Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes

Journal of Medicinal Chemistry

Volumn 51, Issue 22, 2008, Pages 7061-7064

  Christiansen, Elisabeth ^a   Urban, Christian ^b   Merten, Nicole ^c   Liebscher, Kathrin ^d   Karlsen, Kasper K ^a   Hamacher, Alexandra ^b   Spinrath, Andreas ^c   Bond, Andrew D ^a   Drewke, Christel ^c   Ullrich, Susanne ^d   Kassack, Matthias U ^b   Kostenis, Evi ^c   Ulven, Trond ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CINNAMIC ACID DERIVATIVE; FATTY ACID DERIVATIVE; GLUCOSE; GPR 40; GW 9508; INSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RAT;

ANIMALS; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GLUCOSE; HUMANS; INSULIN; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 56749163623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8010178     Document Type: Article

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