Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model

Journal of Immunology

Volumn 181, Issue 7, 2008, Pages 4656-4665

  Shimamura, Takeshi ^a   Fujisawa, Toshio ^a   Husain, Syed R ^a   Kioi, Mitomu ^a   Nakajima, Atsushi ^b   Puri, Raj K ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKYLLYSOPHOSPHOLIPID; AMINO ACID; ASPARTATE AMINOTRANSFERASE; CHOLINE; COLLAGEN TYPE 1; HYBRID PROTEIN; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 4; MESSENGER RNA; RECOMBINANT INTERLEUKIN 13 PSEUDOMONAS EXOTOXIN 38 FUSION PROTEIN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOTOXIN; EXOTOXIN; IL13 PE38; IL13-PE38; INTERLEUKIN 13 RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOTOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG TARGETING; FATTY LIVER; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; LIVER CELL; LIVER FIBROSIS; LIVER SINUSOID; LUNG TOXICITY; NEPHROTOXICITY; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; SPLEEN INJURY; STELLATE CELL; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; DISEASE MODEL; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; ITO CELL; LIVER CIRRHOSIS; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CYTOTOXINS; DISEASE MODELS, ANIMAL; EXOTOXINS; FATTY LIVER; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA2 SUBUNIT; LIVER CIRRHOSIS; MALE; RATS; RATS, INBRED F344; RECEPTORS, INTERLEUKIN-13; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 58149306389     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.7.4656     Document Type: Article

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