Impaired development of Th2 cells in IL-13-deficient mice

Immunity

Volumn 9, Issue 3, 1998, Pages 423-432

  McKenzie, Grahame J ^a   Emson, Claire L ^a   Bell, Sarah E ^b   Anderson, Shannon ^a   Fallon, Padraic ^b   Zurawski, Gerard ^c   Murray, Richard ^c   Grencis, Richard ^d   McKenzie, Andrew N J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; IONOMYCIN; OVALBUMIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPY; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; HELPER CELL; MAST CELL; MOUSE; NEMATODIASIS; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

EID: 0032167664     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80625-1     Document Type: Article

References (58)

1. Aarden, L.A., DeGroot, E.R., Schapp, O.L., and Lansdorp, P.M. (1987). Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17, 1411-1416.
2. Aman, M.J., Tayebi, N., Obiri, N.I., Puri, R.K., Modi, W.S., and Leonard, W.J. (1996). cDNA cloning and characterization of the human interleukin 13 receptor α chain. J. Biol. Chem. 271, 29265-29270.
3. Bancroft, A.J., McKenzie, A.N.J., and Grencis, R.K. (1998). A critical rolefor IL-13 in resistance to intestinal nematode infection. J. Immunol. 160, 3453-3461.
4. Barner, M., Mohrs, M., Brombacher, F., and Kopf, M. (1998). Differences between IL-4Rα-deficientand IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr. Biol. 8, 669-672.
5. Bost, K.L., Holton, R.H., Kincy Cain, T., and Clements, J.D. (1996). In vivo treatment with anti-interleukin-13 antibodies significantly reduces the humoral response against an oral immunogen in mice. Immunology 87, 633-641.
6. Bousquet, J., Chanez, P., Lacoste, J.Y., Barneon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., and Godard, P. (1990). Eosinophilic inflammation in asthma. N. Engl. J. Med. 323, 1033-1039.
7. Brewer, J.M., Conacher, M., Satoskar, A., Bluethmann, H., and Alexander, J. (1996). In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur. J. Immunol. 26, 2062-2066.
8. Brown, K.D., Zurawski, S.M., Mosmann, T.R., and Zurawski, G. (1989). Afamily of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J. Immunol. 142, 679-687.
9. Caput, D., Laurent, P., Kaghad, M., Lelias, J-M., Lefort, S., Vita, N., and Ferrara, P. (1996). Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain. J. Biol. Chem. 271, 16921-16926.
10. Constant, S., Pfeiffer, C., Pasqualini, T., and Bottomly, K. (1995). Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J. Exp. Med. 182, 1591-1596.
11. Curiel, R.E., Lahesmaa, R., Subleski, J., Cippitelli, M., Kirken, R.A., Young, H.A., and Ghosh, P. (1997). Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene. Eur. J. Immunol. 27, 1982-1987.
12. de Waal Malefyt, R., Figdor, C., Huijbens, R., Mohan-Peterson, S., Bennett, B., Culpepper, J., Dang, W., Zurawski, G., and de Vries, J.E. (1993). Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. J. Immunol. 151, 6370-6381.
13. Doherty, T.M., Kastelein, R., Menon, S., Andrade, S., and Coffman, R.L. (1993). Modulation of murine macrophage function by interleukin-13. J. Immunol. 151, 7151-7160.
14. Emson, C.L., Bell, S.E., Jones, A., Wisden, W., and McKenzie, A.N.J. (1998). IL-4-independent induction of IgE, and perturbation of T cell development in transgenic mice expressing interleukin-13. J. Exp. Med. 188, 399-404.
15. Gauchat, J-F., Schlagenhauf, E., Feng, N-P., Moser, R., Yamage, M., Jeannin, P., Alouani, S., Elson, G., Notarangelo, L.D., Wells, T., et al. (1997). A novel 4-kb interleukin-13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur. J. Immunol. 27, 971-978.
16. He, Y-W., and Malek, T.R. (1995). The IL-2 receptor γc chain does not function as a subunit shared by the IL-4 and IL-13 receptors: implication for the structure of the IL-4 receptor. J. Immunol. 155, 9-12.
