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Volumn 54, Issue 3, 2013, Pages 2225-2237

Inflammatory mediators induced by amyloid-beta in the retina and RPE In Vivo: Implications for inflammasome activation in age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [1-40]; CRYOPYRIN; CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN G ANTIBODY; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84875661147     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10849     Document Type: Article
Times cited : (127)

References (67)
  • 1
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of agerelated macular degeneration in the United States
    • The Eye Diseases Prevalence Research Group
    • The Eye Diseases Prevalence Research Group. Prevalence of agerelated macular degeneration in the United States. Arch Ophthalmol. 2004;122:564-572.
    • (2004) Arch Ophthalmol. , vol.122 , pp. 564-572
  • 2
    • 0019020390 scopus 로고
    • The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975
    • Leibowitz HM, Krueger DE, Maunder LR, et al. The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol. 1980;24:335-610.
    • (1980) Surv Ophthalmol. , vol.24 , pp. 335-610
    • Leibowitz, H.M.1    Krueger, D.E.2    Maunder, L.R.3
  • 3
    • 0028934221 scopus 로고
    • An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group
    • Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995;39:367-374.
    • (1995) Surv Ophthalmol. , vol.39 , pp. 367-374
    • Bird, A.C.1    Bressler, N.M.2    Bressler, S.B.3
  • 5
    • 0034832029 scopus 로고    scopus 로고
    • An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-bruch's membrane interface in aging and age-related macular degeneration
    • Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705-732.
    • (2001) Prog Retin Eye Res. , vol.20 , pp. 705-732
    • Hageman, G.S.1    Luthert, P.J.2    Victor Chong, N.H.3    Johnson, L.V.4    Anderson, D.H.5    Mullins, R.F.6
  • 6
    • 0036788613 scopus 로고    scopus 로고
    • Ten-year incidence and progression of age-related maculopathy: The Beaver Dam Eye Study
    • Klein R, Klein BE, Tomany SC, Meuer SM, Huang GH. Ten-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 2002;109:1767-1779.
    • (2002) Ophthalmology. , vol.109 , pp. 1767-1779
    • Klein, R.1    Klein, B.E.2    Tomany, S.C.3    Meuer, S.M.4    Huang, G.H.5
  • 7
    • 79957594942 scopus 로고    scopus 로고
    • Current clinical trials in dry AMD and the definition of appropriate clinical outcome measures
    • Yehoshua Z, Rosenfeld PJ, Albini TA. Current clinical trials in dry AMD and the definition of appropriate clinical outcome measures. Semin Ophthalmol. 2011;26:167-180.
    • (2011) Semin Ophthalmol. , vol.26 , pp. 167-180
    • Yehoshua, Z.1    Rosenfeld, P.J.2    Albini, T.A.3
  • 8
    • 0037015020 scopus 로고    scopus 로고
    • The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    • Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A. 2002;99:11830-11835.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 11830-11835
    • Johnson, L.V.1    Leitner, W.P.2    Rivest, A.J.3    Staples, M.K.4    Radeke, M.J.5    Anderson, D.H.6
  • 9
    • 63549133336 scopus 로고    scopus 로고
    • Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells
    • Bruban J, Glotin AL, Dinet V, et al. Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell. 2009;8:162-177.
    • (2009) Aging Cell. , vol.8 , pp. 162-177
    • Bruban, J.1    Glotin, A.L.2    Dinet, V.3
  • 10
    • 25144499030 scopus 로고    scopus 로고
    • Amyloid beta peptide causes chronic glial cell activation and neuro-degeneration after intravitreal injection
    • Walsh DT, Bresciani L, Saunders D, et al. Amyloid beta peptide causes chronic glial cell activation and neuro-degeneration after intravitreal injection. Neuropathol Appl Neurobiol. 2005;31: 491-502.
    • (2005) Neuropathol Appl Neurobiol. , vol.31 , pp. 491-502
    • Walsh, D.T.1    Bresciani, L.2    Saunders, D.3
  • 11
    • 0037975774 scopus 로고    scopus 로고
    • Amyloid-b is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas
    • Dentchev T, Milam AH, Lee V, Trojanowski JQ, Dunaief JL. Amyloid-b is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis. 2003;9:184-190.
