Discovery of AM-1638: A potent and orally bioavailable GPR40/FFA1 full agonist

ACS Medicinal Chemistry Letters

Volumn 3, Issue 9, 2012, Pages 726-730

  Brown, Sean P ^a   Dransfield, Paul J ^a   Vimolratana, Marc ^a   Jiao, Xianyun ^a   Zhu, Liusheng ^a   Pattaropong, Vatee ^a   Sun, Ying ^a   Liu, Jinqian ^a   Luo, Jian ^a   Zhang, Jane ^a   Wong, Simon ^a   Zhuang, Run ^a   Guo, Qi ^a   Li, Frank ^a   Medina, Julio C ^a   Swaminath, Gayathri ^a   Lin, Daniel C H ^a   Houze, Jonathan B ^a  

^a AMGEN INC   (United States)

Author keywords

AM 1638; AMG 837; FFA1; full agonist; GPR40; insulin secretagogue

Indexed keywords

AM 1638; AMG 837; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; HORMONE RECEPTOR STIMULATING AGENT; PARTIAL AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; GLYCEMIC CONTROL; INSULIN BLOOD LEVEL; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

MUS;

EID: 84866357145     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300133f     Document Type: Article

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