SCOPUS 정보 검색 플랫폼

Volumn 23, Issue 20, 2015, Pages 6666-6672

Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

(8) Li, Zheng a Wang, Xuekun a Xu, Xue a Yang, Jianyong a Qiu, Qianqian a Qiang, Hao a Huang, Wenlong a Qian, Hai a

a CHINA PHARMACEUTICAL UNIVERSITY (China)

Author keywords

Amide linkers; FFA1 agonist; Ligand efficiency; OGTT; Type 2 diabetes

Indexed keywords

ACETAMIDE DERIVATIVE; ANTIDIABETIC AGENT; FASIGLIFAM; FREE FATTY ACID RECEPTOR 1 AGONIST; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; PHENOXYACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG; 2-(2-FLUORO-4-(2-(M-TOLYLOXY)ACETAMIDO)PHENOXY)ACETIC ACID; ACETANILIDE DERIVATIVE; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CHO CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SYNTHESIS; HYPERGLYCEMIA; IN VITRO STUDY; LIPOPHILICITY; MALE; MOLECULAR WEIGHT; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DIABETES MELLITUS, TYPE 2; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; SYNTHESIS;

ACETANILIDES; ANIMALS; CHO CELLS; CRICETULUS; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MALE; MICE, INBRED C57BL; MICE, INBRED ICR; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84943532246 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.09.010 Document Type: Article

Times cited : (33)

References (27)

1
- 77950891085
- O.J. Phung, J.M. Scholle, M. Talwar, and C.I. Coleman JAMA 303 2010 1410
- (2010) JAMA , vol.303 , pp. 1410
- Phung, O.J.¹ Scholle, J.M.² Talwar, M.³ Coleman, C.I.⁴

2
- 39049167200
- M.A. Avery, C.S. Mizuno, A.G. Chittiboyina, T.W. Kurtz, and H.A. Pershadsingh Curr. Med. Chem. 15 2008 61
- (2008) Curr. Med. Chem. , vol.15 , pp. 61
- Avery, M.A.¹ Mizuno, C.S.² Chittiboyina, A.G.³ Kurtz, T.W.⁴ Pershadsingh, H.A.⁵

3
- 84874184400
- S.A. Stein, E.M. Lamos, and S.N. Davis Expert Opin. Drug Saf. 12 2013 153
- (2013) Expert Opin. Drug Saf. , vol.12 , pp. 153
- Stein, S.A.¹ Lamos, E.M.² Davis, S.N.³

4
- 79959601676
- H.E. Lebovitz Nat. Rev. Endocrinol. 7 2011 408
- (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 408
- Lebovitz, H.E.¹

5
- 0037434991
- Y. Itoh, Y. Kawamata, M. Harada, M. Kobayashi, R. Fujii, S. Fukusumi, K. Ogi, M. Hosoya, Y. Tanaka, H. Uejima, H. Tanaka, M. Maruyama, R. Satoh, S. Okubo, H. Kizawa, H. Komatsu, F. Matsumura, Y. Noguchi, T. Shinobara, S. Hinuma, Y. Fujisawa, and M. Fujino Nature 422 2003 173
- (2003) Nature , vol.422 , pp. 173
- Itoh, Y.¹ Kawamata, Y.² Harada, M.³ Kobayashi, M.⁴ Fujii, R.⁵ Fukusumi, S.⁶ Ogi, K.⁷ Hosoya, M.⁸ Tanaka, Y.⁹ Uejima, H.¹⁰ Tanaka, H.¹¹ Maruyama, M.¹² Satoh, R.¹³ Okubo, S.¹⁴ Kizawa, H.¹⁵ Komatsu, H.¹⁶ Matsumura, F.¹⁷ Noguchi, Y.¹⁸ Shinobara, T.¹⁹ Hinuma, S.²⁰ Fujisawa, Y.²¹ Fujino, M.²² more..