    • (2003) Mol Vis. , vol.9 , pp. 184-190
    • Dentchev, T.1    Milam, A.H.2    Lee, V.3    Trojanowski, J.Q.4    Dunaief, J.L.5
  • 12
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003;300:486-489.
    • (2003) Science. , vol.300 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3
  • 13
    • 77949895577 scopus 로고    scopus 로고
    • Soluble and mature amyloid fibrils in drusen deposits
    • Isas JM, Luibl V, Johnson LV, et al. Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci. 2010;51: 1304-1310.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 1304-1310
    • Isas, J.M.1    Luibl, V.2    Johnson, L.V.3
  • 14
    • 0037200117 scopus 로고    scopus 로고
    • Oligomeric and fibrillar species of amyloid-b peptides differentially affect neuronal viability
    • Dahlgren KN, Manelli AM, Stine WB, Baker LK, Krafft GA, LaDu MJ. Oligomeric and fibrillar species of amyloid-b peptides differentially affect neuronal viability. J Biol Chem. 2002;277: 32046-32053.
    • (2002) J Biol Chem. , vol.277 , pp. 32046-32053
    • Dahlgren, K.N.1    Manelli, A.M.2    Stine, W.B.3    Baker, L.K.4    Krafft, G.A.5    LaDu, M.J.6
  • 15
    • 77449129224 scopus 로고    scopus 로고
    • Microarray analysis identifies changes in inflammatory gene expression in response to amyloid-b stimulation of cultured human retinal pigment epithelial cells
    • Kurji KH, Cui JZ, Lin T, et al. Microarray analysis identifies changes in inflammatory gene expression in response to amyloid-b stimulation of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:1151-1163.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 1151-1163
    • Kurji, K.H.1    Cui, J.Z.2    Lin, T.3
  • 16
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    • Halle A, Hornung V, Petzold GC, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008;9:857-865.
    • (2008) Nat Immunol. , vol.9 , pp. 857-865
    • Halle, A.1    Hornung, V.2    Petzold, G.C.3
  • 17
    • 84860883878 scopus 로고    scopus 로고
    • DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
    • Tarallo V, Hirano Y, Gelfand B, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012;149:847-859.
    • (2012) Cell. , vol.149 , pp. 847-859
    • Tarallo, V.1    Hirano, Y.2    Gelfand, B.3
  • 18
    • 84865369140 scopus 로고    scopus 로고
    • Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD)
    • Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD). Immunol Lett. 2012;147:29-33.
    • (2012) Immunol Lett. , vol.147 , pp. 29-33
    • Kauppinen, A.1    Niskanen, H.2    Suuronen, T.3    Kinnunen, K.4    Salminen, A.5    Kaarniranta, K.6
  • 19
    • 39749084641 scopus 로고    scopus 로고
    • Active caspase-1 is a regulator of unconventional protein secretion
    • Keller M, R̈uegg A, Werner S, Beer H. Active caspase-1 is a regulator of unconventional protein secretion. Cell. 2008;132: 818-831.
    • (2008) Cell. , vol.132 , pp. 818-831
    • Keller, M.1    R̈uegg, A.2    Werner, S.3    Beer, H.4
  • 20
    • 79955940404 scopus 로고    scopus 로고
    • Tumor necrosis factoralpha mediates photoreceptor death in a rodent model of retinal detachment
    • Nakazawa T, Kayama M, Ryu M, et al. Tumor necrosis factoralpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011;52:1384-1391.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 1384-1391
    • Nakazawa, T.1    Kayama, M.2    Ryu, M.3
  • 21
    • 80053935409 scopus 로고    scopus 로고
    • Characterisation of amyloidinduced inflammatory responses in the rat retina
    • Howlett D, Bate S, Collier S, et al. Characterisation of amyloidinduced inflammatory responses in the rat retina. Exp Brain Res. 2011;214:185-197.
    • (2011) Exp Brain Res. , vol.214 , pp. 185-197
    • Howlett, D.1    Bate, S.2    Collier, S.3
  • 22
    • 57649119813 scopus 로고    scopus 로고
    • Weekly vaccination with copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration
    • Landa G, Butovsky O, Shoshani J, Schwartz M, Pollack A. Weekly vaccination with copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration. Curr Eye Res. 2008;33:1011-1013.