17. Hilton, D.J., Zhang, J.-G., Metcalf, D., Alexander, W.S., Nicola, N.A., and Willson, T.A. (1996). Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93, 497-501.
18. Hjulström, S., Landin, A., Jansson, L., Holmdahl, R., and Heyman, B. (1995). No role of interleukin-4 in CD23/IgE-mediated enhancement of the murine antibody response in vivo. Eur. J. Immunol. 25, 1469-1472.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
20. Jinquan, T., Deleuran, B., Gesser, H., Maare, H., Deleuran, M., Larsen, C.G., and Thestrup-Pedersen, K. (1995). Regulation of human T lymphocyte chemotaxis in vitro by T cell-derived cytokines IL-2, IFN-γ, IL-4, IL-10, and IL-13. J. Immunol. 154, 3742-3752.
21. Kaplan, M.H., Schindler, U., Smiley, ST., and Grusby, M.J. (1996). State is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4, 313-319.
22. Kondo, M., Takeshita, T., Ishii, N., Nakamura, M., Watanabe, S., Arai, K., and Sugamura, K. (1993). Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262, 1874-1877.
23. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M.C., Bluethmann, H., and Kohler, G. (1993). Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362, 245-248.
24. Kopf, M., Brombacher, F., Hodkin, P.D., Ramsay, A.J., Milbourne, E.A., Dai, WJ., Ovington, K.S., Behm, C.A., Kohler, G., Young, I.G., et al. (1996). IL-5-deficient mice have a developmental defect in CDS+ B-1 cells and lackeosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4, 15-24.
25. Kotanides, H., and Reich, N.C. (1996). Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 271, 25555-25561.
26. Kühn, R., Rajewsky, K., and Müller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
27. Jankovic, D., Kullberg, M.C., Caspar, P., Cheever, A.W., NobenTrauth, N., and Sher, A. (1998). Induction of egg pathology during Schistosoma mansoni infection requires IL-4 receptor, but not IL-4 expression. Second Woods Hole Immunoparasitology Meeting Summary Book, Summary no. 52.
28. Lederer, J.A., Ferez, V.L., DesRoches, L., Kim, S.M., Abbas, A.K., and Lichtman, A.H. (1996). Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 184, 397-406.
29. Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., and Paul, W.E. (1990). Generation of interleukin-4 (IL-4)-producing cells in vitro and in vivo: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J. Exp. Med. 172, 921-929.
30. Lin, J.-X., Migone, T.-S., Tsang, M., Friedman, M., Weatherbee, J.A., Zhou, L. Yamauchi, A., Bloom, E.T., Mietz, J., John, S., et al. (1995). The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2, 331-339.
31. Manetti, R., Parronchi, P., Guidizi, M.G., Piccinni, M.-P., Maggi, E., Trinchieri, G., and Romagnani, S. (1993). Natural killer cell stimulatory factor (interleukin-12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177, 1199-1204.
32. McKenzie, A.N.J., Culpepper, J.A., de Waal Malefyt, R., Briere, F., Punonnen, J., Aversa, G., Sato, A., Dang, W., Cocks, B.G., Menon, S., et al. (1993a). Interleukin-13, a novel T cell-derived cytokine that regulates human monocyte and B cell function. Proc. Natl. Acad. Sci. USA 90, 3735-3739.
33. McKenzie, A.N.J., Li, X., Largaespada, D.A., Sato, A., Kaneda, A., Zurawski, S.M., Doyle, E.L., Milatovich, A., Francke, U., Copeland, N.G., et al. (1993b). Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J. Immunol. 150, 5436-5444.
34. McKenzie, G.J., Bancroft, A., Grencis, R.K., and McKenzie, A.N.J. (1998). A distinct rolefor interleukin-13 in Th2-cell-mediated immune responses. Curr. Biol. 8, 339-342.
35. Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., and Ferrara, P. (1997). Cloning of the human IL-13Ra1 chain and reconstitution with the IL-4Rα of a functional IL-4/IL-13 receptor complex. FEBS Lett. 401, 163-166.
