The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

Retina

Volumn 37, Issue 5, 2017, Pages 819-835

  Boyer, David S ^a   Schmidt Erfurth, Ursula ^b   Van Lookeren Campagne, Menno ^c   Henry, Erin C ^c   Brittain, Christopher ^d  

^a RETINA VITREOUS ASSOCIATES MEDICAL GROUP   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c GENENTECH INC   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Age related macular degeneration; Atrophy; Complement; Eculizumab; Geographic atrophy; Lampalizumab

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX; CRYOPYRIN; ECULIZUMAB; INFLAMMASOME; LAMPALIZUMAB; LECTIN; MONOCLONAL ANTIBODY;

AGE RELATED MACULAR DEGENERATION; AGED; AGING; CELL DEATH; CHRONIC INFLAMMATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; DIAGNOSTIC IMAGING; DISEASE COURSE; ENVIRONMENTAL STRESS; GENETIC RISK; GEOGRAPHIC ATROPHY; HOST CELL; HUMAN; IMMUNOPATHOGENESIS; MEDLINE; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRECLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETINA CELL; RETINA EXAMINATION; REVIEW; SYSTEMATIC REVIEW; CLINICAL TRIAL (TOPIC); COMPLICATION; ENVIRONMENT; MACULAR DEGENERATION; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; PROCEDURES;

AGING; ANTIBODIES, MONOCLONAL, HUMANIZED; CLINICAL TRIALS AS TOPIC; COMPLEMENT SYSTEM PROTEINS; ENVIRONMENT; GEOGRAPHIC ATROPHY; HUMANS; MACULAR DEGENERATION; MOLECULAR TARGETED THERAPY;

EID: 85000766760     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0000000000001392     Document Type: Review

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