Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6/2 fragment model

Experimental Neurology

Volumn 288, Issue , 2017, Pages 167-175

  Hering, Tanja ^a   Kojer, Kerstin ^a   Birth, Nathalie ^a   Hallitsch, Jaqueline ^a   Taanman, Jan Willem ^b   Orth, Michael ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Caspase 3; Cristae integrity; Fission and fusion; Mitofilin; OPA 1 oligomerisation

Indexed keywords

CASPASE 3; CYTOCHROME C; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; MITOFUSIN 2; PROTEIN DRP1; PROTEIN MITOFILIN; PROTEIN OPA1; UNCLASSIFIED DRUG; DNM1L PROTEIN, MOUSE; DYNAMIN; HTT PROTEIN, HUMAN; HUNTINGTIN; MFN1 PROTEIN, MOUSE; MFN2 PROTEIN, MOUSE; MITOCHONDRIAL DNA; NDUFA9 PROTEIN, HUMAN; OPA1 PROTEIN (GTPASE), MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL FUSION; CORPUS STRIATUM; CYTOPLASM; ELECTRON MICROSCOPY; ENZYME ACTIVATION; HUNTINGTON CHOREA; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; GENETICS; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; PATHOLOGY; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; ULTRASTRUCTURE;

ANIMALS; CASPASE 3; CEREBRAL CORTEX; CORPUS STRIATUM; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; DYNAMINS; ELECTRON TRANSPORT COMPLEX I; GTP PHOSPHOHYDROLASES; HUNTINGTIN PROTEIN; HUNTINGTON DISEASE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; TRINUCLEOTIDE REPEATS;

EID: 85000839132     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2016.10.017     Document Type: Article

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