6
- 0037838892
- C.P. Briscoe, M. Tadayyon, J.L. Andrews, W.G. Benson, J.K. Chambers, M.M. Eilert, C. Ellis, N.A. Elshourbagy, A.S. Goetz, D.T. Minnick, P.R. Murdock, H.R. Sauls, U. Shabon, L.D. Spinage, J.C. Strum, P.G. Szekeres, K.B. Tan, J.M. Way, D.M. Ignar, S. Wilson, and A.I. Muir J. Biol. Chem. 278 2003 11303
- (2003) J. Biol. Chem. , vol.278 , pp. 11303
- Briscoe, C.P.¹ Tadayyon, M.² Andrews, J.L.³ Benson, W.G.⁴ Chambers, J.K.⁵ Eilert, M.M.⁶ Ellis, C.⁷ Elshourbagy, N.A.⁸ Goetz, A.S.⁹ Minnick, D.T.¹⁰ Murdock, P.R.¹¹ Sauls, H.R.¹² Shabon, U.¹³ Spinage, L.D.¹⁴ Strum, J.C.¹⁵ Szekeres, P.G.¹⁶ Tan, K.B.¹⁷ Way, J.M.¹⁸ Ignar, D.M.¹⁹ Wilson, S.²⁰ Muir, A.I.²¹ more..

7
- 58149095589
- L.A. Stoddart, N.J. Smith, and G. Milligan Pharmacol. Rev. 60 2008 405
- (2008) Pharmacol. Rev. , vol.60 , pp. 405
- Stoddart, L.A.¹ Smith, N.J.² Milligan, G.³

8
- 69549111756
- P. Wellendorph, L.D. Johansen, and H. Bräuner-Osborne Mol. Pharmacol. 76 2009 453
- (2009) Mol. Pharmacol. , vol.76 , pp. 453
- Wellendorph, P.¹ Johansen, L.D.² Bräuner-Osborne, H.³

9
- 84918814911
- X. Wang, T. Zhao, B. Yang, Z. Li, J. Cui, Y. Dai, Q. Qiu, H. Qiang, W. Huang, and H. Qian Bioorg. Med. Chem. 23 2015 132
- (2015) Bioorg. Med. Chem. , vol.23 , pp. 132
- Wang, X.¹ Zhao, T.² Yang, B.³ Li, Z.⁴ Cui, J.⁵ Dai, Y.⁶ Qiu, Q.⁷ Qiang, H.⁸ Huang, W.⁹ Qian, H.¹⁰

10
- 77956500937
- N. Negoro, S. Sasaki, S. Mikami, M. Ito, M. Suzuki, Y. Tsujihata, R. Ito, A. Harada, K. Takeuchi, N. Suzuki, J. Miyazaki, T. Santou, T. Odani, N. Kanzaki, M. Funami, T. Tanaka, A. Kogame, S. Matsunaga, T. Yasuma, and Y. Momose ACS Med. Chem. Lett. 1 2010 290
- (2010) ACS Med. Chem. Lett. , vol.1 , pp. 290
- Negoro, N.¹ Sasaki, S.² Mikami, S.³ Ito, M.⁴ Suzuki, M.⁵ Tsujihata, Y.⁶ Ito, R.⁷ Harada, A.⁸ Takeuchi, K.⁹ Suzuki, N.¹⁰ Miyazaki, J.¹¹ Santou, T.¹² Odani, T.¹³ Kanzaki, N.¹⁴ Funami, M.¹⁵ Tanaka, T.¹⁶ Kogame, A.¹⁷ Matsunaga, S.¹⁸ Yasuma, T.¹⁹ Momose, Y.²⁰ more..

11
- 84860270451
- S. Mikami, S. Kitamura, N. Negoro, S. Sasaki, M. Suzuki, Y. Tsujihata, T. Miyazaki, R. Ito, N. Suzuki, J. Miyazaki, T. Santou, N. Kanzaki, M. Funami, T. Tanaka, T. Yasuma, and Y. Momose J. Med. Chem. 55 2012 3756
- (2012) J. Med. Chem. , vol.55 , pp. 3756
- Mikami, S.¹ Kitamura, S.² Negoro, N.³ Sasaki, S.⁴ Suzuki, M.⁵ Tsujihata, Y.⁶ Miyazaki, T.⁷ Ito, R.⁸ Suzuki, N.⁹ Miyazaki, J.¹⁰ Santou, T.¹¹ Kanzaki, N.¹² Funami, M.¹³ Tanaka, T.¹⁴ Yasuma, T.¹⁵ Momose, Y.¹⁶

