Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma

Journal of Immunology

Volumn 166, Issue 8, 2001, Pages 5219-5224

  Blease, K ^a   Jakubzick, C ^a   Westwick, J ^a   Lukacs, N ^a   Kunkel, S L ^a   Hogaboam, C M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COLLAGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 13; RECOMBINANT INTERLEUKIN 4;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS FUMIGATUS; BRONCHUS HYPERREACTIVITY; CELL HYPERPLASIA; CONTROLLED STUDY; GOBLET CELL; IMMUNOMODULATION; MOUSE; MYCOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0035871623     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.8.5219     Document Type: Article

References (33)

1. Interleukin-13 and interleukin-4 are coexpressed in atopic asthma
2. IL-13 expression at the sites of allergen challenge in patients with asthma
3. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
4. Requirement for IL-13 independently of IL-4 in experimental asthma
5. Interleukin-13: Central mediator of allergic asthma
6. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
7. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus
8. -/- mice during chronic fungal allergic airway disease
9. -/- mice
10. The roe of allergy in the development of asthma
11. Incidence of immediate sensitivity to Aspergillus fumigatus in a North American asthmatic population
12. Immunomodulatory role of C10 chemokine in a murine model of allergic bronchopulmonary aspergillosis
13. Expression and contribution of endogenous IL-13 in an experimental model of sepsis
14. Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation
15. A sensitive ELISA for the detection of human monocyte chemoattractant protein-1 (MCP-1)
16. Regulation of the expression of the soluble and membrane forms of the murine IL-4 receptor
17. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
18. Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system
19. The murine IL-13 receptor α2: Molecular cloning, characterization, and comparison with murine IL-13 receptor α1
20. Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor
21. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
22. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness
23. Asymptomatic airway hyperresponsiveness: Relationships with airway inflammation and remodelling
24. Airway remodeling in asthma
25. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL- 13:IL-13 is a profibrotic agent
26. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
27. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
28. Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
29. Schistosoma mansoni in IL-4-deficient mice
30. Structural consequences of airway inflammation in asthma
31. A novel role for murine IL-4 in vivo: Induction of MUC5AC gene expression and mucin hypersecretion
32. Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: Enhanced IL-13 production by IL-4-primed human mast cells
33. Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for 1L-13 in the regulation of Th2 responses