Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 13, 2014, Pages 2949-2953

  Takano, Rieko ^a   Yoshida, Masao ^a   Inoue, Masahiro ^a   Honda, Takeshi ^a   Nakashima, Ryutaro ^a   Matsumoto, Koji ^a   Yano, Tatsuya ^a   Ogata, Tsuneaki ^a   Watanabe, Nobuaki ^a   Toda, Narihiro ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Agonist; Diabetes; Glucose lowering; GPR40; Insulin secretagogue

Indexed keywords

3 ARYL 3 ETHOXYPROPANOIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR 40; ORAL ANTIDIABETIC AGENT; SITAGLIPTIN; UNCLASSIFIED DRUG; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR 40, RAT; GLUCOSE BLOOD LEVEL; PROPIONIC ACID; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROCESS OPTIMIZATION; RAT; AGONISTS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; FISCHER 344 RAT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; ZUCKER RAT;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GLUCOSE TOLERANCE TEST; HUMANS; MOLECULAR STRUCTURE; PROPIONATES; RATS; RATS, INBRED F344; RATS, ZUCKER; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901786045     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.065     Document Type: Article

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