12
- 84863115309
- N. Negoro, S. Sasaki, M. Ito, S. Kitamura, Y. Tsujihata, R. Ito, M. Suzuki, K. Takeuchi, N. Suzuki, J. Miyazaki, T. Santou, T. Odani, N. Kanzaki, M. Funami, T. Tanaka, T. Yasuma, and Y. Momose J. Med. Chem. 55 2012 1538
- (2012) J. Med. Chem. , vol.55 , pp. 1538
- Negoro, N.¹ Sasaki, S.² Ito, M.³ Kitamura, S.⁴ Tsujihata, Y.⁵ Ito, R.⁶ Suzuki, M.⁷ Takeuchi, K.⁸ Suzuki, N.⁹ Miyazaki, J.¹⁰ Santou, T.¹¹ Odani, T.¹² Kanzaki, N.¹³ Funami, M.¹⁴ Tanaka, T.¹⁵ Yasuma, T.¹⁶ Momose, Y.¹⁷

13
- 84855673463
- J.B. Houze, L. Zhu, Y. Sun, M. Akerman, W. Qiu, A.J. Zhang, R. Sharma, M. Schmitt, Y. Wang, J. Liu, J. Liu, J.C. Medina, J.D. Reagan, J. Luo, G. Tonn, J. Zhang, J.Y.-L. Lu, M. Chen, E. Lopez, K. Nguyen, L. Yang, L. Tang, H. Tian, S.J. Shuttleworth, and D.C.H. Lin Bioorg. Med. Chem. Lett. 22 2012 1267
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1267
- Houze, J.B.¹ Zhu, L.² Sun, Y.³ Akerman, M.⁴ Qiu, W.⁵ Zhang, A.J.⁶ Sharma, R.⁷ Schmitt, M.⁸ Wang, Y.⁹ Liu, J.¹⁰ Liu, J.¹¹ Medina, J.C.¹² Reagan, J.D.¹³ Luo, J.¹⁴ Tonn, G.¹⁵ Zhang, J.¹⁶ Lu, J.Y.-L.¹⁷ Chen, M.¹⁸ Lopez, E.¹⁹ Nguyen, K.²⁰ more..

14
- 84866357145
- S.P. Brown, P.J. Dransfield, M. Vimolratana, X. Jiao, L. Zhu, V. Pattaropong, Y. Sun, J. Liu, J. Luo, J. Zhang, S. Wong, R. Zhuang, Q. Guo, F. Li, J.C. Medina, G. Swaminath, D.C.H. Lin, and J.B. Houze ACS Med. Chem. Lett. 3 2012 726
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 726
- Brown, S.P.¹ Dransfield, P.J.² Vimolratana, M.³ Jiao, X.⁴ Zhu, L.⁵ Pattaropong, V.⁶ Sun, Y.⁷ Liu, J.⁸ Luo, J.⁹ Zhang, J.¹⁰ Wong, S.¹¹ Zhuang, R.¹² Guo, Q.¹³ Li, F.¹⁴ Medina, J.C.¹⁵ Swaminath, G.¹⁶ Lin, D.C.H.¹⁷ Houze, J.B.¹⁸

15
- 84879092042
- Y. Wang, J. Liu, P.J. Dransfield, L. Zhu, Z. Wang, X. Du, X. Jiao, Y. Su, A.-R. Li, S.P. Brown, A. Kasparian, M. Vimolratana, M. Yu, V. Pattaropong, J.B. Houze, G. Swaminath, T. Thanhvien, N. Khanh, Q. Guo, J. Zhang, R. Zhuang, F. Li, L. Miao, M.D. Bartberger, T.L. Correll, D. Chow, S. Wong, J. Luo, D.C.H. Lin, and J.C. Medina ACS Med. Chem. Lett. 4 2013 551
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 551
- Wang, Y.¹ Liu, J.² Dransfield, P.J.³ Zhu, L.⁴ Wang, Z.⁵ Du, X.⁶ Jiao, X.⁷ Su, Y.⁸ Li, A.-R.⁹ Brown, S.P.¹⁰ Kasparian, A.¹¹ Vimolratana, M.¹² Yu, M.¹³ Pattaropong, V.¹⁴ Houze, J.B.¹⁵ Swaminath, G.¹⁶ Thanhvien, T.¹⁷ Khanh, N.¹⁸ Guo, Q.¹⁹ Zhang, J.²⁰ more..