36. Morawetz, R.A., Gabriele, L., Rizzo, L.V., Noben-Trauth, N., Kühn, R., Rajewsky, K., Muller, W., Doherty, T.M., Finkelman, F., Coffman, R.L., et al. (1996). Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 184, 1651-1661.
37. Mosmann, T.R., Cherwinski, H., Bond, M.W.,Gieldin,M.A., and Coffman, R.L. (1986). Two types of m urine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
38. Mosmann, T.R., and Coffman, R.L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
39. Muchamuel, T., Menon, S., Piscane, P., Howard, M.C., and Cockayne, D.A. (1997). IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNFα, IFN-γ, and IL-12 production. J. Immunol. 158, 2898-2903.
40. Murphy, E., Hieny, S., Sher, A., and O'Garra, A. (1993). Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice. J. Immunol. Methods 162, 211-223.
41. Nicoletti, F., Mancuso.G., Cusumano, V., Di Marco, R., Zaccone, P., Bendtzen, K., and Teti, G. (1997). Prevention of endotoxin-induced lethality in neonatal mice by interleukin-13. Eur. J. Immunol. 27, 1580-1583.
42. O'Garra, A. (1998). Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275-283.
43. Pearce, E.J., Caspar, P., Gryzch, J-M., Lewis, F.A., and Sher, A. (1991). Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 172, 159-166.
44. Pernis, A., Gupta, S., Gollob, K.J., Garfein, E., Coffman, R.L., Schindler, C., and Rothman, P. (1995). Lack of Interferon γ receptor β chain and the prevention of Interferon γ signaling in Th1 cells. Science 269, 245-247.
45. Punnonen, J., Aversa, G., Cocks, B.G., McKenzie, A.N.J., Menon, S., Zurawski, G., de Waal Malefyt, R., and de Vries, J.E. (1993). Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90, 3730-3734.
46. Reiner, S.L., Zheng, S., Corry, D.B., and Locksley, R.M. (1993). Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165, 37-46.
47. + T cells. J. Exp. Med. 3, 461-469.
48. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A.A., et al. (1996). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State gene. Nature 380, 630-633.
49. Smerz-Bertling, C., and Duschl, A.L. (1995). Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270, 966-970.
50. Button, B.J., and Gould, H.J. (1993). The human IgE network. Nature 366, 421-428.
51. Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12Rb2 subunit expression in developing T helper 1 (Th 1) and Th2 cells. J. Exp. Med. 185, 817-824.
52. Takeda, T., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., and Akira, S. (1996). Essential role of State in IL-4 signaling. Nature 380, 627-630.
53. Urban, J.F., Jr., Noben-Trauth, N., Donaldson, D.D., Madden, K.B., Morris, S.C., Collins, M., and Finkelman, F.D. (1998). IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8, 255-264.
54. van der Pouw Kraan, T.C., Boieje, L.C., Troon, J.T., Rutschmann, S.K., Wijdenes, J., and Aarden, L.A. (1996). Human IL-13 production is negatively influenced by CD3 engagement. J. Immunol. 156, 1818-1823.
55. Van der Weld, T., Kopf, M., Köhler, G., and Langhorne, J. (1994). The immune responseto Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur. J. Immunol. 24, 2285-2293.
56. Zurawski, G., and de Vries, J.E. (1994). Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells but not on T cells, Immunol. Today 15, 19-26.
57. Zurawski, S.M., Vega, F., Jr., Huyghe, B., and Zurawski, G. (1993). Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12, 3899-3905.
58. Zurawski, S.M., Chomarat, P., Djousso, O., Bidaud, C., McKenzie, A.N.J., Miossec, P., Banchereau, J., and Zurawski, G. (1995). The primary binding subunit of the interleukin-4 receptor is also a component of the interleukin-13 receptor. J. Biol. Chem. 270, 13869-13878.