    • (2008) Curr Eye Res. , vol.33 , pp. 1011-1013
    • Landa, G.1    Butovsky, O.2    Shoshani, J.3    Schwartz, M.4    Pollack, A.5
  • 23
    • 84875673880 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability study of RN6G in subjects with geographic atrophy secondary to age-related macular degeneration
    • Pfizer. Available at: Accessed January 2, 2013
    • Pfizer. Efficacy, safety and tolerability study of RN6G in subjects with geographic atrophy secondary to age-related macular degeneration. ClinicalTrials. gov. 2012. Available at: http:// www.clinicaltrials.gov/ct2/show/NCT01577381. Accessed January 2, 2013.
    • (2012) ClinicalTrials. gov.
  • 24
    • 80053946788 scopus 로고    scopus 로고
    • Glial and endothelial bloodretinal barrier responses to amyloid-b in the neural retina of the rat
    • Anderson P, Watts H, Hille C, et al. Glial and endothelial bloodretinal barrier responses to amyloid-b in the neural retina of the rat. Clin Ophthalmol. 2008;2:801-816.
    • (2008) Clin Ophthalmol. , vol.2 , pp. 801-816
    • Anderson, P.1    Watts, H.2    Hille, C.3
  • 25
    • 0036311275 scopus 로고    scopus 로고
    • Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms
    • Walsh DT, Montero RM, Bresciani LG, et al. Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms. Neurobiol Dis. 2002;10:20-27.
    • (2002) Neurobiol Dis. , vol.10 , pp. 20-27
    • Walsh, D.T.1    Montero, R.M.2    Bresciani, L.G.3
  • 26
    • 56149088067 scopus 로고    scopus 로고
    • Amyloid-b deposits lead to retinal degeneration in a mouse model of Alzheimer disease
    • Ning A, Cui J, To E, Ashe KH, Matsubara J. Amyloid-b deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci. 2008;49:5136-5143.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , pp. 5136-5143
    • Ning, A.1    Cui, J.2    To, E.3    Ashe, K.H.4    Matsubara, J.5
  • 27
    • 79952576761 scopus 로고    scopus 로고
    • Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT
    • Guo L, Normando EM, Nizari S, Lara D, Cordeiro MF. Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT. Invest Ophthalmol Vis Sci. 2010;51:6504-6513.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 6504-6513
    • Guo, L.1    Normando, E.M.2    Nizari, S.3    Lara, D.4    Cordeiro, M.F.5
  • 29
    • 78049299159 scopus 로고    scopus 로고
    • Viewing ageing eyes: Diverse sites of amyloid beta accumulation in the ageing mouse retina and the up-regulation of macrophages
    • Hoh Kam J, Lenassi E, Jeffery G. Viewing ageing eyes: diverse sites of amyloid beta accumulation in the ageing mouse retina and the up-regulation of macrophages. PLoS One. 2010;5: e13127.
    • (2010) PLoS One. , vol.5
    • Hoh Kam, J.1    Lenassi, E.2    Jeffery, G.3
  • 30
    • 20644467790 scopus 로고    scopus 로고
    • Progression of agerelated macular degeneration: Prospective assessment of Creactive protein, interleukin 6, and other cardiovascular biomarkers
    • Seddon JM, George S, Rosner B, Rifai N. Progression of agerelated macular degeneration: prospective assessment of Creactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol. 2005;123:774-782.
    • (2005) Arch Ophthalmol. , vol.123 , pp. 774-782
    • Seddon, J.M.1    George, S.2    Rosner, B.3    Rifai, N.4
  • 31
    • 0034773951 scopus 로고    scopus 로고
    • Activation of p38, ERK1/2 and NIK pathways is required for IL-1b and TNFa-induced chemokine expression in human retinal pigment epithelial cells
    • Bian Z, Elner SG, Yoshida A, Kunkel SL, Su J, Elner VM. Activation of p38, ERK1/2 and NIK pathways is required for IL-1b and TNFa-induced chemokine expression in human retinal pigment epithelial cells. Exp Eye Res. 2001;73:111-121.
    • (2001) Exp Eye Res. , vol.73 , pp. 111-121
    • Bian, Z.1    Elner, S.G.2    Yoshida, A.3    Kunkel, S.L.4    Su, J.5    Elner, V.M.6
  • 32
    • 26444478610 scopus 로고    scopus 로고
    • The potential role of amyloid beta in the pathogenesis of age-related macular degeneration
    • Yoshida T, Ohno-Matsui K, Ichinose S, et al. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest. 2005;115:2793-2800.
