytokine and Growth Factor Reviews , vol.8 , Issue.3 , pp. 171-179
    • Grotendorst, G.R.1
  • 27
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask, A., and D. J. Abraham. 2004. TGF-beta signaling and the fibrotic response. FASEB J. 18: 816-827.
    • (2004) FASEB J. , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 28
    • 1642452822 scopus 로고    scopus 로고
    • Insights into the Molecular Mechanism of Chronic Fibrosis: The Role of Connective Tissue Growth Factor in Scleroderma
    • DOI 10.1046/j.0022-202X.2003.22133.x
    • Leask, A., C. P. Denton, and D. J. Abraham. 2004. Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma. J. Invest. Dermatol. 122: 1-6. (Pubitemid 38114631)
    • (2004) Journal of Investigative Dermatology , vol.122 , Issue.1 , pp. 1-6
    • Leask, A.1    Denton, C.P.2    Abraham, D.J.3
  • 29
    • 0035066961 scopus 로고    scopus 로고
    • Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis
    • Sedlaczek, N., J. D. Jia, M. Bauer, H. Herbst, M. Ruehl, E. G. Hahn, and D. Schuppan. 2001. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am. J. Pathol. 158: 1239-1244. (Pubitemid 32281287)
    • (2001) American Journal of Pathology , vol.158 , Issue.4 , pp. 1239-1244
    • Sedlaczek, N.1    Jia, J.-D.2    Bauer, M.3    Herbst, H.4    Ruehl, M.5    Hahn, E.G.6    Schuppan, D.7
  • 31
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst, G. R., H. Okochi, and N. Hayashi. 1996. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 7: 469-480. (Pubitemid 26362091)
    • (1996) Cell Growth and Differentiation , vol.7 , Issue.4 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 32
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    • DOI 10.1016/j.jhep.2007.05.015, PII S0168827807003479
    • Gressner, O. A., B. Lahme, I. Demirci, A. M. Gressner, and R. Weiskirchen. 2007. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J. Hepatol. 47: 699-710. (Pubitemid 47503426)
    • (2007) Journal of Hepatology , vol.47 , Issue.5 , pp. 699-710
    • Gressner, O.A.1    Lahme, B.2    Demirci, I.3    Gressner, A.M.4    Weiskirchen, R.5
  • 33
    • 67651165609 scopus 로고    scopus 로고
    • The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis
    • Weng, H. L., Y. Liu, J. L. Chen, T. Huang, L. J. Xu, P. Godoy, J. H. Hu, C. Zhou, F. Stickel, A. Marx, et al. 2009. The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis. Hepatology 50: 230-243.
    • (2009) Hepatology , vol.50 , pp. 230-243
    • Weng, H.L.1    Liu, Y.2    Chen, J.L.3    Huang, T.4    Xu, L.J.5    Godoy, P.6    Hu, J.H.7    Zhou, C.8    Stickel, F.9    Marx, A.10
  • 34
    • 0023275798 scopus 로고
    • The synthesis of proteoglycans in fat-storing cells of rat liver
    • Schäfer, S., O. Zerbe, and A. M. Gressner. 1987. The synthesis of proteoglycans in fat-storing cells of rat liver. Hepatology 7: 680-687. (Pubitemid 17130709)
    • (1987) Hepatology , vol.7 , Issue.4 , pp. 680-687
    • Schafer, S.1    Zerbe, O.2    Gressner, A.M.3
  • 35
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • quiz 691
    • Hershey, G. K. 2003. IL-13 receptors and signaling pathways: an evolving web. J. Allergy Clin. Immunol. 111: 677-690, quiz 691.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 38
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi, Y., and J. Massagué. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 39
    • 0033531948 scopus 로고    scopus 로고
    • Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- And activin-mediated growth arrest and apoptosis in B cells
    • Ishisaki, A., K. Yamato, S. Hashimoto, A. Nakao, K. Tamaki, K. Nonaka, P. ten Dijke, H. Sugino, and T. Nishihara. 1999. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem. 274: 13637-13642.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13637-13642
    • Ishisaki, A.1    Yamato, K.2    Hashimoto, S.3    Nakao, A.4    Tamaki, K.5    Nonaka, K.6    Ten Dijke, P.7    Sugino, H.8    Nishihara, T.9
  • 40
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono, K., Y. Kamiya, and M. Morikawa. 2010. Bone morphogenetic protein receptors and signal transduction. J. Biochem. 147: 35-51.
    • (2010) J. Biochem. , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 42
    • 77949395650 scopus 로고    scopus 로고
    • Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling
    • Chung, A. C., H. Zhang, Y. Z. Kong, J. J. Tan, X. R. Huang, J. B. Kopp, and H. Y. Lan. 2010. Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. J. Am. Soc. Nephrol. 21: 249-260.
