Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease

Journal of Neurochemistry

Volumn 87, Issue 5, 2003, Pages 1184-1192

  Zhang, Yu ^a   Ona, Victor O ^a   Li, Mingwei ^a   Drozda, Martin ^a   Dubois Dauphin, Michel ^b   Przedborski, Serge ^c   Ferrante, Robert J ^f   Friedlander, Robert M ^a,d,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Boston University School of Medicine ^*

Author keywords

Bcl 2; Caspase; Huntington's disease; Transgenic mice

Indexed keywords

CASPASE; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CROSS BREEDING; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; HUNTINGTON CHOREA; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

ANIMALIA; MUS MUSCULUS;

EID: 0344010993     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02105.x     Document Type: Article

References (48)

1. Adams J. M. and Cory S. (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-1326.
2. Alberi S., Raggenbass M., de Bilbao F. and Dubois-Dauphin M. (1996) Axotomized neonatal motoneurons overexpressing the bcl2 protooncogene retain functional electrophysiological properties. Proc. Natl Acad. Sci. USA 93, 3978-3983.
3. Antonsson B., Montessuit S., Sanchez B. and Martinou J. C. (2001) Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J. Biol. Chem. 276, 11615-11623.
4. Bizat N., Hermel J. M., Boyer F. et al. (2003) Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease. J. Neurosci. 23, 5020-5030.
5. Boise L. H., Gonzalez-Garcia M., Postema C. E. et al. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608.
6. Cha J. H. (2000) Transcriptional dysregulation in Huntington's disease. Trends Neurosci. 23, 387-392.
7. Chen M., Ona V. O., Li M. et al. (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat. Med. 6, 797-801.
8. Chen M., He H., Zhan S., Krajewski S., Reed J. C. and Gottlieb R. A. (2001) Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion. J. Biol. Chem. 276, 30724-30728.
9. Chen M., Won D. J., Krajewski S. and Gottlieb R. A. (2002) Calpain and mitochondria in ischemia/reperfusion injury. J. Biol. Chem. 277, 29181-29186.
10. Datta S. R., Katsov A., Hu L., Petros A., Fesik S. W., Yaffe M. B. and Greenberg M. E. (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell 6, 41-51.
11. Du, C., Fang M., Li Y., Li L. and Wang X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42.
12. Dubois-Dauphin M., Frankowski H., Tsujimoto Y., Huarte J. and Mar2tinou J. C. (1994) Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl Acad. Sci. USA 91, 3309-3313.
13. Ferrante R. J., Kowall N. W. and Richardson E. P. Jr (1991) Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry. J. Neurosci. 11, 3877-3887.
14. Fraser A. and Evan G. (1996) A license to kill. Cell 85, 781-784.
15. Friedlander R. M. (2003) Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 348, 1365-1375.
16. Friedlander R. M., Gagliardini V., Hara H. et al. (1997) Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185, 933-940.
17. Gafni J. and Ellerby L. M. (2002) Calpain activation in Huntington's disease. J. Neurosci. 22, 4842-4849.
18. Green D. R. and Reed J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
19. Guegan C., Vila M., Teissman P., Chen C., Onteniente B., Li M., Friedlander R. and Przedborski S. (2002) Instrumental activation of Bid by caspase-1 in a transgenic mouse model of ALS. Mol. Cell Neurosci. 20, 553.
20. Huntington's Disease Collaborative Research Group. (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
21. Kiechle T., Dedeoglu A., Kubilus J., Kowall N. W., Beal M. F., Friedlander R., Hersch S. M. and Ferrante R. J. (2002) Cytochrome c and caspase-9 expression in Huntington's disease. Neuromol. Med. 1, 183-195.
22. Kostic V., Jackson-Lewis V., de Bilbao F., Dubois-Dauphin M. and Przedborski S. (1997) Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277, 559-562.
23. Kroemer G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3, 614-620.
24. Li H., Zhu H., Xu C. J. and Yuan J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501.
25. Li L. Y., Luo X. and Wang X. (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95-99.
26. Li M., Ona V. O., Chen M., Kaul M., Tenneti L., Zhang X., Stieg P. E., Lipton S. A. and Friedlander R. M. (2000a) Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience 99, 333-342.
27. Li M., Ona V. O., Guegan C. et al. (2000b) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288, 335-339.
28. Li P., Nijhawan D., Budihardjo I., Srinivasula S. M., Ahmad M., Alnemri E. S. and Wang X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
29. Li S. H., Lam S., Cheng A. L. and Li X. J. (2000c) Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis. Hum. Mol. Genet. 9, 2859-2867.
30. Luo X., Budihardjo I., Zou H., Slaughter C. and Wang X. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490.
31. Mangiarini L., Sathasivam K., Seller M. et al. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493-506.
32. Martin S. J. and Green D. R. (1995) Protease activation during apoptosis: death by a thousand cuts? Cell 82, 349-352.
33. Nechushtan A., Smith C. L., Lamensdorf I., Yoon S. H. and Youle R. J. (2001) Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell Biol. 153, 1265-1276.
34. Nicholson D. W., Ali A., Thornberry N. A. et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
35. Ona V. O., Li M., Vonsattel J. P. et al. (1999) Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399, 263-267.
36. Pang Z., Bondada V., Sengoku T., Siman R. and Geddes J. W. (2003) Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology. J. Neuropathol. Exp. Neurol. 62, 633-643.
37. Putcha G. V., Moulder K. L., Golden J. P., Bouillet P., Adams J. A., Strasser A. and Johnson E. M. (2001) Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 29, 615-628.
38. Sanchez I., Xu C. J., Juo P., Kakizaka A., Blenis J. and Yuan J. (1999) Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron 22, 623-633.
39. Susin S. A., Lorenzo H. K., Zamzami N. et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446.
40. Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K. and Takahashi R. (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8, 613-621.
41. Talanian R. V., Quinlan C., Trautz S., Hackett M. C., Mankovich J. A., Banach D., Ghayur T., Brady K. D. and Wong W. W. (1997) Substrate specificities of caspase family proteases. J. Biol. Chem 272, 9677-9682.
42. Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salvesen G. S. and Dixit V. M. (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly-(ADP-ribose) polymerase. Cell 81, 801-809.
43. Thornberry N. A., Rano T. A., Peterson E. P. et al. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907-17911.
44. Turmaine M., Raza A., Mahal A., Mangiarini L., Bates G. P. and Davies S. W. (2000) Non-apoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. Proc. Natl Acad. Sci. USA 97, 8093-8097.
45. Yu Z. X., Li S. H., Evans J., Pillarisetti A., Li H. and Li X. J. (2003) Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J. Neurosci. 23, 2193-2202.
46. Yuan J., Shaham S., Ledoux S., Ellis H. M. and Horvitz H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75, 641-652.
47. Zha J., Harada H., Yang E., Jockel J. and Korsmeyer S. J. (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X (L). Cell 87, 619-628.
48. Zou H., Henzel W. J., Liu X., Lutschg A. and Wang X. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413