    • (2005) J Clin Invest. , vol.115 , pp. 2793-2800
    • Yoshida, T.1    Ohno-Matsui, K.2    Ichinose, S.3
  • 33
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-b
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-b. Mol Cell. 2002;10:417-426.
    • (2002) Mol Cell. , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 34
    • 0028786675 scopus 로고
    • Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy
    • Elner S, Elner V, Jaffe G, Stuart A, Kunkel S, Strieter R. Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Curr Eye Res. 1995;14:1045-1053.
    • (1995) Curr Eye Res. , vol.14 , pp. 1045-1053
    • Elner, S.1    Elner, V.2    Jaffe, G.3    Stuart, A.4    Kunkel, S.5    Strieter, R.6
  • 35
    • 57949103669 scopus 로고    scopus 로고
    • Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion
    • Noma H, Funatsu H, Mimura T, Harino S, Hori S. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. Ophthalmology. 2009;116:87-93.
    • (2009) Ophthalmology. , vol.116 , pp. 87-93
    • Noma, H.1    Funatsu, H.2    Mimura, T.3    Harino, S.4    Hori, S.5
  • 36
    • 65549156409 scopus 로고    scopus 로고
    • Amyloid-beta upregulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in agerelated macular degeneration
    • Wang J, Ohno-Matsui K, Yoshida T, et al. Amyloid-beta upregulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: another mechanism of complement activation in agerelated macular degeneration. J Cell Physiol. 2009;220:119-128.
    • (2009) J Cell Physiol. , vol.220 , pp. 119-128
    • Wang, J.1    Ohno-Matsui, K.2    Yoshida, T.3
  • 37
    • 70949092319 scopus 로고    scopus 로고
    • Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: A potential cellular interaction relevant to AMD
    • Ma W, Zhao L, Fontainhas AM, Fariss RN, Wong WT. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PLoS One. 2009;4:e7945.
    • (2009) PLoS One. , vol.4
    • Ma, W.1    Zhao, L.2    Fontainhas, A.M.3    Fariss, R.N.4    Wong, W.T.5
  • 38
    • 77952059124 scopus 로고    scopus 로고
    • Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    • Rosenbaum DM, Degterev A, David J, et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010;88:1569.
    • (2010) J Neurosci Res. , vol.88 , pp. 1569
    • Rosenbaum, D.M.1    Degterev, A.2    David, J.3
  • 39
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14:835-846.
    • (2000) FASEB J. , vol.14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 40
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385-389.
    • (2005) Science. , vol.308 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 41
    • 77955864782 scopus 로고    scopus 로고
    • Interferon c-inducible protein-10 (IP-10) and eotaxin as biomarkers in agerelated macular degeneration
    • Mo FM, Proia AD, Johnson WH, Cyr D, Lashkari K. Interferon c-inducible protein-10 (IP-10) and eotaxin as biomarkers in agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2010; 51:4226-4236.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 4226-4236
    • Mo, F.M.1    Proia, A.D.2    Johnson, W.H.3    Cyr, D.4    Lashkari, K.5
  • 43
    • 77954551693 scopus 로고    scopus 로고
    • Differential accumulation of secreted AbPP metabolites in ocular fluids
    • Prakasam A, Muthuswamy A, Ablonczy Z, et al. Differential accumulation of secreted AbPP metabolites in ocular fluids. J Alzheimers Dis. 2010;20:1243-1253.
    • (2010) J Alzheimers Dis. , vol.20 , pp. 1243-1253
    • Prakasam, A.1    Muthuswamy, A.2    Ablonczy, Z.3
  • 44
    • 0035219629 scopus 로고    scopus 로고
    • Retinal pigment epithelium-immune system interactions: Cytokine production and cytokine-induced changes
    • Holtkamp GM, Kijlstra A, Peek R, de Vos AF. Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retin Eye Res. 2001;20:29-48.
    • (2001) Prog Retin Eye Res. , vol.20 , pp. 29-48
    • Holtkamp, G.M.1    Kijlstra, A.2    Peek, R.3    de Vos, A.F.4
  • 45
    • 0027215297 scopus 로고
    • Retinal pigment epithelial cells produce interleukin-1 beta and granulocyte-macrophage colony-stimulating factor in response to interleukin-1 alpha
    • Planck SR, Huang XN, Robertson JE, Rosenbaum JT. Retinal pigment epithelial cells produce interleukin-1 beta and granulocyte-macrophage colony-stimulating factor in response to interleukin-1 alpha. Curr Eye Res. 1993;12:205-212.