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 249-260
    • Chung, A.C.1    Zhang, H.2    Kong, Y.Z.3    Tan, J.J.4    Huang, X.R.5    Kopp, J.B.6    Lan, H.Y.7
  • 43
    • 1342268353 scopus 로고    scopus 로고
    • Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: Implications for diabetic renal and vascular disease
    • Li, J. H., X. R. Huang, H. J. Zhu, M. Oldfield, M. Cooper, L. D. Truong, R. J. Johnson, and H. Y. Lan. 2004. Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J. 18: 176-178.
    • (2004) FASEB J. , vol.18 , pp. 176-178
    • Li, J.H.1    Huang, X.R.2    Zhu, H.J.3    Oldfield, M.4    Cooper, M.5    Truong, L.D.6    Johnson, R.J.7    Lan, H.Y.8
  • 44
    • 9644284528 scopus 로고    scopus 로고
    • Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway
    • Zhou, G., C. Li, and L. Cai. 2004. Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am. J. Pathol. 165: 2033-2043. (Pubitemid 39578381)
    • (2004) American Journal of Pathology , vol.165 , Issue.6 , pp. 2033-2043
    • Zhou, G.1    Li, C.2    Cai, L.3
  • 46
    • 33845599489 scopus 로고    scopus 로고
    • IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads
    • DOI 10.1016/j.jhep.2006.09.014, PII S0168827806005502
    • Weng, H., P. R. Mertens, A. M. Gressner, and S. Dooley. 2007. IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads. J. Hepatol. 46: 295-303. (Pubitemid 44959156)
    • (2007) Journal of Hepatology , vol.46 , Issue.2 , pp. 295-303
    • Weng, H.1    Mertens, P.R.2    Gressner, A.M.3    Dooley, S.4
  • 47
    • 0141428794 scopus 로고    scopus 로고
    • Controlling the angiogenic switch: A balance between two distinct TGF-b receptor signaling pathways
    • DOI 10.1016/S1050-1738(03)00142-7, PII S1050173803001427
    • Goumans, M. J., F. Lebrin, and G. Valdimarsdottir. 2003. Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways. Trends Cardiovasc. Med. 13: 301-307. (Pubitemid 37159396)
    • (2003) Trends in Cardiovascular Medicine , vol.13 , Issue.7 , pp. 301-307
    • Goumans, M.-J.1    Lebrin, F.2    Valdimarsdottir, G.3
  • 48
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    • DOI 10.1016/S1097-2765(03)00386-1
    • Goumans, M. J., G. Valdimarsdottir, S. Itoh, F. Lebrin, J. Larsson, C. Mummery, S. Karlsson, and P. ten Dijke. 2003. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol. Cell 12: 817-828. (Pubitemid 37352776)
    • (2003) Molecular Cell , vol.12 , Issue.4 , pp. 817-828
    • Goumans, M.-J.1    Valdimarsdottir, G.2    Itoh, S.3    Lebrin, F.4    Larsson, J.5    Mummery, C.6    Karlsson, S.7    Ten, D.P.8
  • 49
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    • DOI 10.1093/emboj/21.7.1743
    • Goumans, M. J., G. Valdimarsdottir, S. Itoh, A. Rosendahl, P. Sideras, and P. ten Dijke. 2002. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 21: 1743-1753. (Pubitemid 34614630)
    • (2002) EMBO Journal , vol.21 , Issue.7 , pp. 1743-1753
    • Goumans, M.-J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    Ten, D.P.6
  • 52
    • 0031587927 scopus 로고    scopus 로고
    • Expression of recombinant rat interleukin-13 (IL-13) and generation of a neutralizing rat IL-13 antiserum
    • DOI 10.1006/bbrc.1997.6832
    • Lakkis, F. G., E. N. Cruet, G. M. Nassar, K. F. Badr, and D. W. Pascual. 1997. Expression of recombinant rat interleukin-13 (IL-13) and generation of a neutralizing rat IL-13 antiserum. Biochem. Biophys. Res. Commun. 235: 529-532. (Pubitemid 27326514)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.3 , pp. 529-532
    • Lakkis, F.G.1    Cruet, E.N.2    Nassar, G.M.3    Badr, K.F.4    Pascual, D.W.5
  • 54
    • 41949121773 scopus 로고    scopus 로고
    • Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: The A-549 cell bioassay
    • Miller, R., R. Sadhukhan, and C. Wu. 2008. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods 334: 134-141.
    • (2008) J. Immunol. Methods , vol.334 , pp. 134-141
    • Miller, R.1    Sadhukhan, R.2    Wu, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.