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Volumn 23, Issue 1, 2015, Pages 132-140
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Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists
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Author keywords
FFA1 agonist; Oral glucose tolerance test; Phenoxyacetic acid oxidation
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Indexed keywords
1 (3 FLUORO 4 HYDROXYPHENYL)ETHANONE;
2 FLUOROPHENYL ACETATE;
2 [2 CHLORO 4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1'BIPHENYL) 3 YL]METHOXY] 2 FLUOROPHENOXY] 2 METHYLPROPANOIC ACID;
2 [2 CHLORO 4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1'BIPHENYL) 3 YL]METHOXY]PHENOXY] 2 METHYLPROPANOIC ACID;
2 [2 CHLORO 4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1'BIPHENYL) 3 YL]METHOXY]PHENOXY]ACETIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] 2 ETHYLPHENOXY]ACETIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] 2 METHYLPHENOXY]ACETIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] PHENOXY] 2 METYLPROPANOIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY]PHENOXY]ACETIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY]PHENOXY]BUTANOIC ACID;
2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY]PHENOXY]PROPANOIC ACID;
2 [4 [[2',6'DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] 2 ETHYLPHENOXY] 2 METHYLPROPANOIC ACID;
2 [4 [[2',6'DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] 2 FLUOROPHENOXY]ACETIC ACID;
3' (BROMOMETHYL) 2,6 DIMETHYL 4 [3 (METHYLSULFONYL)PROPOXY] 1,1' BIPHENYL;
G PROTEIN COUPLED RECEPTOR 40;
GLUCOSE;
HYDRATROPIC ACID;
INSULIN;
METHYL 2 (2 FLUORO 4 HYDROXYPHENOXY)ACETATE;
METHYL 2 (4 ACETOXY 2 FLUOROPHENOXY)ACETATE;
METHYL 2 (4 ACETOXYPHENOXY)ACETATE;
METHYL 2 (4 ACETYL 2 FLUOROPHENOXY)ACETATE;
METHYL 2 (4 ACETYLPHENOXY)ACETATE;
METHYL 2 (4 HYDROXYPHENOXY)ACETATE;
METHYL 2 PHENOXYACETATE;
METHYL 2 [4 [[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL)3 YL]METHOXY]PHENOXY]ACETATE;
METHYL 2 [4 [[2',6'DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] (1,1' BIPHENYL) 3 YL]METHOXY] 2 FLUOROPHENOXY]ACETATE;
PHENOXYACETIC ACID DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
[2',6' DIMETHYL 4' [3 (METHYLSULFONYL)PROPOXY] [1,1' BIPHENYL] 3 YL]METHANOL;
ACETIC ACID DERIVATIVE;
FFAR1 PROTEIN, HUMAN;
G PROTEIN COUPLED RECEPTOR;
PHENOXYACETIC ACID;
AREA UNDER THE CURVE;
ARTICLE;
CONTROLLED STUDY;
DRUG ABSORPTION;
DRUG ACTIVITY;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
EC50;
GLUCOSE BLOOD LEVEL;
HYPOGLYCEMIA;
IN VITRO STUDY;
IN VIVO STUDY;
INSULIN RELEASE;
MOUSE;
NON INSULIN DEPENDENT DIABETES MELLITUS;
NONHUMAN;
ORAL GLUCOSE TOLERANCE TEST;
PANCREAS ISLET BETA CELL;
STRUCTURE ACTIVITY RELATION;
AGONISTS;
ANIMAL;
C57BL MOUSE;
CHEMICAL STRUCTURE;
CHEMISTRY;
DIABETES MELLITUS, TYPE 2;
INSTITUTE FOR CANCER RESEARCH MOUSE;
MALE;
METABOLISM;
RAT;
SYNTHESIS;
MUS;
ACETATES;
ANIMALS;
DIABETES MELLITUS, TYPE 2;
MALE;
MICE;
MICE, INBRED C57BL;
MICE, INBRED ICR;
MODELS, MOLECULAR;
RATS;
RECEPTORS, G-PROTEIN-COUPLED;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84918814911
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.11.016 Document Type: Article |
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Times cited : (30)
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References (28)
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