    • (1993) Curr Eye Res. , vol.12 , pp. 205-212
    • Planck, S.R.1    Huang, X.N.2    Robertson, J.E.3    Rosenbaum, J.T.4
  • 46
    • 33746896241 scopus 로고    scopus 로고
    • Characterization of cytokine responses to retinal detachment in rats
    • Nakazawa T, Matsubara A, Noda K, et al. Characterization of cytokine responses to retinal detachment in rats. Mol Vis. 2006; 12:867-878.
    • (2006) Mol Vis. , vol.12 , pp. 867-878
    • Nakazawa, T.1    Matsubara, A.2    Noda, K.3
  • 47
    • 0026737279 scopus 로고
    • Expression of interleukin-1a, interleukin-1b, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells
    • Jaffe GJ, Van Le L, Valea F, et al. Expression of interleukin-1a, interleukin-1b, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. Exp Eye Res. 1992;55: 325-335.
    • (1992) Exp Eye Res. , vol.55 , pp. 325-335
    • Jaffe, G.J.1    van le, L.2    Valea, F.3
  • 48
    • 0026553503 scopus 로고
    • Interleukin-6 (IL-6) gene expression and secretion by cytokinestimulated human retinal pigment epithelial cells
    • Elner VM, Scales W, Elner SG, Danforth J, Kunkel SL, Strieter RM. Interleukin-6 (IL-6) gene expression and secretion by cytokinestimulated human retinal pigment epithelial cells. Exp Eye Res. 1992;54:361-368.
    • (1992) Exp Eye Res. , vol.54 , pp. 361-368
    • Elner, V.M.1    Scales, W.2    Elner, S.G.3    Danforth, J.4    Kunkel, S.L.5    Strieter, R.M.6
  • 49
    • 0029838545 scopus 로고    scopus 로고
    • Increased cytokine gene expression in rat retina following transient ischemia
    • Hangai M, Yoshimura N, Honda Y. Increased cytokine gene expression in rat retina following transient ischemia. Ophthalmic Res. 1996;28:248-254.
    • (1996) Ophthalmic Res. , vol.28 , pp. 248-254
    • Hangai, M.1    Yoshimura, N.2    Honda, Y.3
  • 51
    • 79953305489 scopus 로고    scopus 로고
    • The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells
    • Chen Y, Yang P, Li F, Kijlstra A. The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells. PLoS One. 2011;6:e18139.
    • (2011) PLoS One. , vol.6
    • Chen, Y.1    Yang, P.2    Li, F.3    Kijlstra, A.4
  • 52
    • 84860671364 scopus 로고    scopus 로고
    • NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
    • Doyle SL, Campbell M, Ozaki E, et al. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med. 2012;18:791-798.
    • (2012) Nat Med. , vol.18 , pp. 791-798
    • Doyle, S.L.1    Campbell, M.2    Ozaki, E.3
  • 53
    • 84855383301 scopus 로고    scopus 로고
    • Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells
    • Bian ZM, Elner SG, Khanna H, Murga-Zamalloa CA, Patil S, Elner VM. Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011;52:8646-8656.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 8646-8656
    • Bian, Z.M.1    Elner, S.G.2    Khanna, H.3    Murga-Zamalloa, C.A.4    Patil, S.5    Elner, V.M.6
  • 54
    • 3142653063 scopus 로고    scopus 로고
    • Effect of NF-jB inhibition on TNF-a-induced apoptosis in human RPE cells
    • Yang P, McKay BS, Allen JB, Jaffe GJ. Effect of NF-jB inhibition on TNF-a-induced apoptosis in human RPE cells. Invest Ophthalmol Vis Sci. 2004;45:2438-2446.
    • (2004) Invest Ophthalmol Vis Sci. , vol.45 , pp. 2438-2446
    • Yang, P.1    McKay, B.S.2    Allen, J.B.3    Jaffe, G.J.4
  • 56
    • 0036875316 scopus 로고    scopus 로고
    • The role of apoptosis in age-related macular degeneration
    • Dunaief JL, Dentchev T, Ying G, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol. 2002; 120:1435-1442.
