GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 23, 2016, Pages 5603-5612

  Chen, Cheng ^a,b   Li, He ^a   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI UNIVERSITY   (China)

Author keywords

Biased agonism; FFA1; Glucose stimulated insulin secretion; GPR40; Type 2 diabetes

Indexed keywords

AM 1638; AM 5262; AMG 837; ANTIDIABETIC AGENT; FASIGLIFAM; G PROTEIN COUPLED RECEPTOR 40; LY 2881835; PARTIAL AGONIST; TUG 424; TUG 488; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; SULFONE; TAK-875;

CHEMICAL STRUCTURE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; HUMAN; INSULIN RELEASE; LIPOPHILICITY; METABOLIC STABILITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACOKINETIC PARAMETERS; PHARMACOLOGICAL PARAMETERS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); RENAL CLEARANCE; REVIEW; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DRUG DEVELOPMENT; METABOLISM; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY;

ANIMALS; BENZOFURANS; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; HUMANS; HYPOGLYCEMIC AGENTS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; RECEPTORS, G-PROTEIN-COUPLED; SULFONES;

EID: 84996537009     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.10.074     Document Type: Review

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