Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 2, 2011, Pages 1119-1126

  Meleth, Annal D ^a   Mettu, Pradeep ^a   Agrón, Elvira ^a   Chew, Emily Y ^a   Sadda, Srinivas R ^b   Ferris, Frederick L ^a   Wong, Wai T ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE EYE; OT 551; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOFLUORESCENCE IMAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EYE FIXATION; EYE FUNDUS; FEMALE; GEOGRAPHIC ATROPHY; HUMAN; IMAGE ANALYSIS; MALE; MICROPERIMETRY; OUTCOME ASSESSMENT; PERIMETRY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA MACULA LUTEA; RETINA SPECTRAL SENSITIVITY; SCOTOMA; VISUAL SYSTEM PARAMETERS; AGED; CLINICAL TRIAL; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA; VISUAL ACUITY;

AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; GEOGRAPHIC ATROPHY; HUMANS; MALE; RETINA; SCOTOMA; VISUAL ACUITY; VISUAL FIELD TESTS;

EID: 79953276957     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6075     Document Type: Article

References (42)

1. Hirvela H, Luukinen H, Laara E, Sc L, Laatikainen L. Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology. 1996;103:871-877.
2. Smith W, Assink J, Klein R, et al. Risk factors for age-related macular degeneration: pooled findings from three continents. Ophthalmology. 2001;108:697-704.
3. Rein DB, Wittenborn JS, Zhang X, Honeycutt AA, Lesesne SB, Saaddine J. Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments. Arch Ophthalmol. 2009;127:533-540.
4. Fleckenstein M, Charbel Issa P, Helb HM, et al. High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:4137-4144.
5. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond). 1988;2(pt 5):552-577.
6. Lindblad AS, Lloyd PC, Clemons TE, et al. Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26. Arch Ophthalmol. 2009;127:1168-1174.
7. Prahs P, Walter A, Regler R, et al. Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 248:651-658.
8. Mata NL, Vogel R. Pharmacologic treatment of atrophic age-related macular degeneration. Curr Opin Ophthalmol. 21:190-196.
9. Sunness JS, Bressler NM, Tian Y, Alexander J, Applegate CA. Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:1761-1769.
10. Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE. Fundus auto-fluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42: 1051-1056.
11. Fleckenstein M, Schmitz-Valckenberg S, Adrion C, et al. Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010;51:3846-3852.
12. Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology. 1991;98:741-756.
13. Sunness JS, Gonzalez-Baron J, Applegate CA, et al. Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology. 1999; 106:1768-1779.
14. Sunness JS, Applegate CA, Gonzalez-Baron J. Improvement of visual acuity over time in patients with bilateral geographic atrophy from age-related macular degeneration. Retina. 2000;20:162-169.
15. Sunness JS, Rubin GS, Applegate CA, et al. Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology. 1997;104: 1677-1691.
16. Sunness JS, Rubin GS, Broman A, Applegate CA, Bressler NM, Hawkins BS. Low luminance visual dysfunction as a predictor of subsequent visual acuity loss from geographic atrophy in agerelated macular degeneration. Ophthalmology. 2008;115:1480-1488, 1488 e1481-1482.
17. Sunness JS, Applegate CA, Haselwood D, Rubin GS. Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. Ophthalmology. 1996;103:1458-1466.
18. Schmitz-Valckenberg S, Bultmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2004;45:4470-4476.
19. Scholl HP, Bellmann C, Dandekar SS, Bird AC, Fitzke FW. Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci. 2004;45:574-583.
20. Shah VA, Chalam KV. Values for macular perimetry using the MP-1 microperimeter in normal subjects. Ophthalmic Res. 2009;41:9-13.
21. Boscarino MA, Johnson TM. Microperimetry in multiple evanescent white dot syndrome. Can J Ophthalmol. 2007;42:743-745.
22. Carpineto P, Ciancaglini M, Di Antonio L, Gavalas C, Mastropasqua L. Fundus microperimetry patterns of fixation in type 2 diabetic patients with diffuse macular edema. Retina. 2007;27:21-29.
23. Charbel Issa P, Helb HM, Holz FG, Scholl HP. Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia. Am J Ophthalmol. 2008;145: 169-175.
24. Schmitz-Valckenberg S, Ong EE, Rubin GS, et al. Structural and functional changes over time in MacTel patients. Retina. 2009;29: 1314-1320.
25. Springer C, Volcker HE, Rohrschneider K. [Central serous chorioretinopathy-retinal function and morphology: microperimetry and optical coherence tomography]. Ophthalmologe. 2006; 103:791-797.
26. Wong WT, Forooghian F, Majumdar Z, Bonner RF, Cunningham D, Chew EY. Fundus autofluorescence in type 2 idiopathic macular telangiectasia: correlation with optical coherence tomography and microperimetry. Am J Ophthalmol. 2009;148:573-583.
27. Rohrschneider K, Bultmann S, Springer C. Use of fundus perimetry (microperimetry) to quantify macular sensitivity. Prog Retin Eye Res. 2008;27:536-548.
28. Wong WT, Kam W, Cunningham D, et al. Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial. Invest Ophthalmol Vis Sci. 2010;51:6131-6139.
29. Springer C, Bultmann S, Volcker HE, Rohrschneider K. Fundus perimetry with the Micro Perimeter 1 in normal individuals: comparison with conventional threshold perimetry. Ophthalmology. 2005;112:848-854.
30. Klein R, Meuer SM, Knudtson MD, Klein BE. The epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye Study. Am J Ophthalmol. 2008;146:692-699.
31. Dreyhaupt J, Mansmann U, Pritsch M, Dolar-Szczasny J, Bindewald A, Holz FG. Modelling the natural history of geographic atrophy in patients with age-related macular degeneration. Ophthalmic Epidemiol. 2005;12:353-362.
32. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463-472.
33. Hwang JC, Chan JW, Chang S, Smith RT. Predictive value of fundus autofluorescence for development of geographic atrophy in agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2006; 47:2655-2661.
34. Klein ML, Ferris FL 3rd, Francis PJ, et al. Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology. 2010;117:1554-1559.
35. Scholl HP, Fleckenstein M, Fritsche LG, et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PloS ONE. 2009;4: e7418.
36. Sunness JS, Applegate CA. Long-term follow-up of fixation patterns in eyes with central scotomas from geographic atrophy that is associated with age-related macular degeneration. Am J Ophthalmol. 2005;140:1085-1093.
37. Crossland MD, Dunbar HM, Rubin GS. Fixation stability measurement using the MP1 microperimeter. Retina. 2009;29:651-656.
38. Tarita-Nistor L, Gonzalez EG, Markowitz SN, Steinbach MJ. Plasticity of fixation in patients with central vision loss. Vis Neurosci. 2009;26:487-494.
39. Tarita-Nistor L, Gonzalez EG, Markowitz SN, Steinbach MJ. Fixation characteristics of patients with macular degeneration recorded with the mp-1 microperimeter. Retina. 2008;28:125-133.
40. Midena E, Vujosevic S, Cavarzeran F. Normal values for fundus perimetry with the microperimeter MP1. Ophthalmology. 117: 1571-1576.e1.
41. Chen FK, Patel PJ, Xing W, et al. Test-retest variability of microperimetry using the Nidek MP1 in patients with macular disease. Invest Ophthalmol Vis Sci. 2009;50:3464-3472.
42. Chen FK, Uppal GS, MacLaren RE, et al. Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration. Clin Experiment Ophthalmol. 2009;37:275-285.