    • (2002) Arch Ophthalmol. , vol.120 , pp. 1435-1442
    • Dunaief, J.L.1    Dentchev, T.2    Ying, G.3    Milam, A.H.4
  • 57
    • 33646252040 scopus 로고    scopus 로고
    • Xaf1 can cooperate with TNFa in the induction of apoptosis, independently of interaction with XIAP
    • Xia Y, Novak R, Lewis J, Duckett C, Phillips A. Xaf1 can cooperate with TNFa in the induction of apoptosis, independently of interaction with XIAP. Mol Cell Biochem. 2006;286:67-76.
    • (2006) Mol Cell Biochem. , vol.286 , pp. 67-76
    • Xia, Y.1    Novak, R.2    Lewis, J.3    Duckett, C.4    Phillips, A.5
  • 58
    • 69349092336 scopus 로고    scopus 로고
    • Downregulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
    • Kempkensteffen C, Fritzsche FR, Johannsen M, et al. Downregulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. BMC Cancer. 2009; 9:276.
    • (2009) BMC Cancer. , vol.9 , pp. 276
    • Kempkensteffen, C.1    Fritzsche, F.R.2    Johannsen, M.3
  • 59
    • 23844463473 scopus 로고    scopus 로고
    • Apolipoprotein E alleledependent pathogenesis: A model for age-related retinal degeneration
    • Malek G, Johnson LV, Mace BE, et al. Apolipoprotein E alleledependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A. 2005;102:11900-11905.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , pp. 11900-11905
    • Malek, G.1    Johnson, L.V.2    Mace, B.E.3
  • 60
    • 42449086469 scopus 로고    scopus 로고
    • Ccl2/Cx3cr1-deficient mice: An animal model for age-related macular degeneration
    • Chan CC, Ross RJ, Shen D, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 2008;40:124-128.
    • (2008) Ophthalmic Res. , vol.40 , pp. 124-128
    • Chan, C.C.1    Ross, R.J.2    Shen, D.3
  • 61
    • 0344676389 scopus 로고    scopus 로고
    • An animal model of agerelated macular degeneration in senescent ccl-2-or ccr-2-deficient mice
    • Ambati J, Anand A, Fernandez S, et al. An animal model of agerelated macular degeneration in senescent ccl-2-or ccr-2-deficient mice. Nat Med. 2003;9:1390-1397.
    • (2003) Nat Med. , vol.9 , pp. 1390-1397
    • Ambati, J.1    Anand, A.2    Fernandez, S.3
  • 62
    • 79961159284 scopus 로고    scopus 로고
    • Dysregulation in retinal parainflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice
    • Chen M, Forrester JV, Xu H. Dysregulation in retinal parainflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One. 2011;6:e22818.
    • (2011) PLoS One. , vol.6
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 63
    • 79951561948 scopus 로고    scopus 로고
    • The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment
    • Wang Y, Wang VM, Chan CC. The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye. 2011;25:127-139.
    • (2011) Eye. , vol.25 , pp. 127-139
    • Wang, Y.1    Wang, V.M.2    Chan, C.C.3
  • 64
    • 0041360231 scopus 로고    scopus 로고
    • Interleukin-6 in retinal ischemia reperfusion injury in rats
    • Sanchez RN, Chan CK, Garg S, et al. Interleukin-6 in retinal ischemia reperfusion injury in rats. Invest Ophthalmol Vis Sci. 2003;44:4006-4011.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , pp. 4006-4011
    • Sanchez, R.N.1    Chan, C.K.2    Garg, S.3
  • 65
    • 2542441798 scopus 로고    scopus 로고
    • Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green
    • Peinnequin A, Mouret C, Birot O, et al. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol. 2004;5:3.
    • (2004) BMC Immunol. , vol.5 , pp. 3
    • Peinnequin, A.1    Mouret, C.2    Birot, O.3
  • 66
    • 1642348866 scopus 로고    scopus 로고
    • Angiogenesis-inflammation crosstalk: Vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
    • Mor F, Quintana FJ, Cohen IR. Angiogenesis-inflammation crosstalk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J Immunol. 2004;172: 4618-4623.
    • (2004) J Immunol. , vol.172 , pp. 4618-4623
    • Mor, F.1    Quintana, F.J.2    Cohen, I.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.