16
- 84902546389
- E. Defossa, and M. Wagner Bioorg. Med. Chem. Lett. 24 2014 2991
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2991
- Defossa, E.¹ Wagner, M.²

17
- 39149097541
- I.G. Tikhonova, C.S. Sum, S. Neumann, S. Engel, B.M. Raaka, S. Costanzi, and M.C. Gershengorn J. Med. Chem. 51 2008 625
- (2008) J. Med. Chem. , vol.51 , pp. 625
- Tikhonova, I.G.¹ Sum, C.S.² Neumann, S.³ Engel, S.⁴ Raaka, B.M.⁵ Costanzi, S.⁶ Gershengorn, M.C.⁷

18
- 84870249445
- C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Adv. Drug Deliv. Rev. 64 2012 4
- (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 4
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

19
- 80053910894
- E. Christiansen, C. Urban, M. Grundmann, M.E. Due-Hansen, E. Hagesaether, J. Schmidt, L. Pardo, S. Ullrich, E. Kostenis, M. Kassack, and T. Ulven J. Med. Chem. 54 2011 6691
- (2011) J. Med. Chem. , vol.54 , pp. 6691
- Christiansen, E.¹ Urban, C.² Grundmann, M.³ Due-Hansen, M.E.⁴ Hagesaether, E.⁵ Schmidt, J.⁶ Pardo, L.⁷ Ullrich, S.⁸ Kostenis, E.⁹ Kassack, M.¹⁰ Ulven, T.¹¹

20
- 77749315417
- M.J. Waring Expert Opin. Drug Discov. 5 2010 235
- (2010) Expert Opin. Drug Discov. , vol.5 , pp. 235
- Waring, M.J.¹

21
- 61649109015
- G.M. Keserü, and G.M. Makara Nat. Rev. Drug Disc. 8 2009 203
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 203
- Keserü, G.M.¹ Makara, G.M.²

22
- 84938495908
- P.D. Leeson, and R.J. Young ACS Med. Chem. Lett. 6 2015 722
- (2015) ACS Med. Chem. Lett. , vol.6 , pp. 722
- Leeson, P.D.¹ Young, R.J.²

23
- 39749181550
- M.P. Gleeson J. Med. Chem. 51 2008 817
- (2008) J. Med. Chem. , vol.51 , pp. 817
- Gleeson, M.P.¹

24
- 1942453243
- A.L. Hopkins, C.R. Groom, and A. Alex Drug Discovery Today 9 2004 430
- (2004) Drug Discovery Today , vol.9 , pp. 430
- Hopkins, A.L.¹ Groom, C.R.² Alex, A.³

25
- 35748934487
- P.D. Leeson, and B. Springthorpe Nat. Rev. Drug Disc. 6 2007 881
- (2007) Nat. Rev. Drug Disc. , vol.6 , pp. 881
- Leeson, P.D.¹ Springthorpe, B.²

26
- 3543009434
- M.S. Winzell, and B. Ahrén Diabetes 53 2004 215
- (2004) Diabetes , vol.53 , pp. 215
- Winzell, M.S.¹ Ahrén, B.²

27
- 70349120958
- J.A. Koehler, L.L. Baggio, B.J. Lamont, S. Ali, and D.J. Drucker Diabetes 58 2009 2148
- (2009) Diabetes , vol.58 , pp. 2148
- Koehler, J.A.¹ Baggio, L.L.² Lamont, B.J.³ Ali, S.⁴ Drucker, D.J.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.